The 5-seat KIA EV5 is the first compact suv suitable for young people.

Today’s automobile market is full of flowers, and there are so many choices that consumers don’t have to be confined to a certain level when buying a car. What I bring to you today is a-. Let’s get to know each other.

Let’s take a look at the appearance of KIA EV5. The front face of KIA EV5 is clean and refreshing, and it looks sporty. Combined with the headlights, it looks quite angular. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car, the body size of the car is 4615MM*1875MM*1715MM. The car adopts tough lines, and the side circumference looks very soft. With large-sized thick-walled tires, it gives people a cool feeling. At the rear of the car, the overall shape of the rear of the car echoes the front of the car, and the taillight style is sharp and neat.

After getting into the car, the interior design of KIA EV5 took a clean route, highlighting the hierarchical effect. The steering wheel of the car is well designed, made of imitation leather, and the visual effect is good. Take a look at the central control, the car is equipped with a touch-sensitive LCD central control screen, which makes the interior design quite layered, and the details are still in place. Let Xiaobian introduce the dashboard and seats. The dashboard design is remarkable and the display effect is excellent. The car adopts leather-like seats, equipped with electric adjustment of auxiliary seats, electric adjustment of seats with memory, seat proportion tilting and other functions, which has good support and comfort.

Kia EV5 matched gearbox, 160KW, 310N.m, with good power performance.

It is still no problem to put two luggage bags in the trunk of KIA EV5, and the rear seats can’t be laid down, which is a pity. At the same time, the car is equipped with fatigue warning, anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), brake force distribution (EBD) main driver airbag, co-pilot airbag, side airbag curtain, front side airbag and other safety configurations.

This class of cars is usually the first choice for most people. First of all, the price is not expensive, and secondly, all the configurations are quite complete, which is still very worth starting with. You can learn more about what you like!

Reply Letter of Shaoxing Housing and Urban-Rural Development Bureau on Proposal No.207th of the Sixth Session of the Eighth National People’s Congress

Dear Representative Wang Yue Ming,

Your proposal No.207 on strengthening the management of the construction site of all urban projects and eliminating urban roads, mud and dust from the source, which was put forward at the Sixth Session of the Eighth National People’s Congress, has been received. The reply is as follows:

First of all, thank you for your concern and support for the management of construction sites in our city.

I. Basic information

At present, our city is at the peak of a new round of urban upgrading and construction. There are 420 construction sites in Yuecheng District alone, with an area of 22 million square meters under construction, 24 sections of rail transit, 83 kilometers of smart expressway, a large number of housing construction projects and renovation of old residential areas, with an average daily unearthed amount of 22,000 square meters. So many criss-crossing projects under construction are promoted at the same time, which not only promotes urban development and improves the living environment, but also objectively creates a certain degree of city.

According to the management measures for the prevention and control of dust pollution in Shaoxing, Interim Provisions on the standardized management of civilized construction in Shaoxing urban construction projects and other documents, as the competent department of the industry, we pay attention to civilized construction and dust control at the same time to minimize the impact of project construction on people’s travel and environmental quality.

Second, the promotion situation

(1) Strengthen industry supervision and standardize system construction. The first is the normalization of supervision and inspection. Since last year, all kinds of random inspections have been carried out from time to time, focusing on the special inspection actions of construction dust control such as "Building Blue Sky No.1", "Building Blue Sky No.2" and "Dust Control with Iron Fist". The city has inspected 9,477 construction sites and filed 47 cases for punishment, with a penalty amount of 1,223,500 yuan. The second is the daily supervision grid. The municipal management project compacts the responsibilities of all parties through the measures of "digitalization, gridding and differentiation", and the municipal quality and safety center distributes all the staff to all projects, forming a dual-post and dual-job management of "safety management department pays attention to the surface and gridding staff pays attention to the point", and differentiates the management of projects that are not rectified, and increases the inspection frequency of projects with poor detection data; Yuecheng District will divide the construction scope into 30 grids, carry out the responsibility to people, and carry out daily inspections. All construction sites in the city require five full coverage, namely enclosure construction, installation and spraying, bare soil coverage, road hardening, and full coverage of clean vehicles. The third is the standardization of system construction. This year, the "Measures for the Assessment of the" Five-to-One "Competition of Municipal Key Projects under Construction in Jiaokou City in 2021" and the "Measures for the Implementation of the Competition Activities for Civilized Construction Management of Construction Projects in the City in 2021" have been successively issued, with the competition ratio as the starting point, forcing all participating units to compact the main responsibility; It is planned to issue the Work Plan for Consolidation and Improvement of Ambient Air Quality of Shaoxing Construction System in 2021 and the Assessment Method for Consolidation and Improvement of Ambient Air Quality of Shaoxing Construction System in 2021, to further clarify the objectives and tasks and implement dust control measures.

(2) Intensify law enforcement and focus on dust control. According to the requirements of the Provincial Construction Department and the Municipal Blue Sky Office, we will actively organize inspection forces and increase the inspection of construction sites. Focus on checking the implementation of "eight hundred percent" in the construction site, requiring 100% closed enclosure on the construction site, 100% hardening of main roads on the construction site, 100% covering of exposed sand on the construction site, 100% washing and sealing of transport vehicles, 100% installation of dense mesh safety net on external scaffolding, 100% wet operation of earth and stone, 100% greening of uncut land and 100% off-road mobile machinery on the construction site. This year, the city organized a total of 1,270 inspections, inspected 2,200 construction sites, and punished 21 cases, with a total penalty of 467,000 yuan.

(three) to carry out competition activities, improve the reward and punishment mechanism. Set up two carriers to carry out "five-to-five" competitions for major projects (progress, quality, safety, investment and civilized construction), and carry out "civilized construction, creating excellence and winning cups" competitions for general housing construction and municipal projects, focusing on evaluating civilized construction and noise and dust reduction in construction sites. By setting up a "red and black list", we will increase rewards and punishments, add points for good integrity, and expose poor media, and incorporate the evaluation results into the assessment of SASAC, so as to force the implementation of the main responsibility. At present, there are 4 red list items and 1 black list item in the "Five-to-Five" competition. For 833 projects in the city, please refer to the civilized construction competition.

(4) Promote digital reform and realize smart governance. The first phase invested 6 million yuan to build a "smart construction" platform, effectively improved the level of safe and civilized construction on the construction site by means of information technology, and comprehensively promoted the online monitoring of dust and the installation and networking of video surveillance. At present, all the construction projects over 5,000 square meters in the city have completed the on-line monitoring of dust and the installation of over-standard alarm system, improved the data collection and analysis of the monitoring platform, optimized the supervision and management tendency according to the data analysis, carried out video capture inspections, strengthened the real-time supervision of the construction site, and helped win the blue sky defense war.

