On November 27, 2009, Cai Jian [2009] No.853

　　

Shanghai, Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, Hubei, Hunan, Guangdong, Guangxi, Hainan, Chongqing, Sichuan, Guizhou, Yunnan, Tibet, Heilongjiang, Jilin, Inner Mongolia, Liaoning Province (autonomous regions and municipalities directly under the Central Government) Finance Department (bureau), Grain Bureau, China Grain Reserve Management Corporation, COFCO Group Co., Ltd., China Hualiang Logistics Group Company,

　　In order to give full play to the role of market mechanism, stabilize the domestic corn market price, and protect the interests of grain farmers, with the approval of the State Council, after the newly-produced corn in Northeast China (including Heilongjiang, Jilin, Liaoning and Inner Mongolia, the same below) was listed in 2009, the central government gave a one-time fixed-fee subsidy to the southern feed-consuming provinces that purchased the newly-produced corn in Northeast China and transported it to the local area. In order to do a good job in subsidy management, we hereby print and distribute the Measures for Financial Management of Subsidies for New Corn Production in Northeast China in 2009 to you, please implement them carefully.

　　Attachment: Financial Management Measures for Subsidies of New Corn Production in Northeast China in 2009 by Southern Feed Consumption Provinces

　

　　Cc: General Office of the State Council, Shanghai, Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, Hubei, Hunan, Guangdong, Guangxi, Hainan, Chongqing, Sichuan, Guizhou, Yunnan, Tibet, Heilongjiang, Jilin, Inner Mongolia, Liaoning (autonomous regions and municipalities directly under the Central Government) People’s Government, Development and Reform Commission, Agricultural Development Bank branches, and the Ministry of Finance in Beijing, Shanghai and Inner Mongolia.

　　

Attachment:

Southern feed consumption provinces purchase new corn produced in Northeast China in 2009.

Measures for the financial management of expense subsidies

　　

　　In order to give full play to the role of market mechanism, stabilize the domestic corn market price, and protect the interests of grain farmers, with the approval of the State Council, after the newly-produced corn in Northeast China (including Heilongjiang, Jilin, Liaoning and Inner Mongolia, the same below) was listed in 2009, the central government gave a one-time fixed-fee subsidy to the southern feed-consuming provinces that purchased the newly-produced corn in Northeast China and transported it to the local area. To this end, these measures are formulated.

　　I. Scope of subsidies

　　(1) The southern feed consumption provinces include 16 provinces (autonomous regions and municipalities) such as Shanghai, Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, Hubei, Hunan, Guangdong, Guangxi, Hainan, Chongqing, Sichuan, Guizhou, Yunnan and Tibet.

　　(II) Under the leadership of the provincial people’s government, the local grain reserve companies and corn feed processing enterprises in the above-mentioned provinces are entrusted by the provincial grain administrative department and the financial department to purchase the newly-produced corn in China in 2009 in Northeast China under the principle of voluntary and independent declaration and at their own risk, and each province (autonomous region, city) entrusts 1-2 enterprises with the qualification of grain operation, and then uniformly transports them back to the local area and applies for subsidies. The list of specific enterprises should be announced to the public in a timely manner.

　　(III) The corn purchased by the grain enterprises directly under the central government (including the enterprise headquarters) in the above-mentioned provinces in the northeast and transported back to the above-mentioned provinces, as well as the corn purchased by the central reserve enterprises in the above-mentioned provinces from the northeast and used for reserve rotation, enjoy the same subsidy policy. The specific enterprise list shall be examined and determined by the enterprise headquarters, and the enterprise headquarters shall uniformly organize and apply for subsidies.

　　(four) the relevant provinces and enterprises directly under the central government shall report to the Ministry of Finance, the State Grain Bureau and other relevant departments for the record after selecting and determining the specific enterprise list; The State Grain Bureau shall make a summary and make it public in time. Once the list of enterprises is published, it will not be adjusted.

　　Second, the subsidy conditions and standards

　　(five) enterprises included in the scope of subsidies shall meet the following conditions when applying for subsidies:

　　1 enterprises entrusted by the provincial administrative department of food jointly with the financial department shall have the qualification of food business and the entrustment documents jointly issued by the local provincial food and financial departments. Grain enterprises and reserve enterprises directly under the central government need to be audited and confirmed by the enterprise headquarters.

　　2. The price purchased by enterprises from farmers in Northeast China shall not be lower than 0.76 yuan/kg in Inner Mongolia and Liaoning, 0.75 yuan/kg in Jilin and 0.74 yuan/kg in Heilongjiang (third class in the national standard, the same below). When purchasing third-class corn higher or lower than the national standard, the purchase price can be raised or lowered by 0.02 yuan/kg for each grade raised or lowered according to the national standard.

　　3. The purchased corn must be the newly produced corn in China in 2009.

　　4. The procurement period for enjoying the expense subsidy is from December 1, 2009 to April 30, 2010.

　　5. The purchased corn must be delivered to this province (autonomous regions and municipalities) before June 30, 2010.

　　6 enterprises applying for subsidies must be consistent with the goods receiving unit of the transport certificate.

　　7. The total amount of corn purchased by the central reserve enterprises applying for subsidies shall not exceed the reasonable annual rotation plan for the local subsidy period issued by the relevant state departments and China National Grain Storage Corporation.

　　(VI) The corn actually purchased by the enterprise according to the above provisions and transported back to the province (autonomous regions and municipalities) shall be subsidized by the central government at a one-time fixed cost of 0.035 yuan per catty according to the number of corn converted into standard products (moisture ≤14% and impurities ≤1%). The subsidized corn is sold by the enterprise itself and is responsible for its own profits and losses.

　　(seven) enterprises included in the scope of subsidies, one of the following acts, once found, cancel all financial subsidies of the enterprise, and through social media and other public notification:

　　1 enterprises will not yet arrived in the province (autonomous regions and municipalities) to apply for subsidies for corn.

　　2. The enterprise will apply for subsidies for the corn purchased within the non-subsidized procurement period or the corn newly produced in Northeast China in 2009.

　　3. The enterprise fails to submit the monthly statistical report of purchase, sale and storage to the local administrative department of grain according to the provisions of the statistical system, and the grain and oil processing enterprise fails to submit the statistical report of grain and oil processing industry according to the provisions, and refuses to report false statistical data.

　　4 other acts of obtaining state subsidies through fraud.

　　(eight) according to the monitoring results of the relevant state departments, when the price of corn directly purchased from farmers in Northeast China rose to an average of 0.8 yuan/kg (third-class national standard), the central government stopped subsidizing it.

　　Third, the starting and ending period of subsidy policy

　　(9) The subsidized corn shall be purchased in Northeast China from December 1, 2009 to April 30, 2010 and delivered to the provinces (autonomous regions and municipalities) where the grain purchasing enterprises are located before June 30, 2010.

　　(10) The procurement time shall be based on the time when the procurement contract is signed.

　　(eleven) the arrival deadline refers to the time of transportation to the province where the grain purchasing enterprise is located. According to the date indicated on the legal transportation documents, it is determined according to the following principles:

　　1. Direct inter-provincial railway transportation shall be based on the date when the goods arrive at the platform;

　　2. The combined transport of hot metal and public water shall be based on the date of arrival at the loading dock;

　　3. Direct road transportation shall be based on the date when the goods arrive at the destination.

　　Iv. application for subsidy funds

　　(12) Time of application. Enterprises enjoying this subsidy need to submit an application before July 15, 2010, and local procurement enterprises shall submit the subsidy application and valid vouchers to the provincial grain administrative department according to the above-mentioned prescribed time limit; Enterprises affiliated to the central government shall submit subsidy applications and valid vouchers to the enterprise headquarters. The subsidy application includes all materials for corn procurement and transportation, as well as the sales and inventory of corn transported back to the province (autonomous regions and municipalities).

　　(thirteen) the subsidy application materials include:

　　1. Voucher of purchasing link: For direct purchase from farmers in Northeast China, there should be a unified invoice (copy) for grain and oil purchase uniformly printed by the local tax department, and this invoice should have an audit stamp stamped by the tax department. Unified procurement from grain enterprises in Northeast China should have a legal procurement contract and a special invoice for local tax value-added tax (copy). A new grain certificate issued by the county-level grain administrative department or quality inspection unit where the purchase is located. At the same time, the purchaser of the small ticket or the buyer of the purchase contract must be the subsidy application enterprise announced by the State Grain Bureau to the public.

　　2. Vouchers for transport links: waybills and delivery vouchers uniformly printed by railway, transportation and shipping departments. Among them, the place of dispatch is Northeast China, the place of arrival is the subsidized province stipulated in these Measures, and the consignee is a subsidy application enterprise made public by the State Grain Bureau.

