武汉夜生活网论坛|武汉桑拿论坛|武汉狼盟|武汉品茶网

Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text

　　On October 26th, an exclusive interview with DRIs was held in Beijing.

　　Yang Yuexin, Chairman of China DRIs Revision Expert Committee and Chairman of China Nutrition Society, Ma Aiguo, Deputy Chairman of the Revision Committee and Executive Vice Chairman of China Nutrition Society, Ding Gangqiang, Deputy Chairman of the Revision Committee, Secretary of the Party Committee of China Nutrition Society and Director of the Institute of Nutrition and Health of China CDC, Yang Xiaoguang, Vice Chairman of China Nutrition Society and researcher of the Institute of Nutrition and Health of China Center for Disease Control and Prevention, Peng Xianwu, the supporting unit of DRIs revision and general manager of Amway (China) Science and Technology Innovation Center, attended the interview and interpreted the new revision.

　　Yang Yuexin introduced that the 2023 edition of China DRIs is the ninth edition. The revised expert committee and technical working group composed of nearly 100 nutrition experts lasted for three years. Based on the four basic principles of scientificity, advancement, integrity and continuity, the different reference intakes of 20 age groups including energy, nutrients and other dietary ingredients and pregnant women and lactating mothers totaled more than 70 nutrients and other dietary ingredients, which were revised and confirmed, and were held at the 14th Asian Nutrition Conference in September 2023.

　　The revision of DRIs in 2023 mainly includes four aspects. First, the concepts and procedures have been improved and perfected. Different procedures for determining different reference values of nutrients have been newly formulated, and the technical points of each link of the formulation procedures have been uniformly determined. The concepts and connotations of recommended intake and specific recommended values for reducing the risk of diet-related non-communicable diseases have been further clarified and improved. Secondly, the basic reference values of China population were formulated and revised, including age grouping, representative weight, reference value of breast milk composition, recommended weight gain of pregnant women, PAL of physical activity level, etc. Thirdly, the new research results of nutrients and other dietary components in the past decade at home and abroad in the fields of function, evaluation, requirement, safety and prevention of chronic diseases have been included, and more research results targeting China residents have been included. Fourth, from the writing framework, format and other styles, it highlights the positioning of reference books centered on quantitative values.

　　Peng Xianwu believes that this revision has far-reaching guiding significance for the big health industry, such as the data of newly added plant nutrients such as coenzyme Q10 and Lycium barbarum polysaccharide, and the quantification of nutrients such as proanthocyanidins, which will help Amway and industry to develop products and guide consumers to use them.

　　Peng Xianwu introduced that in 2022, Amway and China Nutrition Society established Nutrilite Special Fund for Plant Functional Components and Health Research, aiming at attracting more research institutions and personnel to participate in the research direction of plant nutrients, opening up production, learning and research, transforming research results into products faster, and making more scientific research results benefit the public.

　　This revision has greatly changed the protein intake of the elderly and the calcium supplement standard for adults. Yang Xiaoguang believes that China has entered an aging society, and the elderly and ordinary people can’t meet the demand for protein, which is easy to lead to sarcopenia. Therefore, it is necessary to improve the dietary structure of the elderly and increase the intake of protein. Yang Xiaoguang introduced: "The 2023 edition of DRIs revised the requirement of protein for the elderly aged 65 and above in China, and its recommended intake increased from 0.98 g/(kg day) to 1.17 g/(kg day), which is an important achievement".

　　Ding Gangqiang said that in recent years, the health awareness of Chinese residents has been continuously strengthened, and dietary nutrition and healthy behaviors have been continuously formed, but chronic diseases related to nutrition are still increasing. It is hoped that the release of the 2023 edition of DRIs will further guide the needs of China residents in all aspects of dietary nutrition, especially how to achieve a reasonable and balanced diet, and complete the objectives of the second largest action of Healthy China Action-Reasonable Diet Action.

　　The revision of DRIs has a wide range of significance and value. First, it has scientific value, which determines the types and quantities of nutrients that each person should consume every day qualitatively and quantitatively. Second, social value is an important basic data support for formulating relevant policies, regulations and standards; The third is the value of technical support, which plays an important guiding role in the dietary design and evaluation of collective feeding units such as schools and nursing homes, the nutrition labeling of prepackaged foods, and the product research and development of food enterprises.

　　On Tuesday (April 2), Eastern Time, the second quarter of the US stock market seemed to have a bad start. The three major indexes of the US stock market fell across the board overnight. They all fell more than 1% in intraday trading, and the Dow fell nearly 400 points to a two-week low, the biggest daily decline in four weeks with S&P. The expectation of interest rate cuts in the first half of the year was frustrated, and the yield of US bonds rose again, which suppressed the market to some extent. However, the performance of gold is still strong and continues to refresh.

　　At the close, the S&P 500 index fell 0.72% to 5205.81 points; The Dow Jones index fell 1.00% to 39,170.24 points; The Nasdaq index fell 0.95% to 16,240.45.

　　In terms of US bond yield, the 10-year US bond yield once rushed above 4.4% to close at 4.36%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, closed at 4.70%.

　　Since Powell reiterated last week that he was in no hurry to cut interest rates, the market sentiment has not been high. And overnight, internal officials of the Federal Reserve once again consolidated this statement, and market sentiment was once again hit.

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. The former "big hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　It is worth noting that the economic data of the United States even triggered speculation about whether the Fed will cut interest rates three times this year. The data released on Tuesday showed that the number of job vacancies in the United States has not changed much compared with the previous value, or it indicates that the labor demand is still stable at a high level in the high interest rate environment.

　　LPL Financial analysts pointed out that although the Fed does expect to cut interest rates sometime this year, the argument that interest rates will be higher for a longer period of time is playing a role again, so this worries the market. He also explained from another angle why the market will pull back. A healthy market really needs to pull back. The current trend is not necessarily a bad thing. The S&P 500 index has still risen by about 9% so far this year. Therefore, the market outlook still needs to keep a close eye on the US economic data.

　　On the enterprise side, Tesla released the latest car delivery data, which was not as good as the market expectation. The share price fell by 4.9% overnight, and it has fallen by nearly one-third during the year, and its market value has been erased by 260 billion US dollars. The data shows that Tesla’s delivery volume in the first quarter decreased by 8.5% year-on-year to about 386,800 vehicles, which was far lower than the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected in history. During the same period, about 433,400 vehicles were produced, which was also lower than expected.

　　This is also the first time that Tesla has fallen below the 400,000-vehicle mark since the third quarter of 2022, a decrease of over 8.5% compared with the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　In the first quarter, Tesla faced a double blow of reduced demand for electric vehicles and high interest rates. Analysts had previously lowered their expectations for Tesla’s delivery. Some analysts pointed out that Tesla would experience the first year-on-year sales decline since the early days of the epidemic.

　　In addition, Tesla also faced many obstacles in the first quarter, such as the interruption of the supply of spare parts in the Red Sea caused by the attack of Houthi militia and the temporary suspension of production in the German factory. Although the next generation model is the key to growth, the production of this model is not expected to start until late next year, which means that the company may face the risk of slowing down growth before this.

　　[Hot stocks]

　　Among the popular US stocks, Microsoft fell by 0.74%, Google A by 0.60%, NVIDIA by 1.01%, Amazon by 0.16%, Apple by 0.70%, Meta by 1.23%, AMD by 2.53%, Arm Holdings by 2.07% and Netflix by 0.02%.

　　Due to the delivery of Q1 far less than expected, Tesla fell by 4.9%, and has fallen by nearly one-third during the year.

