Domestic Suzuki New Alto appeared in Beijing.

　　Recently, when Sohu netizens went to a 4S shop in Changan Suzuki for maintenance, they found a new Alto parked in the corner of the shop, which had been heated by major media. They walked over and observed it carefully, and found that the whole car was fine in workmanship, and the pink metallic paint was very bright. The teardrop-shaped headlights on the front of the car were the highlights of the whole car, which raised a lot of spirits for this car. The large-mouth grille follows the design idea of big brother Audi, but it has a lovely appearance on Alto’s little face. The Suzuki "S" chrome-plated logo on the big mouth is huge and eye-catching, which plays a finishing touch for this cute and playful little face.

Car side modeling dynamic fashion body length 3500mm.

　　The side shape of the car body feels familiar. The relatively long front door and short rear door are typical design ideas of a five-door mini-car. The lower edge of the window that rises all the way extends from the A-pillar to the C-pillar, which is dynamic and fashionable. However, due to the body length of 3500mm and the narrow rear door design, the rear door window has become a triangle-like shape. However, the domestic Alto of Changan Suzuki version is different from the European version. The rear door window does not use a low-cost negative pressure ventilation window, but is replaced by an electric lifting window to cater to the tastes of Chinese people, which greatly improves the convenience of use. The overall shape of the side of the car body is similar to that of Global Hawk Panda and BYD F0 listed earlier, which is fashionable and full of vigor.

　　The domestic new Alto’s wheelbase of 2340mm belongs to the middle and upper class among mini-cars, which is longer than that of Global Hawk Panda and BYD F0, and similar to that of Changan Benben of 2365mm. The body width of 1600mm is slightly narrower than that of competitors, and the height of 1470mm is basically the same as that of Panda and F0, and slightly shorter than that of Changan Benben.

Unique tail shape

The tailgate opening is slightly narrow and the trunk is shallow.

　　The shape of the rear part of the car body is unique, probably because the bumper is lifted to a higher position to protect the shorter car body, and the whole rear wall occupies about 2/5 of the rear of the car, which is very full. However, this design also brings inconvenience, that is, the opening of the tailgate becomes higher, and the fashionable three-dimensional crystal diamond combined taillights occupy a large area, which makes the opening of the tailgate narrow, the depth of the trunk is shallow, and it is difficult to enlarge something. The overall shape of the tail is avant-garde, and the logo of Changan Suzuki shows its domestic identity. The high-position brake lights are dotted on the small tail behind the roof, which not only attaches importance to safety but also does not lose fashion.

Design of front McPherson independent suspension and rear trailing arm independent suspension plus lateral stabilizer bar

　　In the aspect of suspension, the new Alto adopts the typical small car design of front McPherson independent suspension and rear trailing arm independent suspension plus lateral stabilizer bar, which saves cost and chassis space while ensuring certain comfort.

Alto adopts 155/65 R14 Jinhu tire and 8 aluminum alloy wheels

　　In terms of wheels, the new Alto high-profile model uses 14-inch 8 aluminum alloy wheels, which are fashionable in shape. 155/65 R14 Jinhu tire seems to be not very kind, and its main competitors are almost all 165 treads. The narrower tire reduces handling but has an advantage in fuel consumption.

　　Like domestic cars with the same price, New Alto is equipped with front disc and rear drum brakes, which is enough for cars with less than 1 ton.

　　Open the door and get into the car. Like Swift and SX4, the interior of the new Alto focuses on simple and fashionable routes, with the same color scheme as the mainstream sedan. The steering wheel shape makes people see at a glance that this is a Suzuki model, which is exactly the same as SX4 and Swift. It is made of PVC, but it looks very big in the petite cockpit of Alto, and it should be more harmonious if it can be designed with smaller points. The new Alto dashboard has a distinctive shape. The huge speedometer occupies the front of the driver’s line of sight. Under the orange background light, the automatic gear position is displayed, and all kinds of warning lights are arranged around the speedometer. On the LCD panel below, information such as clock, mileage and fuel gauge is integrated. The cancellation of the water thermometer shows Suzuki’s confidence in the product.

　　The highlight is the new Alto’s tachometer. On the dashboard in front of the driver’s line of sight on the left, a tachometer is independently designed, which is similar to BYD F0’s design, except that the new Alto’s instrument uses a red background light with a scarlet letter on a black background, which is very outstanding in modification style and adds features to the overall interior modeling.

　　Looking at the whole interior, the new Alto, as a joint venture model, has no outstanding advantages in terms of materials and equipment quality. Under the cost control, the overall level is close to that of domestic models. In terms of vehicle configuration, this experience is an automatic top-mounted vehicle. The gear shifting mechanism is the same as that of Swift, and the shape of the gear shifting base and handle is basically the same. Double airbags, ABS brakes, manual air conditioners, electric rearview mirrors, four-door electric windows with central door locks and remote control keys have become standard equipment for high-equipped vehicles, while four-speaker single-disc CD audio and AUX interface cater to the tastes of young people. The seat adopts manual 4-way adjustment, and the material is a combination of gray flannel and light leather material. In design, the front seat uses the integrated design of seat headrest and has the logo of ALTO, which makes it more comfortable to sit on, but the wrapping is not strong. The headrest of the rear seat is detachable, but the backrest is straight, so I’m afraid it’s uncomfortable to sit for a long time. The whole interior is mainly practical, and there are many necessary conveniences and equipment, while others can be saved. The interior made of plastic and flannel is basically in line with the market positioning of Alto, a mini car.