　　3. Payment voucher: the grain purchase voucher or bank remittance voucher printed by the tax department. Among them: the payer and the payee of the payment voucher must correspond to the buyer and the seller of the purchase contract; At the same time, the payment before June 30, 2010 must exceed 80% of the contract amount.

　　4. Sales inventory certificate: sales contract and special VAT invoice (copy), inventory statistics.

　　5 central reserve corn storage enterprises, but also need to provide the relevant state departments and China Grain Storage Corporation issued the annual rotation plan documents.

　　When applying for subsidies, all vouchers are provided with photocopies (which must be stamped with the official seal of the unit), but the applicant enterprise must keep the vouchers for verification. The application materials provided by the enterprise shall be registered and tabulated, and shall be responsible for the authenticity of all materials. At the same time, the enterprise shall keep all the original documents by itself, and the relevant departments shall conduct random inspection when auditing and checking.

　　V. Audit of subsidy funds

　　(fourteen) the audit of the application materials of local procurement enterprises. The provincial food department shall timely summarize, sort out and preliminarily examine the application materials for enterprise subsidies, and report them to the provincial finance department for review within 15 working days. The provincial finance department shall complete the review within 15 working days, and submit an application report for pre-allocation of subsidy funds to the central finance, and send a copy of the application report to the local financial Ombudsman office of the Ministry of Finance for examination and confirmation. The provincial food department and the financial department shall be responsible for the authenticity and completeness of the application materials of enterprises (after the preliminary examination by the provincial food administrative department in Tibet, the provincial financial department shall review and report on its own).

　　(fifteen) the audit of the application materials of enterprises directly under the central government. Enterprise headquarters shall, after timely summarizing, sorting out and preliminary examining the application materials for enterprise subsidies, submit an application report for pre-allocation of subsidy funds to the Ministry of Finance before the end of July 2010, and send a copy of the application report to the Office of the Financial Ombudsman of the Ministry of Finance in Beijing for examination and confirmation. The enterprise headquarters shall be responsible for the authenticity and completeness of the application materials of the directly affiliated enterprises.

　　(sixteen) the Office of the Financial Ombudsman shall, on the basis of the audit of the relevant departments at the provincial level and the headquarters of the enterprise, review the application materials, and at least select 1~2 enterprises for on-the-spot verification. The Office of the Commissioner shall submit the examination results to the Ministry of Finance within 30 working days after accepting the application report.

　　Six, the allocation of subsidy funds

　　(seventeen) the Ministry of Finance shall, according to the application report of subsidy funds submitted by the provincial financial department and the enterprise headquarters, allocate the amount of corn subsidies determined by the Office of the Financial Ombudsman and the subsidy standards. Subsidies from local enterprises are allocated by the central government to provincial financial departments; Subsidies from enterprises directly under the central government shall be allocated by the central finance to the enterprise headquarters.

　　(eighteen) after receiving the central financial allocation, the provincial financial department shall directly allocate it to the subsidy application enterprise within 10 working days.

　　VII. Supplementary Provisions

　　(nineteen) the subsidy funds allocated by the central government, as subsidy income, shall be managed and used by enterprises according to the current accounting requirements.

　　(twenty) business disputes, accidents, etc., which occurred during the subsidy period, shall be settled by the enterprise according to the relevant laws and regulations.

　　(twenty-one) enterprises included in the scope of subsidies must conscientiously implement national policies, accurately and timely fill in relevant statistical statements, and truthfully submit subsidy application materials according to regulations. Relevant regions and departments should earnestly perform their duties of supervision and inspection, and it is strictly forbidden to resort to deceit or falsely report the subsidy funds.

　　(twenty-two) the Ministry of Finance shall be responsible for the interpretation of these Measures.

　　"Low carbon" is one of the hottest words at the two sessions this year. CPPCC members’ proposals are piled up with "low carbon", and NPC deputies discuss "low carbon" hotly, and group discussions are also inseparable from the topic of "low carbon". "Low carbon" has become the "new favorite" that people pay attention to for a time. So, what is "low carbon" and what does agriculture and rural areas do in developing low carbon? The insights of the deputies explain the "low carbon" of agricultural and rural development from different angles.

　　The meaning of the transformation of agricultural development mode

　　"Low-carbon agriculture is first of all an idea and a development direction of agricultural transformation development mode. The essence of the low-carbon concept is to save energy. " Shang Xunwu, member of Chinese People’s Political Consultative Conference and deputy director of Gansu Agriculture and Animal Husbandry Department, said.

　　Zhang Quanguo, member of Chinese People’s Political Consultative Conference and dean of the School of Mechanical and Electrical Engineering of Henan Agricultural University, further explained low-carbon agriculture. He said: "Agriculture, as the basic industry of the national economy, is one of the main sources of greenhouse gases, and it is also increasingly affected by the greenhouse effect. How to formulate low-carbon agricultural development policies and reduce carbon emissions in agricultural production has increasingly become the focus of attention from all walks of life and one of the key areas to be considered in regional economic development. It is imperative to change the agricultural production mode as soon as possible and develop low-carbon and high-efficiency agriculture. "

　　At present, in China’s agricultural production mode, some production habits do not meet the requirements of low carbon, which is neither economical nor polluting the environment. Taking fertilization as an example, Meng Tieying, deputy stationmaster of soil and fertilizer station in Xincheng County, Guangxi Province, said that because there is a lot of local rain, heavy rain usually causes farmland to be flooded. Traditional fertilization methods make the loss of fertilizer very serious, which not only increases the cost, but also pollutes the environment. Farmers urgently need a fertilizer that can control the release rate. Data show that the low utilization rate of chemical fertilizers in China is the main reason for environmental pollution caused by chemical fertilizers. In addition to crop absorption and utilization and soil residue, more than 50% of nitrogen is not absorbed by crops and lost to farmland, which has caused a series of environmental and food safety problems, such as eutrophication of water, soil hardening, greenhouse effect and degradation of agricultural products quality.

　　Zhang put forward a proposal to develop low-carbon agriculture. He believed that it is necessary to cultivate the management concept of low-carbon agriculture, vigorously promote the innovation of agricultural production system, implement the management assessment responsibility system for energy saving and emission reduction in agriculture-related production, and gradually develop and improve agricultural energy efficiency standards from the height of national laws and regulations. He also proposed that we should pay attention to the research on low-carbon agriculture, including the integrated application research of carbon emission reduction and carbon sink expansion technologies such as energy, environment, building structure, water supply and drainage, and green space.

　　Science and technology support low carbonization of agricultural production

　　Shang Xunwu said that there are many articles that can be done to develop modern agriculture and realize the development of agriculture from extensive to refined. It can be said that in the agricultural field, it is very feasible to achieve low carbon.

　　He said that many aspects of agriculture can consider how to achieve low carbon. For example, he said that from the perspective of agricultural inputs, such as water resources, agriculture consumes a lot of water, but now the way of using water is unreasonable, causing great waste. Water is used for irrigation, but also consumes electricity. If water is saved, irrigation energy is saved, and it is low-carbon.

　　Zhang Quanguo gave a concept of low-carbon agriculture. "Low-carbon agriculture is a modern agricultural development model. Through various means such as technological innovation, institutional innovation, industrial transformation, and new energy development and utilization, energy consumption and carbon emissions are reduced as much as possible to achieve a win-win situation for agricultural production development and ecological environment protection." He further explained that low-carbon agriculture is the further development of eco-agriculture and green agriculture, which not only advocates less use of chemical fertilizers and pesticides and efficient agricultural production like eco-agriculture, but also pays more attention to the reduction of overall agricultural energy consumption and carbon emissions in the process of planting, transportation and processing, when the use of energy such as electricity, oil and gas is increasing.

　　Shang Xunwu gave his own suggestions on how to promote low-carbon agriculture. First, strengthen the role of technology and promote low-carbon technology in agriculture. The second is the innovation of production mode. For example, intensive production, through cooperatives and professional associations to promote centralized production and management, improve efficiency.

　　Zhang Quanguo also holds the same view: supporting the sustainable development of agriculture by improving the technical content of low-carbon agriculture.

　　Taking the scientific and technological development of fertilizer research and development as an example, China has supported the low-carbon fertilization in fertilizer technology research and development. Liu Jianwen, a representative from Agricultural Economics Center of Agriculture Bureau of Linshu County, Shandong Province, said that in recent years, fertilizer enterprises in Linshu have achieved remarkable results in research and development, production and popularization of slow-release fertilizers in low carbon. For example, he said that hundreds of slow-release fertilizer products developed and promoted by Jin Zhengda Group, the largest production base of slow-release fertilizers in Asia, are suitable for field crops in China. Xu Weigang, deputy director of Wheat Research Center of Henan Academy of Agricultural Sciences, summed up the advantages of slow-release fertilizers in low carbon: slow-release fertilizers can control nutrient release according to crop nutrient demand, which changes the shortcomings that fertilizers can not meet the different demands of crops at different growth stages because of rapid dissolution and nutrient loss, and can greatly improve the utilization rate of fertilizers, protect the environment, save energy, simplify crop production technology and help farmers reduce costs and increase income.