　　Global stock index

　　In the European stock market, the FTSE 100 index in Britain fell slightly by 0.22% to 7935 points. The French CAC40 index fell slightly by 0.92% to 8130 points. Germany’s DAX index fell 1.13% to 18,283 points.

　　In Asian stock markets, the Hang Seng Index rose 2.36% to 16,932 points. The index of state-owned enterprises rose 2.58% to 5961 points. The Nikkei 225 index fell 0.73% to 39,625 points.

　　[China Stock Market]

　　Nasdaq China Jinlong Index closed up 0.32%. In terms of popular Chinese stocks, Pinduoduo fell by 0.77%, TSMC by 0.88%, Weilai by 2.16%, Xpeng Motors by 2.26%, Alibaba by 0.61%, Baidu by 0.08% and Netease by 1.88%.

　　[foreign exchange commodities]

　　The US dollar index rose first and then fell, once standing above the 105 mark in intraday trading, and once fell to an intraday low of 104.67 during the US session, then rebounded and finally closed down by 0.19% to 104.81.

　　Gold futures for June delivery in the New York Mercantile Exchange closed up 1.09% at $2,281.80 an ounce, a record closing high, having risen to $2,297.70 an ounce in intraday trading. May silver futures closed up 3.39% at $25.923 an ounce.

　　Geopolitical risks have enhanced the attractiveness of gold, while traders have avoided the shadow cast by the strong economic data of the United States on the prospect of the Fed raising interest rates.

　　Oil prices continue to rise due to supply concerns. WTI crude oil rushed above $85 in intraday trading, rising more than 2% in the day, and continued to hit a new high since October last year, finally closing up 1.76% to $85.47/barrel; Brent crude oil also hit a new high since October last year, and finally closed up 2.12% to $89.27/barrel.

　　[Highlights]

　　The Fed reiterated that it is not in a hurry to cut interest rates, but it is still possible to start in June?

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. Regardless of changing the inflation target, the continuous rise in oil prices will become a problem; The former "Great Hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　Job vacancies in the United States in February were slightly higher than expected

　　The voluntary turnover rate is the lowest since 2020, and the number of layoffs is the highest in nearly a year. The number of JOLTS vacancies in the United States in February was 8.756 million, slightly better than expected, and the value was revised down to 8.748 million before January. The voluntary turnover rate in February was 2.2%, the lowest level since 2020. Due to the increase in layoffs in the leisure and hotel industries, the number of layoffs has risen to the highest level in the past year.

　　Tesla’s quarterly delivery dropped for the first time in nearly four years, and its market value has evaporated by $260 billion in the year.

　　On Tuesday, Tesla Corporation, an American electric vehicle manufacturer, released a report on automobile production and delivery in the first quarter of 2024. According to the specific data, Tesla delivered a total of 386,810 vehicles in the first three months of this year, far below the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected. This is also the first time that the company has fallen below the 400,000-vehicle mark since the third quarter of 2022, which is over 8.5% lower than the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　Intel’s report shows that the loss of its foundry business expanded in 2023.

　　In a document submitted by Intel on Tuesday, Intel said that the sales of its new manufacturing division, Intel Foundry, in 2023 were $18.9 billion, down from $27.5 billion in the previous year, and the operating loss increased from $5.2 billion in 2022 to $7 billion. It is estimated that the loss will reach its peak in 2024 and will be realized at the operational level "in the middle of now to the end of 2030". Intel shares fell more than 2% after the report was released. Intel’s entry into outsourcing chip production is one of the biggest transformations in the company’s history. CEO Pat Gelsinge’s recovery plan also includes restoring the company’s once impeccable technological advantage, which the chip giant lost in the years before he took office in 2021.

　　A major breakthrough in AI pharmaceutical! Stanford SyntheMol model develops new antibiotics

　　According to a report by Stanford Medical College on March 28th, researchers from Stanford Medical College and McMaster University have made important progress in this field. They have developed an AI model called SyntheMol, which can synthesize drugs and create formulas for chemists in the laboratory.

　　The model creatively designed six new drugs for drug-resistant bacterial strain Acinetobacter baumannii, which is one of the main pathogens causing antibiotic resistance-related deaths. The model not only created a new drug structure, but also provided a detailed formula for chemical synthesis, enabling chemists to synthesize these drugs in the laboratory.

　　Abbott’s heart valve repair system has been approved by FDA to provide patients with new treatment options.

　　On Tuesday, US medical and health company Abbott announced that its heart valve repair system has been approved by the US Food and Drug Administration (FDA), which is suitable for patients with potentially fatal heart disease. Abbott’s minimally invasive transcatheter TriClip repair system aims to treat tricuspid regurgitation (TR), which is a disease in which the valve between the right ventricle and the right atrium of the heart cannot be closed normally, resulting in blood reflux. Abbott has incorporated TriClip into its so-called "Fab 5" () equipment portfolio, which is expected to promote the company’s sales growth in the next few years, representing Abbott’s technological innovation and market leadership in their respective fields.

　　[financial calendar]

BEIJING, January 7, 2022/PRNewswire/-At present, the Ministry of Tourism of the Philippines is making every effort to promote 100% vaccination against COVID-19 in the first-line tourism professionals to support the national vaccination plan of "Bayanihan, Bakunahan" in the Philippines. At the same time, the Philippine Ministry of Tourism plans to open international tourism to green countries and regions soon, China.Ranked among them.

Year-endThe tail teeth arrived as scheduled, and the working people who were attacked by a wave of cold air were busy with the annual summary, but they still didn’t stop thinking about the sunny beach, the blue sea and the blue sky, and imagined taking off their heavy coats and putting on vest shorts to be spiritual islanders.

According to relevant surveys, 60% of tourists in China are considering starting outbound travel after the epidemic. Among them, 58% of tourists want to swim in tropical islands (Source: Investigation Report on Tourists’ Willingness to Travel after the Epidemic). It can be said that the island, as a spiritual gas station for modern working people, is the warmest expectation for life beyond KPI.

Among the islands, Boracay must be the warmest hometown of the spiritual islanders trapped in front of the work station.

01 C debut Boracay, what’s different?

In the choice of islands, "only choose the right one, not too tired."

Boracay is located in the middle of the Philippines, and the temperature is between 23 and 36 degrees Celsius all the year round. November to April is the best time to travel. The 7-kilometer-long coastline winds in the western Pacific Ocean, of which the 4-kilometer-long white sand beach is divided into three docks and stretches on the west bank of the island. Listen to the waves lapping on the shore at Pier 1 (S1) and enjoy the quiet and luxurious holiday time; Come to Pier 2 (S2) to raise a glass and enjoy a warm island style; Pier 3 (S3) retains the original coconut grove on the beach, which is the best choice for experiencing natural interest.

be electedBoracay, the second best island in the world, won the reader’s choice award of Condé Nast Traveler in 2020.far and awayThat’s not all.

Yapak Beach, located on the north coast, is the second largest beach on the island. The beaches are covered with shells with different shapes and colorful colors, which witnessed the development of the prosperous shell jewelry industry in Boracay decades ago. Surrounded by hills, Balinghai Beach is located in the north of Boracay.Interpersonal scarcity,beAn uncut island paradise.Brapoh Beach on the east coast is home to all kinds of water activities.It’s sports.A paradise for lovers.

Lying bored, there are many adventure paradise on the island waiting for outdoor enthusiasts to unlock. Bat Caves, located in the northeast of Yabo Beach, is home to cave bats, flying foxes and fruit bats.alsoA paradise for cave explorers and naturalists.