Third, the next step plan

(1) Further strengthen the linkage between departments and lay a good combination of dust control on construction sites. Cooperate with environmental protection, comprehensive law enforcement and other departments to jointly formulate relevant management measures; According to the territorial management mode, grid management is implemented by using the big data platform, and the responsibility lies with people; In-depth development of non-road mobile machinery, enclosure settings, pavement damage and other key rectification work, the implementation of joint punishment for enterprises that are not in place.

(2) Further intensify inspections and weave a protective net for dust control on construction sites. Improve the frequency of site inspections, strictly require construction enterprises to operate according to the specifications according to the requirements of "eight hundred percent", ensure that vehicles leaving the site are strictly washed, and implement closed management of easily scattered objects for engineering vehicles. Strengthen the monitoring of the construction site, make full use of the "digital construction" platform, conduct all-day video monitoring of the construction site, and promptly investigate and punish those who violate the rules and request to stop work for rectification.

(three) to further carry out civilized construction competition activities, to improve the level of civilized construction in the city. Combined with daily supervision and inspection, the competition work was carried out on the construction situation of Cheng Wenming within the jurisdiction, and the frequency and intensity of inspection were increased for the projects that ranked lower in the competition for two consecutive months; Zero tolerance will be given to those who violate the rules on the project construction site. Enterprises who violate the rules seriously or repeatedly will be recorded in the credit system, and if the circumstances are serious and cause adverse effects, their safety production licenses will be cancelled.

Finally, I sincerely thank you for your concern and support for urban construction!

Contact: Zhu Yingying; Contact information: 0575-85122383.

Shaoxing housing and urban construction bureau

June 8, 2021

Source of information: Municipal Construction Bureau

Nanjing Earth Building: A Unique Large Rammed Earth Residential Building in Mountainous Areas

  Nanjing Tianluokeng Tulou Group, the landmark building of Fujian Tulou in the night. Photo by Xiao Guohe

  Southeast Network Zhangzhou November 10 (reporter Su Haisen of this website) Fujian Tulou, hometown of Nanjing. Nanjing, Zhangzhou is the hometown of Fujian Tulou and the main heritage site of Fujian Tulou, a world cultural heritage. It has more than 15,000 tulou, including more than 1,300 large tulou, which is called "Tulou Kingdom". The oldest, largest, smallest, tallest and most exquisite earth buildings are located in Nanjing County. In 2008, 20 earth buildings in Tianluokeng Earth Building Group, Hekeng Earth Building Group, Huaiyuan Building and Hegui Building in Nanjing County were upgraded to World Heritage sites.

  On November 8, "E Road Peer ‘ Zhang ’ Charming "The 2019 national key online media interview group came to Nanjing County to visit and feel the charm of the unique large-scale rammed earth residential buildings in mountainous areas in the world.

  In the interview group, many people saw tulou for the first time, and they were amazed at tulou architecture and its rich and rich culture. "Quiet and natural, folk art." This is the biggest feeling of People’s Daily reporter Chen Xiaozhen after visiting Yuchang Building, the oldest tulou in Nanjing, and Tianluokeng Tulou Group, the landmark building of Tulou in Fujian.

  There are many earth buildings in Taxia Village, Nanjing, which are spectacular. Photo by Xiao Guohe

  "The hard work and wisdom of Hakka people are shocking and admirable." Su Yuru, a reporter from the public network in the north, said that the form of settlement in which the same clan lives in the same building is basically invisible in the north. "In addition to living, tulou has the function of resisting foreign enemies, and this design is amazing."

  It is reported that in 2018, the number of tourists received by Nanjing has exceeded 4 million, and the number of tourists received by Tulou has exceeded 2 million. "In recent years, the popularity of Nanjing Tulou has become higher and higher, and we have gradually explored ‘ Traditional culture+global tourism+tourism activity industry chain+tourism promotion output ’ A full industrial chain model with multi-format integration. " Liu Yongsheng, deputy secretary of the Party Working Committee of Tulou in Nanjing County and director of Tulou Management Committee, said that with the increasing number of tourists in Tulou every year, the protective measures for Tulou in Nanjing County are constantly strengthening, such as fire safety, which is inspected by a large number of firefighters every day. In addition, the government’s funds for the protection and repair of earth buildings are also increasing.

  Related links:

  Representative scenic spots of Fujian Tulou (Nanjing) tourist scenic spot

  Tianluokeng Tulou Group — — Fujian Tulou landmark building

  Tianluokeng Tulou Group, a landmark building of Fujian Tulou, commonly known as "four dishes and one soup". Photo courtesy of Propaganda Department of Nanjing County Committee

  Tianluokeng Tulou Group is a unique and mythical architectural model in mountainous areas in the world. It is a creative masterpiece of earthy architecture, which embodies the perfect combination of the oriental philosophy of "harmony between man and nature" and the architectural planning theory of "Feng Shui". It consists of five large-scale earth buildings, with a square building in the middle and three round buildings and an oval building around it. These earth buildings are undulating according to the mountain, patchwork and peculiar layout, and become the most exquisite combination group.

  These earth buildings not only adapt to the requirements of living and defense, but also reflect the perfect integration of earth building settlements and natural ecological environment, and have strong architectural characteristics of mountain residential buildings. In May 2001, Tianluokeng Tulou Group was identified as a national key cultural relics protection unit.

  Yuchang Building — — A strange garden of architecture slanting in the east and west

  The wall of Yuchang Building, the oldest earth building in Nanjing with a history of more than 600 years, is well preserved. Photo by Chen Shuguang

  Yuchang Building, built in 1308, is the oldest existing earth building in Fujian. Yuchang Building has five floors of 18.2 meters and 270 rooms. There are five stairs in the whole building, which are divided into five hexagrams. There are 22 wells in the kitchen on the ground floor, which is the earth building with the most wells in Fujian.

  The most striking feature of Yuchang Building is that its columns are staggered, with a maximum inclination of 15 degrees, which looks shaky. However, it has stood the test of 700 years of wind and rain erosion and numerous earthquakes, and is still as close as ever, becoming a living specimen of ancient residential buildings.

  Cloud and water ballads — — Graceful and agile Jiangnan style

  The quaint ancient town of Yunshuiyao. Photo by Xiao Guohe

  Yunshuiyao ancient town is an ancient village with a long history. The long ancient roads, century-old banyan trees, magical earth buildings and the clear water of Lingshan all give people a sense of detachment. The Yunshuiyao Scenic Area in Nanjing County has world cultural heritage, expensive buildings and Huaiyuan buildings, the highest, largest and most concentrated Millennium banyan trees in Fujian Province, a century-old street and a Millennium ancient road.

  The ancient town of Yunshuiyao has two world-heritage earth buildings, as well as diaojiao building, bamboo pole building, mansion-style earth building and so on, with unique scenery. The unique natural landscape and unique human resources of Yunshuiyao ancient town have attracted groups of film directors and producers to take pictures here.

