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During the Spring Festival holiday in 2025, the number of traffic trips exceeded 2.3 billion.

On the 5th, the reporter learned from the 2025 Spring Festival travel rush Comprehensive Transportation Work Class that during the Spring Festival holiday this year (from January 28th to February 4th), the cross-regional personnel flow of the whole society was 2,306.845 million.

Specifically, the passenger traffic by railway is 96.26 million, the passenger flow by road is 2,182.93 million (the passenger travel by non-operating passenger cars on expressways and provincial highways is 1,989.65 million, and the passenger traffic by road is 193.28 million), the passenger traffic by waterway is 9.413 million, and the passenger traffic by civil aviation is 18.2415 million.

　　Strictly administering the Party in an all-round way is the fundamental guarantee for completing the historical mission.

　　Feng Jun, Deputy Director of the Central Party History Research Office

　　Realizing the great rejuvenation of the Chinese nation is the greatest dream of the Chinese nation in modern times, and it is also the historical mission of the Communist Party of China (CPC). Under the leadership of the CPC Central Committee with the Supreme Leader as the core, we have never been closer to the goal of realizing the great rejuvenation of the Chinese nation. In his important speech on "July 26th", General Secretary of the Supreme Leader emphasized that if the Party wants to unite and lead the people in a great struggle, advance a great cause and realize a great dream, it must unswervingly uphold and improve the Party’s leadership, unswervingly push forward the new great project of Party building, and make the Party stronger and stronger.

　　Strengthen political construction, comprehensively strengthen the party’s leadership and enhance the party’s cohesion, combat effectiveness, leadership and appeal. Party, government, military and civilian studies, east, west, north and south, the party is the leader of everything. Party member cadres should strictly abide by political discipline and rules, safeguard the authority of the CPC Central Committee, safeguard the unity and centralized leadership of the Party, firmly establish political awareness, overall situation awareness, core awareness and conformity awareness, and always maintain a high degree of consistency with the CPC Central Committee with the Supreme Leader as the core in ideological and political actions.

　　Strengthen the education of ideals and beliefs and stick to the spiritual home of communist party people. The lofty ideal of communism and the common ideal of Socialism with Chinese characteristics are the spiritual pillar and political soul of the Communist Party of China (CPC) people. The majority of party member cadres must unswervingly adhere to the guiding position of Marxism, earnestly study the theoretical systems of Marxism–Leninism, Mao Zedong Thought and Socialism with Chinese characteristics, conscientiously study the spirit of the series of important speeches by the Supreme Leader General Secretary and the new ideas, new ideas and new strategies for governing the country and making up the "calcium" of the spirit.

　　Adhere to the close combination of ideological party building and institutional party management, and put institutional construction throughout all aspects and the whole process of party building. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee has formulated and revised a number of inner-party laws and regulations, which has tightened the cage of the system. The promulgation and implementation of the inner-party laws and regulations, such as the Regulations on Patrol Work in the Communist Party of China (CPC), the Regulations on Accountability in the Communist Party of China (CPC), the Code of Integrity and Self-discipline in the Communist Party of China (CPC), and the Regulations on Disciplinary Actions in the Communist Party of China (CPC), have enabled the party to be strictly governed in an all-round way. In particular, the Sixth Plenary Session of the 18th CPC Central Committee adopted "Several Guidelines on Inner-Party Political Life under the New Situation" and "Regulations on Inner-Party Supervision in the Communist Party of China (CPC)", which provided an important system for strengthening and standardizing inner-party political life and strengthening inner-party supervision under the new situation.

　　Adhere to strict management of officials and do a good job of leading cadres, the "key minority." Adhering to the correct orientation of selecting and appointing people, selecting and appointing cadres must adhere to the principle of having both ability and political integrity, putting morality first, adhering to all corners of the country, appointing people on their merits, and adhering to the standards of good cadres with firm beliefs, serving the people, being diligent and pragmatic, daring to take responsibility, and being honest and clean. Leading cadres should be strictly self-disciplined, cautious and cautious, start from themselves and manage from people around them.