Through the jungle, explore the mysteries in the depths of the cave, and when thousands of bats fly overhead looking for food,maybeWill be like the main character in the movie,Discover some true meaning of life.

Crystal Cave is a natural stalactite cave, and the seawater is sapphire blue, which is suitable for snorkeling, exploration and tracing.downThe mysterious tunnel goes down vertically, and then the dark green light is found in a winding path..This wonderful experience that can only be found in dreams,make oneNever forget. Sunken Forest is at the southernmost tip of Brapoh Beach. Dead underwater mangroves are rare natural "works of art". Numerous photographers and adventure lovers choose to visit this place in person, and then permanently imprint these works of art with natural philosophy on the film.Philippines BoracayAlways inadvertentlyPresent a copyAn unforgettable surprise.

02 "Fei" every experience rule: follow your heart

rightFor people in the workplace, it is necessary to be able to lie flat and have fun on vacation. Pick up the c island,also want toTake a picture of 9 squares,Become a circle of friendsCool guy.Water, land and air in Boracay.Qiqi came to help.

Water activities:

Snorkeling under the calm sea with few storms in Boracay,canfeelThe sea is as smooth as silk.Wandering freely with tropical fish in the blue ocean.

Get on the Mini submarine, put on your helmet,To "bump" into strange creatures on the bottom of the sea. In this activity, Xian Yi, young and old, even friends who can’t swim, can enjoy the colorful underwater world under the guidance of the coach. How colorful is it? Colorful corals and tropical fish will give you the answer.

The diving environment in Boracay is comparable to the "live version" of Finding Nemo..Became a member of the underwater world, shuttled through the cool water, looking for corals, starfish and sea urchins, playing with colorful tropical fish and exploring the "true face" of the ocean..

When the sunset reddened the clouds, take a sailboat without power equipment,existThe breeze drifted to the end of the horizon with the sound of waves. Watching the sunset sink into the water a little bit, in the afterglow of the sunset,Feel Boracay.Sunset.

In addition, "banana boats sit in rows" canExperience the coolness of the sea beating on your body, and it seems that you can forget all your troubles in an instant.. "lClass version of the "two ships in one, when overturned, people will be left further."Bring a more joyful experience.

Air activities:

Ride and dragTravel around the open sea with an umbrella, and get a panoramic view of Boracay’s coastal scenery from another angle.

In addition, visitors can also chooseTake a helicopter and cruise the whole island,Enjoy this paradise-like island completely. The charming coastal curve, lush hillside and soft white sandy beach are a beautiful picture that will be deeply reflected in the fundus. Go back to the amazing and intoxicated Boracay and see it from the air.The whole picture.There is a 10-minute/15-minute/20-minute ride plan for helicopter tour around the island.To choose from.

Land activities:

Apart from going to sea, Boracay also has a wealth of land activities to experience. Luhuo Mountain is the most suitable place for "love" in Boracay, because it is the commanding height of the island..andloveClimb to the top of the mountain and watch a sunset, which will bebecomeAn unforgettable "instant eternity".

In Boracay, you can also find local people to braid an authentic dirty braid, fix the rainbow on your head, and experience the original island customs.

Boracay also has an award-winning best spa in Asia and a distinctive cost-effective beach massage.. The antique Chi spa is mainly based on the traditional health preserving method in China, and combines the local nursing concept in the Philippines to create a unique hydrotherapy course.Suitable for recuperation. Noble and luxurious Poseidon Spa, featuring morinda citrifolia in Tahiti, has obvious anti-aging effect.Suitable for relaxing the body.Mandala spaMainly in the quiet and green environment to relax the bones and muscles, a variety of spa treatments including petal bath, exfoliation, detoxification oil pressure, etc., among whichSignboard SpaThe course of treatment has won the best Spa in Asia many times.Rong.

In addition, tourists can also choose outdoor massage.Signs of outdoor massage can be seen everywhere on the white sand beach road in Boracay. White recliners, smiling masseurs, coconut wind and sea charm and slowly under the waves, try to get a set of coconut oil full-body massage, sniffing the sweet smell in the air, as if the dream has become different, which is also the essence of Boracay’s relaxation..

White-collar holiday recipes: eat and drink.

As a star in the island world, Boracay is rich in online celebrity cuisine. for exampleFruit smoothies, made of fresh mangoes, bananas, pineapples, etc., it is full of tropical customs when you drink it..For example, Coco Mama coconut ice cream with super high value is packed in a coconut shell bowl, dotted with sweet and sour mango granules, and its taste is refreshing and not greasy, which is quite popular among dessert lovers.

alsoCharacteristic of the PhilippinesHalo-Halo shaved ice, with a smoothie added with condensed milk as the base, then covered with various fruits, jellies, beans and puddings, and finally put the purple taro ice cream, only 50-100 pesos, which is delicious and affordable..

Boracay’s tastes are international. All kinds of fresh ingredients are cooked into Filipino food, Chinese food, American fast food, Japanese food, etc.Bring rich tastes to tourists.

The nightlife herenorInferior to the bustling city. Binhai bars and pubs are quite distinctive.You can order a cup of tropical fruit special, sit on the beach and blow the sea breeze, or go to a bar with a dance floor to be a prom friend.

Although the epidemic situation has changedhumanChildren’s travel patterns and consumption habits, but it can never beChange rightMemories and expectations of travel itself. Although it is still a luxury to fly to the island at the moment, the sea breeze is still so sweet and the sun is still shining, and Boracay is still the "dream hometown" of every spiritual islander.

Good luck, Boracay.Waiting. thinkLearn more about Boracay,Please pay attentionPhilippine National Tourism Administration (ID：PDOT_China）.

September 21, 2011, my hometown in Feicheng, Shandong. According to the custom in the village, on the third day after marriage, Wang Zhibao took Han Ping to the grave, saying that he wanted his new wife to visit his ancestors.

On March 15th, 2013, Wang Zhibao’s mother was hospitalized due to illness in Feicheng Hospital, Shandong Province. Hearing that his mother was unwell, Wang Zhibao hurried back by coach.

February 9, 2013, my hometown in Feicheng, Shandong. On New Year’s Eve, Wang Zhibao had a New Year’s Eve dinner with relatives and friends, while his wife looked after the crying children.

On December 18, 2015, Jinan, Shandong Province, had to go to work during the day, and Wang Zhibao and his wife followed the intermediary to see the second-hand house at night. There is no light in the top building facing the street, so they have to use their mobile phones for lighting.

　　Photographer Liu Lei recorded the life of rural youth Wang Zhibao and his wife Han Ping for seven years in this 10-square-meter rental house in a village in Jinan. From marriage, having children to their daughter’s going to school, they travel between their hometown and the city, with meager income and light sorrow … …

　　In 1986, Wang Zhibao was born in panzhuang, Feicheng City, Tai ‘an City, Shandong Province. Like other children of similar age in the village, he spent his childhood in the dirt. The experience of helping adults do farm work filled his primary school memory. He became familiar with the agricultural knowledge handed down by his ancestors and knew when to plant and when to harvest.

　　The knowledge in books is more difficult to learn than farm work, and Wang Zhibao’s academic performance is always bad. In his own words, the academic performance at that time belonged to the level of "idiot", and the teachers were too lazy to take care of him. But he is optimistic about this — — There are several other "idiots" in the same village: Er Dan in the south of the village, Yandong &hellip in the west of the village; … They naturally became good friends. Although more than ten years have passed, he can still quickly and accurately list the "idiot" students who were connected with the same life at any time, and these students, like his current state, are doing some temporary work in a city and running between the city and the countryside.