　　In terms of space, as long as the height is not higher than 185cm, the head space is still sufficient, while the leg space is slightly cramped. There is no problem in short-distance transportation in the city. If you are too tall for a long distance, you will feel bad.

　　It is understood that this car is a trial version of the model, and it is still quite different from the model listed later in the interior and engine compartment.

　　When the car is on fire when the sales are not available, I feel that the sound of ignition is fragile and light. During idling, the car vibrates very little. You even suspect that it uses a 3-cylinder engine, giving people the feeling of a high-end car. Suzuki K10B is really a good machine. Listen to the idling noise on the door. If the tachometer doesn’t point to 800 revolutions, I even doubt whether the engine is running. I found the secret of silence when I opened the hood. It turns out that the new Alto is there. On the nameplate below the car body, the engine power is written as 48Kw, and the compression ratio is reduced and adjusted compared with the previously publicized machine with 50Kw compression ratio of 11: 1. In order to adapt domestic Alto to the ration of 93rd gasoline, it is worthwhile to sacrifice some power.

Photo of old and new Alto

　　Due to the small space, I didn’t test drive for a short experience, but I was deeply impressed by the new Alto. Typical urban scooter and automatic transmission models are very suitable for shuttle in cities, and the 1.0L engine has obvious advantages in fuel consumption. In terms of energy saving and styling design, it has won the favor of many people. In September, the new Alto will be listed soon. In the highly competitive car market, the role of price guiding sales is very obvious. The new Alto has already occupied the absolute advantage of brand and reputation. So, can this old car sell well? Let’s wait for the price of the new Alto, and please continue to pay attention to Sohu Auto’s follow-up reports on the new Alto.

　　Copyright statement: This article is the exclusive manuscript of Sohu Auto, and the copyright belongs to Sohu Auto. It may not be reproduced without permission, and will be investigated once it is found.

General rule

On the evening of March 19th, the 2023 performance report was disclosed.

In 2023, the operating income reached 372.6 billion yuan, up 5.0% year-on-year, and the net profit returned to the mother reached 8.2 billion yuan, up 12% year-on-year, achieving double-digit increase for seven consecutive years; The return on net assets reached 5.1%, achieving a good level in recent years; The capital expenditure is 73.9 billion yuan, and the network investment shows an inflection point.

Over the past year, we have focused on the coordinated development of the two main businesses, successfully achieved effective improvement in quality and reasonable growth in quantity, and laid a solid foundation for long-term development. Behind this is always solidly promoting the deepening of the strategic system, focusing on both scale growth and value enhancement.

Responsible for the main business, fruitful business performance has reached a new high.　　

In recent years, with the promotion of national policies,Data application promotion, etc., the number of Internet users continues to expand.,It has promoted emerging forms such as artificial intelligence and big data to continuously empower the development of traditional industries.,The continuous emergence of industrial digital integration application results has promoted the continuous release of data traffic market demand. As a leading enterprise in the field of communication, it has ushered in broad development opportunities.

Under the wave of digital economy development,Actively embrace the strategic opportunities brought by the same frequency resonance between Chinese modernization and the new generation of digital revolution.In 2023, innovation and transformation will continue to deepen. The business of computing network and intelligence realized a revenue of 75.2 billion yuan, which brought more than half of the new income to the company.

Among them, "Unicom Cloud" business continued to grow steadily, achieving a revenue of 51 billion yuan, a year-on-year increase of 41.6%. The sales of cloud resources exceeded one million cores, a year-on-year increase of 186%, and the coverage of cloud resources has exceeded 230 cities. In 2023, innovations were made in technological innovation and ecological co-construction, the level of independent research and development was further improved, and the dual-engine bases of "virtualization" and "cloud native" were continuously optimized. More than 3,300 sets of self-developed operating system CULinux2.2 were deployed.

With the empowerment of 5G technology, the large-scale development of digital intelligence applications has also achieved remarkable results. There are 30,000 application projects in the 5G industry, covering 71 categories of the national economy, serving over 8,500 customers of 5G private networks, and forming a leading edge in key industries such as industrial Internet, digital government and car networking.

In the 2024 work conference, it was pointed out that it is necessary to solidly promote high-level security. In the past year, we focused on key directions such as network security, data security and information security, and strengthened the strategic business layout of big security. Not only did it build the first digital security operation center for super-large cities in China for customers, but it also landed more than 50 benchmark projects, and actively promoted open cooperation in security ecology, supporting the growth of network security income by 120% year-on-year.

Today, the industry share of data services has exceeded 50% for five consecutive years, leading the industry. With the rapid development of the network intelligence service, the network communication service has also made steady progress.

In 2023, the revenue of networked communication business was 244.6 billion yuan, and the scale of connection was further expanded, with more than 1 billion networked communication users, an increase of about 140 million compared with the end of 2022. Among them, the number of mobile users reached 333 million. In 2023, the net increase of users increased by 90% year-on-year, and the penetration rate of 5G package users also increased by 12 percentage points to 78% compared with last year. The "basic disk" was further consolidated.

Scientific and technological innovation speeds up and the dividend level reaches a record high.