　　Maintain the overwhelming trend of the anti-corruption struggle. Shortly after the 18th National Congress of the Communist Party of China closed, the Political Bureau of the Central Committee formulated and promulgated eight regulations, which sent a strong signal that discipline should be maintained and the Party should be strictly governed. Since the 18th National Congress of the Communist Party of China, the Central Committee of the Communist Party of China, with the determination of a strong man to break his wrist, curbs the bones and cures the poison and cures the furuncle with fierce drugs, and insists that corruption must be countered and greed must be eliminated, thus effectively curbing the spread of corruption. To adhere to the comprehensive and strict administration of the party, we must maintain the overwhelming trend of the anti-corruption struggle and constantly win the hearts and minds of the party.

　　Stressing politics is a prominent feature and advantage of our party.

　　Tang Zhouyan, Party Secretary of Shandong Academy of Social Sciences

　　General Secretary of the Supreme Leader has repeatedly stressed that our party, as a Marxist political party, stresses politics as a prominent feature and advantage. Deeply understanding and grasping the spiritual essence of this important thesis is of great significance for promoting the comprehensive and strict management of the Party, advancing the new great project of Party building and winning new victories in Socialism with Chinese characteristics.

　　Taking a clear-cut stand and talking about politics is an important magic weapon for the Communist Party of China (CPC) people to defeat the enemy. As a Marxist political party, the Communist Party of China (CPC) has never denied his political attributes, and has always taken a clear-cut stand on politics. This is our party’s outstanding characteristics and advantages, and it is also an important magic weapon for our party to grow stronger and defeat the enemy. As early as the Gutian Conference, Comrade Mao Zedong clearly proposed to "improve the political level within the Party" and "make party member’s thoughts and life within the Party politicized and scientific". Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has unswervingly promoted the comprehensive and strict administration of the Party and repeatedly stressed that leading cadres should take a clear-cut stand and stress politics. Throughout the course of our party’s struggle, when the whole party stresses politics and the political life within the party is normal and healthy, the party’s cause will flourish; On the contrary, it may be full of ills and cause serious losses to the party’s cause. Standing at a new historical starting point, if we want to create a new situation in the cause of Socialism with Chinese characteristics, we must carry forward this outstanding feature and advantage of our Party and stress politics with a clear-cut stand.

　　Take a clear-cut stand and say that the key to politics is to firmly establish the "four consciousnesses". Strengthening the "four consciousnesses" is the concentrated embodiment and inevitable requirement of taking a clear-cut stand and stressing politics. We should firmly establish political consciousness, adhere to the correct political direction and position, maintain a clear political mind and keen political discernment, always take the party’s banner as the banner, take the party’s direction as the direction, take the party’s will as the will, and maintain a high degree of political consistency with the CPC Central Committee; Firmly establish a sense of the overall situation, establish a correct view of the overall situation, consciously understand, obey and safeguard the overall situation, and effectively unify thoughts and actions with the decision-making and deployment of the CPC Central Committee. As long as things that are beneficial to the overall situation are done well, as long as words and deeds that hinder the overall situation are resolutely opposed, the whole party will always be guaranteed to play a game of chess; Firmly establish the core consciousness, resolutely safeguard the core position of the supreme leader’s general secretary, take the maintenance of the core as the first political requirement, and achieve full trust in thought, resolute maintenance in politics, conscious obedience in organization, deep recognition in emotion, and always follow in action; Firmly establish a sense of conformity, take the initiative to align with the CPC Central Committee with the supreme leader as the core, take the initiative to align with the party’s theory, line, principles and policies, and take the initiative to align with the decision-making and deployment of the CPC Central Committee.

　　To promote the comprehensive and strict management of the party and develop in depth, we must take a clear-cut stand and stress politics. Standing at a new historical starting point, promoting the comprehensive and strict development of the party requires us to speak politics more clearly. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has persisted in focusing on, examining and solving outstanding problems within the Party politically, and has grasped the root of strictly administering the Party in an all-round way. In the process of strictly administering the party in an all-round way, we can’t just solve the problem of corruption and not solve political problems. Political problems of cadres are no less harmful to the party than corruption, and some are even more serious than corruption. At present, the strict administration of the party in an all-round way has entered a new stage, which requires us to speak politics more clearly.