　　Wang Zhibao said that people who have never studied in their ancestors for generations seem to need genetic inheritance to read good books. Moreover, the older generation in the village always warned the younger generation that there would be no great promise in farming. Before the second day of junior high school, Wang Zhibao left the village, went to the county to be an apprentice, and began to work.

　　The hardened asphalt road in the county is smoother than the dirt road in the village. Wang Zhibao, who came to the city, felt relieved. Away from my mother’s nagging, I seem to be an independent and mature man in an instant.

　　Later, 17-year-old Wang Zhibao came to Jinan, the provincial capital. He worked as a cable worker, cleaner, hotel room cleaner and chess room attendant. At the age of 22, Wang Zhibao entered the stone renovation industry to do odd jobs, which continues to this day. Wages rose from 70 yuan at that time to 150 yuan now, and sometimes you can earn 200 yuan one lucky day, but you have to wait for the foreman’s phone call to recruit.

　　After some ignorant and failed contacts, he met his wife Han Ping through a friend’s introduction. She came to work in Jinan from Heze rural area with a low education level, but she has a good personality, which can tolerate Wang Zhibao’s natural rebellious temper and does not dislike his meager income. Wang Zhibao also feels that Han Ping is "the kind of person who lives a down-to-earth life". At the end of 2005, Han Ping moved into a 10-square-meter hut he rented near Xishilihe Street in Jinan.

　　In 2011, Wang Zhibao married Han Ping back to his hometown of Feicheng panzhuang. Han Ping was four months pregnant when she stood at the wedding scene in a wedding dress. In order to make up enough months for the unit to pay medical insurance for itself, Han Ping insisted on going to work normally in the shopping mall with a big belly. Wang Zhibao said that this can get maternity leave wages, plus maternity insurance can earn a lot of money.

　　The cost of Jinan hospital is large, and the cost of caesarean section alone is more than 8 thousand yuan, as well as nutrition and other expenses. It’s far from home. If relatives come to take care of Han Ping, their food, drink and accommodation will be another expense, so Wang Zhibao took his wife to his hometown hospital with relatively poor conditions to give birth.

　　In 2012, my daughter fell to the ground. The fortune teller said that his daughter, LMNT, had little soil. After calling many people for advice, he added the word "Yu" to her name.

　　Wang Zhibao’s family of three has rented a 10-square-meter cabin in the village of Jinan, and the house price in the nearby community doubled in 2017 compared with that in 2013. Wang Zhibao had the idea of buying a second-hand house. At the end of 2015, at the instigation of his younger brother, he took a fancy to a street-facing old-top building with an area of 40 square meters and a selling price of 280,000 yuan. After calculation, they still feel that they can’t stand the pressure of paying a down payment of 80,000 yuan and a monthly loan of more than 1,000 yuan, and finally give up. But in just one year, the price of the same type of house has risen to about 400,000 yuan.

　　Without their own house, there is no shortage of happiness in the life of a family of three. The small home is full of her daughter’s snacks and toys, with her paintings and awards on the walls, and photos of a family of three. The aisle at the door was neatly covered with Han Ping’s laundry. On weekends, Wang Zhibao will take his wife and daughter to the park to play. Seeing his daughter running with other children, he wanted to lie on the lawn and have a good sleep.

　　Wang Zhibao said that he likes the freedom and vastness of the city, but his mother who is alone in his hometown is deeply concerned. My father died 10 years ago, and my 70-year-old mother is in poor health, but it is difficult to adapt to the life in the city. He and his younger brother, who also work in Jinan, had to take turns to visit.

　　The villagers said that their family is a real person. Wang Zhibao looks forward to working in the city every day, and works sincerely. Even if his income is meager, his worries drift lightly, and he turns back and forth between his hometown and rented house, year after year. Their daughter will go to primary school next year. According to Jinan’s policy, migrant children must meet the condition that both parents pay social security for one year. There is nothing wrong with Han Ping’s social security. However, Wang Zhibao worked in Jinan for 15 years, but never paid social security … …

　　I don’t know how his sorrow fell this time.

In the domestic auto market, if you are going to buy a car with a hybrid electric system, then this Japanese car with a very smooth technology is worth considering. If everyone’s budget is around 200,000, Nissan Qijun e-POWER, Honda CR-V e:HEV and Toyota Rongfang are all worthy of consideration. Below, we will interpret the selling points of the three models and the highlights of hybrid technology respectively. You can choose one according to the needs of car purchase.

1. Nissan Qijun e-POWER

The appearance of Nissan Qijun e-POWER adopts Nissan’s latest V-motion design language, and its shape is still very atmospheric, which conforms to the aesthetics of home users. The big sofa seat inside is very comfortable, and it is not easy to feel tired after sitting for a long time.

The intelligent configuration of this car is a highlight, especially the intelligent safety. It is equipped with an enhanced version of ProPILOT super intelligent driving, and has a number of intelligent driving assistance functions, such as reversing car side warning, moving object/pedestrian detection warning, over-the-horizon collision warning, etc. It can be said that car safety can be guaranteed in different scenarios.

In terms of power, Nissan Qijun e-POWER is composed of a 1.5T range extender and dual motors. Although it uses the engine to supply power to the motor just like the extended range system, the e-POWER is different from it, because the engine only has the job of "power supply" and the motor is responsible for all the driving forces. This has the advantage that the fuel consumption can be effectively reduced, and its minimum comprehensive fuel consumption is only 6.36L. At the same time, this technology does not need to be equipped with a large-capacity battery, so it will naturally not occupy the seating space.

In addition, this car is also equipped with Snow Fox electric four-wheel drive e-4ORCE, which has five driving modes such as snow and off-road. Because it is completely electronically controlled for four-wheel drive, the response is very fast, the control and tracking are also highlights, and the driving experience is more guaranteed.

2. Honda CR-V e:HEV

Honda Cr-V E: The appearance of HEV continues the design of the fuel version, with an atmospheric shape and a certain sporty atmosphere. The interior part is still introverted, with many physical buttons and convenient operation.

The biggest attraction of intelligence is the addition of Honda SENSING 360 safety extrasensory function, which can monitor the driver’s status and surrounding conditions in real time, and prompt and assist braking in time if potential danger occurs.

In terms of power, Honda CR-V e:HEV adopts the fourth-generation i-MMD dual-motor hybrid technology, which consists of a 2.0L engine and a drive motor. Compared with the previous-generation hybrid system, the fourth-generation i-MMD hybrid system improves the power of the drive motor, and the efficiency of the two-speed clutch is also higher, thus effectively reducing fuel consumption, and its comprehensive fuel consumption is only 5.49L, making it very easy to maintain a car. In addition, compared with the fuel version, due to the addition of the motor, the ride comfort of the model is more outstanding when starting and driving at low speed.

3. Toyota Rongfang Double Engine

The appearance of Toyota Rongfang twin engines is tough, and the interior part looks old-fashioned, but the materials are still willing, such as leather steering wheel and leather seats.

In addition, the new Toyota Rongfang dual-engine launched last year has improved the intelligent driving assistance system a lot, adding functions such as emergency steering assistance and active deceleration in corners to ensure smoother driving.

In terms of power, Rongfang Twin Engine adopts Toyota’s fifth-generation THS II hybrid system, which consists of a 2.5L engine and a motor. A major feature of this system is to replace the Ni-MH battery that has been used for many years with a lithium battery. In this case, the battery volume is greatly reduced, and the power control unit has also been lightened, and the comprehensive power has been improved to some extent.