　　For supporting the development of low-carbon agriculture with science and technology, Zhang put forward more specific suggestions. He suggested: First, improve the low-carbon agricultural infrastructure in the core grain producing areas. Intensify integration, focusing on the construction of modern facility agriculture demonstration parks, ecological animal husbandry, grain (leafy vegetables) functional areas and other projects to lay a good foundation for accelerating the development of modern agriculture. Second, strengthen the cultivation of excellent varieties adapted to low-carbon environment. At the same time, we should vigorously promote the innovation of farming system and promote a number of development models such as stable grain and high efficiency, farming-pastoral cycle, and paddy-upland rotation. Third, greatly reduce the use of chemical fertilizers and pesticides, and reduce the carbon content in agricultural development. Such as using manure, compost or organic fertilizer instead of chemical fertilizer, and increasing soil nutrients through returning straw to the field.

　　The era of low-carbon rural life is coming.

　　Low-carbon mode not only has great achievements in agricultural production, but also the conditions for developing low-carbon in rural areas are ripe. Zhang Quanguo said that to develop low-carbon agriculture, it is necessary to develop new energy sources in rural areas and realize the diversification of rural energy consumption structure. Such as comprehensive utilization of straw, livestock manure, solar energy and other renewable energy resources to meet the needs of rural domestic cooking energy, rural domestic electricity and domestic hot water.

　　Twenty years ago, Tengtou Village, Ningbo City, Zhejiang Province, which wrote environmental protection into the villagers’ convention and established the only village-level environmental resources protection committee at that time, was the forerunner of rural low-carbon. Fu Qiping, the general secretary of the village party branch, said that building a "low-carbon" ecological village was the golden key to rural development. "To develop a’ low-carbon’ economy and achieve harmony between man and the natural environment, rural areas should also shoulder the burden." Fu Qiping believes that the future "low-carbon" life is a high-quality, healthy and civilized lifestyle.

　　"A large number of solar cookers in the western rural areas will greatly reduce greenhouse gases such as carbon dioxide produced by burning firewood (grass, wood), gas and coal." Ren Qixing, member of Chinese People’s Political Consultative Conference and deputy director of the Population, Resources and Environment Committee, said. He said that the western region of China has a long sunshine time and relatively rich solar energy resources, which is most suitable for popularizing solar cookers in large quantities. Ren Qixing suggested establishing financial support policies and giving appropriate financial subsidies to the purchase of solar cookers in rural areas. At the same time, vigorously support solar cooker manufacturers, give tax incentives, and help enterprises improve output, quality and scientific and technological content to meet the needs of promoting the use of solar cookers in rural areas.

　　Coincidently with Ren Qixing, Hao Yuan, member of Chinese People’s Political Consultative Conference, vice governor of Gansu Province and chairman of the Provincial Federation of Industry and Commerce, is also very concerned about the utilization of solar energy. He put forward the Proposal of Implementing the Solar Energy "South Wall Plan" at the two sessions. Its core idea is to use the south facade of the building facing the sun, including the heat collection wall, air collector and additional sunshine room on the south facade, to convert the collected solar radiation energy into heat energy as much as possible, and then transfer it to the room to achieve the purpose of heating and warming.

　　In order to promote a lower-carbon lifestyle in rural areas, Zhang also suggested that the development and application of biogas technology should be widely promoted, and at the same time, the agricultural and sideline residues should be fully utilized to improve the low-carbon utilization of straw. He said that China’s annual crop straw output is about 700 million tons, half of which can be used as energy, equivalent to 150 million tons of standard coal. He suggested focusing on the research and development of "trinity" complete technology and equipment for low-carbon utilization of straw. The core grain producing areas such as Henan Province are selected to carry out innovative research and demonstration application of low-carbon agricultural renewable energy and energy-saving engineering technology integration.

　　Beijing, March 1 ST "The 19th National Congress of the Communist Party of China proposed to build an educational power, which is an arduous, historic and grand task. To build an educational power, we must first improve the quality of basic education, and we must first improve the quality of Chinese and mathematics." Recently, Wang Wenzhan, former director of the Department of Basic Education of the Ministry of Education and deputy chief inspector, said this at the launching ceremony of the national "Shui Mu Hsinchu Yingchun Cup" national youth mathematics comprehensive ability exhibition sponsored by the Central Network Film and Television Center of the Communist Youth League, undertaken by Future Network and Shui Mu Hsinchu Education, and supported by the Education Research Center of China Teacher magazine.

　　Launching Ceremony of "Shui Mu Hsinchu Yingchun Cup" National Youth Mathematical Comprehensive Ability Exhibition.

　　Wang Wenzhan, former director of the Department of Basic Education of the Ministry of Education and deputy inspector general, stressed that the activities should adhere to the "three natures" and "three noes", which are not only public welfare, exhibition and interesting, but also do not exceed the standard, increase the burden on students and rank second. It is also pointed out that basic education is the foundation of the whole education, Chinese and mathematics are the foundation of the foundation, and the education for teenagers in the whole country is the most important part of the education system, while the basic education for teenagers is the foundation of all education. Our country’s achievements in mathematics are excellent in the world, and it ranks among the top in the world. This excellent momentum will continue, and it needs the joint efforts of people from all walks of life who are enthusiastic about education.

　　Wang Wenzhan, former Director of the Department of Basic Education of the Ministry of Education and Deputy Chief Inspector.

　 　

　　Xin Tianhao, executive editor-in-chief of the Communist Youth League Central Network Film and Television Center and Future Network.

　　"Mathematical culture, as a spiritual and non-cognitive psychological level, is eternal, which can influence and achieve people’s life." Xin Tianhao, executive editor-in-chief of the Network Film and Television Center of the Central Committee of the Communist Youth League and Future Network, introduced it at the launching ceremony.

　　Lin Yuanlie, Professor of Mathematics Department of Tsinghua University

　　Lin Yuanlie, a professor of mathematics at Tsinghua University, and the leaders and guests present deeply discussed the charm of mathematics. He explained in detail two famous sayings of predecessors: "Mathematics is the key to open the door to science" and "Mathematics is the queen of science", and called on the vast number of young people in China to explore the endless treasure in mathematics.

　　Tian Yumin, Director of Education Research Center of China Teacher Magazine.

　　Tian Yumin, director of the Education Research Center of China Teachers magazine, also said that this kind of comprehensive ability exhibition has a positive role in promoting students’ learning ability and learning habits, and should be strongly supported by all sectors of society. The "Shui Mu Hsinchu Yingchun Cup" national youth comprehensive mathematical ability exhibition is a good start, and he is looking forward to more positive public welfare comprehensive ability exhibition activities.

　　

　　Wang Zhengpu, General Manager of Beijing Shui Mu Hsinchu Education Technology Co., Ltd.

　　"The purpose of this exhibition is to promote the mathematics culture, set off an upsurge of loving, learning and using mathematics in the whole country, and make students understand, like and enjoy mathematics more comprehensively, so as to continuously improve their mathematics literacy." Wang Zhengpu, general manager of Beijing Shui Mu Hsinchu Education Technology Co., Ltd., also said in his speech that students will appreciate the beauty of mathematics, build a spiritual communication between me and mathematics, and realize that mathematics plays an inestimable role in the development of human culture.

　　It is understood that the purpose of the "Shui Mu Hsinchu Yingchun Cup" National Youth Mathematical Comprehensive Ability Exhibition is to promote mathematical culture, stimulate the interest of primary and secondary school students in learning mathematics, explore more outstanding mathematics talents, develop their intelligence, popularize mathematical science, help the majority of young people discover their own mathematical talents, and enable students to fully understand, like and enjoy mathematics, and constantly improve their mathematical literacy. The proposition of this activity is universal and interesting, and all the topics seem simple, but students need to think hard in the process of solving them, and there are many solutions, which are helpful for students to open up their minds and stimulate the potential of mathematical comprehensive ability. Some topics combined with real-time hot spots make mathematics, an abstruse subject, return to life, and encourage students to apply what they have learned to solve practical problems in life with mathematical thinking.

　　From now on, the "Shui Mu Hsinchu Yingchun Cup" national youth mathematics comprehensive ability demonstration activity will be carried out one after another throughout the country, and the majority of young people who love mathematics can sign up for the activity.

Yu Xueyuan reminds

A new batch of influenza vaccine

Appointment vaccination has been opened.

Hurry up before the flu peak comes.

Arrange it for the children!

(Bao, it’s time for an injection)

Recently, a new batch (2023~2024 batches) of influenza vaccine has arrived in various places one after another, and it can be vaccinated by appointment.

On September 5th, China CDC suggested in the latest Technical Guide for Influenza Vaccination in China (2023-2024):

All people who are over 6 months old and have no contraindications should be vaccinated against influenza.

