Related news:　　　From May 1st, the ban on overseas cartoons will be extended by one hour.　　　　

　　　　CCTV.com News: The news broadcast of Guizhou People’s Broadcasting Station ignored the orders of the State Administration of Radio, Film and Television (SARFT), wantonly played up sexual life, sexual experience, sexual experience and sexual organs in several sets of radio programs, and boasted about the function of sexual drugs. Today, it was severely criticized by SARFT, and the illegal programs were stopped and cancelled.

　　　　According to the website of the State Administration of Radio, Film and Television, on September 13, 2007, Guizhou People’s Broadcasting Station broadcasted sexual obscenity and indecent programs on urban and economic frequencies, which was explicitly stopped by the State Administration of Radio, Film and Television. On November 12th, 2007, Guizhou People’s Broadcasting Station changed the name of Jin Tao’s Talk about Sex, which was stopped, to Jin Tao’s Night Talk, and was ordered by the State Administration of Radio, Film and Television to investigate and deal with it again. Since mid-January, 2008, when the whole province of Guizhou is united in fighting against the snowstorm and freezing disaster, the news broadcast of Guizhou People’s Broadcasting Station has continued to broadcast obscene and obscene programs that exaggerate sexual life, sexual experience, sexual experience, sexual organs and sexual medicine functions in the programs of Health Special Line and Healthy World. The informed criticism issued by the State Administration of Radio, Film and Television to Guizhou People’s Broadcasting Station was copied to the CPC Guizhou Provincial Committee and the Guizhou Provincial People’s Government.

　　　　The State Administration of Radio, Film and Television (SARFT) pointed out that since September 2007, radio, film and television administrative departments at all levels in China and radio and television broadcasters have conscientiously implemented the spirit of the Central Committee, and in accordance with the unified arrangements of SARFT, seriously rectified and severely investigated pornographic and obscene programs, and achieved remarkable results, which were fully affirmed by the Central Committee and praised by the broad masses. The fact that Guizhou People’s Broadcasting Station refuses to implement the provisions of the State Administration of Radio, Film and Television, and its programs involving sexual obscenity and obscenity are repeatedly banned fully shows that Guizhou People’s Broadcasting Station is indifferent in orientation and position awareness, lax in political discipline and propaganda discipline, lacking due social responsibility and professional quality, lax in rules and regulations, and weak in propaganda management, which must be dealt with seriously.

　　　　The State Administration of Radio, Film and Television severely criticized Guizhou People’s Broadcasting Station and its principal responsible persons, and informed the whole country.

　　　　The State Administration of Radio, Film and Television ordered the Guizhou Provincial Radio and Television Bureau to immediately stop broadcasting and cancel the sexually obscene and obscene programs such as Health Line and Healthy World of Guizhou People’s Broadcasting Station, seriously rectify Guizhou People’s Broadcasting Station, severely investigate and deal with relevant personnel and persons in charge of Guizhou People’s Broadcasting Station and news broadcasting in strict accordance with relevant regulations, and report the investigation to the State Administration of Radio, Film and Television as soon as possible.

　　　　The State Administration of Radio, Film and Television requires that all provincial, district (city) radio, film and television bureaus should be duty-bound, strictly implement the relevant publicity management regulations of the State Administration of Radio, Film and Television, earnestly perform their publicity management duties, and once again conduct a comprehensive and thorough clean-up and inspection of radio and television broadcasters within their jurisdiction, especially those at prefecture (city) and county levels. It is necessary to take measures to check at all levels, implement responsibilities, and not neglect their duties, perfunctory, and whitewash. To strengthen the work of listening and watching, strict supervision and management, to prevent the resurgence of pornographic programs, and in March 10, 2008, the clean-up inspection will be reported to the State Administration of Radio, Film and Television. The administrative departments of radio, film and television at all levels and radio and television broadcasters should conscientiously organize study, convey and implement the spirit of a series of documents issued by the State Administration of Radio, Film and Television on the thorough rectification of pornographic and obscene programs, strengthen the sense of orientation and position, emphasize social responsibility and post responsibility, improve the censorship system and broadcasting system, be serious about political discipline and propaganda discipline, increase supervision and investigation, and resolutely ban them to ensure the correct orientation of radio and television propaganda.

　　　　The State Administration of Radio, Film and Television emphasizes that radio, film and television administrative departments at all levels and radio and television broadcasters should thoroughly implement the spirit of the 17th Party Congress, vigorously publicize the socialist core value system, adhere to the orientation of advanced socialist culture, firmly grasp the correct direction of public opinion, keep in mind the social responsibility of radio and television, resolutely safeguard the good image of radio and television, always put social benefits first, advocate the concept of harmony, cultivate the spirit of harmony and build a harmonious culture.