　　Firmly establish the "four consciousnesses" and resolutely safeguard the authority of the CPC Central Committee

　　Zhang Lei, deputy editor-in-chief of Economic Daily

　　Firmly establishing the "four consciousnesses" and resolutely safeguarding the authority of the CPC Central Committee are the inevitable requirements for upholding and consolidating the party’s leadership and ensuring the smooth development of the cause of the party and the state. The Sixth Plenary Session of the 18th CPC Central Committee pointed out: "A country and a political party have a core of leadership." "Resolutely safeguarding the authority of the CPC Central Committee and ensuring that all party orders are prohibited are the future and destiny of the party and the country and the fundamental interests of the people of all ethnic groups in the country."

　　From the development history of Marxist political parties, it is a basic principle of Marxist political party construction to safeguard the central authority and the core of leadership. In the practice of leading the communist movement, Marx and Engels always emphasized the importance of authority, which they believed was related to the success or failure of the revolutionary cause. The history of socialist development in the world shows that the proletariat not only needs authority to carry out revolution, but also needs such authority in the process of consolidating political power, construction and reform. The failure of the CPSU also illustrates this truth from the opposite side: once a Marxist political party with a glorious history and once very strong destroys the central authority and abandons the party’s leadership, it will inevitably lead to the tragic situation of the party and the country. This is a lesson of blood, which we must remember deeply.

　　Judging from the development history of our party in 1996, maintaining the central authority and the core of leadership is the fundamental guarantee for the continuous development of the party’s cause and the long-term stability of the country. Comrade Deng Xiaoping emphasized: "Any leading collective must have a core, and leadership without a core is unreliable.". He also pointed out that in history, the main reason for the frustration and failure of our party before Zunyi Conference was that it did not form a mature CPC Central Committee and a core of leadership that was widely expected. It was not until the central collective leadership with Comrade Mao Zedong as the core was formed that the China Revolution embarked on the smooth development. Similarly, in the historical process of promoting reform and opening up, the mature core of leadership also plays an irreplaceable role. The Communist Party of China (CPC) has gone through a glorious course of 96 years and has been in power for 68 years in a row. The reason why he has achieved the historic achievement of standing out from the rest of the world is that he has always emphasized upholding the leadership of the Party and safeguarding the authority of the CPC Central Committee.

　　Judging from the conditions of the times faced by our party, maintaining the central authority and the core of leadership is the need to shoulder the historical responsibility of the party and complete the historical task of the party. Great and profound changes are taking place in the world today. China is in the decisive stage of building a well-off society in an all-round way. The Party is faced with the historical task of carrying out great struggles, building great projects, advancing great undertakings and realizing great dreams. Our party has made great achievements that have attracted worldwide attention and accumulated extremely rich ruling experience, but the "four tests" and "four dangers" are still grim, and the "rushing for the exam" is far from over. Today, Socialism with Chinese characteristics is like a big ship sailing through the waves in the sea of Wang Yang. More than ever, it needs a capable, experienced and authoritative helmsman to guide it. Since the 18th National Congress of the Communist Party of China, General Secretary of the Supreme Leader has led the whole party, the whole army and the people of all nationalities in China to create a brand-new situation in the development of Socialism with Chinese characteristics’s cause, and has made a series of great achievements with great practical significance and far-reaching historical significance in reform, development and stability, internal affairs, foreign affairs and national defense, and in managing the party, country and army, and won the heartfelt love and support of the whole party, the whole army and the people of all nationalities in China. General Secretary of the Supreme Leader is the core of the CPC Central Committee and the whole Party formed in the practice of the new great struggle. Firmly safeguarding the authority of the CPC Central Committee and the core position of the Supreme Leader General Secretary are important guarantees for us to strive for new and greater victories.