  Huaiyuan Building — — The most exquisite tulou

  Huaiyuan Building, with a history of over a hundred years, is a masterpiece of traditional residential architecture. Photo by Chea Chang

  Huaiyuan Building is the best-preserved and most culturally meaningful double-ring round earth building in Nanjing, and it is also a typical representative of the corridor-style round building in Fujian. Huaiyuan Building has a complete defense function, and the outer ring earth building has four defense facilities, namely, anti-theft, anti-bandits, fire prevention and waterproof.

  Huaiyuan Building has a very strong cultural atmosphere, which is an outstanding example of the perfect combination of all the architectural achievements of Fujian Tulou and Confucian culture, and it is also a physical witness of important historical events in modern China. In 2006, Huaiyuan Building was designated as a national key cultural relic protection unit.

  And your building — — The tallest square building

  And your building in the early morning. Photo by Xiao Guohe

  Hegui Building is a typical representative of the corridor-style square building in Fujian Tulou, and it is one of the few large-scale square buildings that still exist today. It was built in the tenth year of Yongzheng in Qing Dynasty (1732) and formed ‘ Bao Lou, Bao Lou CuO ’ The plane layout of. Tulou people have always attached importance to culture and education, and a private school with "three rooms and one hall" has been built in the courtyard of your building.

  And your building has high architectural research value. And the wall of your building is rammed with soil. The bottom wall is 1.4 meters thick and shrinks step by step. The total height of the wall is 17.95 meters, and the height-thickness ratio of the soil wall reaches 13: 1. Visible, as early as more than 200 years ago, Fujian Tulou has pushed the traditional rammed earth technology level in China to the peak. What’s even more amazing is that Heguilou, a square earth building resembling a castle, was actually built on a swamp of 3,000 square meters, which is still like an ark on land. Now it has passed through more than 200 spring and autumn. The ancestors of tulou created the cutting foundation construction technology with pine as the bottom, which successfully solved this technical problem, which is shocking enough. In 2001, Hegui Building was designated as a national key cultural relics protection unit.

  background information

  Fujian Earth Building: Earth Building with Great Aesthetic Feeling

  Overlooking the Tulou Group in Tianluokeng, the landmark building of Fujian Tulou. Photo by Xiao Guohe

  Fujian Tulou came into being in the Song and Yuan Dynasties. After the development in the early and middle Ming Dynasty, it gradually matured in the late Ming Dynasty, the Qing Dynasty and the Republic of China, and it has continued to this day. Fujian Tulou is a unique large-scale rammed earth residential building in mountainous areas in the world. It is a self-contained, economical, strong and defensive high-rise building type, which absorbs the "Feng Shui" concept of China’s traditional architectural planning, adapts to the requirements of living and defense of living together, and skillfully uses the narrow flat land in the mountains and local building materials such as raw soil, wood and pebbles.

  The building materials of Fujian tulou are very strange, which are composed of clay, glutinous rice, brown sugar, bamboo chips and water. The tulou built is warm in winter and cool in summer, and it is very magical to resist typhoons and earthquakes. Fujian Tulou is an outstanding representative of China’s traditional culture "Fiona Fang" thought; It is a shining example of "harmony between man and nature" in China residential buildings; It is a historical witness to the peak of China’s rammed earth technology and national harmony; It is the most potential world business card for China’s ecological and cultural tourism.

Measures for the administration of real estate surveying and mapping

  The "measures" for the administration of real estate surveying and mapping have been deliberated and adopted by the 31st executive meeting of the Ministry of Construction on October 8, 2000 and the executive meeting of the State Bureau of Surveying and Mapping on October 26, 2000 (the State Bureau of Surveying and Mapping is authorized by the Ministry of Land and Resources), and are hereby promulgated and shall come into force as of May 1, 2001.

  Chapter I General Provisions

  Article 1 In order to strengthen the management of real estate surveying and mapping, standardize the behavior of real estate surveying and mapping, and protect the legitimate rights and interests of housing owners, these Measures are formulated in accordance with the Surveying and Mapping Law of People’s Republic of China (PRC) and the Urban Real Estate Management Law of People’s Republic of China (PRC).

  Article 2 These Measures shall be observed when engaging in real estate surveying and mapping activities and implementing real estate surveying and mapping management in People’s Republic of China (PRC).

  Third real estate surveying and mapping units shall strictly abide by the relevant laws and regulations of the state, implement the national real estate surveying norms and relevant technical standards and regulations, and be responsible for the quality of their completed real estate surveying and mapping results.

  Real estate surveying and mapping units shall adopt advanced technology and equipment, improve the level of surveying and mapping technology, and accept the technical guidance and business supervision of the real estate administrative department and the surveying and mapping administrative department.

  Article 4 Real estate surveying and mapping practitioners shall ensure the completeness and accuracy of surveying and mapping results, and shall not engage in illegal surveying and mapping, practise fraud, or harm the national interests, social public interests and the legitimate rights and interests of others.

  Fifth the State Council Surveying and mapping administrative departments and the State Council construction administrative departments shall be responsible for the supervision and management of real estate surveying and mapping and the application of the results according to the division of responsibilities determined by the State Council.

  The surveying and mapping administrative departments of the people’s governments of provinces, autonomous regions and municipalities directly under the Central Government (hereinafter referred to as the provincial surveying and mapping administrative departments) and the construction administrative departments of the people’s governments of provinces and autonomous regions and the real estate administrative departments of the people’s governments of municipalities directly under the Central Government (hereinafter referred to as the provincial real estate administrative departments) are responsible for the supervision and management of real estate surveying and mapping and the application of results according to the division of responsibilities determined by the people’s governments of provinces, autonomous regions and municipalities directly under the Central Government.

  Chapter II Entrustment of Real Estate Surveying and Mapping

  Article 6 In any of the following circumstances, the applicant for housing rights, the owner of housing rights or other interested parties shall entrust a real estate surveying and mapping unit to conduct real estate surveying and mapping:

  (1) Houses applying for initial registration of property rights;

  (2) Houses whose natural conditions have changed;

  (three) the housing rights or other interested parties require surveying and mapping houses.

  Real estate surveying and mapping required in real estate management shall be entrusted by the real estate administrative department to conduct real estate surveying and mapping units.

  Seventh real estate surveying and mapping results should be consistent with the natural conditions of real estate. When the natural conditions of the real estate change, the real estate change measurement shall be implemented in time.

  Eighth commissioned by the real estate surveying and mapping, the client and the real estate surveying and mapping unit shall sign a written contract for real estate surveying and mapping.

  Ninth real estate surveying and mapping units should be independent economic entities, and shall not have an interest in the client.

  Tenth real estate surveying and mapping costs paid by the client.

  Real estate surveying and mapping fees in accordance with the relevant provisions of the state.

  Chapter III Qualification Management

  Article 11 The State implements the qualification examination and certification system for real estate surveying and mapping units.