　　　　The State Administration of Radio, Film and Television (SARFT) said that it would continue to supervise and inspect the rectification of pornographic and obscene radio and television programs in various places. Anyone who refuses to implement the provisions of the General Administration will be found together and investigated together, and the mechanism of punishment, accountability and withdrawal of radio and television broadcasters will be started in accordance with relevant regulations. At the same time, the audience is welcome to report, and the telephone number of illegal programs of the State Administration of Radio, Film and Television is 010-86095315; The online reporting address is http://www.chinasarft.gov.cn/.　

Editor: Feng Ye

Video shooting/video editing: Liang Xuhao

Luo Zhengxiang, reporter Liang Yihao, photo

[Guangdong famous doctor who has been a doctor for 70 years]

Jinyang. com reporter Feng Xixi correspondent Yue Weixin Zhang Lanxi Zhang Lingling Yuting

Professor Luo Zhengxiang, 93, is a famous expert in cardiothoracic and vascular surgery in China. He used to be the president of Guangdong Provincial People’s Hospital and the director of Guangdong Institute of Cardiovascular Diseases. From a handsome young boy to a white-haired old man today, years have left traces, but he can never change the "passion" in his heart-"saving lives" is his lifelong pursuit.

Under his leadership, Guangdong took the lead in establishing the Institute of Cardiovascular Diseases in China, and its reputation is still far-reaching. This famous cardiovascular expert also won the honor of "Outstanding Contribution Award of China Cardiothoracic Surgery".

The "best student" was admitted to medical college.

Luo Zhengxiang, 93, has gray hair, but his figure is straight. He is still a handsome elder in a suit. His thinking is very clear. When he is free, he watches movies and listens to classical music. When he goes out, he takes a mobile phone and "scans the code to pay" like a young man. He is a "grandfather". This "post-90 s" grandfather has made outstanding contributions to the development of cardiovascular disease in China.

In 1947, Luo Zhengxiang did not study business or economics as expected by his father. "When I was a child, I loved reading history books and wanted to be a hero. At that time, the best students could be admitted to medical school, so I went after the hardest." With an indomitable spirit, he successfully passed the West China University of Medical Sciences.

In 1954, Luo Zhengxiang came to work in Guangdong Provincial People’s Hospital, and chose the most difficult and complicated major in the medical field at that time-cardiac surgery. Since then, he has embarked on a journey of "heart" for more than half a century.

Cardiac surgery was difficult to start in China at that time. But Luo Zhengxiang never gave up his research on heart disease-heart surgery is extremely demanding, starting with the most basic hemostasis practice. The great blood vessel was accidentally broken and the blood was shocking. Luo Zhengxiang looked at the shadowless lamp, pressed it, pressed it, pinched it, and stitched the wound with a big curved needle. He was calm and calm for a few times: OK. The valves are stitched one by one, and repeated actions are done over and over again, which is simple and boring. 1 hour, 2 hours … Some doctors have been standing on their legs and looking at them, but Luo Zhengxiang is staring, unhurried and meticulously crafted.

"I used to have surgery and the conditions were very bad. Eating a dollar at noon is simple; There is no air conditioning in the operating room. Everyone is sweating after the operation and can only drink more water after the operation. " Luo Zhengxiang said that although the conditions are difficult, everyone can work together with Qi Xin. "The director of the department takes the lead in suffering, and the doctors and nurses will follow suit. This is a kind of atmosphere and a kind of culture."

The first generation of artificial biological heart valve in China has been developed.

In 1974, after visiting Beijing, Shanghai and Guangzhou, Argentine cardiovascular experts decided to invite Guangdong experts to study cardiovascular technology in Argentina. On March 16th, 1974, a technical team organized by the Ministry of Health, mainly from Guangdong Provincial People’s Hospital (Xiang Xiangyao, Luo Zhengxiang, Chen Chuanrong, Wei Wanchang, Chen Zhiming, Wang Tailai and Jin Si Lan from the First Affiliated Hospital of Sun Yat-sen Medical College) went to Argentina for a one-year medical investigation. This year’s study was fruitful, and Luo Zhengxiang and his party brought back advanced valve technology. In 1977, Luo Zhengxiang and Cai Zengxin went to an Italian hospital in Argentina again to study heart valve technology. In 1975, the first domestic aortic valve replacement was successfully implemented, and the first domestic pediatric valve replacement was successfully implemented in the same year …

In the 1970s, rheumatic heart disease and rheumatic fever prevailed in southern China, but for these patients who need valve replacement, heart valves need to be imported, which is expensive and few people can afford it. Luo Zhengxiang and his colleagues are determined to make Chinese’s own heart valve. In 1976, Guangdong Institute of Cardiovascular Diseases set up a research room for artificial heart biological valves, and then cooperated with Australian medical expert Dr. Zhang Renqian to set up Pacific Biological Products Company in Huangpu District of Guangzhou with full reference to international standards to develop and produce artificial heart valves. In 1977, the first generation of artificial biological heart valve in China, Guangdong Type I, was developed and applied in clinic, taking the lead in the perioperative management of cardiac surgery and the application of intra-aortic balloon counterpulsation in critical heart surgery. In 1987, Guangdong II artificial heart biological valve was successfully developed, and in 1988, the artificial mechanical heart valve was successfully developed in cooperation with Australian experts and applied in clinic. Domestic valves greatly reduce the cost of patients’ surgery and shorten the gap between cardiothoracic surgery in China and advanced countries in the world.