This year’s government work report not only clearly puts forward "vigorously developing the digital economy", but also puts forward clear requirements for "accelerating the development of new quality productive forces" and "promoting industrial innovation with scientific and technological innovation". As one of the three major operators, it is timely and timely to develop new quality productivity.

It is said that the field of artificial intelligence has become an important strategic direction. The company is accelerating the layout of emerging industries of artificial intelligence, combining its advantages in computing network infrastructure, rich business scenarios and extensive customer contacts, and making efforts to create a large model development and application paradigm with Unicom characteristics. At the Mobile World Congress, the "Yuanjing" large model system was launched, and multi-parameter versions were arranged according to different functional requirements to promote the large model to better empower the real economy application scenarios. Relevant achievements were selected as "Wu Wenjun Artificial Intelligence Science and Technology Award", and the innovation ability was further enhanced.

At the same time, it is emphasized that the overall layout of satellite communication will be further accelerated in the later period, and the industrialization and systematic development of integrated communication between heaven and earth will be actively promoted.

In 2023, we will actively promote key core technology research, focus on promoting industrial innovation with scientific and technological innovation, and continuously enhance core competitiveness. During the year, 2,287 patents were granted, up 37% year-on-year, and attention was paid to the construction of scientific and technological innovation talents, whose proportion reached 40%. Standing at a new starting point, scientific and technological innovation has been further intensified, and it has actively become a national strategic scientific and technological force and a "vanguard" for developing new quality productive forces.

With the arrival of the computing power era, the long-term prospects of the company are further optimistic by investors. It also actively gives back to the trust and support of investors. The annual report shows that in 2023, the final dividend per share will be 0.0524 yuan (including tax), together with the already distributed interim dividend of 0.0796 yuan per share, and the total annual dividend per share will be 0.132 yuan, up 21.1% year-on-year, significantly higher than the growth of basic earnings per share of 11.5%, and the cash dividend level will reach a record high.

Talking about the key work in 2024, Chairman Chen Zhongyue said that he would persist in striving for progress while maintaining stability, and thoroughly implement the five strategies of strengthening enterprises through science and technology, talents, reform, digital intelligence and brand, and thoroughly implement the nine key action plans of networking communication development, computer network integration development, digital intelligence application development, internationalization development, big data innovation, artificial intelligence innovation, new digital infrastructure, high-quality service and network information security, and accelerate to become. We are confident that we will continue to maintain steady growth in operating income and double-digit growth in total profits.

Recently, a doctor in Rizhao City, Shandong Province was arrested for allegedly broadcasting gynecological surgery clips online, which aroused social concern and boarded a hot search. On the evening of 18th, WeChat official account, WeChat of Donggang Branch of Rizhao Public Security Bureau issued a briefing: At about 16: 00 on January 18th, 2022, Donggang Branch of Rizhao Public Security Bureau received a report from the masses that a doctor was suspected of broadcasting a video of gynecological surgery online, so it immediately investigated the relevant personnel of the hospital involved and arrested Li Mou, the doctor involved, at about 18: 00.

In response, bilibili said: After internal verification, the studio was repeatedly warned and cut off during the live broadcast on January 15th, and then it was permanently banned. At present, we have reported to the public security organs and will actively cooperate with the police to carry out investigation and evidence collection.

Coincidentally, on January 17th, some netizens revealed that some users uploaded surveillance videos in bilibili that were suspected to be obtained after cracking cameras in public places.

Judging from the live screen shots, these live images should come from surveillance cameras in public places such as schools and hospitals. Netizens suspect that there are gangs specializing in cracking surveillance videos in schools, hospitals and other public places, which are used for live broadcast to attract traffic and attract users to pay for it.

In view of this situation, bilibili official Weibo issued a handling notice on January 17th: "Today, we received a report from a user that someone suspected of using illegal means to crack the camera and upload a video surveillance screen to bilibili. We organized the investigation for the first time and removed the relevant content. "

Bilibili said that this kind of behavior is a serious violation of personal privacy, which is illegal. Once found, it will be dealt with seriously according to law. If users find such content, please contact online customer service immediately.

In this regard, netizens questioned the effectiveness of bilibili’s audit mechanism. Why do users need to find problems and bilibili will deal with them? A live broadcast of a problem like a doctor’s live broadcast of gynecological surgery, when discovered by users, has actually caused privacy leakage and spread of problems. Is it necessary for bilibili to do this kind of thing all the time?

Upstream Xiaobian consulted bilibili customer service about the standards and principles of live audit, but did not receive a response.

In this regard, some people in the industry said that because the live content belongs to real-time streaming media, the platform can’t review the "content that hasn’t happened". Therefore, before the broadcast of the anchor, the anchor is generally required to sign a live broadcast specification agreement. "In fact, it is the responsibility to move forward and tell the anchor what content is illegal and can’t be broadcast, and the punishment that will be faced after the live broadcast is illegal. As long as the anchor broadcasts, it means recognition and consent." The source said that at present, the live broadcast industry adopts this method, so whether the live broadcast content is illegal or not can basically only rely on the anchor’s consciousness. What the platform can do is only to conduct audit and supervision during the live broadcast.

The above-mentioned person further introduced that at present, the audit in live broadcast mainly adopts the combination of AI audit and manual audit.