  Twelfth real estate surveying and mapping units shall, in accordance with the "People’s Republic of China (PRC) Surveying and Mapping Law" and the provisions of these measures, obtain the "Surveying and Mapping Qualification Certificate" issued by the surveying and mapping administrative department of the people’s government at or above the provincial level, which specifies the real estate surveying and mapping business.

  Thirteenth unless otherwise stipulated in these measures, the qualification examination, grading standards, operation limits and annual inspection of real estate surveying and mapping shall be implemented in accordance with the relevant provisions of the state.

  Fourteenth units applying for the qualification of real estate surveying and mapping shall submit a written application to the local provincial administrative department of surveying and mapping, and submit relevant materials in accordance with the requirements of surveying and mapping qualification examination and management.

  The provincial administrative department of Surveying and mapping shall, within 5 days from the date of acceptance, transfer it to the provincial administrative department of real estate for preliminary examination. Provincial real estate administrative departments shall, within 15 days, put forward written preliminary opinions and feedback to the provincial administrative departments of Surveying and mapping; Among them, the preliminary examination opinions on applying for the qualification of Grade A real estate surveying and mapping shall be submitted to the construction administrative department of the State Council for the record.

  To apply for the qualification of Grade A real estate surveying and mapping, the provincial administrative department of surveying and mapping shall report to the administrative department of surveying and mapping of the State Council for approval and certification; Those who apply for the qualification of real estate surveying and mapping below Grade B shall be examined and approved by the provincial administrative department of surveying and mapping.

  Units that have obtained Grade A real estate surveying and mapping qualifications shall be jointly announced to the public by the administrative departments of surveying and mapping in the State Council and construction in the State Council. Units that have obtained the qualification of real estate surveying and mapping below Grade B shall be jointly announced to the public by the provincial administrative department of surveying and mapping and the provincial administrative department of real estate.

  Fifteenth "Surveying and mapping qualification certificate" is valid for 5 years, 3 months before the expiration, the holder shall submit it for review, and the issuing authority shall be responsible for the review and replacement. For real estate surveying and mapping projects, the issuing authority shall solicit the opinions of the real estate administrative department at the same level when reviewing and replacing the certificate.

  Within the validity period of the "Surveying and Mapping Qualification Certificate", the qualification of real estate surveying and mapping shall be inspected by the administrative department of surveying and mapping. During the annual inspection, the surveying and mapping administrative department shall solicit the opinions of the real estate administrative department at the same level. Units that have been demoted or disqualified from real estate surveying and mapping in the annual inspection shall be jointly announced to the public by the surveying and mapping administrative department of the annual inspection and the real estate administrative department at the same level.

  Apply for upgrading the qualification of real estate surveying and mapping within the validity period of the "Surveying and mapping qualification certificate", and re-apply for qualification examination procedures in accordance with the provisions of Article 14 of these Measures.

  Chapter IV Results Management

  Sixteenth real estate surveying and mapping results include: real estate books, real estate data and real estate atlas.

  Seventeenth parties have objections to the results of real estate surveying and mapping, you can entrust a nationally recognized appraisal agency for real estate surveying and mapping results.

  Article 18 The real estate administrative department shall examine and verify the qualifications of the surveying and mapping unit, the applicability of the surveying and mapping results, the accuracy of the boundary points, the basis and method of area measurement, etc. for the results of real estate surveying and mapping used for real estate management such as housing ownership registration. After the audit of real estate surveying and mapping results into the unified management of real estate files.

  Article 19. Providing, giving away and selling unpublished data of real estate surveying and mapping achievements to organizations and individuals outside the country (territory), and entrusting institutions outside the country (territory) to print real estate surveying and mapping maps shall be handled in accordance with the People’s Republic of China (PRC) Surveying and Mapping Law, the Regulations on the Administration of Surveying and Mapping Achievements in People’s Republic of China (PRC) and the relevant provisions of national security and confidentiality.

  Chapter V Legal Liability

  Article 20 Whoever engages in real estate surveying and mapping business without obtaining the Surveying and Mapping Qualification Certificate which specifies the real estate surveying and mapping business and undertakes the real estate surveying and mapping task beyond the business scope and operation limit of real estate surveying and mapping stipulated in the Surveying and mapping Qualification Certificate shall be punished in accordance with the provisions of the People’s Republic of China (PRC) Surveying and Mapping Law and the Administrative Provisions on Surveying and Mapping Qualification Examination and Certification.

  Twenty-first real estate surveying and mapping units in any of the following circumstances, the real estate administrative departments of the people’s governments at or above the county level shall give a warning and order it to make corrections within a time limit, and may impose a fine of not less than 10 thousand yuan but not more than 30 thousand yuan; If the circumstances are serious, the issuing authority shall demote or cancel its qualification for real estate surveying and mapping:

  (a) the national standards, norms and regulations are not implemented in the calculation of real estate area;

  (two) in the calculation of real estate area, fraud, deception of housing rights;

  (three) the calculation of the real estate area is wrong, causing great losses.

  Twenty-second in violation of the provisions of article nineteenth of these measures, according to the "People’s Republic of China (PRC) Surveying and Mapping Law", "People’s Republic of China (PRC) Surveying and Mapping Achievements Management Regulations" and the provisions of national security and confidentiality laws and regulations.

  Twenty-third real estate surveying and mapping management personnel, staff dereliction of duty, abuse of power, corruption, shall be given administrative sanctions; If a crime is constituted, criminal responsibility shall be investigated according to law.

  Chapter VI Supplementary Provisions

  Twenty-fourth provincial real estate administrative departments and surveying and mapping administrative departments may formulate detailed rules for implementation according to these measures.

  Twenty-fifth approach by the administrative department of construction in the State Council and the administrative department of Surveying and mapping in the State Council jointly explained.

  Twenty-sixth the implementation since May 1, 2001.

Guizhou People’s Broadcasting Station’s pornographic programs have been repeatedly banned and severely punished.

    Related news:   From May 1st, the ban on overseas cartoons will be extended by one hour.    


    CCTV.com News: The news broadcast of Guizhou People’s Broadcasting Station ignored the orders of the State Administration of Radio, Film and Television (SARFT), wantonly played up sexual life, sexual experience, sexual experience and sexual organs in several sets of radio programs, and boasted about the function of sexual drugs. Today, it was severely criticized by SARFT, and the illegal programs were stopped and cancelled.


    According to the website of the State Administration of Radio, Film and Television, on September 13, 2007, Guizhou People’s Broadcasting Station broadcasted sexual obscenity and indecent programs on urban and economic frequencies, which was explicitly stopped by the State Administration of Radio, Film and Television. On November 12th, 2007, Guizhou People’s Broadcasting Station changed the name of Jin Tao’s Talk about Sex, which was stopped, to Jin Tao’s Night Talk, and was ordered by the State Administration of Radio, Film and Television to investigate and deal with it again. Since mid-January, 2008, when the whole province of Guizhou is united in fighting against the snowstorm and freezing disaster, the news broadcast of Guizhou People’s Broadcasting Station has continued to broadcast obscene and obscene programs that exaggerate sexual life, sexual experience, sexual experience, sexual organs and sexual medicine functions in the programs of Health Special Line and Healthy World. The informed criticism issued by the State Administration of Radio, Film and Television to Guizhou People’s Broadcasting Station was copied to the CPC Guizhou Provincial Committee and the Guizhou Provincial People’s Government.