3. Lead the Institute of Mind Research to break through difficulties and create brilliance.

In 1958, Guangdong Provincial Institute of Thoracic Diseases was established in Guangdong Provincial People’s Hospital. For various reasons, the development of the institute was quite tortuous. On August 7th, 1978, Guangdong Provincial Party Committee agreed to rename Guangdong Thoracic Disease Research Institute as "Guangdong Cardiovascular Disease Research Institute", and the Ministry of Health listed Guangdong Cardiovascular Disease Research Institute as one of the three key cardiovascular disease research institutes in China (Beijing, Shanghai and Guangdong).

In this way, the Guangdong Institute of Cardiovascular Diseases was established, but how to go next is a problem that Luo Zhengxiang has to face. Now, 93-year-old Luo Zhengxiang goes back to the Institute every day to see this old place where he has been "cultivating" for decades. Every time he walks past the entrance of Dongchuan Road, Guangzhou, he will think of the difficulties of that year: "The Institute had no funds at first, and we ran to the cement factory to find the cement. I wear leather shoes to the construction site every day to supervise the work. After that, I change my clothes and go back to the operating room for surgery. " In this way, with the concerted efforts of everyone’s Qi Xin, the Institute of Mind Research has grown up slowly.

Today, it has gone through 61 years. Over the past 61 years, the Institute has trained a large number of experts for the country, treated tens of thousands of patients and laid the foundation for the prevention of cardiovascular diseases. Created countless national firsts, first cases, and even world firsts.

Young doctors love to chat with Luo Zhengxiang, and he is also willing to communicate with young people. He said that he likes to chat with patients when he sees a doctor, and it is easier to build trust when he gets familiar with each other. "When you are a doctor, you must be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am saving with my heart. Whether the doctor is careful or not can be seen by patients and their families. "

[famous doctor said]

When you are a doctor, you should devote yourself to the patients.

When you are a doctor, you should be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am trying to save them.

Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text

　　On October 26th, an exclusive interview with DRIs was held in Beijing.

　　Yang Yuexin, Chairman of China DRIs Revision Expert Committee and Chairman of China Nutrition Society, Ma Aiguo, Deputy Chairman of the Revision Committee and Executive Vice Chairman of China Nutrition Society, Ding Gangqiang, Deputy Chairman of the Revision Committee, Secretary of the Party Committee of China Nutrition Society and Director of the Institute of Nutrition and Health of China CDC, Yang Xiaoguang, Vice Chairman of China Nutrition Society and researcher of the Institute of Nutrition and Health of China Center for Disease Control and Prevention, Peng Xianwu, the supporting unit of DRIs revision and general manager of Amway (China) Science and Technology Innovation Center, attended the interview and interpreted the new revision.

　　Yang Yuexin introduced that the 2023 edition of China DRIs is the ninth edition. The revised expert committee and technical working group composed of nearly 100 nutrition experts lasted for three years. Based on the four basic principles of scientificity, advancement, integrity and continuity, the different reference intakes of 20 age groups including energy, nutrients and other dietary ingredients and pregnant women and lactating mothers totaled more than 70 nutrients and other dietary ingredients, which were revised and confirmed, and were held at the 14th Asian Nutrition Conference in September 2023.

　　The revision of DRIs in 2023 mainly includes four aspects. First, the concepts and procedures have been improved and perfected. Different procedures for determining different reference values of nutrients have been newly formulated, and the technical points of each link of the formulation procedures have been uniformly determined. The concepts and connotations of recommended intake and specific recommended values for reducing the risk of diet-related non-communicable diseases have been further clarified and improved. Secondly, the basic reference values of China population were formulated and revised, including age grouping, representative weight, reference value of breast milk composition, recommended weight gain of pregnant women, PAL of physical activity level, etc. Thirdly, the new research results of nutrients and other dietary components in the past decade at home and abroad in the fields of function, evaluation, requirement, safety and prevention of chronic diseases have been included, and more research results targeting China residents have been included. Fourth, from the writing framework, format and other styles, it highlights the positioning of reference books centered on quantitative values.

　　Peng Xianwu believes that this revision has far-reaching guiding significance for the big health industry, such as the data of newly added plant nutrients such as coenzyme Q10 and Lycium barbarum polysaccharide, and the quantification of nutrients such as proanthocyanidins, which will help Amway and industry to develop products and guide consumers to use them.