AI audit is to take screenshots of live pictures at regular intervals, and then intelligently identify the pictures. "AI audit can’t accurately understand the live content, and the recognition accuracy of illegal pictures will be different according to the AI ? ? engine used." The source said that the higher the recognition rate and the faster the recognition speed, the higher the AI deployment cost, which puts higher demands on the funds of the live broadcast platform, and it is difficult for some small platforms to bear high technical costs.

The upstream Xiaobian search "AI Audit" found that many companies in China have developed related software and platforms. Some of these platforms clearly stated in the introduction to the live AI audit that "screenshots are supported".

"To accurately identify whether the live content is illegal, manual review is the most reliable." The above-mentioned people said that bilibili had always been famous for its strict auditing, because it was rumored in the industry that bilibili was fully audited manually. "But the biggest drawback of manual auditing is its slow speed." He explained that the mainstream live broadcast platform has thousands of live broadcast rooms at the same time, but it is impossible for the platform to be equipped with so many auditors. Therefore, when the manual audit finds problems, the illegal live broadcast content may have been broadcast for some time. "This is why bilibili encourages users to report, which is equivalent to asking users to be free auditors." The person said.

[Disclaimer] Manuscripts not marked with "Source: Upstream News" or "Upstream News LOGO, Watermark Text, Pictures, Audio and Video" on the upstream news client are all reposted. If the reposted manuscript involves copyright issues, pleaseContact upstream.

　　On April 25th, 2024, the 18th auto china will officially open in Shunyi Pavilion of China International Exhibition Center. At that time, BYD will land at booth W106 in Hall W1, in which the lineup of Ocean Network will be exposed, and a number of brand-new models, such as Seal 06DM-i, Sea Lion 07EV and concept car OCEAN-M, will be unveiled hand in hand.

　　The new medium-sized car, Seal 06DM-i will be equipped with the latest technology.

　　Seal 06DM-i is a brand-new medium-sized car under BYD Ocean Network, which is positioned between destroyer 05 and seal DM-i.. It is reported that Seal 06DM-i will be equipped with BYD’s latest technology, and the chassis quality and safety control will be greatly improved. The sword refers to the joint venture fuel medium-sized car market.

　　Seal 06DM-i continues the marine aesthetic design, with a body size of 4830*1875*1495mm and a wheelbase of 2790mm, reaching the level of mainstream medium-sized cars; In terms of power, Seal 06DM-i will adopt a 1.5L engine and provide 120kW and 160kW motors.

　　Ocean Net’s first medium-sized pure electric SUV, Sea Lion 07EV is equipped with "Eye of God" high-order intelligent driving.

　　BYD Haishi 07EV is positioned as a "medium-sized urban smart electric SUV", which is based on BYD’s latest pure electric platform technology. It is the first medium-sized pure electric SUV of Ocean Net and the first model of Ocean Net’s brand-new Haishi IP. Sea lion 07EV combines the latest pure electric platform technology and forward-looking aesthetic thought, and integrates face value, safety, comfort, intelligence, performance and efficiency. At the same time, based on the advanced electronic and electrical architecture, Sea Lion 07EV adopts the advanced version of intelligent cockpit -DiLink 100 and the advanced intelligent driving assistance system of Eye of God -DiPilot 100, which brings users a full-scale intelligent travel experience.

　　BYD Sea Lion 07EV will further expand the product matrix of Ocean Net, strengthen the layout of Ocean Net in the field of high-value products, and meet the yearning and pursuit of more young consumers for high-quality driving life.

　　The industry’s first hatchback rear-drive pure electric steel gun, the world’s first show of OCEAN-M concept car.

　　The brand-new concept car OCEAN-M will also make its world debut. As the first rear-drive pure electric steel gun model in the industry, it has a brand-new advanced aesthetic design and is equipped with a brand-new pure electric platform. It is another masterpiece of BYD Ocean, which focuses on the promotion and popularization of new energy vehicles, and deserves continuous attention.

　　Summary:

　　BYD Ocean Network brought a number of brand-new models to the Beijing Auto Show. Seal 06DM-i and Sea Lion 07EV will form a brand-new "Gemini", which will empower new experiences with the latest technology and become the most anticipated new energy vehicle at this Beijing Auto Show. OCEAN-M concept car will show the future charm of Ocean Network with the posture of seeing the future now. On April 25th, auto china BYD booth, let’s pay attention together!

　　In 2018, a realistic Dying to Survive hit a 3.1 billion summer box office champion. While countless people are sighing and moving, how to make the "sky-high life-saving medicine" accessible to ordinary patients has become a topic of general public concern.

　　The leukemia drug in this film — — Gleevec (imatinib mesylate) is a microcosm of high-priced drugs. This drug developed by Novartis Pharmaceutical entered China in early 2004, and the price of the original drug was as high as.23,500 yuan(120 tablets/box).

　　According to the first financial reporter, in the past decade, more and more manufacturers have entered the market of leukemia treatment drugs, making the price of this "life-saving medicine" drop again and again.