The CDC believes that

"This winter and next spring, you may face the risk of interaction or co-epidemic of respiratory infectious diseases such as COVID-19 and influenza."

In this situation, it is obviously necessary to vaccinate against influenza.

Is it too early to get a flu shot? How old can the child be vaccinated? How to choose several types of vaccines? ……There are still many concerns about the flu vaccine.

The following small series has compiled 9 frequently asked questions. Parents who are concerned about influenza vaccine should not miss today’s content ~

(Note: The new vaccination guide involves some updates and adjustments, and the following contents will also be popularized according to the new guide, so you may find that some information is different from what you have learned before, so it is recommended to take the new guide as the reference standard ~)

01

The flu vaccine is in place

Call now, is it early?

Say the answer first, not early, and just right.

Research data show that the epidemic season of influenza in winter and spring in China is usually from the middle and late October to the middle and early March of the following year.

After vaccination, the immune effect will not reach its peak until one month later.

According to the new guidelines: "The antibody protection level can be maintained for at least 6 months after influenza vaccination."

Vaccination now can just cover the upcoming peak of influenza in autumn and winter and the flu season in early spring next year.

When the flu peak comes, the antibody is just at the peak level, which can play a better protective effect.

02

The most important thing to vaccinate.

Who are they?

The new guidelines give priority to the timely vaccination of key and high-risk groups, including:

· Medical personnel, including clinical rescue personnel, public health personnel, health quarantine personnel, etc.;

·Older people aged 60 and over;

· People suffering from one or more chronic diseases;

· Vulnerable people and employees in old-age care institutions, long-term care institutions, welfare homes and other crowd gathering places;

· Pregnant women;

·Children aged 6-59 months (about 5 years old);

· Family members and caregivers of infants under 6 months old;

· People in key places such as kindergartens, primary and secondary schools, and supervision places.

Influenza vaccines are self-funded vaccines, but some areas have some free policies. Take Beijing as an example:

People over the age of 60, students in primary and secondary schools and emergency support personnel for major events can be vaccinated free of charge.

You can pay attention to the vaccination policy in your area.

03

What are the types of influenza vaccine?

How many shots? How to fight?

At present, there are trivalent inactivated influenza vaccine (IIV3), tetravalent inactivated influenza vaccine (IIV4) and trivalent live attenuated vaccine (LAIV3) approved for marketing in China, which are produced and supplied by different manufacturers.

In order to facilitate understanding, you can look at this table for specific vaccine types and applicable populations:

(Adults and children can refer to this table.)

Babies under the age of 6 months are also indirectly protected through the vaccination of their mothers during pregnancy and the vaccination of their caregivers and family members against influenza.

In order to gain sustained immunity,It is recommended that children be vaccinated against influenza once a year.Because the influenza virus is easy to mutate, the composition of the vaccine will be adjusted every year according to the prevalent strains of the year.

04

3 or 4, which is better?

Trivalent influenza vaccine can prevent influenza caused by influenza A (H1N1), H3N2 and Victoria B virus, while tetravalent influenza vaccine can alsoPrevent one more Yamagata virus B.

Source: Network

Although the virus coverage of tetravalent vaccine is wider than that of trivalent vaccine, the transmission ability and antigenic pathogenicity of influenza B virus are not as strong as that of influenza A virus.Therefore, vaccination with trivalent influenza vaccine can also prevent influenza virus.

There is no need for everyone to miss the best vaccination time in order to wait for the fourth price. After all,It is the most important thing to get vaccinated and protected in time!

05

Injection or nasal spray, which is better?

Whether it is injection or nasal spray, there is not much difference in safety and effectiveness.

You should notice that the injected vaccine is "inactivated" and the nasal spray is "attenuated". The difference lies in:

● Injection of influenza vaccine is to inactivate the virus, so that the virus loses its pathogenic ability but retains its antigenicity.

● Nasal spray vaccine is to culture and purify the live influenza virus, so that its virulence is weakened, but it can stimulate the human body to produce antibodies without pathogenic ability.

For babies who are very afraid of injections or dizzy needles, the nasal spray inoculation method is more moderate. But there is no need to pursue it deliberately. Again, timely vaccination is the most important thing.

06

The child has got the flu

Do you still need vaccination?

Need.

If the child accidentally gets the flu and has not been vaccinated against it before, he still needs to be vaccinated again after the baby gets better.

Because of influenza A,There is no cross-protection between different types.For example, if you have had H1N1 before, you will still get sick if you are infected with H3N2 next time.

07

Influenza vaccine can be combined with other vaccines

At the same time?

There are two situations.

Inactivated influenza vaccine (injection):Can be inoculated in different parts at the same time with other inactivated or attenuated influenza vaccines.

Attenuated vaccine (nasal spray):Can not be vaccinated with another attenuated vaccine at the same time, at least 4 weeks between them.

Can it be vaccinated at the same time as COVID-19 vaccine?

Over the age of 18, you can get inactivated influenza vaccine and COVID-19 vaccine at the same time;

Under the age of 18, it is recommended that the vaccination interval be greater than 14 days.

08

Taboos for influenza vaccination

Can egg allergy be vaccinated after all?

Egg allergy can be vaccinated against influenza.

People’s Republic of China (PRC) Pharmacopoeia (2010 edition, 2015 edition and 2020 edition) does not take people who are allergic to eggs as a taboo for vaccination.

The real vaccination taboos are the following!

You can’t get any flu vaccine.

(1) Those who are allergic to any ingredients contained in the vaccine (including auxiliary materials, formaldehyde, cracking agents and antibiotics) or have a history of severe allergic reaction to any kind of influenza vaccination.

(2) Patients suffering from acute diseases, severe chronic diseases or acute attacks of chronic diseases and fever are advised to be vaccinated after recovery or stable control.

(3) Guillain-Barre syndrome occurred within 6 weeks after previous influenza vaccination, which needs to be evaluated by a doctor.

Can’t be vaccinated with nasal spray attenuated influenza vaccine.

(1) Persons with low immune function due to drug use, HIV infection and other reasons.

(2) Children and adolescents treated with drugs containing aspirin or salicylic acid for a long time.

(3) Children with asthma aged 2-4 years.

(4) Have a history of Guillain-Barre syndrome.

(5) antiviral drugs such as oseltamivir and zanamivir were used 48 hours before inoculation, or palamivir was used 5 days before inoculation, or balosha was used 17 days before inoculation.

(6) In case of severe nasal congestion, it is suggested to suspend the inoculation of attenuated vaccine by nasal spray.

(7) Children with cochlear implants should avoid using nasal spray attenuated vaccine one week before and two weeks after operation.

(8) Pregnant women

There are still many contraindications for nasal spray attenuated vaccine.ofBefore choosing to vaccinate your child, you must pay attention to the above situation.

09

After vaccination

Will you still get the flu?

Maybe.

No vaccine can prevent the disease 100%, but vaccination can reduce the risk of infection andGreatly reduce the risk of serious illness and death.

According to the research data mentioned in the new guide, when influenza and COVID-19 are co-epidemic, after vaccination,At least it can achieve more than 70% protection effect.

Therefore, if no contraindications are involved, it is recommended to vaccinate in time, especially for the elderly and children.

Even if you are vaccinated against influenza, everyone should pay attention to prevention and maintain good hygiene habits.

Wash your hands frequently, ventilate frequently, go to crowded places less, wear masks when going to crowded places, and cover your nose and mouth when sneezing.

If you don’t know where to get a vaccine, you can refer to the following ways:

(1) Gaode or 114 inquires the telephone number of local hospitals, communities and epidemic prevention stations, and makes a phone call to consult about seedlings;

(2) Pay attention to WeChat official account, a local hospital, community and epidemic prevention station, and check whether there is an entrance for online seedling appointment;

（3）微信内搜索【疫苗服务预约】，选择所在城市，根据分类预约。

另外，育学园旗下北京弘和妇产医院也可约苗，在北京的朋友想了解可以拨打电话咨询??

咨询电话：(010)6549 1911

对流感疫苗还有其他问题，可以评论留言，小编会积极给大家解答~

最后，记得戳戳【在看】，和小编一起提醒大家，该！打！疫！苗！啦！

参考资料:

[1]中国疾病预防控制中心《中国流感疫苗预防接种技术指南（2023-2024）》

[2]上海疾控《流感疫苗可以安排了，给身体留出足够时间做准备》

[3]北京日报

免责声明：本文内容更新于2023年。文章仅提供一般的医疗、健康、用药、养育等方面的科普信息，不能代替任何个人的医学诊断和治疗。个人的医疗、用药问题请咨询医生。

授权转载：原创内容，欢迎转发，转载请留言。

01

这个孩子抹上脸的东西，可能导致性早熟！家里有的赶紧扔！

02

挨骂也要说，这种油别再吃了，家里有的赶紧扔！

03

扩散！这种家电每天都在释放「大量致癌物」！赶快提醒家里人

阅读原文」，下载育学园APP

　　CCTV News:On the morning of October 9, local time in Sweden, the Royal Swedish Academy of Sciences announced in Stockholm that it would award the 2019 Nobel Prize in Chemistry to John B. Goodenough, M. Stanley Wittingham and Yoshino Akira in recognition of them."developing lithium-ion batteries"The contribution of. They will share the prize of 9 million Swedish kronor (about 6.5 million yuan).