　　Peng Xianwu introduced that in 2022, Amway and China Nutrition Society established Nutrilite Special Fund for Plant Functional Components and Health Research, aiming at attracting more research institutions and personnel to participate in the research direction of plant nutrients, opening up production, learning and research, transforming research results into products faster, and making more scientific research results benefit the public.

　　This revision has greatly changed the protein intake of the elderly and the calcium supplement standard for adults. Yang Xiaoguang believes that China has entered an aging society, and the elderly and ordinary people can’t meet the demand for protein, which is easy to lead to sarcopenia. Therefore, it is necessary to improve the dietary structure of the elderly and increase the intake of protein. Yang Xiaoguang introduced: "The 2023 edition of DRIs revised the requirement of protein for the elderly aged 65 and above in China, and its recommended intake increased from 0.98 g/(kg day) to 1.17 g/(kg day), which is an important achievement".

　　Ding Gangqiang said that in recent years, the health awareness of Chinese residents has been continuously strengthened, and dietary nutrition and healthy behaviors have been continuously formed, but chronic diseases related to nutrition are still increasing. It is hoped that the release of the 2023 edition of DRIs will further guide the needs of China residents in all aspects of dietary nutrition, especially how to achieve a reasonable and balanced diet, and complete the objectives of the second largest action of Healthy China Action-Reasonable Diet Action.

　　The revision of DRIs has a wide range of significance and value. First, it has scientific value, which determines the types and quantities of nutrients that each person should consume every day qualitatively and quantitatively. Second, social value is an important basic data support for formulating relevant policies, regulations and standards; The third is the value of technical support, which plays an important guiding role in the dietary design and evaluation of collective feeding units such as schools and nursing homes, the nutrition labeling of prepackaged foods, and the product research and development of food enterprises.

In the domestic auto market, if you are going to buy a car with a hybrid electric system, then this Japanese car with a very smooth technology is worth considering. If everyone’s budget is around 200,000, Nissan Qijun e-POWER, Honda CR-V e:HEV and Toyota Rongfang are all worthy of consideration. Below, we will interpret the selling points of the three models and the highlights of hybrid technology respectively. You can choose one according to the needs of car purchase.

1. Nissan Qijun e-POWER

The appearance of Nissan Qijun e-POWER adopts Nissan’s latest V-motion design language, and its shape is still very atmospheric, which conforms to the aesthetics of home users. The big sofa seat inside is very comfortable, and it is not easy to feel tired after sitting for a long time.

The intelligent configuration of this car is a highlight, especially the intelligent safety. It is equipped with an enhanced version of ProPILOT super intelligent driving, and has a number of intelligent driving assistance functions, such as reversing car side warning, moving object/pedestrian detection warning, over-the-horizon collision warning, etc. It can be said that car safety can be guaranteed in different scenarios.

In terms of power, Nissan Qijun e-POWER is composed of a 1.5T range extender and dual motors. Although it uses the engine to supply power to the motor just like the extended range system, the e-POWER is different from it, because the engine only has the job of "power supply" and the motor is responsible for all the driving forces. This has the advantage that the fuel consumption can be effectively reduced, and its minimum comprehensive fuel consumption is only 6.36L. At the same time, this technology does not need to be equipped with a large-capacity battery, so it will naturally not occupy the seating space.

In addition, this car is also equipped with Snow Fox electric four-wheel drive e-4ORCE, which has five driving modes such as snow and off-road. Because it is completely electronically controlled for four-wheel drive, the response is very fast, the control and tracking are also highlights, and the driving experience is more guaranteed.

2. Honda CR-V e:HEV

Honda Cr-V E: The appearance of HEV continues the design of the fuel version, with an atmospheric shape and a certain sporty atmosphere. The interior part is still introverted, with many physical buttons and convenient operation.

The biggest attraction of intelligence is the addition of Honda SENSING 360 safety extrasensory function, which can monitor the driver’s status and surrounding conditions in real time, and prompt and assist braking in time if potential danger occurs.

In terms of power, Honda CR-V e:HEV adopts the fourth-generation i-MMD dual-motor hybrid technology, which consists of a 2.0L engine and a drive motor. Compared with the previous-generation hybrid system, the fourth-generation i-MMD hybrid system improves the power of the drive motor, and the efficiency of the two-speed clutch is also higher, thus effectively reducing fuel consumption, and its comprehensive fuel consumption is only 5.49L, making it very easy to maintain a car. In addition, compared with the fuel version, due to the addition of the motor, the ride comfort of the model is more outstanding when starting and driving at low speed.

3. Toyota Rongfang Double Engine

The appearance of Toyota Rongfang twin engines is tough, and the interior part looks old-fashioned, but the materials are still willing, such as leather steering wheel and leather seats.

In addition, the new Toyota Rongfang dual-engine launched last year has improved the intelligent driving assistance system a lot, adding functions such as emergency steering assistance and active deceleration in corners to ensure smoother driving.