At the same time, the addition of lithium battery reduces the energy loss of the motor by 19%, and the driving force of the motor is stronger. Not only is the power strong, the comprehensive fuel consumption is still economical, and the minimum fuel consumption is only 5.1L, so it is very easy to maintain a car. In addition, Toyota Rongfang dual-engine four-wheel drive technology is also worth mentioning. It has three four-wheel drive systems: electronic four-wheel drive, dynamic torque vector control system and dynamic torque control system. The output torque of the rear wheel is obviously improved, and the torque distribution ratio of the rear wheel is added, so that maneuverability and stability are guaranteed.

general comment

It can be seen that the compact SUVs blessed by the three hybrid electric power systems are very atmospheric in shape. Although the interior can’t keep up with the trend, it still has certain intelligent functions and comfortable configuration, and the power system is naturally the biggest highlight of the three joint venture vehicles. With the addition of the motor, driving can get better ride comfort, and the key fuel consumption is much more economical than that of similar oil vehicles, and the cost of car use can be effectively reduced. Which of the above three oil-mixed SUVs do you prefer?

　　Recently, Hu Yue, associate professor and doctoral supervisor of Huazhong University of Science and Technology, has caused a heated discussion because he published 60 SCI papers in five years.

　　According to the teacher’s personal homepage of Huazhong University of Science and Technology, Hu Yue received a bachelor’s degree in applied chemistry from East China University of Science and Technology in 2012 and a doctorate in chemistry from Edinburgh University in 2016.

　　In the same year, she joined Wuhan Photoelectric National Research Center of Huazhong University of Science and Technology, and has been engaged in theoretical and experimental research of photovoltaic materials for solar cells for a long time.

　　In self-introduction, Hu Yue mentioned that in the past five years, she has published more than 60 SCI papers, including 21 papers by the first correspondent, including 1 paper by Science, 1 paper by Joule and 1 paper by Advanced Materials. At present, there are 2 highly cited papers on ESI.

　　Nine groups of journalists found that in the statistical table of journal impact factors released in June this year, the impact factor of Science was 47.728, that of Joule was 41.248, and that of Advanced Materials was 30.849. Impact factor refers to the frequency with which articles in a periodical are cited in a specific year or period. Generally speaking, the higher the impact factor, the greater the influence of the journal.

　　Some netizens said that before Hu Yue joined Huazhong University of Science and Technology, there were only four papers by the first author, and one paper was output on average one month after joining the company, and his paper was suspected of "irrigation".

　　"Our teacher didn’t do anything wrong, but the mistake was too much exposure." On the afternoon of December 13th, han hongwei, the leader of Hu Yue’s research group and professor of Huazhong University of Science and Technology, responded to the reporter.

　　"Our research group has a large number of people and published many articles, which has caused some misunderstandings." Han hongwei said.

　　The leader of the research group responded: The mistake is that there is too much exposure.

　　"We didn’t expect the heat to be so high, and this matter was misinterpreted." Han hongwei said.

　　His office is next door to Hu Yue. On December 13th, he answered the phone all afternoon and walked in a hurry. Referring to Hu Yue, he said angrily, "Our teacher didn’t do anything wrong, but the mistake was too much exposure."

　　On December 8th, a post-90s doctoral supervisor was often recognized as a "teacher elder sister"! The introduction is very eye-catching! The article was reprinted by many media, allowing Hu Wei to enter the public eye. While gaining praise, Hu Yue’s resume also sparked heated discussion.

　　In the article, Hu Yue said that her grandfather graduated from Zhejiang University with a bachelor’s degree and a master’s degree, and she has been engaged in chemical-related work. Her interest in scientific research was enlightened by her grandfather. In 2008, Hu Yue was admitted to the School of Chemistry and Molecular Engineering of East China University of Science and Technology. In 2009, she joined the team of Academician Tian He and participated in the national innovative experimental program for college students to carry out research on "dye-sensitized solar cells". Therefore, some netizens speculated that Hu Yue relied on his grandfather to obtain academic resources.

　　On December 14th, Hu Yue responded in an interview with China Science News that his grandfather was a retired engineer of former Wuhan Chemical Industry Bureau, not an academician of Internet communication. According to public reports, Hu Yue scored 626 points in the college entrance examination that year, ranking first among Hubei candidates admitted by East China University of Science and Technology. With such good grades, she joined the Department of Science and Technology Excellence of East China University of Science and Technology, and had the opportunity to choose Professor Tian He as her tutor.

　　On the teacher’s personal homepage of Huazhong University of Science and Technology, Hu Yue briefly mentioned that in the past five years, she has published more than 60 SCI papers, including 21 first/correspondent papers. Including 1 science, 1 Joule, 1 advanced materials, 2 advanced energy materials, 2 advanced functional materials, 1 ACS energy letter and 1 energy & environmental science. At present, Google Scholar has cited more than 1,800 times, with an H index of 24, and 2 papers have been selected as highly cited papers in ESI.

　　Hu Yue’s research field. Network screenshot

　　Han hongwei explained why the number of Hu Yue’s articles is as high as 60: "As a teacher of the research group, we will collectively take a group of students to give guidance from different angles and different professional backgrounds. If the teacher contributes, we will write his name in." He added that apart from the first author, co-first author and correspondent, other teachers are only participants, and their contribution may be only 1% or 10%, and they are not responsible for the article.

　　According to WeChat official account, the official of Huazhong University of Science and Technology, at present, Hu Yue and Professor han hongwei have jointly trained five doctoral students and five master students independently. Three master students have graduated, two have entered Huawei and one has gone to Zhejiang University for further study.

　　"Our research group has a large number of people and published many articles, which has caused some misunderstandings." Han hongwei said.

　　He was promoted to associate professor in two years and became a doctoral supervisor in three years.

　　"Young" and "excellent" are Hu Yue’s most conspicuous labels. The short film "Chasing the Light — — In Hu Yue, Hu Yue said: "I am an associate professor and doctoral supervisor born in the 1990s. When I first returned to China, many students were even older than me."

　　During the undergraduate course, she studied with Professor Hua Jianli of East China University of Science and Technology and Academician Tian He. In the representative papers listed by Professor Hua Jianli in official website, East China University of Science and Technology, Hu Yue’s name appeared in the author list of six papers, and the publishing time was from 2014 to 2017.

　　In 2012, after graduating from Hu Yue University, he applied for a full scholarship with excellent results and entered the University of Edinburgh to continue solar cell research. In 2016, Hu Yue received his Ph.D. and joined Huazhong University of Science and Technology through the postdoctoral talent introduction program.

　　According to the upstream news report, there are four papers published by Hu Yue in 2016, which are neither the first author nor the correspondent author, and of these four papers, only one is more valuable, but it is not the top publication. Therefore, some netizens think: "At this level, if the postdoctoral experience is not gilded, it is difficult to get a teaching position in a school like Huake."

　　In this regard, Hu Yue said in an interview with China Science News that during her doctoral period, she published more than 10 papers, among which 6 were first authors or co-first authors. After graduating from Ph.D., she first entered Huazhong University of Science and Technology as a postdoctoral fellow and stayed at school after leaving the station.

　　Official website of Huazhong University of Science and Technology shows that Hu Yue went to Oxford University, London Imperial College London and Lausanne Federal Institute of Technology for cooperation and exchange for one or three months during his doctoral studies.