　　Lithium-ion batteries have completely changed our lives and are used in all applications, from mobile phones to laptops and electric cars. Through the work of the winners, this year’s Nobel Prize winner in chemistryIt laid the foundation for a wireless and fossil fuel-free society..

　　In the early 1970s, M. Stanley Wittingham, who won this year’s Nobel Prize in Chemistry, was developing.The first functional lithium batteryAt that time, the great power of lithium was used to release its external electrons.

　　John B. Goodenough, winner of the 2019 chemistry prize.The potential of the lithium battery is doubled.It creates suitable conditions for more powerful and useful batteries.

　　This year’s Nobel Prize winner in chemistry, Akira Yoshino, succeeded inPure lithium was removed from the battery.Instead, it is based on lithium ions that are safer than pure lithium. This makes the battery feasible in practice.

　　John B. Goodenough isFather of lithium batteryHe made the lithium battery smaller, larger and more stable in use, thus realizing commercialization and at the same time starting the process of portable electronic equipment. At present, he is Professor department of mechanical engineering of the University of Texas at Austin, USA. At the age of 97, he is a famous solid physicist, the inventor of cathode materials of lithium cobaltate, lithium manganate and Ferrous lithium phosphate, and one of the founders of lithium-ion batteries. He designs new materials by studying the relationship between chemistry, structure and solid electron/ion properties, and solves material science problems. Sony produced the world’s first commercial lithium battery after adopting Goodenough theory in 1991. Since then, mobile phones, cameras, hand-held cameras and even electric vehicles have entered the era of portable new energy.

　　M Stanley Whitingham is currently a professor of chemistry and director of the Institute of Materials and the Department of Materials Science and Engineering at Binghamton University, State University of New York.

　　Akira Yoshino, a Japanese chemist, is currently a researcher at Asahi Kasei and a professor at meijo university. He was commended by Zi Zi. Yoshino is the inventor of modern lithium-ion batteries, and has won the highest honor in engineering, the Global Energy Award and the Charles Stark Draper Award. (CCTV reporter Hao Xiaoli)

Albinism is a kind of hereditary leukoplakia caused by melanin deficiency or synthesis disorder of skin and accessory organs due to tyrosinase deficiency or functional decline.

According to clinical manifestations, albinism can be divided into three categories: ocular albinism (OA), ocular skin albinism (OCA) and albinism-related syndrome, among which ocular skin albinism (OCA) is the most common and albinism-related syndrome is the rarest.

This paper mainly expounds the clinical manifestations, genetic causes and genetic counseling of OA and OCA.

Clinical manifestations of OA and OCA

Only the eye pigment in OA patients is reduced or lacking, while the eye, skin and hair in OCA patients are obviously reduced or lacking.

1, eye performance

① Iris transillumination defect (TID)-91% ~ 100% albino patients have TID.

② nystagmus

③ Fundus hypopigmentation —— It is caused by the decrease of retinal pigment epithelium and/or choroidal pigmentation, which often leads to obvious choroidal vessels in the posterior pole. It is reported that more than 94% patients with albinism have fundus hypopigmentation.

④ hypoplasia of fovea-characterized by the continuation of the inner layer of retina behind fovea and the decrease of cone photoreceptor specialization.

⑤ optic nerve abnormality

⑥ ametropia

2. Skin manifestations

The skin and hair color of albino patients may change with age.

① Skin and hair pigmentation score

Skin and hair pigmentation scores help to objectively determine the influence of hypopigmentation.

② Skin diseases

Including all albinos, regardless of skin color, the risk of ultraviolet (UV) light-related skin diseases will increase. The most important of these is skin cancer, which includes squamous cell carcinoma, basal cell carcinoma, melanoma and less common Merkel cell carcinoma.

Genetic causes of OA and OCA

The following table summarizes the genes known to be related to nonsyndromic OCA and OA. All nonsyndromic OCA are inherited by autosomal recessive mode. OA (always non-syndrome) is inherited in an x-linked manner.

The following table summarizes the genes known to be related to OCA syndrome:

Genetic counseling

1. Inheritance mode

Nonsyndromic ocular skin albinism (OCA) caused by pathogenic variation in TYR, OCA2, SLC45A2, SLC24A5, LRMDA (C10orf11) or DCT (TYRP1) is inherited in autosomal recessive way.

Ocular albinism (OA) caused by pathogenic variation in GPR143(OA1) is inherited by X linkage.

If an individual suffers from a specific syndrome related to OCA (such as Hermansky-Pudlak syndrome or Chediak-Higashi syndrome), genetic counseling is needed for this disease.

2. Autosomal recessive inheritance-risk to family members

Parents of the proband:

The parents of the affected children are presumed to be heterozygotes causing the pathogenic variation of OCA.

If molecular diagnosis has been established in the proband, it is suggested that the parents of the proband should be tested for molecular genes to confirm that both parents are heterozygotes causing the pathogenic variation of OCA and allow reliable recurrence risk assessment.

If the pathogenic variation is detected only in one parent, and the parental identity test has confirmed biological motherhood and parent-child relationship, one of the pathogenic variations identified in the proband may occur as a newborn event in the proband or as a zygote in the mosaic parent. If the proband seems to have homozygous pathogenic variation (that is, the same two pathogenic variations), other possibilities to be considered include:

The deletion of single exon or multiple exons in the proband was not detected by sequence analysis, which led to artificial homozygosity;

Parental chromosomes and single parent homomorphism of pathogenic variation lead to homozygosity of pathogenic variation among proband.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Siblings of the proband:

If it is known that both parents are heterozygotes of pathogenic variants that cause OCA, each sibling of the affected individual has a 25% chance of being affected at conception, a 50% chance of becoming asymptomatic carriers, and a 25% chance of inheriting any familial pathogenic variants.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Descendants of the proband:

The offspring of autosomal recessive OCA individuals are obligate heterozygotes (carriers) that cause the pathogenic variation of OCA.

Other family members:

Every brother and sister of the proband’s parents has a 50% risk of becoming the carrier of OCA’s pathogenic variation.

Carrier detection:

It is necessary to identify the pathogenic variation that causes OCA in the family in advance for carrier detection of at-risk relatives.

3. X-linked inheritance-risk to family members

Parents of male proband:

The father of the affected man will not suffer from this disease, nor will he be a hemizygote of the pathogenic variant GPR143; Therefore, he does not need further evaluation/testing.

In a family with more than one affected individual, the mother of the affected male is an obligate heterozygote. Note: If a woman has more than one affected child and no other affected relatives, and if family pathogenic variation cannot be detected in her white blood cell DNA, she is likely to have germline chimera.

If the male is the only affected family member (i.e., a simple case), the mother may be heterozygote, the affected male may have new pathogenic variation (in this case, the mother is not heterozygote), or the mother may have somatic/germline chimera.

It is suggested that the mother should be tested for molecular genes to confirm her genetic status and make a reliable recurrence risk assessment.

Brothers and sisters of male proband:

The risk of siblings depends on the mother’s genetic status:

If the proband’s mother has the pathogenic variation of GPR143, the chance of transmission in each pregnancy is 50%.

Men with genetic disease variation will be affected;

The female with genetic pathogenic variation will be heterozygote (i.e. carrier). Heterozygotes are usually unaffected, although they can show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

If the proband represents a simplex case and the pathogenic variation cannot be detected in the mother’s leukocyte DNA, it is assumed that the risk of sibs is low, but the risk is higher than that of the general population because of the possibility of maternal lineage mosaic.

Descendants of male proband:

The affected men spread the disease-causing mutation of GPR143 to all their daughters, but not to their sons.

Other family members:

Menstruation and maternal cousins of the male proband may be at risk of GPR143.

Note: Molecular genetic testing may be able to identify family members with new pathogenic mutations, and this information can help determine the genetic risk status of large families.

Heterozygote detection:

To identify female heterozygotes, it is necessary to identify the pathogenic variation of GPR143 in the family in advance.

Note: As carriers of this X-linked disease, women are heterozygotes, which are usually not affected, but they may show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

Source | Metz Medical official website

Write | ｜Anna.An

Original title: Inheritance and Manifestation of Albinism

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Investment & Pensions Europe(IPE), an internationally renowned financial media organization, officially released the list of "Top 500 Asset Managers 2023".