In terms of power, Rongfang Twin Engine adopts Toyota’s fifth-generation THS II hybrid system, which consists of a 2.5L engine and a motor. A major feature of this system is to replace the Ni-MH battery that has been used for many years with a lithium battery. In this case, the battery volume is greatly reduced, and the power control unit has also been lightened, and the comprehensive power has been improved to some extent.

At the same time, the addition of lithium battery reduces the energy loss of the motor by 19%, and the driving force of the motor is stronger. Not only is the power strong, the comprehensive fuel consumption is still economical, and the minimum fuel consumption is only 5.1L, so it is very easy to maintain a car. In addition, Toyota Rongfang dual-engine four-wheel drive technology is also worth mentioning. It has three four-wheel drive systems: electronic four-wheel drive, dynamic torque vector control system and dynamic torque control system. The output torque of the rear wheel is obviously improved, and the torque distribution ratio of the rear wheel is added, so that maneuverability and stability are guaranteed.

general comment

It can be seen that the compact SUVs blessed by the three hybrid electric power systems are very atmospheric in shape. Although the interior can’t keep up with the trend, it still has certain intelligent functions and comfortable configuration, and the power system is naturally the biggest highlight of the three joint venture vehicles. With the addition of the motor, driving can get better ride comfort, and the key fuel consumption is much more economical than that of similar oil vehicles, and the cost of car use can be effectively reduced. Which of the above three oil-mixed SUVs do you prefer?

Affected by this round of "refrigerator-level" cold wave, freezing rain and snow occurred in Lechang, Ruyuan and Nanxiong in Shaoguan City, which is located in the alpine mountain area of northern Guangdong Province, resulting in the interruption of many roads, among which the northern section of Shaoguan (Beijing-Zhuhai-North) of Beijing-Hong Kong-Macao Expressway was closed for more than 100 hours by noon on January 26th due to road icing and snow.

On the 30th, the reporter learned from the traffic police department of Shaoguan Expressway that although the traffic police department has separately diverted vehicles to Guangle Expressway at Ruyuan Toll Station Interchange in the northbound direction of Beijing-Zhuhai and Pingshi North Interchange (K5) in the southbound direction since the early morning of the 26th, there are still vehicles that "mistakenly entered" Beijing-Zhuhai North and stayed on the icy expressway.

On the morning of January 29th, Shaoguan high-speed traffic police found a large truck with Zhengzhou license plate in Henan parked on the expressway when they were inspecting the Beijing-Zhuhai North Bridge section which had been closed due to snow and ice. The traffic police came forward to ask and learned that the driver of the large truck "mistakenly broke into the restricted area" when passing through the traffic control section and drove to the icy section, so the vehicle could not move on and it was worth stopping on the road. The traffic police department immediately sent a batch of food and warm items for the drivers of large trucks to resist hunger and cold.

At noon on the 30 th, the road icing situation near the parking position of the big truck improved. The traffic police department immediately assisted the driver of the big truck to install anti-skid facilities and commanded the big truck to slowly reverse and leave the expressway.

On the morning of 29th, during an interview in Ruyuan Bridge Town, the reporter found that a car with Shenzhen number plate was parked on an icy uphill section of Bridge Town on G240 National Highway, and the windshield, rearview mirror and body were covered with a thick layer of ice and snow, and the car was empty. A triangular warning sign was placed about 30 meters behind the car, and the car was suspected to have been temporarily "abandoned" by its owner.

The roads with snow and ice are prone to traffic accidents. The picture shows the traffic police urgently handling the accident vehicles on Guangle Expressway.

The traffic police reminded the majority of car owners not to drive on ice and snow roads as much as possible, especially most Guangdong drivers who lack experience in driving on ice and snow roads. If they must drive on ice and snow roads, they should install snow chains as much as possible, and try to keep driving at a constant speed during the driving process. If there are wheel tracks in front of them, they can follow the rut; When the vehicle is accelerating, lightly step on the accelerator to prevent the driving speed from suddenly rising and slipping, or the two wheels encounter different resistances during the rapid acceleration, resulting in lateral sliding; Don’t hit the steering wheel when driving, slow down in advance when turning, and increase the turning radius appropriately to prevent sideslip.

At the same time, the traffic police reminded that because the friction of ice and snow pavement is smaller than that of dry pavement, it is necessary to increase the safe distance during driving to prevent rear-end collision. Don’t slam on the brakes when braking. The correct way is to "point the brakes" and use the engine to slow down the speed. When parking, park in a sheltered and flat place as far as possible. When parking on a slope road, it is necessary to prevent the car from slipping. Bricks or stones can be used to pad the bottom wheel position.

　　Cctv newsNine times out of ten, life is not satisfactory, only a little joy.