　　Serious inner-party political life is the basis of strictly administering the party in an all-round way.

　　Ji Zhengju, Deputy Director of the Central Compilation Bureau

　　The General Secretary of the Supreme Leader pointed out: "Serious inner-party political life is the fundamental basic work of strictly administering the party in an all-round way and is a major task of the whole party." If the party wants to manage the party, it must manage the political life within the party; To strictly manage the party, we must start from the political life within the party. The "Several Guidelines on Political Life within the Party under the New Situation" and a series of important expositions by the Supreme Leader General Secretary on comprehensively administering the Party strictly have profoundly expounded the great significance, fundamental principles, basic requirements and scientific path of serious political life within the Party under the new situation, which is a scientific summary and theoretical sublimation of our Party’s experience in managing the Party and providing important compliance and institutional guarantee for comprehensively administering the Party strictly.

　　Serious inner-party political life is the Communist Party of China (CPC)’s fine tradition and political advantage. Over the past 96 years, one of the important reasons why our party has been able to maintain its advanced nature and purity forever is to attach importance to the role of inner-party political life in party building and make it a fine tradition and heirloom. As early as 1926, our party began to use the concept of party life in the central document. In the long-term practice, our party has gradually formed the basic norms of inner-party political life with seeking truth from facts, integrating theory with practice, keeping close contact with the masses, criticizing and self-criticizing, democratic centralism and strict party discipline as the main contents, which has provided an important guarantee for the development of the cause of the party and the state.

　　Serious inner-party political life is the golden key to solve the contradictions and problems existing in the party. History has proved that when the political life within the party is serious, the cause of the party and the people will flourish; Whenever the political life within the party is abnormal, the cause of the party and the people will encounter setbacks. One of the most important reasons why the Communist Party of China (CPC) can constantly overcome all kinds of difficulties and dangers and move from victory to victory is that he can overcome all kinds of contradictions and negative factors existing in the party in a timely and effective manner through regular, serious and serious political life within the party, such as dogmatism, empiricism, liberalism, hedonism, bureaucracy and sectarianism. Under the new situation, only by effectively solving the problems existing in the party through the political life within the party can our party maintain its advanced nature and purity in the face of "four major tests" and "four dangers".

　　Serious inner-party political life is a melting pot for party member cadres to exercise their party spirit. Political life within the Party is the main platform for Party organizations to educate and manage party member and exercise party spirit. Party member cadres’ ability and prestige are closely related to whether they have been seriously trained in inner-party political life. Serious inner-party political life is like a melting pot, in which party member cadres consciously accept the baptism of thought and party style and discipline, and constantly temper party spirit, so that they can keep fit and be tempered into steel.

　　Serious inner-party political life is a purifier of pure party style. What kind of inner-party political life there is, there is what kind of cadre style in party member. Political life within the party can not only purify the party style, but also promote the improvement of political style, folk customs and social atmosphere by stirring up turbidity, strengthening the body resistance and eliminating evil spirits. It can not only ensure the purity and health of cadres in party member, but also enable the Party organizations to constantly eliminate "dust" and "viruses", realize self-purification, self-improvement, self-innovation and self-improvement, and promote the continuous development of the comprehensive and strict administration of the Party.

　　Strictly administering the Party in an all-round way inevitably requires strengthening inner-party supervision.

　　Xie Feng, Professor of Party Building Teaching and Research Department of Central Party School

　　General Secretary of the Supreme Leader attaches great importance to strengthening inner-party supervision and has made many important expositions on strengthening inner-party supervision. Both history and reality show that strengthening inner-party supervision is an inevitable requirement of strictly administering the party in an all-round way.