　　According to the data of CHIS kaisi system of Zhongkang Technology, the retail terminal price of Gleevec has been declining in the past three years, and the retail market price in 2022 will be6449.32 yuan. The reporter saw on an e-commerce platform on July 22 that the price of Gleevec’s original drug was mostly1700 yuan ~1800 yuanBetween

　　With the approval of more and more domestic generic drugs, the lowest price of domestic imatinib mesylate tablets has dropped to.144 yuan/boxIt is about 1.2% of the original price of the drug. At present, the sales price of Gleevec on the e-commerce platform is more than 1,700 yuan, which is nearly 90% lower than when Novartis first entered the China market.

　　The price of "life-saving medicine" continues to drop.

　　On July 19th, Hubei Provincial Medical Insurance Bureau posted a Notice on Publicizing the Information about the First to Fifth Batch of Non-selected Varieties in Centralized Drug Purchase by the State Organization, which stated that the first to fifth batches of centralized drug purchase by the State Organization had been carried out with the non-selected varieties under the generic name over-evaluated, the online price adjusted, the online suspension and the handling of complaints. On this basis, the medical insurance payment standard and other related work were drawn up, and a list of non-selected varieties to be online was formed. The publicity date of this list is from July 19 to July 23, 2023.

　　The online price of drugs refers to the published price of drugs on the centralized procurement platform of medical equipment in Hubei Province for the procurement of public medical institutions in the province. According to the regulations, all public medical institutions in Wuhan must purchase the drugs that have been hung on the net through the provincial centralized procurement platform for medical equipment when implementing the online procurement policy, and must not purchase from offline and other non-prescribed channels. The price of drugs hanging on the net is the highest price limit of public medical institutions in the city.

　　The list of the first batch of non-selected varieties to be hung on the net shows that there are6 imatinib mesylateAmong them, in addition to the original research drug Novartis Pharmaceutical, there are also five models, namely Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical, Chongqing Yaoyou and Sinopharm Yixin, all of which have been evaluated.

　　In terms of price, the highest hanging net is still Gleevec.7182 yuan. Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical and Sinopharm are all interested in imatinib mesylate. The online price is only.More than 500Yuan.

　　Even if the net price is 7,182 yuan, the price of the original drug Gleevec has dropped by nearly 40% compared with 23,500 yuan (120 tablets/box) when it first entered the China market.

　　According to the data of CHIS kaisi system of Zhongkang Technology, although the price of Gleevec in the hospital has remained at around 7182 yuan in the past three years, the price of retail terminals has been declining. In 2022, the retail market price will be6449.32 yuan.

　　The reporter’s search for "imatinib mesylate" on an e-commerce platform shows that the price of Gleevec’s original drug is only 0.1g*60 tablets/box as the standard in most pharmacies.1700 yuan ~1800 yuanBetween, and the price of domestic medicine is in500 yuanAbout. For example, the price of Xinwei tablets in Jiangsu Haosen is 430 yuan, the price of Genico capsules in Zhengda Tianqing is 441.88 yuan, and the lowest price is Shengdika tablets produced by Chongqing Shenghuaxi Pharmaceutical Co., Ltd., with an estimated hand price of 144 yuan.

　　nineDomestic companies were approved for production.

　　More and more cheap domestic "life-saving drugs" appeared, which was related to the end of the protection period of the compound patent of imatinib in China in April 2013, and domestic generic drugs began to be produced and listed.

　　From June 2013 to October 2014, three domestic generic drugs of Jiangsu Haosen, Zhengda Tianqing and Shiyao Ouyi obtained production approval. Because the efficacy of generic drugs has not been verified, the original drug of Novartis, Gleevec, still occupied most of the market. According to public data, in 2016, imatinib mesylate tablets sold more than 4 billion US dollars worldwide.

　　The competitiveness of domestic drugs began to improve after 2018. From 2018 to 2020, the above three drugs passed the consistency evaluation successively. On July 5, 2018, Jiangsu Haosen Pharmaceutical Co., Ltd. said that it had received the Approval Document for Supplementary Application of Imatinib, a chemical drug approved and issued by National Medical Products Administration, and the National Drug Testing Center recommended that it pass the consistency evaluation, making it the first enterprise to pass the consistency evaluation of this drug.

　　Overevaluation means that drugs have reached the passing line in quality and efficacy, and generic drugs have become more competitive. In September 2018, Hansen Pharmaceutical (Haosen Pharmaceutical) disclosed the prospectus for listing in Hong Kong, showing that the sales revenue of the core product imatinib mesylate in 2017 was RMB 2.5 billion, up by 7.3% since 2016, and up to June 30, 2018, up by 34.5% compared with the same period of last year.

　　With the entry of imatinib mesylate tablets into the medical insurance catalogue in 2017, more manufacturers entered this field. National Medical Products Administration website shows that the domestic imatinib mesylateNine manufacturers have been approved.Unacon Ouyi Pharmaceutical, Zhengda Tianqing, Qilu Pharmaceutical, Shenzhen Xinlitai Pharmaceutical, Chongqing Yaoyou Pharmaceutical, Lianyungang Runzhong Pharmaceutical, Shanghai Nuochuang Pharmaceutical, Fujian Nanfang Pharmaceutical and Chongqing Shenghuaxi Pharmaceutical, among which Shanghai Nuochuang Pharmaceutical and Fujian Nanfang Pharmaceutical successivelyMay and June this yearJust approved.

　　What followed was that prices kept falling.