The top 10 institutions in global asset management are BlackRock, Pioneer Pilot, Fidelity, State Street Global, Morgan Asset Management, Goldman Sachs Asset Management, Capital Group, Credit Suisse Oriental, Pinhao and new york Mellon Asset Management. There are 41 asset management institutions in China on the list, with excellent overall performance and greatly improved scale and ranking.

"Top 500 Global Asset Management Institutions List" is one of the annual reports of IPE. Headquartered in London, England, IPE is a well-known European financial media organization affiliated to IPE International Publishers Media Group, and enjoys a high reputation among global institutional investors and pension operators. IPE publishes authoritative lists such as the top 500 global asset management companies through market open data every year, and launches trend development reports, which has become an important vane in the global asset management field.

Top 20 of Global Asset Management 500 in 2023

Rank the total management scale of the headquarters of the asset management company at the end of 2022.

1. BlackRock US$ 8,052.9 billion.

2. Vanguard Investment Management US$ 6,743.3 billion.

3. Fidelity Investments US$ 3,653.6 billion.

4. State Street Global Advisors US$ 3,262.1 billion.

5. J.P.Morgan Asset Management US$ 2,616.4 billion.

6. Goldman Sachs Asset Management International US$ 2,152.1 billion.

7. Capital Group (US$ 2,044.3 billion)

8. Amundi France’s $1,904 billion.

9. PIMCO US/Germany USD 1,631.1 billion.

10. new york Mellon Asset Management US$ 1,615 billion.

11. Legal & General Investment Management UK $1,351.1 billion.

12. Jing Shun US/UK $1,320.7 billion.

13. Franklin Templeton US$ 1,296.4 billion.

14. Prudential Investment Management (PGIM) US$ 1,290.6 billion

15. Morgan Stanley Investment Management US$ 1,222.4 billion.

16. T. Rowe Price US$ 1,194.4 billion.

17. Wellington Management International US$ 1,082.4 billion.

18. Natixis Investment Management of France: US$ 1,078.8 billion.

19. Nuveen US$ 1,018.2 billion.

20. UBS Asset Management (UBS Asset Management) Switzerland 996.7 billion US dollars.

41 listed asset management companies in China

Rank company name

31. China Life Asset Management Co., Ltd.

36. Ping An Asset Management Co., Ltd.

64. Taikang Asset Management Co., Ltd.

E Fund Management Co., Ltd.

71. CMB Finance Co., Ltd. 85. Xingyin Finance Co., Ltd.

91. Jianxin Wealth Management Co., Ltd.

97. southern fund Management Company Limited.

99. Huaxia Fund Management Co., Ltd.

100. Agricultural Bank of China Finance Co., Ltd.

102. ICBC Wealth Management Co., Ltd.

103. BOC Wealth Management Co., Ltd.

ICBC Credit Suisse Fund Management Co., Ltd.

106. harvest fund Management Co., Ltd.

110. Guangfa Fund Management Co., Ltd.

112. Boss Fund Management Co., Ltd.

113. Xinyin Wealth Management Co., Ltd.

119. Pacific Asset Management Co., Ltd.

120. Xinhua Asset Management Co., Ltd

China Merchants Fund Management Co., Ltd.

122. China PICC Asset Management Co., Ltd.

124. Jianxin Fund Management Co., Ltd.

126. CITIC Securities Co., Ltd.

131. Fuguo Fund Management Co., Ltd.

142. Taiping Asset Management Co., Ltd.

145. Everbright Financial Management Co., Ltd.

151. Tianhong Fund Management Co., Ltd

153. Huitianfu Fund Management Co., Ltd

154. Penghua Fund Management Co., Ltd.

155, Yangtze River Pension Insurance Co., Ltd.

158. Bank of Communications Wealth Management Co., Ltd.

166. Everyone Asset Management Co., Ltd.

186, Yin Hua Fund Management Co., Ltd.

190, Ping An Finance Co., Ltd.

191. Minsheng Financial Management Co., Ltd.

194. Puyin Wealth Management Co., Ltd.

197. China Post Finance Co., Ltd.

200. cathay pacific fund Management Co., Ltd.

202. Sunshine Asset Management Co., Ltd.

208. Huatai Asset Management Co., Ltd.

210. China International Capital Corporation Limited

Contact PR Newswire

+86-10-5953 9500

info@prnasia.com

Original title: "The list of the top 500 global asset management institutions in 2023 was announced, and 41 Chinese state-owned assets management institutions were on the list | List 1"

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Special feature of 1905 film network In the last shot, Tommy Tam handcuffed himself with Leslie Cheung’s handcuffs, and also handcuffed the originally broken Song brotherhood back; After 31 years, the first official poster is two handcuffed hands, and behind it is still about brotherhood.

　

*Intertextuality between the Final Scene of Hero and the Poster of Chasing.

　

Last Friday, "The True Color of Heroes" was released for more than 30 years, and it was restored for the first time in mainland China, and it monopolized 20 million box office in just three days. Many people go into the cinema to relive this classic Hong Kong film, perhaps for the sake of "brother" Leslie Cheung, perhaps for the sake of Mark with a long trench coat, or perhaps for the sake of enjoying John Woo’s violent aesthetics exclusively.

　

　

Then this Friday, the film Chasing officially landed in the cinema. This film is a Chinese gun battle film made by John Woo after 25 years. After the series, the master of violent aesthetics has gained more tenderness, which seems to be more appropriate to describe with his own debut, and it is a kind of "iron man’s tenderness" temperament.

　

Chasing is a master’s idolize

　

"I have always admired Gao Cangjian very much." Wu Yusen has said this sentence for more than ten times.

　

　

This sentence is not simply for film promotion, but a master’s heartfelt recognition of the actor superstar. In the early days, John Woo started to use Chow Yun Fat, just because of his similar temperament with Gao Cangjian. Even in the modeling of the film, letting Chow Yun Fat wear sunglasses and a trench coat is a tribute to Gao Cangjian.

　

It’s just a pity that John Woo, who has cooperated with Tom Cruise, Ben Affleck, Nicolas Cage and other first-line Hollywood actors, has never been able to form a cooperation with Gao Cangjian. Now, it is in memory of Gao Cangjian that the present Hunting is produced.

　

* The original "Crossing the River of Anger"

　

In fact, the process of winning the copyright of Hunting is also very bumpy. As the Japanese film "Chasing" was unwilling to sell the film copyright, Huanya directly bought the copyright of the original novel "Crossing the River of Anger" and found Wu Yusen, hoping to complete a new adaptation with his personal style. The views of both sides just fit, so this work came into being.

　

　

After all, the adaptation of this version of the story has become the most "difficult" thing. The original novel is a story that happened in the 1960s, and many events and events are out of date for the present. At the same time, there are also concerns that the audience will compare the two versions of the film. As a result, a team of seven screenwriters led by Chen Jiashang adapted the whole story into an escape story in a modern city.

　

Although from the film title signature, neither the scriptwriter, editor nor producer belongs to Wu Yusen, but the content style is still another extension of his "violent aesthetics", and the iconic symbols such as "Double Heroes" and "Dove" are all available.

　

After watching John Woo’s works in different periods for two weeks, I can feel that Wu Dao seems to have changed, but he seems to be the same John Woo who can successfully make Hollywood commercial movies.

Next page:The typical "double male" configuration remains the same.

　　In 2018, a realistic Dying to Survive hit a 3.1 billion summer box office champion. While countless people are sighing and moving, how to make the "sky-high life-saving medicine" accessible to ordinary patients has become a topic of general public concern.

　　The leukemia drug in this film — — Gleevec (imatinib mesylate) is a microcosm of high-priced drugs. This drug developed by Novartis Pharmaceutical entered China in early 2004, and the price of the original drug was as high as.23,500 yuan(120 tablets/box).

　　According to the first financial reporter, in the past decade, more and more manufacturers have entered the market of leukemia treatment drugs, making the price of this "life-saving medicine" drop again and again.

　　According to the data of CHIS kaisi system of Zhongkang Technology, the retail terminal price of Gleevec has been declining in the past three years, and the retail market price in 2022 will be6449.32 yuan. The reporter saw on an e-commerce platform on July 22 that the price of Gleevec’s original drug was mostly1700 yuan ~1800 yuanBetween

　　With the approval of more and more domestic generic drugs, the lowest price of domestic imatinib mesylate tablets has dropped to.144 yuan/boxIt is about 1.2% of the original price of the drug. At present, the sales price of Gleevec on the e-commerce platform is more than 1,700 yuan, which is nearly 90% lower than when Novartis first entered the China market.

　　The price of "life-saving medicine" continues to drop.