　　The four children got what they wanted, and they all had their own places after the college entrance examination; Three families bumped into each other, experienced anxiety and pain, and finally gained their own little joy … The hit TV series Little Joy, which has been unhappy all the time, finally ushered in a relatively "satisfactory" ending.

　　Little Tao Hong, who hasn’t taken the role for many years, didn’t expect Little Joy to be so popular. At first, he didn’t want to take the role of "Song Qian". He just joined in with the mentality of helping, and only agreed after turning on the phone, not to make a strong comeback. "I don’t have a play, but I don’t have nothing to do every day. I’m busy." Since he married Xú Zhēng, Tao Hong Jr. has gradually faded out of people’s sight and devoted himself to his wife. After having a daughter in 2008, accompanying her to grow up day by day became the happiest thing for Tao Hong Jr.

　　It’s not easy to tidy up a home. It took 10 years to learn how to be a mother. After returning to the family, Tao Hong Jr. once again attracted attention with the image of such a paranoid mother and became the most discussed mother in Little Joy. The audience remembered that Tao Hong, who had a pair of peach eyes, had interpreted so many classic characters. She has been clever and charming in Black Eyes, Empty Mirror, Sunny Days and Pig with Bright Spring, and she never forgets anything.

　　Interestingly, on the one hand, he became famous too early and left the screen for too long, so that many young viewers didn’t know little Tao Hong at all; On the other hand, the image of "Song Qian", an unlovable but true "Chinese-style" mother, makes people see Tao Hong’s acting again. "I feel great, don’t know me, so I can ‘ Do whatever you want ’ Play more different roles. "

　　Not long ago, Christina’s speech at the FIRST Film Festival calling on directors and producers to give Mesozoic actresses a chance caused a heated discussion. The passive situation that the subject matter is far away, the role is missing, and the older actress has no play is once again put on the table. In "Little Joy", in addition to the formidable young actors, the excellent acting skills of six middle-aged actors are the quality guarantee of the whole play.

　　Tao Hong Jr. thinks that this is not something that a middle-aged actress can’t play in the final analysis, but something that the whole middle-aged women group is not concerned by the society. "Without corresponding attention, there will be no film and television works, and no works will tell them. Who will we play?" Nowadays, Tao Hong Jr. is more relaxed. He never picks up plays at random, and he doesn’t need to prove that he can act. If he has good works, he will come out and perform. With inner satisfaction and family harmony, Tao Hong Jr. no longer "competes" with herself, and the pressure and anxiety of middle-aged actresses do not exist here.

　　Yongmei and George W. Tao Hong are old acquaintances. It’s been 20 years since they first collaborated on Where Dreams Start to Little Joy. In the play, Yongmei’s gentle and intellectual mother "liujing" is not only in sharp contrast with Tao Hong’s tough mother "Song Qian", but also has a special friendship with Song Qian’s daughter "Eiko". Many viewers reported that they were often moved to tears by this unforgettable friendship between liujing and Eiko.

　　Making friends with a child, supporting each other and making progress is also Yongmei’s favorite counterpart. Playing mother is nothing new to Yongmei. In "Little Joy", Yongmei, who has never been a mother, just deduced the most ideal mother in the hearts of countless people, giving this role the most comfortable and appropriate appearance, and his acting skills can be seen.

　　Yongmei has always been the kind of actor whose audience is particularly familiar with but whose name is unknown. Liujing, who is as gentle as jade and generous in understanding, has more or less Yongmei’s own shadow. She often gives people the impression of extraordinary temperament. She speaks slowly and eloquently, and people and voices are very comfortable. It seems that seeing her will make her feel better.

　　After 23 years of debut, Yongmei, a non-trained actress, is not a prolific actress. In the entertainment industry, she is even less eager to achieve success and pursue fame and fortune. At the beginning of the year, it seems that the afterheat of Yongmei’s winning the first Berlin film in the mainland with Wang Xiaoshuai’s film Auld Lang Syne has just dissipated. Little Joy is so gentle that liujing in her bones is once again surrounded by powder, and Yongmei, who has always been low-key, has reached a new high in fans and attention, which has made everyone have new expectations for her.

　　The audience slowly understood her story. She has always maintained a cautious sense of alienation in the entertainment industry. After four years without filming, she once said, "I am waiting for the role that belongs to me. I am not in a hurry, so don’t worry." Yongmei, who is in no hurry, still has a temper when she has an opinion. When there is no filming, there are works to find her, and she can only play some unnecessary wife roles. "How to say, like a shelf without a soul." Yongmei refused.

　　"I also have times when I am not gentle, more stubborn and more individual, and sometimes when I am unreasonable." As long as it’s a good character, dynamic and touching, even if it’s repeated, Yongmei thinks it can be played. It’s not that she doesn’t feel the confusion of middle-aged actresses, especially in domestic scripts, which are always stereotyped and faceless, lacking all kinds of middle-aged female images. Therefore, when he meets a good role and cast, Yongmei cherishes it especially. There are some phenomena that she doesn’t agree with and can’t change, but she believes that the current situation that there is no market for powerful actors is slowly changing. At present, it is most important to be yourself.