　　Deeply understand the significance of inner-party supervision to the comprehensive and strict administration of the party. This important significance can be understood from three aspects: first, from the historical experience of the party in power. Our party has deeply realized in its ruling practice that unsupervised power will inevitably lead to corruption, which is an iron law. As the ruling party, the biggest challenge our party faces is how to effectively supervise the power and keep the party’s advanced nature and purity forever. Among them, the most important supervision is the party’s own supervision, that is, inner-party supervision. The second is to learn from the failure of communist party in the Soviet Union. One of the main reasons for the collapse of the CPSU in the 1990s after more than 70 years in power was the lack of inner-party supervision and the abuse of power. This warns us that we should attach great importance to inner-party supervision and strictly manage the party. The third is to understand the problems faced by our party in the new period. At present, there are still many problems that need to be solved urgently in our Party. One of the important reasons is that the Party rules and regulations in party constitution have not been well implemented. To solve the problems existing in the Party, we must tighten inner-party supervision, promote the management of the Party from "loose and soft" to "strict and hard", ensure the effective implementation of party rules and discipline in party constitution, and provide an important guarantee for the comprehensive and strict management of the Party.

　　Promote the comprehensive and strict administration of the party by strengthening inner-party supervision. First, build a scientific inner-party supervision system. At present, a new inner-party supervision system with clear division of labor, clear responsibilities and three-dimensional complementarity has been formed, namely, unified leadership by the CPC Central Committee, comprehensive supervision by party committees (party groups), special supervision by discipline inspection organs, functional supervision by party departments, daily supervision by party grass-roots organizations and democratic supervision by party member. We should give full play to the role of the inner-party supervision system and promote the comprehensive and strict management of the party. Second, seize the "key minority". The object of inner-party supervision includes ordinary party member, but the focus is on leading organs and leading cadres, which is the key to strictly administering the party and strengthening inner-party supervision. Grasping the "key minority", especially solving the supervision problem of the top leaders, can play a leading and exemplary role and is of great benefit to curbing corruption and creating a good political ecology. Third, make full use of various means of inner-party supervision. These means include criticism and self-criticism, reminding conversation and admonishing conversation, debriefing and commenting on honesty, letters and visits, etc. Among them, we should pay special attention to the role of criticism and self-criticism. Criticism and self-criticism are the party’s fine traditions and good ways to find and correct shortcomings and mistakes. We must make good use of this weapon for self-defense and treatment. Fourth, strengthen the formulation and implementation of the inner-party supervision system. Adhere to the problem orientation and improve the relevant system of inner-party supervision; By adhering to the above rate, strengthening study and education, and strengthening supervision and inspection, we will do a good job in the implementation of the inner-party supervision system. Fifth, adhere to the combination of inner-party supervision and non-party supervision. The ruling position of our party determines that inner-party supervision is the most basic and the first.Only by strengthening inner-party supervision can we promote non-party supervision. At the same time, we should pay attention to the role of non-party supervision, realize the effective combination of inner-party supervision and non-party supervision, complement each other’s advantages and exert their overall strength, so as to maximize the effectiveness of supervision.

　　Strengthening ideals and beliefs and supplementing the "calcium" of the spirit

　　Guo Guangyin, former Party Secretary of Southeast University

　　Communist party people’s ideals and beliefs are their faith in Marxism, socialism and communism, and their loyalty to the Party and the people. General Secretary of the Supreme Leader pointed out: "Ideals and beliefs are the spiritual’ calcium’ of communist party people. Without ideals and beliefs, ideals and beliefs will be’ calcium deficiency’ and’ rickets’." Today, if we want to push forward the new great project of party building, strictly manage the party and make the party stronger, we must ask party member cadres to make up the spiritual "calcium" of ideals and beliefs more consciously.

　　To strictly manage the party in an all-round way, we must first strengthen our ideals and beliefs. Strictly administering the party in an all-round way is a systematic project, and strengthening ideals and beliefs is the theme that runs through this project. Judging from the Party’s organization, the Communist Party of China (CPC) adhered to the ideals of socialism and communism, which enabled the Party to make clear the direction of its efforts ideologically and politically, unite people’s strength, and maintain unity and unity. From party member’s individual point of view, ideals and beliefs are the political foundation and spiritual home for communist party people to settle down, which plays a key role in guiding and directing their thoughts and actions. Some party member cadres are politically deteriorated, economically greedy, morally degenerated and corrupted in life. In the final analysis, they lack the "calcium" of the spirit of ideals and beliefs.