　　After entering Huazhong University of Science and Technology, the number of articles published by Hu Yue increased significantly. The reporter found in Google Academic Search that Hu Yue published 13 papers in 2017.

　　In 2018, she and associate professor Rong Guangguang of Huazhong University of Science and Technology and Dr. Mei Anyi published a paper as the co-first author, which was published in Science magazine, and the project also won the support of major research plan integration projects and key projects of the National Natural Science Foundation.

　　In the same year, Hu Yue was promoted to associate professor and became a doctoral supervisor in 2019.

　　The office door is covered with cartoon images.

　　At five o’clock on the afternoon of December 13th, the building of Wuhan Optoelectronic National Research Center in the east campus of Huazhong University of Science and Technology was full of busy students.

　　In the corridor, five students around the round table discussed the group work fiercely. A black boy wearing headphones came out of the laboratory and stared blankly out of the window. There were four graduate students at the corner of the stairs to define the division of labor for the next project presentation.

　　Hu Yue works on the eighth floor. In a row of offices, hers is the most special. The gray door is covered with the image of opening, an orange cat sticker is stuck by the door, and the stills of Naruto are skewed in the center, with two molecular formulas sandwiched between them.

　　Hu Yue’s office. Figure/Nine School News Ma Jieying

　　The reporter found that Hu Yue had only one project practice class recently.

　　Liu Yilin (pseudonym), a graduate student at the School of Optoelectronic and Information, Huazhong University of Science and Technology, said that Hu Yue spends most of her time in the laboratory, but recently, because of her graduation thesis defense, she rarely appears in this building. "I am not here these days." Liu Yilin said.

　　Liu Yilin’s impression of Hu Yue is "tenderness". Because they are not in the same research group, there is not much communication. The only communication between him and Hu Yue was when he defended his graduation thesis last year. At that time, as soon as he showed the results of his paper, Hu Yue asked a question about energy management, but Liu Yilin’s research direction was different from this. He didn’t answer it. "I was very nervous at that time, but the teacher was very gentle and didn’t answer it."

　　Opposite Hu Yue’s office is the student office, where several graduate students work. The computer screen of the girl sitting at the door is covered with experimental pictures, and there are unfinished English papers in the document.

　　A student from other research groups told reporters that she had read online queries and hoped not to interview Mr. Hu. "Teacher Hu is usually very kind to us."

Southeast Network is the official news portal of Fujian, which is headed by the Propaganda Department of Fujian Provincial Committee of the Communist Party of China and sponsored by Fujian Daily Newspaper Group.

recent days

Website of the State Administration of Market Supervision

Announce the latest batch

Motor vehicle recall information

Involving Guangqi Honda and Dongfeng Honda

Land Rover, Mercedes-Benz, Volvo, etc.

↓↓↓

Guangqi Honda Automobile Co., Ltd.

Dongfeng Honda automobile co., ltd

Recall some domestic hybrid electric vehicles

Recently, Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall, and decided to recall the following vehicles from now on.

I Guangqi Honda Automobile Co., Ltd.

A total of 87,092 domestic hybrid BREEZE and plug-in hybrid BREEZE cars produced between January 4, 2019 and December 29, 2022 were recalled.

Second, Dongfeng Honda Automobile Co., Ltd.

A total of 169,000 domestic hybrid cars (CR-V) and plug-in hybrid cars (CR-V) produced between June 8, 2017 and August 17, 2022 were recalled.

For the vehicles within the scope of this recall, due to the layout problem of the battery positive wiring harness, when the left front part of the front of the car collides at a specific angle, the battery positive wiring harness may be damaged, and there is a risk of short circuit and fire.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will replace the improved battery positive wire harness for vehicles within the recall range free of charge to eliminate potential safety hazards.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will notify the relevant users of the recall by registered mail, and take the initiative to contact the users through authorized special sales service stores to make an appointment to arrange the recall and maintenance. Users of Guangqi Honda can call the service hotlines: 800-830-8999 (fixed-line users only), 400-830-8999 and the hotlines of special sales service stores for consultation, or visit Guangqi Honda’s website for recall information. Users of Dongfeng Honda can call the service hotlines: 800-880-9899 and 400-880-6622 (by mobile phone) for consultation, or visit the website of Dongfeng Honda for recall information. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Jaguar Land Rover (China) has limited investment.

The company recalled some imports.

Land Rover Range Rover Sport Series Cars

A few days ago, Jaguar Land Rover (China) Investment Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From March 29th, 2024, some imported 2023 Land Rover Range Rover Sport cars produced from July 4th, 2022 to November 30th, 2022 were recalled, totaling 1,987 vehicles.

Due to the factory assembly, the right taillight of the vehicles within the scope of this recall may get water and fail during use, which can not provide effective signals for the rear vehicles, increasing the risk of vehicle collision and posing potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will replace the taillights on the right side of the tailgate and the right side of the car body for vehicles within the recall range free of charge to eliminate potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will notify relevant users of this recall by registered mail. Users can call the Land Rover brand customer service hotline: 400-820-0187 through landline or mobile phone for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Mercedes-Benz (China)

Automobile sales co., ltd. recalled

Some imported GLE SUV cars

A few days ago, Mercedes-Benz (China) Automobile Sales Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From now on, a total of 118 imported GLE SUV vehicles with production dates from February 9, 2021 to November 18, 2021 will be recalled.

Some vehicles within the scope of this recall are not properly fixed with the grounding fixing bolts of the 12V battery grounding wire, resulting in an increase in the resistance of the fixed area and a large current passing through it, which may lead to an abnormal temperature rise in this area and a fire risk.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will inspect and retighten the grounding wire fixing bolts for vehicles within the recalled scope free of charge through Mercedes-Benz authorized dealers, and replace the grounding wire if it is damaged, so as to eliminate potential safety hazards.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will notify the relevant owners of the recall by registered mail. Users can call the service hotline: 400-818-1188 through landline or mobile phone for consultation (service time is 24 hours a day from Monday to Sunday). In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Volvo automobile sales (Shanghai)

Co., ltd. recalled some imports

XC90 automobile

A few days ago, Volvo Car Sales (Shanghai) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some imported XC90 cars from 2015 to 2024, which were produced between December 1, 2014 and September 23, 2023, with a total of 1,200 vehicles.

The fixing bolts of the seat belts in the second row of some vehicles within the scope of this recall are not tightened according to the regulations. When a vehicle collides, the fixing bolts of the seat belts may be loose, which will affect the restraint effect of the seat belts, increase the risk of passengers being injured, and pose potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will tighten the seat belt fixing bolts according to the specified torque for the vehicles within the recall range free of charge through authorized dealers of Volvo Cars to eliminate potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will notify relevant users by registered mail. Authorized dealers of Volvo Cars will also take the initiative to contact the relevant car owners to arrange the recall. Users can call the Volvo car after-sales service hotline: 10108666 for consultation through mobile phones and fixed telephones. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

China Heavy Duty Truck Group Jinan Truck Co., Ltd.

Recall part of limited company

Haowo brand traction car

Recently, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some Hauwo brand traction vehicles produced from April 23, 2020 to November 29, 2020, totaling 37 vehicles.

Due to manufacturing problems, the rear position lights on both sides of the top of the cab were not installed in the vehicles within the scope of this recall. At night or under poor road lighting conditions, the outline of the vehicle may not be displayed, which may pose a safety hazard.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will replenish the rear position light assemblies on both sides of the rear top of the cab free of charge for vehicles within the scope of recall, so as to eliminate potential safety hazards.