    The State Administration of Radio, Film and Television (SARFT) pointed out that since September 2007, radio, film and television administrative departments at all levels in China and radio and television broadcasters have conscientiously implemented the spirit of the Central Committee, and in accordance with the unified arrangements of SARFT, seriously rectified and severely investigated pornographic and obscene programs, and achieved remarkable results, which were fully affirmed by the Central Committee and praised by the broad masses. The fact that Guizhou People’s Broadcasting Station refuses to implement the provisions of the State Administration of Radio, Film and Television, and its programs involving sexual obscenity and obscenity are repeatedly banned fully shows that Guizhou People’s Broadcasting Station is indifferent in orientation and position awareness, lax in political discipline and propaganda discipline, lacking due social responsibility and professional quality, lax in rules and regulations, and weak in propaganda management, which must be dealt with seriously.


    The State Administration of Radio, Film and Television severely criticized Guizhou People’s Broadcasting Station and its principal responsible persons, and informed the whole country.


    The State Administration of Radio, Film and Television ordered the Guizhou Provincial Radio and Television Bureau to immediately stop broadcasting and cancel the sexually obscene and obscene programs such as Health Line and Healthy World of Guizhou People’s Broadcasting Station, seriously rectify Guizhou People’s Broadcasting Station, severely investigate and deal with relevant personnel and persons in charge of Guizhou People’s Broadcasting Station and news broadcasting in strict accordance with relevant regulations, and report the investigation to the State Administration of Radio, Film and Television as soon as possible.


    The State Administration of Radio, Film and Television requires that all provincial, district (city) radio, film and television bureaus should be duty-bound, strictly implement the relevant publicity management regulations of the State Administration of Radio, Film and Television, earnestly perform their publicity management duties, and once again conduct a comprehensive and thorough clean-up and inspection of radio and television broadcasters within their jurisdiction, especially those at prefecture (city) and county levels. It is necessary to take measures to check at all levels, implement responsibilities, and not neglect their duties, perfunctory, and whitewash. To strengthen the work of listening and watching, strict supervision and management, to prevent the resurgence of pornographic programs, and in March 10, 2008, the clean-up inspection will be reported to the State Administration of Radio, Film and Television. The administrative departments of radio, film and television at all levels and radio and television broadcasters should conscientiously organize study, convey and implement the spirit of a series of documents issued by the State Administration of Radio, Film and Television on the thorough rectification of pornographic and obscene programs, strengthen the sense of orientation and position, emphasize social responsibility and post responsibility, improve the censorship system and broadcasting system, be serious about political discipline and propaganda discipline, increase supervision and investigation, and resolutely ban them to ensure the correct orientation of radio and television propaganda.


    The State Administration of Radio, Film and Television emphasizes that radio, film and television administrative departments at all levels and radio and television broadcasters should thoroughly implement the spirit of the 17th Party Congress, vigorously publicize the socialist core value system, adhere to the orientation of advanced socialist culture, firmly grasp the correct direction of public opinion, keep in mind the social responsibility of radio and television, resolutely safeguard the good image of radio and television, always put social benefits first, advocate the concept of harmony, cultivate the spirit of harmony and build a harmonious culture.


    The State Administration of Radio, Film and Television (SARFT) said that it would continue to supervise and inspect the rectification of pornographic and obscene radio and television programs in various places. Anyone who refuses to implement the provisions of the General Administration will be found together and investigated together, and the mechanism of punishment, accountability and withdrawal of radio and television broadcasters will be started in accordance with relevant regulations. At the same time, the audience is welcome to report, and the telephone number of illegal programs of the State Administration of Radio, Film and Television is 010-86095315; The online reporting address is http://www.chinasarft.gov.cn/. 


























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Editor: Feng Ye

Adjust the suggested retail price to mark Feitian Maotai, and speed up the high-end Wuliangye?

Recently, the news that Wuliangye suggested that the retail price should be adjusted to 1499 yuan attracted attention, which was interpreted by the outside world as wanting to bid for 53-degree flying Maotai.
On March 27th, the Beijing News reporter visited a Wuliangye store in Haidian, Beijing. At present, the price of the eighth-generation Wuliangye 52-degree 500ml single bottle has been adjusted to 1499 yuan. In the official flagship store of Wuliangye, the e-commerce platform, the price of this product is also displayed as 1499 yuan. However, the actual purchase price is lower than 1499 yuan, ranging from 1100 yuan to 1200 yuan.
Some Wuliangye dealers confirmed to the Beijing News reporter that "the eighth-generation Wuliangye price adjustment notice was recently received from the manufacturer". In its view, "the market price of Wuliangye has not kept pace with the retail price. Adjusting the retail price may affect the profit of distributors, but it will also be a test of survival of the fittest for channel terminals."
In February this year, Wuliangye ushered in a new head and started a new round of high-quality development. The industry believes that the proposed retail price adjustment releases the signal that Wuliangye will enhance its quality value and brand potential. At the same time, it also means the transformation and upgrading of Wuliangye, paying more attention to terminal marketing, and helping to cultivate brand value.
Some dealers have received the price adjustment notice. 
On March 27th, the Beijing News reporter visited a Wuliangye specialty store in Haidian, Beijing. The price of a 52-degree eighth-generation Wuliangye 500ml single bottle was 1499 yuan. The staff in the store introduced, "(retail price) has just been adjusted, and the price of goods can be cheaper, with a single bottle of 1100 yuan; Get the whole box, a single bottle of 1050 yuan. " At the same time, the clerk also said that "the price tag has been adjusted, and the actual transaction price may be adjusted in the future."
A Wuliangye store in Haidian, Beijing, the price tag of the eighth generation Wuliangye shows 1499 yuan. Beijing News reporter Qin Shengnan/photo