　　Strengthening ideals and beliefs should be based on "four possibilities" and "six noes". Regarding whether party member cadres have ideals and beliefs, the Supreme Leader General Secretary put forward the objective criterion of "four possibilities". He pointed out, "There are objective standards to measure whether a Communist party member and a leading cadre have lofty ideals of communism. It depends on whether he can adhere to the fundamental purpose of serving the people wholeheartedly, whether he can bear hardships first and enjoy later, whether he can work diligently and be honest, and whether he can work hard, struggle and give all his energy and even his life for his ideals." As for the firmness of ideals and beliefs, the General Secretary of the Supreme Leader further put forward the standard of "six noes", which mainly depends on whether party member cadres can have political determination in the face of major political tests, whether they can establish a firm sense of purpose, whether they can be extremely responsible for their work, whether they can bear hardships first and enjoy them later, whether they can bravely shoulder heavy burdens in the face of urgent and dangerous tasks, and whether they can withstand the temptation of power, money and beauty. The criteria of "Four Musts" and "Six Musts" endow the firm ideals and beliefs with real connotations, and provide a practical yardstick for each Communist party member to test and reflect on his political consciousness, emotional attitude and behavior.

　　Make up the "calcium" of the spirit of ideals and beliefs based on reality. With ideals and beliefs and objective standards to follow, it is not enough to ensure that ideals are always firm, beliefs are always persistent, and actions are always correct. Firm and persistent ideals and beliefs will not come into being spontaneously, but we should try our best to learn, believe, understand and do things all our lives. Only by making efforts to supplement the "calcium" of the spirit of ideals and beliefs based on reality can we cultivate a "indestructible body" that can stand firm, stand the test, resist corrosion and resist risks. The firmness of ideals and beliefs comes from the power of truth, which requires party member cadres to seriously study Marxist classics and systematically master the basic Marxist theories, standpoints and methods. To strengthen ideals and beliefs, we must also strengthen the cultivation of party spirit and constantly strengthen the "four consciousnesses." The firmness of ideals and beliefs will ultimately start with doing a good job in front of you.

　　Democratic centralism is an important magic weapon to safeguard the unity and unity of the party.

　　Xin Xiangyang, Vice President of Information and Information Research Institute of China Academy of Social Sciences

　　Democratic centralism is the fundamental organizational system and leadership system of our party, the basic criterion for regulating political life and handling relations within the party, a scientific and effective system for ensuring the correct formulation and implementation of the party’s line, principles and policies, and an important magic weapon for safeguarding the party’s unity and unity.

　　Democratic centralism ensures the unity of the will of the whole party and lays an ideological foundation for the unity and unity of the party. There are many factors that affect the unity and unity of the party, one of which is the ideological factor. Our party has always emphasized the principle and system of democratic centralism. With this principle and system, we can deny the party’s leadership, China’s socialist system and reform and opening up, violate, distort and deny the party’s basic line, distort, vilify and deny Socialism with Chinese characteristics’s words and deeds, distort, vilify and deny the party’s history, People’s Republic of China (PRC)’s history and the people’s army’s history, and distort, vilify and deny the party’s leaders and heroic models.

　　Democratic centralism ensures the healthy development of political life within the party and provides basic norms for the unity and unity of the party. The "Several Guidelines on Inner-Party Political Life under the New Situation" adopted by the Sixth Plenary Session of the 18th CPC Central Committee pointed out: "In the long-term practice, our party has insisted on carrying out serious inner-party political life as an important task of party building, and formed the basic norms of inner-party political life with seeking truth from facts, integrating theory with practice, keeping close contact with the masses, criticizing and self-criticizing, democratic centralism and strict party discipline as the main contents." As the basic norm of inner-party political life, democratic centralism is conducive to unifying party member’s ideological understanding, solving some problems within the party and ensuring the healthy development of inner-party political life.