　　On July 19th, Hubei Provincial Medical Insurance Bureau posted a Notice on Publicizing the Information about the First to Fifth Batch of Non-selected Varieties in Centralized Drug Purchase by the State Organization, which stated that the first to fifth batches of centralized drug purchase by the State Organization had been carried out with the non-selected varieties under the generic name over-evaluated, the online price adjusted, the online suspension and the handling of complaints. On this basis, the medical insurance payment standard and other related work were drawn up, and a list of non-selected varieties to be online was formed. The publicity date of this list is from July 19 to July 23, 2023.

　　The online price of drugs refers to the published price of drugs on the centralized procurement platform of medical equipment in Hubei Province for the procurement of public medical institutions in the province. According to the regulations, all public medical institutions in Wuhan must purchase the drugs that have been hung on the net through the provincial centralized procurement platform for medical equipment when implementing the online procurement policy, and must not purchase from offline and other non-prescribed channels. The price of drugs hanging on the net is the highest price limit of public medical institutions in the city.

　　The list of the first batch of non-selected varieties to be hung on the net shows that there are6 imatinib mesylateAmong them, in addition to the original research drug Novartis Pharmaceutical, there are also five models, namely Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical, Chongqing Yaoyou and Sinopharm Yixin, all of which have been evaluated.

　　In terms of price, the highest hanging net is still Gleevec.7182 yuan. Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical and Sinopharm are all interested in imatinib mesylate. The online price is only.More than 500Yuan.

　　Even if the net price is 7,182 yuan, the price of the original drug Gleevec has dropped by nearly 40% compared with 23,500 yuan (120 tablets/box) when it first entered the China market.

　　According to the data of CHIS kaisi system of Zhongkang Technology, although the price of Gleevec in the hospital has remained at around 7182 yuan in the past three years, the price of retail terminals has been declining. In 2022, the retail market price will be6449.32 yuan.

　　The reporter’s search for "imatinib mesylate" on an e-commerce platform shows that the price of Gleevec’s original drug is only 0.1g*60 tablets/box as the standard in most pharmacies.1700 yuan ~1800 yuanBetween, and the price of domestic medicine is in500 yuanAbout. For example, the price of Xinwei tablets in Jiangsu Haosen is 430 yuan, the price of Genico capsules in Zhengda Tianqing is 441.88 yuan, and the lowest price is Shengdika tablets produced by Chongqing Shenghuaxi Pharmaceutical Co., Ltd., with an estimated hand price of 144 yuan.

　　nineDomestic companies were approved for production.

　　More and more cheap domestic "life-saving drugs" appeared, which was related to the end of the protection period of the compound patent of imatinib in China in April 2013, and domestic generic drugs began to be produced and listed.

　　From June 2013 to October 2014, three domestic generic drugs of Jiangsu Haosen, Zhengda Tianqing and Shiyao Ouyi obtained production approval. Because the efficacy of generic drugs has not been verified, the original drug of Novartis, Gleevec, still occupied most of the market. According to public data, in 2016, imatinib mesylate tablets sold more than 4 billion US dollars worldwide.

　　The competitiveness of domestic drugs began to improve after 2018. From 2018 to 2020, the above three drugs passed the consistency evaluation successively. On July 5, 2018, Jiangsu Haosen Pharmaceutical Co., Ltd. said that it had received the Approval Document for Supplementary Application of Imatinib, a chemical drug approved and issued by National Medical Products Administration, and the National Drug Testing Center recommended that it pass the consistency evaluation, making it the first enterprise to pass the consistency evaluation of this drug.

　　Overevaluation means that drugs have reached the passing line in quality and efficacy, and generic drugs have become more competitive. In September 2018, Hansen Pharmaceutical (Haosen Pharmaceutical) disclosed the prospectus for listing in Hong Kong, showing that the sales revenue of the core product imatinib mesylate in 2017 was RMB 2.5 billion, up by 7.3% since 2016, and up to June 30, 2018, up by 34.5% compared with the same period of last year.

　　With the entry of imatinib mesylate tablets into the medical insurance catalogue in 2017, more manufacturers entered this field. National Medical Products Administration website shows that the domestic imatinib mesylateNine manufacturers have been approved.Unacon Ouyi Pharmaceutical, Zhengda Tianqing, Qilu Pharmaceutical, Shenzhen Xinlitai Pharmaceutical, Chongqing Yaoyou Pharmaceutical, Lianyungang Runzhong Pharmaceutical, Shanghai Nuochuang Pharmaceutical, Fujian Nanfang Pharmaceutical and Chongqing Shenghuaxi Pharmaceutical, among which Shanghai Nuochuang Pharmaceutical and Fujian Nanfang Pharmaceutical successivelyMay and June this yearJust approved.

　　What followed was that prices kept falling.

　　In 2018, imatinib mesylate tablets of Jiangsu Haosen Pharmaceutical Co., Ltd. won the bid in four municipalities directly under the Central Government, including Beijing, Tianjin, Shanghai and Chongqing, and 11 cities (referred to as "4+7" cities) including Shenyang, Guangzhou, Chengdu and Xi ‘an, with the winning price of 623.82 yuan per box. In 2019, the "4+7" procurement expanded, and Zhengda Tianqing won the bid at a price of 586.39 yuan, further reducing the price of this drug.

　　In August, 2022, Shanghai issued a price adjustment notice, and the adjusted purchase price of imatinib mesylate tablets produced by Shiyao Ouyi has dropped to 180 yuan/box.

　　The lower price of domestic drugs also impacts the price of original drugs.

　　In 2018, the joint bargaining of imported anticancer drugs in 14 provinces including Shaanxi was completed, and 47 anticancer drugs including Gleevec were successfully negotiated. According to the announcement, the bargaining result of Gleevec’s specification of 0.1g*60 tablets was 9998 yuan.

　　In 2019, according to the previous report of CBN, the price of the original drug Gleevec in Shanghai has dropped to 7182 yuan/box, which is about 30% lower than the market price of around 11,000 yuan at that time.

　　New progress

　　It is worth mentioning that with the increase of drug resistance caused by long-term medication, Gleevec’s R&D iteration has also attracted much attention.

　　The second and third generation BCR-ABL inhibitors have been developed in order to solve the drug resistance problem and improve the safety. Dashatinib from Bristol-Myers Squibb and Nilotinib from Novartis were introduced one after another, which made the second generation BCR-ABL inhibitors gradually occupy an important position in the first-line and second-line treatment of chronic myeloid leukemia. However, the problem of drug resistance still exists during the use of the second generation BCR-ABL inhibitors.

　　In November, 2021, Nilik, known as the "third generation Gleevec" made in China, was approved for marketing in National Medical Products Administration, China, and was used to treat adult patients who were resistant to any tyrosine kinase inhibitor (TKI) and were diagnosed as chronic myeloid leukemia (CML) with T315I mutation in chronic phase (CP) or accelerated phase (AP) by fully verified detection methods.

　　This year, on July 6th, Yasheng Medical Officer Wei announced that Nilik had obtained the clinical trial permission from National Medical Products Administration Drug Evaluation Center, and would carry out a key registered phase III clinical trial of combined chemotherapy compared with imatinib combined chemotherapy in the treatment of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (referred to as "Ph+ALL").

　　At the end of 2022, Novartis decided not to be responsible for the sales promotion of Gleevec in China.

　　The official micro-display of Sinopharm Holdings shows that from January 1, 2023, Sinopharm Holdings officially obtained the commercial promotion right of Novartis Gleevec in China market. Xie Jiong, director of the Drug Shield Public Welfare Fund, said in an interview with the media that for many drugs, it is necessary to adjust the inherent marketing model after a certain development cycle, so as to drive the second peak of sales. This will not only prolong the life cycle of drug sales, but also greatly enhance the accessibility of drugs and benefit a wider range of patients.

　　Our reporter Lin Zhiyin also contributed to this article.

　　Xinhua News Agency, Hong Kong, June 27th　Title: Seize new opportunities and start a new journey — — Hong Kong focuses on development and opens a new chapter.

　　Xinhua news agency reporter

　　&hellip, the first financial center in Asia and one of the longest-lived regions in the world; … Since its return to the motherland 25 years ago, Hong Kong has been full of vitality and proved to the world that "one country, two systems" is the best system to ensure Hong Kong’s long-term prosperity and stability.

　　Twenty-five years, a bright report card.

　　"In the past 25 years, despite many challenges, ‘ One country, two systems ’ The practice in Hong Kong has achieved world-recognized success. " Chairman of the Supreme Leader met with Li Jia, the sixth chief executive of the Hong Kong Special Administrative Region.

　　Economic performance is an important measure — — Hong Kong’s GDP increased from HK$ 1.37 trillion in 1997 to HK$ 2.86 trillion in 2021; Per capita GDP (in nominal terms) increased from HK$ 192,000 before the reunification to HK$ 387,100 in 2021; The fiscal reserves increased from HK$ 457.5 billion in 1997-1998 to HK$ 957.2 billion in 2021-2022.

　　Hong Kong people have more personal feelings about development.