　　In 2018, imatinib mesylate tablets of Jiangsu Haosen Pharmaceutical Co., Ltd. won the bid in four municipalities directly under the Central Government, including Beijing, Tianjin, Shanghai and Chongqing, and 11 cities (referred to as "4+7" cities) including Shenyang, Guangzhou, Chengdu and Xi ‘an, with the winning price of 623.82 yuan per box. In 2019, the "4+7" procurement expanded, and Zhengda Tianqing won the bid at a price of 586.39 yuan, further reducing the price of this drug.

　　In August, 2022, Shanghai issued a price adjustment notice, and the adjusted purchase price of imatinib mesylate tablets produced by Shiyao Ouyi has dropped to 180 yuan/box.

　　The lower price of domestic drugs also impacts the price of original drugs.

　　In 2018, the joint bargaining of imported anticancer drugs in 14 provinces including Shaanxi was completed, and 47 anticancer drugs including Gleevec were successfully negotiated. According to the announcement, the bargaining result of Gleevec’s specification of 0.1g*60 tablets was 9998 yuan.

　　In 2019, according to the previous report of CBN, the price of the original drug Gleevec in Shanghai has dropped to 7182 yuan/box, which is about 30% lower than the market price of around 11,000 yuan at that time.

　　New progress

　　It is worth mentioning that with the increase of drug resistance caused by long-term medication, Gleevec’s R&D iteration has also attracted much attention.

　　The second and third generation BCR-ABL inhibitors have been developed in order to solve the drug resistance problem and improve the safety. Dashatinib from Bristol-Myers Squibb and Nilotinib from Novartis were introduced one after another, which made the second generation BCR-ABL inhibitors gradually occupy an important position in the first-line and second-line treatment of chronic myeloid leukemia. However, the problem of drug resistance still exists during the use of the second generation BCR-ABL inhibitors.

　　In November, 2021, Nilik, known as the "third generation Gleevec" made in China, was approved for marketing in National Medical Products Administration, China, and was used to treat adult patients who were resistant to any tyrosine kinase inhibitor (TKI) and were diagnosed as chronic myeloid leukemia (CML) with T315I mutation in chronic phase (CP) or accelerated phase (AP) by fully verified detection methods.

　　This year, on July 6th, Yasheng Medical Officer Wei announced that Nilik had obtained the clinical trial permission from National Medical Products Administration Drug Evaluation Center, and would carry out a key registered phase III clinical trial of combined chemotherapy compared with imatinib combined chemotherapy in the treatment of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (referred to as "Ph+ALL").

　　At the end of 2022, Novartis decided not to be responsible for the sales promotion of Gleevec in China.

　　The official micro-display of Sinopharm Holdings shows that from January 1, 2023, Sinopharm Holdings officially obtained the commercial promotion right of Novartis Gleevec in China market. Xie Jiong, director of the Drug Shield Public Welfare Fund, said in an interview with the media that for many drugs, it is necessary to adjust the inherent marketing model after a certain development cycle, so as to drive the second peak of sales. This will not only prolong the life cycle of drug sales, but also greatly enhance the accessibility of drugs and benefit a wider range of patients.

　　Our reporter Lin Zhiyin also contributed to this article.

CCTV News:The Paris Olympic Games is in full swing, and the spirit of Olympic athletes’ tenacious struggle and self-breakthrough in the Olympic Games is inspiring. The TV programs of the Paris Olympic Games of the Central Radio and Television General Station were broadcast live in more than 800 cinemas across the country, attracting many viewers to watch the games.

On the evening of August 4th, Beijing time, the men’s singles table tennis final of the Paris Olympic Games began, and China’s Fan Zhendong played against Sweden. In a movie theater on BeijingRoad, Guangzhou, the audience cheered for China’s Fan Zhendong.

There is a strong atmosphere in the cinema to watch the Olympic Games. When the games enter a stalemate, the audience hold their breath and say hello. When the China athletes scored a point, the audience cheered loudly and waved flags to cheer.

In the end, Fan Zhendong won 4-1, winning the third gold medal for the China table tennis team. When the national flag was raised and the national anthem was played, all the audience in the cinema stood up and sang the national anthem, and their hearts surged.

Watching the Olympics in cinemas: covering more than 800 cinemas in Beijing, Shanghai, Shenzhen and Chengdu.

"Watching the Olympics in the cinema" is the first time in China to broadcast the Olympic Games live on the cinema screen. At the same time, the Olympic Games were broadcast on the main station "100 cities and 1000 screens". The audience felt the fighting style of Olympic athletes in the diverse scenes between domestic cinemas and urban streets.

The film list of the live broadcast of "Watching the Olympics in the Cinema" was attended by the China team and at 18: 00 Beijing time — The popular games that started at 21: 00 are mainly, covering more than 800 cinemas in Beijing, Shanghai, Shenzhen, Chengdu and other cities. Among them, table tennis, badminton, women’s volleyball and other traditional advantage events of China delegation were welcomed by the audience.

The introduction of the Olympic Games into cinemas not only provides a new channel for the masses to watch the Paris Olympic Games, but also builds a new platform for the audience to appreciate the elegance of China athletes, feel the spirit of sports and unite national feelings.