Subsequently, the Beijing News reporter visited chain liquor stores and supermarkets, and some liquor store clerks said that they had heard about the proposed retail price adjustment.
In the official flagship store of Tmall Wuliangye, the price of a 52-degree eighth-generation Wuliangye 500 ml single bottle is 1499 yuan, and it is 1220 yuan after participating in the activity of 1499 minus 279. The Beijing News reporter consulted the customer service as a consumer whether the manufacturer’s guide price of this product was raised, and the customer service replied that "the prices of goods are all audited by the company and uniformly priced". According to the pictures provided by customer service, the activity of subtracting 279 from 1499 will end on April 15, 2022.
In Wuliangye’s new retail APP, the price of a 52-degree eighth-generation Wuliangye 500 ml single bottle shows 1220 yuan, but there is also a underlined price on the page showing 1499 yuan.
Screenshot of Wuliangye’s new retail APP (left) and the official flagship store of Wuliangye on Taobao platform.
On March 27, the Beijing News reporter from HenanoneThe distributor of Wuliangye learned that "a few days ago, it was informed by the manufacturer that the suggested retail price of the eighth generation Wuliangye has indeed been adjusted, from 1399 yuan to 1499 yuan per bottle". The distributor said that the adjustment "should be nationwide, mainly based on Wuliangye’s own development and market conditions".
Talking about whether to mark Feitian Maotai,The dealer believes that,Maotai is the representative of Maotai-flavor and Wuliangye is the representative of Luzhou-flavor. There is no comparability between them.
The research report issued by Ping An Securities pointed out that with the structural upgrading of consumption, the number of liquor enterprises above designated size continued to decrease, the concentration of the industry accelerated, and the price increase contributed to the main growth. The rising price of Feitian Maotai has opened the ceiling of high-end liquor and sub-high-end liquor. Wuliangye will continue to benefit from the high-end consumption spillover under the supply restriction of Maotai, and it will be a high probability event to realize the sale at a favorable price after the price increase.
As of press timeWuliangye official did not release the price adjustment news, and Wuliangye related staff also told the Beijing News reporter that it was not clear about this matter for the time being.
Forced dealers to transform and upgrade.
In recent years, there has been an upsurge of sauce-flavor liquor in the market, which makes Wuliangye, as the "boss" of Luzhou-flavor liquor, have to face the pressure from sauce-flavor liquor and carefully deal with the possible changes in consumers’ drinking preferences under the new consumption mode.
On February 18 this year, Wuliangye setTuanyingThe new head of the company once served as Party Secretary and Chairman of Wuliangye Group, and Party Secretary and Chairman of Wuliangye Co., Ltd.. Starting a new round of high-quality development and reaching a new level of development is the starting point and focus of Wuliangye’s "coaching change".
The Beijing News reporter noted that on March 11th, Wuliangye held the 2022 investor communication meeting by live online. Focusing on the development goal, Zeng Congqin proposed to make every effort to build Wuliangye with the five-in-one of "ecology, quality, culture, digital and sunshine" and sustained, steady and high-quality development, including upgrading and building the largest solid-state pure grain brewing base in the industry, continuously improving the industry-leading quality management system, improving the famous liquor rate of Wuliangye and adhering to "quality Wuliangye"; Build "Digital Wuliangye" and set a benchmark for digital transformation of China liquor industry.
According to media reports, Wuliangye has adjusted its ex-factory price at the beginning of this year. The planned ex-factory price of the eighth generation Wuliangye is still 889 yuan/bottle, but the unplanned price has increased from 999 yuan/bottle to 1089 yuan/bottle. Superimposing the proposed retail price adjustment, in the eyes of the industry, this means that Wuliangye is taking a series of measures to consolidate the advantage of thousand yuan price belt, and it is also a manifestation of enhancing its brand value.
However, in the view of the above-mentioned dealers, since the current market price of Wuliangye has not kept pace with the retail price, adjusting the retail price may affect the profit of distributors. "This adjustment is also a test of the strength of distributors, and the survival of the fittest will force distributors to continuously transform and upgrade, and the advantages of distributors with good performance will become more prominent, while distributors without stable customer base may face greater challenges. Overall, it may be more conducive to the long-term development of Wuliangye. "
Xiao Zhuqing, a liquor analyst, told the Beijing News reporter that the suggested retail price should be adjusted to 1,499 yuan, which can widen the price difference and improve the enthusiasm of the whole terminal channel. "In the past, Wuliangye mainly relied on large agents, and its marketing methods were relatively rough. From simple channel promotion and advertising, it now attaches great importance to terminal marketing, attaches importance to more accurate big data marketing, word-of-mouth sharing, etc., and at the same time builds cultural IP and begins to pay attention to the control of social inventory. These are all measures for the development of Wuliangye’s refined marketing."
According to the 2021 annual performance forecast released by Wuliangye recently, it is estimated that the revenue in 2021 will be about 66.2 billion yuan, an increase of about 15% year-on-year; It is estimated that the net profit will be about 23.35 billion yuan, a year-on-year increase of about 17%. As for the reasons for the change in performance, Wuliangye said that it was mainly due to the continuous growth of the volume and price of the company’s core products.
Beijing News reporter Qin Shengnan 
Editor Zhu Fenglan proofreads Liu Baoqing.

Luo Zhengxiang, a famous expert in cardiothoracic vascular surgery in China, developed the "China Heart" valve to lead the Institute of Cardiology to the world.

Video shooting/video editing: Liang Xuhao

Luo Zhengxiang, reporter Liang Yihao, photo

[Guangdong famous doctor who has been a doctor for 70 years]

Jinyang. com reporter Feng Xixi correspondent Yue Weixin Zhang Lanxi Zhang Lingling Yuting

Professor Luo Zhengxiang, 93, is a famous expert in cardiothoracic and vascular surgery in China. He used to be the president of Guangdong Provincial People’s Hospital and the director of Guangdong Institute of Cardiovascular Diseases. From a handsome young boy to a white-haired old man today, years have left traces, but he can never change the "passion" in his heart-"saving lives" is his lifelong pursuit.

Under his leadership, Guangdong took the lead in establishing the Institute of Cardiovascular Diseases in China, and its reputation is still far-reaching. This famous cardiovascular expert also won the honor of "Outstanding Contribution Award of China Cardiothoracic Surgery".

The "best student" was admitted to medical college.

Luo Zhengxiang, 93, has gray hair, but his figure is straight. He is still a handsome elder in a suit. His thinking is very clear. When he is free, he watches movies and listens to classical music. When he goes out, he takes a mobile phone and "scans the code to pay" like a young man. He is a "grandfather". This "post-90 s" grandfather has made outstanding contributions to the development of cardiovascular disease in China.

In 1947, Luo Zhengxiang did not study business or economics as expected by his father. "When I was a child, I loved reading history books and wanted to be a hero. At that time, the best students could be admitted to medical school, so I went after the hardest." With an indomitable spirit, he successfully passed the West China University of Medical Sciences.

In 1954, Luo Zhengxiang came to work in Guangdong Provincial People’s Hospital, and chose the most difficult and complicated major in the medical field at that time-cardiac surgery. Since then, he has embarked on a journey of "heart" for more than half a century.

Cardiac surgery was difficult to start in China at that time. But Luo Zhengxiang never gave up his research on heart disease-heart surgery is extremely demanding, starting with the most basic hemostasis practice. The great blood vessel was accidentally broken and the blood was shocking. Luo Zhengxiang looked at the shadowless lamp, pressed it, pressed it, pinched it, and stitched the wound with a big curved needle. He was calm and calm for a few times: OK. The valves are stitched one by one, and repeated actions are done over and over again, which is simple and boring. 1 hour, 2 hours … Some doctors have been standing on their legs and looking at them, but Luo Zhengxiang is staring, unhurried and meticulously crafted.