　　Democratic centralism ensures the correct orientation of selecting and employing people within the party and lays a cadre foundation for the unity and unity of the party. The development of the party’s cause is inseparable from a grand cadre team, and the formation of this team is based on democratic centralism. Based on democratic centralism, our party can constantly select outstanding talents to the jobs it needs. As the General Secretary of the Supreme Leader said: "Our current cadre selection mechanism is also at the first level. For example, I have worked in the countryside, served as the party branch secretary of the brigade, and worked in counties, cities, provinces and the central government." The first-level selection mechanism makes the selection of cadres not only reflect the wishes of the people, but also stand the test of political life. Without democratic centralism, some cadres will believe in the "circle culture" of cliques and consider how to pull relationships and find ways. If we earnestly implement the requirements of democratic centralism, we can train a large number of good cadres with firm beliefs, serving the people, being diligent and pragmatic, daring to take responsibility, and being honest and clean.

　　Practice has proved that democratic centralism is an important magic weapon to stimulate the creativity and vitality of the party and maintain the unity and unity of the party. We should adhere to the principle of democratic centralism to handle all kinds of relations within the Party, solve contradictions and problems within the Party, jointly safeguard unity based on the principle of party spirit, and ensure that the Party always keeps ahead of the times in the historical process of profound changes in the world situation, always becomes the backbone of the people throughout the country in the historical process of coping with various risks and tests at home and abroad, and always becomes a strong leadership core in the historical process of upholding and developing Socialism with Chinese characteristics.

Guo Liang was an early proletarian revolutionary of our party, a famous leader of the workers’ movement, and a close comrade-in-arms who organized and led the workers’ movement with Mao Zedong. Mao Zedong praised him as "a famous organizer of the workers’ movement". On March 29th, 1928, Guo Liang was secretly killed by Kuomintang reactionaries in Qianping, Simenkou, Changsha, at the age of 27. In Guo Liang’s short life, although there are not many poems left behind, they show Shi Ce’s unyielding heart and courage to fight.

"Ask the society, what is the truth?"

Guo Liang, formerly known as Guo Jing Jia, was born in 1901 in Wenjiaba, Sheshan, Tongguan Town, Wangcheng County, Hunan Province (now Guo Liang Village, Tongguan Street). At the age of 11, he changed his name to Guo Liang, hoping to be as resourceful as Zhuge Liang. When Guo Liang was a teenager, he paid close attention to the poor life of the people who were hungry and toiling, and thought deeply about it. He wrote a sharp new-style poem "Ask the Society": A strange question is not worth mentioning by scholars and juren, and it is also common sense for teachers, but they know nothing about it! Where did the Gu Mi of the rich come from? Why do farmers carry grain into the rich man’s barn? Ask the society, what is the truth? Where did the rich man’s house come from? Why do poor people build houses and rich people live in peace? Ask the society, what is the truth? Where do the clothes of the rich come from? Why don’t people who grow cotton and weave clothes cover their bodies? Ask the society, what is the truth? People live in the same world, why are the rich and the poor different? Ask the society, what is the truth? This poem tells the people’s sufferings in plain language and lashes out at social injustice in extremely sharp language, which is particularly easy to resonate and soon spread.

It is also in order to answer these doubts in Ask the Society that Guo Liang read more and more historical books, cared about his family and country, and began to explore the truth actively. In the autumn of 1915, 14-year-old Guo Liang was admitted to Changjun Middle School. With the anti-Japanese patriotic struggle of Hunan people constantly emerging, Guo Liang participated in the patriotic anti-Japanese struggle of Changsha students. In 1916, Guo Liang saw the heads of the murdered revolutionaries on the streets of Changsha, and angrily chanted poems: "How much blood and tears are there?"? Revenge needs to pour water into the cave, and patriotism can’t be afraid of hanging its head! " Grief and indignation gushed out from this poem, and the patriotic fire took root in the young man’s heart.