This recall was carried out under the condition that the State Administration of Market Supervision initiated a defect investigation. Affected by the investigation, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. decided to take recall measures to eliminate potential safety hazards.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will notify relevant users by registered mail or telephone through dealers, and arrange for free recall and maintenance. Users can also call the 24-hour service hotline: 4001888666 for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Original title: "A large number of recalls! Check yourself quickly! Your family may also have it.

Read the original text

Messi wrote his own legend in Barcelona.

In the early morning of January 31st, Beijing time, Barcelona beat Leganés 5-0 in the fourth round of the King’s Cup, and Messi scored twice for his 500th victory in Barcelona. The team’s full firepower seemed to send a signal to the outside world: even if no striker was introduced in the winter window, Barcelona could still score.

When Messi came out of power, his old rival Cristiano Ronaldo had to face embarrassment. According to a online celebrity analysis website, although there are as many as 200 million Portuguese social network fans, as many as 25% of them belong to "zombie fans".

Before the winter transfer in Europe was closed, some important players decided on their next homes one after another, including Manchester United official bruno fernandez, whose highest transfer price is expected to reach 80 million euros. In addition, Paco’s joining Villarreal also broke the transfer record in team history.

Messi has left more and more names on Barcelona’s record list.

King’s Cup Barcelona 5-0, Messi 500 wins milestone?

In the early morning of 31st, the fourth round of the Spanish King’s Cup in 2019-2020 was contested at Camp Nou. Barcelona beat Leganés 5-0 at home and Messi scored twice.

In the face of Leganés, who ranked second to last in the league, Barcelona fought a bloody battle. Gleizman, Langlais and Artur all scored goals. Messi himself scored two goals in the 59th and 89th minutes. Although the victory was easy, it was a milestone for Messi. This victory was his 500th victory for Barcelona. Since winning for Barcelona for the first time on October 16th, 2004, Messi has never stopped.

Messi has won the most games in the history of Barcelona, followed by Harvey, with 476 games. In addition, Messi has won 86 teams, including as many as 29 victories against Seville.

In this campaign, Setien, the coach of Barcelona, changed his formation back to 433, which Barcelona used to be used to. After the game, the new coach also gave an answer to the lack of signings in Barcelona’s winter window. "Dembele will be back soon in these weeks. He has special abilities and we will try our best to let him find his best state. (Not signing) Maybe there will be some risks when a player is injured, but I believe in my players."

Interestingly, L ‘Equipe revealed that Bakambu, a foreign aid who played for Beijing Guoan, had already entered Barcelona’s signing list. Guoan even received an offer from Barcelona, and Guoan, who was preparing for the pre-season in South Korea, decided to release him. The problem was that when Bakambu arrived in Hong Kong to transfer to Spain, he received a phone call from Abidar, director of Barcelona, and was told that Barcelona finally decided to withdraw his offer, so the player had to fly back to South Korea. Afterwards, Bakambu posted a passage on social media, in which he said with a little ridicule, "Please add’ Almost Joining Barcelona’ to my transfer history in Transfer Market. No matter what happens, I believe in the fate process, thank God. Gleizman, let’s meet again sometime. "

Among C Ronaldo’s social network fans, there are a large number of "suspicious accounts".

C Ronaldo also has zombie fans?

Not long ago, Cristiano Ronaldo’s Ins fans reached an astonishing 200 million, and he even published an Ins status celebration. However, a online celebrity analysis website named HypeAuditor found that 72% of Cristiano Ronaldo’s 200 million fans were real people, 2.1% were online celebrity, another 18.7% were "suspicious accounts", and the remaining 6.4% were "automatically following fans"-that is, the number of followers exceeded.

"Ins robots" are classified as suspicious accounts. They are used to handle likes or comments and also play a role in buying powder. Therefore, 25%-about 50 million fans are not real people. It is worth mentioning that as early as 2015, the Daily Sports Daily broke the news that as many as 64% of Cristiano Ronaldo’s Twitter followers were "zombie fans". The media said that as many as 21 million Cristiano Ronaldo’s Twitter followers were behind him, their Twitter accounts were inactive. Of course, all this may have nothing to do with Cristiano Ronaldo himself. Celebrity social accounts will be run by related teams, and it is reasonable to "buy powder". In fact, another research and analysis in November last year showed that 51% of Cristiano Ronaldo’s former teammate Cross’s fans are "zombie fans", which is the highest among Ins users.

This time, HypeAuditor also analyzed the composition of C Ronaldo’s fans. 49% fans are not interested in sports, but pay more attention to music and even fashion. In addition, 72% of C Ronaldo’s fans are men and 28% are women. There are more fans from India than other places, with 22% fans from India; The second place is Iran, with 15%; There are 3% fans from Madrid, the city where Cristiano Ronaldo’s old club Real Madrid is located. In terms of language use, 44% are English users, 9% are Persian and 9% are Arabic.

Manchester United need to pay up to 80 million euros for Fernandez.

Manchester United officially announced bruno fernandez.

In the early morning of the 31st, Manchester United officially announced that bruno fernandez had joined the club. It is reported that the two parties signed a contract for five and a half years, and there is a one-year renewal option.

In fact, 24 hours ago, Manchester United reached an agreement with Portuguese Sports on the transfer of Fernandez. According to the figures released by Portuguese Sports, Manchester United needs to pay him a maximum of 80 million euros, including 55 million fixed transfer fee plus 25 million floating amount. According to the relevant provisions, 5 million euros is related to the number of appearances, and another 5 million euros depends on whether Manchester United can qualify for the Champions League. In addition, 15 million euros depends on Fernandez’s personal achievements in Manchester United in the future. It is reported that if Fernandez switches to another team in the future, Portuguese sports can still reap 10% income from the transfer fee.

During his two and a half seasons in Portuguese sports, Fernandez played excellent data, with 16 goals and 20 assists in 2017-18 and 32 goals and 18 assists in 2018-19. He has scored 15 goals and 14 assists in the middle of this season. According to the outside world, his joining will inject vitality into Manchester United’s frontcourt attack. Head coach Oleskjaer also said in an interview: "We have been paying attention to Fernandez for several months, and he.

I wonder if Paco can reproduce his previous style in Villarreal.

Paco joined Villarreal, and the transfer fee broke the team history record.

A few days ago, Villarreal officially announced the signing of Spanish striker Paco Alcácer from Dortmund for five and a half years.

According to the previous report of Kicker, the transfer fee of Dortmund striker Paco to Villarreal totaled about 30 million euros, while the version of AS newspaper was 23 million euros, while Dortmund originally signed Paco from Barcelona at a cost of 23 million euros. In any case, Paco’s transfer fee broke the record of "Yellow Submarine" when 20 million euros signed Gerard Moreno two seasons ago.

Last season, Paco scored 18 goals in 26 Bundesliga games, but this season he only played 11 Bundesliga games and contributed 5 goals and 1 assist. With the arrival of Harland, his position has been gradually marginalized. Paco came from Valencia youth training. At the age of 18, he scored 28 goals in 27 games in a single season. He played for the first team of Bat Corps for 3 seasons, scoring 43 goals and assisting 17 times in 124 appearances. In the 2016/17 season, Barcelona signed him for 30 million euros. He played for Barcelona for one and a half seasons, made 50 appearances, scored 15 goals and made 8 assists, won the league championship and the King’s Cup on behalf of Barcelona, and then landed in the Bundesliga … Now Villarreal has introduced Paco with a record transfer fee, so I naturally hope that he will regain his previous style.

Deschamps is very dissatisfied with being labeled as "discrimination".