　　Zhang Tiansheng is the first generation of brokers in Hong Kong. He joined the industry in 1958 and witnessed the whole process of Hong Kong stock market from birth to growth.

　　"When I entered the business, I never thought that the Hong Kong stock market could develop to such a scale." He said.

　　The data shows that the total market value of the spot stock market in Hong Kong rose from HK$ 4.86 trillion at the end of 2000 to HK$ 37.60 trillion on June 17, 2022. The income of the Hong Kong Stock Exchange has increased tenfold in the past 20 years.

　　While the status of international financial, shipping, trade center and international aviation hub continues to be consolidated, the new positioning of international innovation and technology center, Asia-Pacific international legal and dispute resolution service center, regional intellectual property trade center and Chinese-foreign cultural and artistic exchange center is clear, and Hong Kong is better and faster integrated into the overall situation of national development.

　　American James Thompson moved his corporate headquarters from Japan to Hong Kong in 1978. He said that he never thought of leaving here. "In the 25 years since the return of Hong Kong, our business has grown bigger and bigger, and our business ability has been improved in many aspects."

　　The well-being of Hong Kong people is constantly improving. In order to let more residents share the fruits of economic development, the SAR Government has long been committed to building a caring society, taking care of the disadvantaged groups and providing more and better services to the citizens. According to statistics, the recurrent expenditure of the current SAR Government on social welfare has risen sharply from HK$ 65.3 billion in 2017-2018 to HK$ 105.7 billion in 2021-2022, making it the largest policy category.

　　In 2003, Mr. Zhang, a Hong Kong citizen, applied for a public housing. The residence in Dajia Building, Baoda Village, Kowloon is clean and tidy, and the area is small, but it is designed as three bedrooms, one living room, one kitchen and one bathroom, which is enough for their family to live in.

　　Housing is one of the pain points of Hong Kong society, and people from all walks of life expect the new SAR Government to take practical actions to solve the people’s worries.

　　"We must do a good job so that Hong Kong people can truly feel the benefits brought by development and enhance their sense of gain and happiness." Chen Maobo, Financial Secretary of the Hong Kong SAR Government, said.

　　The development pattern has broken through again

　　Five years ago, Yan Yaohui, a young man from Hong Kong, gave up his stable career as an actuary and joined the wave of technological entrepreneurship with his partners to set up Bowtie, an insurance technology company. At the end of 2018, the company obtained the first virtual insurance license in Hong Kong and became a pathfinder for technological transformation in the insurance industry in Hong Kong.

　　"As a traditional industry, the insurance industry has gradually become out of touch with technology. We hope to use technology to re-establish an insurance company. " Yan Yaohui said. This enterprise, regarded by the industry as the next batch of "unicorns" in Hong Kong, was conceived by one of the largest digital innovation communities in Hong Kong — — Cyberport.

　　Faced with the problems of single industrial structure and narrow spatial layout in the process of development, the Hong Kong SAR Government has taken the initiative to explore new development space.

　　From putting forward the Cyberport for developing scientific and technological information projects, to building a science park with a relatively complete innovation ecosystem, and then to setting up a government department &hellip to support the development of innovation; … Developing creative industries is becoming the main force to promote economic diversification in Hong Kong.

　　In the past five years, the SAR Government has invested more than HK$ 150 billion to support the development of science and technology innovation, and the overall science and technology innovation ecology in Hong Kong has become increasingly active. Among them, the number of start-ups increased from about 1,500 in 2015 to about 4,000 in 2021, and more than 10 "unicorn" enterprises were born.

　　"How can I get a treatment plan without operating on the patient?" In the "InnoHK Innovation Hong Kong R&D Platform" of Hong Kong Science Park, the Medical Robot Innovation Technology Center of the Chinese University of Hong Kong is committed to applying scientific research results and contributing to the development of science and technology in Hong Kong.

　　This platform aims to develop Hong Kong into a global research cooperation center. Internationally renowned universities and research institutions have set up R&D laboratories for scientific research cooperation, and nearly 30 R&D laboratories have been selected.

　　“‘ InnoHK innovates Hong Kong R&D platform ’ It is necessary to bring Hong Kong’s scientific research to the world stage and bring world-renowned institutions to Hong Kong. " Cen Meixia, vice president of the Chinese University of Hong Kong, said.

　　The cultural industry has also added new impetus to Hong Kong’s move towards a diversified economy. The West Kowloon Cultural District, which integrates world-class culture, art exhibition, public entertainment and consumption, broke ground in 2013. At present, the Opera Center, the Contemporary International Museum of Visual Culture M+ and other places have been completed and put into operation. The highly anticipated Hong Kong Palace Museum of Culture will also be officially opened to the public in July this year.

　　Integrate into national development and achieve greater achievements

　　Liu Dabang, the ever honorary chairman of the Hong Kong Federation of Small and Medium-sized Enterprises, is engaged in the trade of building raw materials. A few years ago, it planned to add new production lines in ASEAN countries, but it was temporarily put on hold due to the epidemic.

　　"Setting up factories in ASEAN countries is a bit like ‘ Fight alone ’ It is difficult for the local government to provide many preferential policies for individual factories. I hope that after signing the memorandum, Hong Kong enterprises can get more benefits. " He said.

　　The Memorandum mentioned by Liu Dabang refers to the Memorandum on Promoting High-quality Development and Cooperation in Overseas Economic and Trade Cooperation Zones signed by the Ministry of Commerce and the Hong Kong SAR Government in 2021, aiming at promoting Hong Kong’s deep participation in the construction of the Belt and Road Initiative.

　　Not only the "Belt and Road" construction, but also with the implementation of the national "14 th Five-Year Plan", Hong Kong is welcoming a new round of historical development opportunities.

　　The outline of the 14th Five-Year Plan has established a new development orientation for Hong Kong. Guangdong-Hong Kong-Macao Greater Bay Area has set up a broad platform for Hong Kong; "Cross-border wealth management", Qianhai Shenzhen-Hong Kong Modern Service Industry Cooperation Zone and Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone have created new development opportunities for Hong Kong’s financial, service and creative industries … … With the strong support of the state, there is no limit to the future development of Hong Kong.

　　The Outline of Guangdong-Hong Kong-Macao Greater Bay Area Development Plan published in early 2019 clearly stated that it supports the construction of the third runway of Hongkong Airport. In September 2021, the completion ceremony of the third runway laying project was held. The central government supports the construction of the third runway of Hong Kong Airport, aiming at supporting Hong Kong to consolidate its position as an international air traffic hub and maintain and enhance its overall competitiveness.

　　The annual passenger traffic of Hong Kong International Airport was about 28 million in its initial operation. After more than 20 years of development, the highest annual passenger traffic before the epidemic reached about 75 million, making it one of the busiest airports in the world.

　　"It is the development of the country and Hong Kong that drives the development of Hong Kong International Airport." Fred Lam, Chief Executive Officer of Hong Kong Airport Authority, said that with the support of the state and the advantages of Hong Kong, the aviation industry in Hong Kong will gradually recover after the outbreak, and he is full of confidence in Hong Kong as an international aviation hub.

　　Actively integrate into the overall situation of national development and open up unlimited possibilities for the development of Hong Kong. In the new era and new journey, the central government has paid more attention to the special advantages and unique role of Hong Kong. A series of strategic plans have "Hong Kong role", and the "interface" for Hong Kong to integrate into the overall situation of national development has been increasing. The mainland of the motherland has become a broader stage for the development of the cause of Hong Kong compatriots.

　　In 2016, Lin Hengyi, a post-80s maker, set up a subsidiary in Qianhai Shenzhen-Hong Kong Youth DreamWorks, which has since opened a busy and fulfilling "Twin City Life".

　　"Over the past few years, our R&D experience, contacts and sales market have been greatly expanded, and our entrepreneurial achievements are very good, which has driven the turnover of the entire Hong Kong company to increase several times." Lin Hengyi lamented that industries and achievements that have done well in Hong Kong should be brought to the mainland market for expansion and radiation.

　　He said: "Hong Kong can define its position more clearly, give full play to its strengths and interact with other cities."

　　"Country ‘ Fourteenth Five-Year Plan ’ The opportunities brought by the planning and construction of Guangdong-Hong Kong-Macao Greater Bay Area to all walks of life in Hong Kong are superimposed. The future cooperation between Hong Kong and the Mainland is not limited to traditional manufacturing and trade, but also includes financial services, professional services and technological innovation. " Leung Chun-ying, Vice Chairman of the National Committee of CPPCC said that Hong Kong should continue to play the role of "super contact" under "one country, two systems", which will not only contribute to the country, but also gain a broader development space for itself.

　　A new starting point, new opportunities and new hopes. Hong Kong, the "Pearl of the Orient", will start another brand-new journey. (Reporter Liu Mingyang, Niu Qi, Liu Huan, Cha Wenyu)