In addition, this year’s Paris Olympic Games brought a brand-new watching experience to the national audience with the help of the general station "100 cities and 1000 screens". Through 1075 ultra-high-definition large screens of diversified scenes such as core business districts, city squares and transportation hubs in 112 cities including Tianjin, Shanghai, Fujian and Sichuan, the contents of 8k ultra-high-definition Olympic Games will be continuously broadcast, so that urban audiences can share the wonderful moments of this sports feast.

[Global Network Technology Comprehensive Report] On the evening of August 8, Alibaba Group officially announced the brand-new membership plan of "88VIP" at the "88 Member Annual Stars Festival" in Guangzhou, redefining the traditional membership system.

According to reports, "88VIP" is a "all-in-one card" integrating Ali’s new retail ecology and multi-membership status, covering almost all the core services of Alibaba, and also providing a series of compound rights and interests in conjunction with 88 domestic and foreign brands among the 150,000 brands on Tmall. These exclusive discounts run through the whole year, even in double 11, and "88VIP" can be discounted and then discounted.

Users who have spent money on Ali retail platforms such as Taobao and Tmall in the past year will automatically become 88 members, and each member will correspond to different naughty values. If you are a naughty svip with a value of over 1000, you can only use 88 yuan to get this "88VIP" that non-members have to spend 888 yuan to buy. After preliminary calculation, the value of "88VIP" running through Ali’s ecological rights and interests is nearly 2000 yuan.

After becoming "88VIP", not only can you enjoy the annual "credit" of double 11 discount, but also the high-quality goods from Tmall Supermarket, Tmall International Direct Marketing and 88 brands around the world are all 15% off for the whole year; You can also enjoy annual exclusive discounts on imported milk, imported rice and other necessities; What’s even more surprising is that "88VIP" enjoys the exclusive status of "Eat, Drink and Play in One Train" under Ali, and is automatically upgraded to annual card members including Youku, Hungry, Shrimp and Taobao Film. In this way, according to the average user’s consumption level, becoming "88VIP" can save nearly 2000 yuan a year.

Take a bottle of Newsland fresh milk from 49 yuan as an example. "88VIP" can enjoy 72-hour direct fresh milk from New Zealand Ranch for only 19.9 yuan.

Roughly calculate, suppose a white-collar worker with a monthly salary of 5,000 yuan spends 888 yuan to become an "88VIP", and according to the average user consumption level, he can save 1,596 yuan, which is equivalent to getting 708 yuan for nothing. If it happens to be 88 svip, he only needs 88 yuan to get the "88VIP" status, which is equivalent to getting 1,508 yuan for nothing. Suppose a student party with limited pocket money can save its card fee in one month after spending 88 yuan as an "88VIP", and the following 11 months are pure "bonus hunter".

"Naughty value" is still the cornerstone of Alibaba’s membership system and the basis for the classification of Ali members. Naughty value of 1000 is a demarcation point. Those below 1000 are called 88 members, and those above 1000 are 88 svip. Besides enjoying the special price of "88VIP", they have distinguished privileges in daily shopping, payment and entertainment.

Ali’s new retail ecosystem is continuing to add more value and services to its members. Different consumption and life scenes face the same crowd. They not only order take-away food on the top every day, shop in Taobao Tmall, but also listen to shrimp on the way to and from work and watch the World Cup in Youku. They live in the ecology of Ali’s new retail every day. Compared with the traditional membership mechanism focusing on a certain field, "88VIP" has created a brand-new membership system based on Ali Ecology.

Those senior "hands-on parties" who are naughty and worth more than a thousand dollars have increased their sense of identity and belonging to the Ali ecological platform through the opening of the membership system. They are no longer entangled in the opening, renewal and maintenance of individual membership rights. As long as they have an "88VIP" card, those scenes that are frequently used in daily life can communicate with each other, which not only saves worry and money, but also makes the experience smoother.

This highly integrated Alibaba ecosystem is bringing great value to enterprises and promoting them to better carry out brand operation, user management, channel expansion and product development. For a wide range of merchants active in Ali’s new retail platform, the upgrading and opening of membership systems of different platforms can make them more deeply bound with consumers, not only further opening up online and offline, but also greatly expanding the original membership system.

Today, I took the time to go to the 4S shop and test drive the two-wheel drive version. To tell the truth, after reading so many photos online, it’s better to actually experience the real car.

The appearance of this car is very charming, the front face is full, the silver logo is added, and there are quite a few decorative strips on the wheel hub cover, which is a high-end feeling as a whole.

The interior workmanship can be felt very fine. In addition to the leather bag near the door and the central control, the roof is also wrapped with suede material, which is very comfortable to the touch. The triple screen and head-up display are also very easy to use. Let’s sum up the space in one sentence. People and things are enough.

At present, I have visited several 4S stores, and the prices are different. If you buy a car, I suggest shopping around more. At present, the price is calculated. The most expensive loan is 16w, and the cheapest loan is 14.9w I am going to grind it again and book one at the full price. # China Star Let the World See Dongfang Yao # Geely Automobile #L # Xingyue L Dongfang Yao # Good Car Recommendation # Test Drive

　　3 according to the application of public government information charges.