　　Sha Yi had only eight episodes in Little Joy, and as a special actor, he was a veritable "supporting role". However, as soon as he appeared, "Qiao Weidong" who opened his mouth "Eiko, open the door, stay" contracted all the jokes of the audience. Sha Yi’s "Qiao Weidong" was originally an out-and-out "love rat" image, dressed in flowery shirts, whiskers and crew cut, and quickly won the title of "rustic old man".

　　You can feel the "greasy" of "Qiao Weidong" through the screen. However, it is such a father who is full of humor, afraid of his wife and loves his daughter, and has become the favorite of the audience among the three fathers. Some people say that just seeing Sha Yi’s face makes him want to laugh, and he is a man with his own jokes. With superb acting skills, Sha Yi has successfully promoted the role of "Qiao Weidong" to one of the important leading roles, and more and more scenes have been played.

　　Sha Yi, who had a childhood filter, frequently searched for Little Joy. The charming Bai Zhantang disappeared completely and was replaced by the good father "Old Joe" who knew, loved and cared for children.

　　Over the years, Sha Yi has never faded out of public view, but it seems that he has only done one thing, being a good father to Angie and Xiaoyu. Although not yet a son, Sha Yi, who relies on his two sons to perform variety shows frequently, teases himself that he has ushered in the second spring of his career, which makes him feel helpless.

　　Time is like killing a pig, getting fat and getting out of the dimple. It is hard for people to think that "Qiao Weidong" and "Bai Zhantang" are the same person in Sha Yi now. Legend of the Wulin is indeed the pinnacle of Sha Yi’s popularity and career, but since then, although he has played some roles intermittently, the audience’s impression of him still stays in "Bai Zhantang". Sha Yi seems to be used to it, too. It is much more difficult for him to be a father to his two sons and accompany them to grow up than to be an actor. He doesn’t mind being a green leaf in the family.

　　It is precisely because every character in the play is so lively and all the actors are acting online that "Little Joy" has left so many viewers wanting more. The actors we knew as children are no longer young or even forgotten by us, but when they appear, they are always warm and bright. Just as the director said, life is like "looking for sugar in glass slag" to "joy", and every grain is precious. (Text/Wang Jiaying)

　　Beijing, March 1 ST "The 19th National Congress of the Communist Party of China proposed to build an educational power, which is an arduous, historic and grand task. To build an educational power, we must first improve the quality of basic education, and we must first improve the quality of Chinese and mathematics." Recently, Wang Wenzhan, former director of the Department of Basic Education of the Ministry of Education and deputy chief inspector, said this at the launching ceremony of the national "Shui Mu Hsinchu Yingchun Cup" national youth mathematics comprehensive ability exhibition sponsored by the Central Network Film and Television Center of the Communist Youth League, undertaken by Future Network and Shui Mu Hsinchu Education, and supported by the Education Research Center of China Teacher magazine.

　　Launching Ceremony of "Shui Mu Hsinchu Yingchun Cup" National Youth Mathematical Comprehensive Ability Exhibition.

　　Wang Wenzhan, former director of the Department of Basic Education of the Ministry of Education and deputy inspector general, stressed that the activities should adhere to the "three natures" and "three noes", which are not only public welfare, exhibition and interesting, but also do not exceed the standard, increase the burden on students and rank second. It is also pointed out that basic education is the foundation of the whole education, Chinese and mathematics are the foundation of the foundation, and the education for teenagers in the whole country is the most important part of the education system, while the basic education for teenagers is the foundation of all education. Our country’s achievements in mathematics are excellent in the world, and it ranks among the top in the world. This excellent momentum will continue, and it needs the joint efforts of people from all walks of life who are enthusiastic about education.

　　Wang Wenzhan, former Director of the Department of Basic Education of the Ministry of Education and Deputy Chief Inspector.

　　Xin Tianhao, executive editor-in-chief of the Communist Youth League Central Network Film and Television Center and Future Network.

　　"Mathematical culture, as a spiritual and non-cognitive psychological level, is eternal, which can influence and achieve people’s life." Xin Tianhao, executive editor-in-chief of the Network Film and Television Center of the Central Committee of the Communist Youth League and Future Network, introduced it at the launching ceremony.

　　Lin Yuanlie, Professor of Mathematics Department of Tsinghua University

　　Lin Yuanlie, a professor of mathematics at Tsinghua University, and the leaders and guests present deeply discussed the charm of mathematics. He explained in detail two famous sayings of predecessors: "Mathematics is the key to open the door to science" and "Mathematics is the queen of science", and called on the vast number of young people in China to explore the endless treasure in mathematics.

　　Tian Yumin, Director of Education Research Center of China Teacher Magazine.