"I used to have surgery and the conditions were very bad. Eating a dollar at noon is simple; There is no air conditioning in the operating room. Everyone is sweating after the operation and can only drink more water after the operation. " Luo Zhengxiang said that although the conditions are difficult, everyone can work together with Qi Xin. "The director of the department takes the lead in suffering, and the doctors and nurses will follow suit. This is a kind of atmosphere and a kind of culture."

The first generation of artificial biological heart valve in China has been developed.

In 1974, after visiting Beijing, Shanghai and Guangzhou, Argentine cardiovascular experts decided to invite Guangdong experts to study cardiovascular technology in Argentina. On March 16th, 1974, a technical team organized by the Ministry of Health, mainly from Guangdong Provincial People’s Hospital (Xiang Xiangyao, Luo Zhengxiang, Chen Chuanrong, Wei Wanchang, Chen Zhiming, Wang Tailai and Jin Si Lan from the First Affiliated Hospital of Sun Yat-sen Medical College) went to Argentina for a one-year medical investigation. This year’s study was fruitful, and Luo Zhengxiang and his party brought back advanced valve technology. In 1977, Luo Zhengxiang and Cai Zengxin went to an Italian hospital in Argentina again to study heart valve technology. In 1975, the first domestic aortic valve replacement was successfully implemented, and the first domestic pediatric valve replacement was successfully implemented in the same year …

In the 1970s, rheumatic heart disease and rheumatic fever prevailed in southern China, but for these patients who need valve replacement, heart valves need to be imported, which is expensive and few people can afford it. Luo Zhengxiang and his colleagues are determined to make Chinese’s own heart valve. In 1976, Guangdong Institute of Cardiovascular Diseases set up a research room for artificial heart biological valves, and then cooperated with Australian medical expert Dr. Zhang Renqian to set up Pacific Biological Products Company in Huangpu District of Guangzhou with full reference to international standards to develop and produce artificial heart valves. In 1977, the first generation of artificial biological heart valve in China, Guangdong Type I, was developed and applied in clinic, taking the lead in the perioperative management of cardiac surgery and the application of intra-aortic balloon counterpulsation in critical heart surgery. In 1987, Guangdong II artificial heart biological valve was successfully developed, and in 1988, the artificial mechanical heart valve was successfully developed in cooperation with Australian experts and applied in clinic. Domestic valves greatly reduce the cost of patients’ surgery and shorten the gap between cardiothoracic surgery in China and advanced countries in the world.

3. Lead the Institute of Mind Research to break through difficulties and create brilliance.

In 1958, Guangdong Provincial Institute of Thoracic Diseases was established in Guangdong Provincial People’s Hospital. For various reasons, the development of the institute was quite tortuous. On August 7th, 1978, Guangdong Provincial Party Committee agreed to rename Guangdong Thoracic Disease Research Institute as "Guangdong Cardiovascular Disease Research Institute", and the Ministry of Health listed Guangdong Cardiovascular Disease Research Institute as one of the three key cardiovascular disease research institutes in China (Beijing, Shanghai and Guangdong).

In this way, the Guangdong Institute of Cardiovascular Diseases was established, but how to go next is a problem that Luo Zhengxiang has to face. Now, 93-year-old Luo Zhengxiang goes back to the Institute every day to see this old place where he has been "cultivating" for decades. Every time he walks past the entrance of Dongchuan Road, Guangzhou, he will think of the difficulties of that year: "The Institute had no funds at first, and we ran to the cement factory to find the cement. I wear leather shoes to the construction site every day to supervise the work. After that, I change my clothes and go back to the operating room for surgery. " In this way, with the concerted efforts of everyone’s Qi Xin, the Institute of Mind Research has grown up slowly.

Today, it has gone through 61 years. Over the past 61 years, the Institute has trained a large number of experts for the country, treated tens of thousands of patients and laid the foundation for the prevention of cardiovascular diseases. Created countless national firsts, first cases, and even world firsts.

Young doctors love to chat with Luo Zhengxiang, and he is also willing to communicate with young people. He said that he likes to chat with patients when he sees a doctor, and it is easier to build trust when he gets familiar with each other. "When you are a doctor, you must be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am saving with my heart. Whether the doctor is careful or not can be seen by patients and their families. "

[famous doctor said]

When you are a doctor, you should devote yourself to the patients.

When you are a doctor, you should be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am trying to save them.

Immune aging that cannot be underestimated: old age may lead to ineffective vaccines.

Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text

How to balance the diet? Expert Interpretation of Reference Intake of Dietary Nutrients for China Residents (2023 Edition)

  On October 26th, an exclusive interview with DRIs was held in Beijing.

  Yang Yuexin, Chairman of China DRIs Revision Expert Committee and Chairman of China Nutrition Society, Ma Aiguo, Deputy Chairman of the Revision Committee and Executive Vice Chairman of China Nutrition Society, Ding Gangqiang, Deputy Chairman of the Revision Committee, Secretary of the Party Committee of China Nutrition Society and Director of the Institute of Nutrition and Health of China CDC, Yang Xiaoguang, Vice Chairman of China Nutrition Society and researcher of the Institute of Nutrition and Health of China Center for Disease Control and Prevention, Peng Xianwu, the supporting unit of DRIs revision and general manager of Amway (China) Science and Technology Innovation Center, attended the interview and interpreted the new revision.

Expert Interpretation of Reference Intake of Dietary Nutrients for China Residents (2023 Edition)

  Yang Yuexin introduced that the 2023 edition of China DRIs is the ninth edition. The revised expert committee and technical working group composed of nearly 100 nutrition experts lasted for three years. Based on the four basic principles of scientificity, advancement, integrity and continuity, the different reference intakes of 20 age groups including energy, nutrients and other dietary ingredients and pregnant women and lactating mothers totaled more than 70 nutrients and other dietary ingredients, which were revised and confirmed, and were held at the 14th Asian Nutrition Conference in September 2023.

  The revision of DRIs in 2023 mainly includes four aspects. First, the concepts and procedures have been improved and perfected. Different procedures for determining different reference values of nutrients have been newly formulated, and the technical points of each link of the formulation procedures have been uniformly determined. The concepts and connotations of recommended intake and specific recommended values for reducing the risk of diet-related non-communicable diseases have been further clarified and improved. Secondly, the basic reference values of China population were formulated and revised, including age grouping, representative weight, reference value of breast milk composition, recommended weight gain of pregnant women, PAL of physical activity level, etc. Thirdly, the new research results of nutrients and other dietary components in the past decade at home and abroad in the fields of function, evaluation, requirement, safety and prevention of chronic diseases have been included, and more research results targeting China residents have been included. Fourth, from the writing framework, format and other styles, it highlights the positioning of reference books centered on quantitative values.