　　In accordance with the requirements of the Notice of the Municipal Finance Bureau and the Municipal Development and Reform Commission on Cleaning up and Regulating a Batch of Relevant Policies for Administrative Charges (J.C.Z. [2017] No.569), since April 1, 2017, this Municipality has stopped charging fees for disclosing government information upon application. As of March 31, 2017, all administrative organs in the city charged 20,147.6 yuan for searching, copying, mailing and other fees for providing government information upon application in accordance with the Measures of Beijing Municipality on Charges for Providing Government Information upon Application. For rural five-guarantee recipients, urban and rural residents’ minimum living guarantee recipients, and special care recipients who receive state pension subsidies, the relevant expenses are exempted in accordance with the law, totaling 1,185.5 yuan.

　　(four) administrative reconsideration, administrative litigation and reporting.

　　1. Administrative reconsideration

　　The city’s administrative organs accepted 1330 cases of administrative reconsideration of government information disclosure, including 376 cases accepted by the municipal government, 515 cases accepted by 16 district governments and 439 cases accepted by government departments with administrative reconsideration functions. A total of 1,386 cases of administrative reconsideration of government information disclosure were concluded in the whole year (including cases carried over from the previous year), of which 975 were informed of the government information disclosure reply made by the administrative organ, 249 were revoked, 27 were confirmed to be illegal, 19 were ordered to perform their statutory duties within a time limit, 35 were rejected by the applicant, 80 were voluntarily withdrawn by the applicant, and the case was closed by other means.

　　2. Administrative litigation

　　The city’s courts have tried 2300 administrative litigation cases related to government information disclosure. Accepted 1370 cases of first instance. Among them, 467 claims were rejected, 61 administrative actions were revoked, 25 administrative organs were judged to perform their statutory duties, 20 cases were judged to be illegal, 524 cases were dismissed, 32 cases were rejected, 131 cases were dismissed, 26 cases were transferred to other courts, and 84 cases were not concluded. 930 cases of second instance were accepted. Among them, 390 judgments were upheld, 3 judgments were revoked, 457 rulings were rejected, 2 rulings were sent back for retrial, 21 rulings were withdrawn, and 57 cases were not concluded.

　　Step 3 report

　　The city’s administrative organs received 535 reports related to the disclosure of government information. The Office of Information and Government Affairs Openness of the Municipal Government received 44 reports related to the disclosure of government information, and suggested that informants report 10 cases to relevant authorities in accordance with relevant procedures, and handled 34 cases (after investigation, 7 cases were true and 27 cases were inaccurate).

　　(5) Institution building and security training.

　　There are 884 specialized agencies for government information disclosure in this city, and 1440 government information disclosure access points have been set up. There are 3,178 staff engaged in government information disclosure, including 543 full-time staff and 2,635 part-time staff. The special fund for government information disclosure is 6,353,100 yuan. In the whole year, the city held 2257 meetings or special conferences on government information disclosure, held 1288 training courses of various types, and received 59557 trainees.

　　Fourth, the existing shortcomings and key work in 2018

　　(A) the existing deficiencies

　　First, the development of government information and government affairs disclosure is uneven, so it is necessary to adapt to the new era and new requirements, achieve a refined, personalized and characteristic publicity effect, and strive to upgrade from "standard specification" to "precise service". Second, the research on the people’s "information demand side" is not deep, the public information is not practical enough, and there is a gap in serving people’s lives and facilitating people’s work. The pertinence, quality and effect of policy interpretation need to be strengthened. Third, there are too many open platforms, which are inconvenient to find and retrieve, insufficient analysis of people’s habits and ways to obtain information, weak pertinence and differentiation of open channels, low arrival rate of new media and poor coverage.

　　(II) Key tasks in 2018

　　First, continue to promote information disclosure in key areas. We will fully implement the "Opinions on Comprehensively Promoting the Openness of Government Affairs" and the relevant requirements of the detailed rules for implementation, conscientiously implement the series of decision-making arrangements made by the CPC Central Committee and the State Council on promoting the openness of government information in key areas, and continue to do a good job in the information disclosure of financial budgets and final accounts, the allocation of public resources, the approval and implementation of major construction projects, and the construction of social welfare undertakings.

　　The second is to improve the interpretation level of government work. Further innovative interpretation of communication forms, comprehensive use of digital, graphic, animation video and other vivid ways to enhance affinity, guidance, communication and influence.

　　The third is to do a good job in the pilot project of standardization of grassroots government affairs openness in China. We will promote mechanism innovation in decision-making, policy interpretation, public participation, and public release of official documents in the five pilot areas, strengthen the standardization of government affairs openness, and promote the "streamline administration, delegate power, strengthen regulation and improve services" reform and "internet plus government affairs" in coordination, carry out the collection and selection of typical practices of grassroots government affairs openness to serve the masses, and build a demonstration benchmark for grassroots government affairs openness.

　　The fourth is to continue to promote public participation. We will establish a long-term mechanism for the dynamic management of government affairs, benefit the people and facilitate the map, enrich the map content according to the people’s experience and feedback, and build it into an information service platform with high public utilization rate and high satisfaction. Promote the normalization of government affairs open days, expand the scope, frequency and depth, and extend to districts, streets (towns) and communities (villages).

　　The fifth is to promote the intensive innovation and development of government websites. Further standardize the construction and development of the city’s government websites, complete the standardization and integration of the city’s government websites before the end of the year, promote the intensive sharing of government websites, build a unified interactive exchange platform, optimize functions such as online interviews and public opinion collection, and actively explore the use of artificial intelligence technology to help users accurately find and obtain government information and services.