　　Tian Yumin, director of the Education Research Center of China Teachers magazine, also said that this kind of comprehensive ability exhibition has a positive role in promoting students’ learning ability and learning habits, and should be strongly supported by all sectors of society. The "Shui Mu Hsinchu Yingchun Cup" national youth comprehensive mathematical ability exhibition is a good start, and he is looking forward to more positive public welfare comprehensive ability exhibition activities.

　　Wang Zhengpu, General Manager of Beijing Shui Mu Hsinchu Education Technology Co., Ltd.

　　"The purpose of this exhibition is to promote the mathematics culture, set off an upsurge of loving, learning and using mathematics in the whole country, and make students understand, like and enjoy mathematics more comprehensively, so as to continuously improve their mathematics literacy." Wang Zhengpu, general manager of Beijing Shui Mu Hsinchu Education Technology Co., Ltd., also said in his speech that students will appreciate the beauty of mathematics, build a spiritual communication between me and mathematics, and realize that mathematics plays an inestimable role in the development of human culture.

　　It is understood that the purpose of the "Shui Mu Hsinchu Yingchun Cup" National Youth Mathematical Comprehensive Ability Exhibition is to promote mathematical culture, stimulate the interest of primary and secondary school students in learning mathematics, explore more outstanding mathematics talents, develop their intelligence, popularize mathematical science, help the majority of young people discover their own mathematical talents, and enable students to fully understand, like and enjoy mathematics, and constantly improve their mathematical literacy. The proposition of this activity is universal and interesting, and all the topics seem simple, but students need to think hard in the process of solving them, and there are many solutions, which are helpful for students to open up their minds and stimulate the potential of mathematical comprehensive ability. Some topics combined with real-time hot spots make mathematics, an abstruse subject, return to life, and encourage students to apply what they have learned to solve practical problems in life with mathematical thinking.

　　From now on, the "Shui Mu Hsinchu Yingchun Cup" national youth mathematics comprehensive ability demonstration activity will be carried out one after another throughout the country, and the majority of young people who love mathematics can sign up for the activity.

CCTV News:In Wonsan, the eastern city of North Korea, there is a famous factory that produces leather shoes. The "Yingfengshan" brand leather shoes produced here have excellent workmanship and fashionable styles, which are well received by the Korean people. This factory is Yuanshan Leather Shoes Factory.

At the North Korean National Footwear Exhibition in 2018 and 2019, a leather shoes brand named "Yingfengshan" made a big splash for two consecutive years and won the first prize and the special prize respectively. This brand came from Yuanshan Leather Shoes Factory.

Yuanshan Leather Shoes Factory was founded in 1959 and has a history of 60 years. Kim Jong-un, the current top leader of North Korea, came to Yuanshan Leather Shoes Factory five times since 2014, and it was from 2014 that the development of Yuanshan Leather Shoes Factory entered the fast lane.

CCTV reporter Dong Haitao:This pair of shoes on the exhibition platform was produced in 2007, while this pair of shoes on this side was produced in 2017. It can be seen that there are great differences in texture, design and workmanship between them in the past ten years.

Independent research and development, independent manufacturing and self-reliance

According to the factory commentator, the entire production system of the factory is independently developed by North Korea, and the raw materials for shoemaking are also independently produced by North Korea, while the electricity is provided by national power stations such as Yuanshan Military and Civilian Power Station. They are at the forefront of North Korea’s footwear industry in implementing national policies and realizing self-reliant production, and factory employees are particularly proud.

Zhao Mingshi, head of technical department of Yuanshan Leather Shoes Factory:We received many favorable comments and won the special prize at this spring national footwear exhibition in North Korea.

Cui Hua, a female worker in Yuanshan Leather Shoes Factory:I am a shoe-maker, and I like the ladies’ sandals produced by our factory best. Sandals are women’s favorite footwear products in summer, and we have successfully controlled the weight of women’s sandals within 250 grams.

Nowadays, the vast majority of shoemaking employees in the factory have more than 5 years of shoemaking experience, and the factory will arrange different kinds of leather shoes production plans according to the season, personnel arrangement and product demand.

CCTV reporter Dong Haitao:I’m at the end of the production line of Yuanshan Leather Shoes Factory, where all kinds of leather shoes are displayed. I’m going to have a try now. Let’s try on this pair of pointed leather shoes first. They look very fashionable. The sole is solid and powerful, and it walks steadily. It is a good pair of shoes.

Leather shoes factory is looking forward to expanding production.

Since 2014, the quality of "Yingfengshan" brand leather shoes has been continuously improved, but the price is very close to the people. Take the pair of leather shoes that I just tried on as an example. The ex-factory price is only 25,000 yuan, which is equivalent to about 20 yuan, which is quite good and cheap. The factory commentator told me that the supply of factory products to the Korean people is already in short supply, and they hope to expand production in the future and strive to make "Yingfengshan" brand leather shoes go global.