Reference Intake of Dietary Nutrients for China Residents (2023 Edition) (DRIs)

  Peng Xianwu believes that this revision has far-reaching guiding significance for the big health industry, such as the data of newly added plant nutrients such as coenzyme Q10 and Lycium barbarum polysaccharide, and the quantification of nutrients such as proanthocyanidins, which will help Amway and industry to develop products and guide consumers to use them.

  Peng Xianwu introduced that in 2022, Amway and China Nutrition Society established Nutrilite Special Fund for Plant Functional Components and Health Research, aiming at attracting more research institutions and personnel to participate in the research direction of plant nutrients, opening up production, learning and research, transforming research results into products faster, and making more scientific research results benefit the public.

Peng Xianwu, General Manager of Technical Regulations of Amway (China) Science and Technology Innovation Center

  This revision has greatly changed the protein intake of the elderly and the calcium supplement standard for adults. Yang Xiaoguang believes that China has entered an aging society, and the elderly and ordinary people can’t meet the demand for protein, which is easy to lead to sarcopenia. Therefore, it is necessary to improve the dietary structure of the elderly and increase the intake of protein. Yang Xiaoguang introduced: "The 2023 edition of DRIs revised the requirement of protein for the elderly aged 65 and above in China, and its recommended intake increased from 0.98 g/(kg day) to 1.17 g/(kg day), which is an important achievement".

  Ding Gangqiang said that in recent years, the health awareness of Chinese residents has been continuously strengthened, and dietary nutrition and healthy behaviors have been continuously formed, but chronic diseases related to nutrition are still increasing. It is hoped that the release of the 2023 edition of DRIs will further guide the needs of China residents in all aspects of dietary nutrition, especially how to achieve a reasonable and balanced diet, and complete the objectives of the second largest action of Healthy China Action-Reasonable Diet Action.

  The revision of DRIs has a wide range of significance and value. First, it has scientific value, which determines the types and quantities of nutrients that each person should consume every day qualitatively and quantitatively. Second, social value is an important basic data support for formulating relevant policies, regulations and standards; The third is the value of technical support, which plays an important guiding role in the dietary design and evaluation of collective feeding units such as schools and nursing homes, the nutrition labeling of prepackaged foods, and the product research and development of food enterprises.

Buy a Japanese hybrid SUV, these three models are worth choosing, and the energy consumption is lower than that of the same class cars.

In the domestic auto market, if you are going to buy a car with a hybrid electric system, then this Japanese car with a very smooth technology is worth considering. If everyone’s budget is around 200,000, Nissan Qijun e-POWER, Honda CR-V e:HEV and Toyota Rongfang are all worthy of consideration. Below, we will interpret the selling points of the three models and the highlights of hybrid technology respectively. You can choose one according to the needs of car purchase.

1. Nissan Qijun e-POWER

The appearance of Nissan Qijun e-POWER adopts Nissan’s latest V-motion design language, and its shape is still very atmospheric, which conforms to the aesthetics of home users. The big sofa seat inside is very comfortable, and it is not easy to feel tired after sitting for a long time.

The intelligent configuration of this car is a highlight, especially the intelligent safety. It is equipped with an enhanced version of ProPILOT super intelligent driving, and has a number of intelligent driving assistance functions, such as reversing car side warning, moving object/pedestrian detection warning, over-the-horizon collision warning, etc. It can be said that car safety can be guaranteed in different scenarios.

In terms of power, Nissan Qijun e-POWER is composed of a 1.5T range extender and dual motors. Although it uses the engine to supply power to the motor just like the extended range system, the e-POWER is different from it, because the engine only has the job of "power supply" and the motor is responsible for all the driving forces. This has the advantage that the fuel consumption can be effectively reduced, and its minimum comprehensive fuel consumption is only 6.36L. At the same time, this technology does not need to be equipped with a large-capacity battery, so it will naturally not occupy the seating space.

In addition, this car is also equipped with Snow Fox electric four-wheel drive e-4ORCE, which has five driving modes such as snow and off-road. Because it is completely electronically controlled for four-wheel drive, the response is very fast, the control and tracking are also highlights, and the driving experience is more guaranteed.

2. Honda CR-V e:HEV

Honda Cr-V E: The appearance of HEV continues the design of the fuel version, with an atmospheric shape and a certain sporty atmosphere. The interior part is still introverted, with many physical buttons and convenient operation.

The biggest attraction of intelligence is the addition of Honda SENSING 360 safety extrasensory function, which can monitor the driver’s status and surrounding conditions in real time, and prompt and assist braking in time if potential danger occurs.

In terms of power, Honda CR-V e:HEV adopts the fourth-generation i-MMD dual-motor hybrid technology, which consists of a 2.0L engine and a drive motor. Compared with the previous-generation hybrid system, the fourth-generation i-MMD hybrid system improves the power of the drive motor, and the efficiency of the two-speed clutch is also higher, thus effectively reducing fuel consumption, and its comprehensive fuel consumption is only 5.49L, making it very easy to maintain a car. In addition, compared with the fuel version, due to the addition of the motor, the ride comfort of the model is more outstanding when starting and driving at low speed.

3. Toyota Rongfang Double Engine

The appearance of Toyota Rongfang twin engines is tough, and the interior part looks old-fashioned, but the materials are still willing, such as leather steering wheel and leather seats.

In addition, the new Toyota Rongfang dual-engine launched last year has improved the intelligent driving assistance system a lot, adding functions such as emergency steering assistance and active deceleration in corners to ensure smoother driving.

In terms of power, Rongfang Twin Engine adopts Toyota’s fifth-generation THS II hybrid system, which consists of a 2.5L engine and a motor. A major feature of this system is to replace the Ni-MH battery that has been used for many years with a lithium battery. In this case, the battery volume is greatly reduced, and the power control unit has also been lightened, and the comprehensive power has been improved to some extent.

At the same time, the addition of lithium battery reduces the energy loss of the motor by 19%, and the driving force of the motor is stronger. Not only is the power strong, the comprehensive fuel consumption is still economical, and the minimum fuel consumption is only 5.1L, so it is very easy to maintain a car. In addition, Toyota Rongfang dual-engine four-wheel drive technology is also worth mentioning. It has three four-wheel drive systems: electronic four-wheel drive, dynamic torque vector control system and dynamic torque control system. The output torque of the rear wheel is obviously improved, and the torque distribution ratio of the rear wheel is added, so that maneuverability and stability are guaranteed.

general comment

It can be seen that the compact SUVs blessed by the three hybrid electric power systems are very atmospheric in shape. Although the interior can’t keep up with the trend, it still has certain intelligent functions and comfortable configuration, and the power system is naturally the biggest highlight of the three joint venture vehicles. With the addition of the motor, driving can get better ride comfort, and the key fuel consumption is much more economical than that of similar oil vehicles, and the cost of car use can be effectively reduced. Which of the above three oil-mixed SUVs do you prefer?