Deschamps took cantona to court.

A few days ago, according to the news of French media RMC, the case of French team coach Deschamps suing cantona will be officially opened in Paris at the end of February.

The contradiction between them stems from cantona’s inappropriate comments on Deschamps’ selection of players in 2016. At that time, cantona thought that Deschamps’ national team discriminated against players with North African descent, which made them have an issue. Although it has been three years, Deschamps decided to resort to the law.

In an interview with the Guardian before the 2016 European Cup, cantona said: "Benzema is a great player, and so is Ben Alpha, but Deschamps has a real French name. He may be the only person in France who really has a French name. No one in his family has been combined with people of other descent, so I am not surprised when he did not take Benzema to the European Cup. Ben Alpha may be the best player in France.

Cantona’s meaning is very clear. Because both players are of North African descent, they were abandoned by the head coach, but this statement obviously doesn’t work. Deschamps’ team is a powerful whole composed of players of different colors and bloodlines. In 2016, he won the runner-up in the European Cup and reached the peak in the 2018 World Cup. A large number of black players such as Bogba and Mbappé are still the absolute core. Deschamps has no reason to exclude players with North African descent. In fact, Ben Alfa has already gone from bad to worse, and Benzema can’t make it because of the fierce competition in the front.

Deschamps responded at the first time: "I don’t understand what he is saying at all, and I will never forgive him for slandering me."

In 2017, Deschamps entrusted a lawyer to prepare to sue cantona, but the case did not enter the final judicial procedure until today. It is reported that the court will hold a hearing on February 28th, and judging from the current situation, cantona, who has no secret words, may be overwhelmed.

Ding Junhui continued his ups and downs.

Ding Junhui missed the top 16 in the German Masters.

On January 30th, German snooker master Sai Ding Junhui lost to Scottish Donaldson 4-5 and missed the top 16, which was his second defeat to the same opponent in a week.

Last week’s European master Sai Ding Junhui just met Donaldson, when he lost to his opponent 2-5 in the second round and missed the quarter-finals. Fighting again after a week, Ding Junhui failed to take revenge and add new hatred. Before the game, the two sides were evenly divided in the first four games. Ding Junhui scored 55 points in the third game and Donaldson shot 132 in the fourth game. After the break, Ding Junhui won two games in a row 60-50 and 72-0 to get the match point, but Donaldson chased two games in a row; Although Ding Junhui scored 50 points in the deciding game, it was a pity that Donaldson still scored 52 points in one shot, which was a pity.

It is worth mentioning that Donaldson lost against Ding Junhui three times in a row before these two confrontations. Now the player ranked 24th in the world seems to have found the confidence to beat Ding Junhui. On the other hand, Ding Junhui, after winning the championship in the British Championship at the end of 2019 and ending the shortage of ranking titles for more than two years, was frustrated again in 2020, with a round of snooker masters, a round of European masters and a round of German masters … He was depressed.

　　[Aika Auto Domestic New Car Original]

　　On September 17th, 2023, Geely Automobile officially announced the prices of two new models of the Star Yue L in Xi ‘an Black Light Factory, namely the Yun Qi version with a guide price of 157,700 yuan and the Skyline version with a guide price of 168,700 yuan. As new models, Yun Qi version and Skyline version have added exclusive design on the basis of Star Yue L, and are equipped with the latest vehicle system of Galaxy OS 2.0. While announcing the selling price, Geely Automobile also announced the car purchase courtesy including financial gift, rejuvenation gift, quality gift, maintenance gift and flow gift. At the same time, Geely Automobile also announced that it will push the Galaxy OS 2.0 car system for all old users OTA of Xingyue L for free.

　　The exclusive designs for these two models include the far-Dai matte gray car paint and the ink-splashing environment-friendly suede interior. Among them, the official guide price of Yuandai frosted gray car paint is 6,000 yuan, and the official guide price of splash-ink environment-friendly suede interior is 3,000 yuan, while the Sky Edition will come standard with splash-ink environment-friendly suede interior. The environment-friendly chamois interior is covered with a large area of environment-friendly chamois. The covering rate of the seat surface is 68.8%, the ceiling is 100%, and the door panel and instrument panel are all covered with chamois. Not only has the touch been improved, but the sense of advanced has also been filled. In addition, the Galaxy OS 2.0 car system has a brand-new UI design, which is more fashionable and beautiful. The voice wake-up speed reaches millisecond level, and the whole scene can be seen. At the same time, a custom desktop that is more in line with the operating habits of the mobile terminal is adopted to create a more intelligent and non-inductive interactive experience for users.

　　A quick look at the highlights of new cars

　　·　Newly added exclusive designs, including Yuan Dai matte gray car paint and splash-ink environment-friendly suede interior.

　　·　Equipped with the latest Galaxy OS 2.0 car system.

　　·　2.0T+8AT

　　New car introduction

　　In terms of appearance, Geely Xingyue L adopts the family-style design language of Geely Automobile 4.0 generation products, and continues to maintain the high value of atmospheric dynamics. In terms of details, the front face of Xingyue L adopts the iconic straight waterfall air intake grille, and the black middle net is decorated with chrome trim, which makes the front face look very delicate and dynamic. The headlight with full LED light source energy matrix is very sharp in shape, and the two-stage design is highly recognizable. A chrome-plated decorative strip is added to the front enclosure that runs through the design, which is perfectly integrated with the L-shaped chrome-plated decorative strips on both sides.

　　Viewed from the side, Xingyue L adopts a muscular line design, which, together with the burly body size, makes the side look very atmospheric. In terms of body size, the L length/width/height of Xingyue is 4770*1895*1689mm, and the wheelbase is 2845 mm.. The rear of the car continues the family’s atmospheric and steady design style. The biggest highlight is the adoption of the popular through taillights, and the interior adopts the "aurora dot matrix" design, which is full of scientific and technological sense.

　　As for the interior, Xingyue L has adopted a brand-new design concept of "Symphony of Time and Space", and all designs have demonstrated the people-oriented design idea. High-grade suede fabric is widely used in the interior, and the exquisite pearl stitching is used. With the special suede seat with the ultimate skin-friendly touch, the exquisite, elegant and unique car interior is created for the vehicle. In addition, three large 12.3-inch screens are also a highlight of the interior. The 12.3-inch central control screen uses Qualcomm Snapdragon 8155 chip, while the 12.3-inch screen in front of the driver integrates rich functions such as watching videos, listening to songs, games, Tik Tok and karaoke.

　　In the power part, the two new models are equipped with the high-power version of the Drive-E series 2.0TD engine, with a maximum power of 175kW(238 HP) and a peak torque of 350Nm. The transmission is equipped with the 8AT gearbox from Aisin.

　　Editor’s point of view: Up to today, the cumulative sales volume of China Star Series has exceeded 730,000 vehicles, among which the cumulative sales volume of Xingyue L has exceeded 300,000 vehicles, with an average monthly sales volume of over 10,000 vehicles. It is worth mentioning that in August, the sales volume was 17,169 vehicles, with the monthly sales exceeding 15,000 vehicles for three consecutive months. In the past five months, the sales volume of high-equipped 8AT products accounted for over 65%. The addition of the two new models not only brings a more exclusive design, but also brings a richer choice of models for consumers who are concerned about Xingyue L.

　　Wonderful content review:

　　The release of Geely Panda Knight is expected to be launched in early September.

　　Geely Panda mini "Asian Games Bear" has been listed for 29,900 times.

　　Geely Panda mini is officially listed at a price of 39,900 yuan.