"A trickle of water sinks into a huge stream"

Once the patriotic fire is lit, it burns in Guo Liang’s young chest. He sympathized with the sufferings of the people and helped the poor to destroy their homes. In the process of dealing with the masses, I also deeply felt the turbulent but confused revolutionary enthusiasm. It seems that Guo Liang, who is surrounded by mountains and mountains, is eager to explore the way of struggle and the direction of progress. In 1919, Mao Zedong founded Xiangjiang Review in Changsha to spread and introduce new ideas. Guo Liang, who has been trying hard to explore the road of saving the country and the people, was struck by Mao Zedong’s article and soon became a loyal reader of Xiangjiang Review. In 1920, Guo Liang was admitted to Hunan No.1 Normal University, and met Mao Zedong by chance. From then on, he often asked Mao Zedong for advice on how to reform the society. Introduced by Mao Zedong, Guo Liang joined Xinmin Society, and then participated in Hunan Marxist Research Association organized by Mao Zedong, He Shuheng and Fang Weixia. In the practice of struggle, Guo Liang began to have a clear revolutionary ideal and struggle ideas, and firmly believed that nothing could be done without transforming the country.

In the winter of 1921, introduced by Mao Zedong, Guo Liang joined the Communist Party of China (CPC) and became one of the earliest party member in Hunan. When joining the party, Guo Liang made a generous statement: "Some people just give an empty mouth, and I, Guo Liang, are willing to give my head to the party." Guo Liang, who joined the Communist Party of China (CPC), finally belonged, and wrote a poem to express his feelings: "A trickle of water sinks into a huge stream, and it turns around without stopping; The back waves push the front waves and fly over the mountains to be free. " He compared his personal strength to a trickle, which, once put into the arms of the Party organization, converged into stormy waves and condensed into a majestic force of revolutionary struggle under the guidance of party flag.

"When will I wash away all my worries?"

After gloriously joining the Party, Guo Liang became more and more mature in thought, and more and more deeply realized that only by mobilizing millions of working people to work together can the action of saving the country have a steady stream of power. In the summer of 1922, after graduating from Hunan No.1 Normal School, Guo Liang immediately joined the revolutionary movement. In August of the same year, appointed by Mao Zedong, Guo Liang went to Yuezhou to carry out the work of Guangdong-Han railway labor movement. When he sailed down the Xiangjiang River to Dongting Lake, he was full of thoughts and couldn’t help chanting, "Xiao Shui, Xiang Shui, flows into the Yangtze River without a head." Long Jun sent me Dongting water, when will I wash away all my worries? " Guo Liang knew that the trip was bumpy and arduous, but he had no time to think about the severity of the difficulties, but immediately devoted himself to the fiery labor movement. On September 9th, Guo Liang organized and led a strike of 3,000 workers on the Guangdong-Han Railway, which shocked the whole country and opened the prelude to the first labor movement climax in Hunan. At the end of the same year, Guo Liang led the kindling of the workers’ movement to his hometown Tongguan. In the struggle, Guo Liang made good use of concise language to complain about the sufferings of ceramic workers, such as: "Digging clay bent his waist, pushing clay bowed his back, burning kiln goods burned his heart, making kiln goods worn his hand, and selling kiln goods lost his leg." In a few words, the injustice of the poor life of ceramic workers for generations was revealed, which aroused the workers’ resonance, condensed the struggle force, led the ceramic workers to resist the so-called "kiln door tax" and organized the establishment of the Tongguan ceramic trade union. On the day when the Tongguan Ceramics Trade Union was established, the Hunan District Committee of the Communist Party of China sent a pun couplet. The first part is "Don’t say that loose sand can’t make a great instrument", and the second part is "You should know that soil can turn into gold".Highly praised Guo Liang for leading generate, a ceramic worker.

In leading the Guangdong-Han railway workers’ strike, the pottery workers’ struggle against taxes and taxes, and the Changsha workers’ struggle against imperialism and feudal warlords, Guo Liang has increasingly demonstrated his ability to approach and inspire the masses. At that time, Bolshevik, the central theoretical publication, commented on Guo Liang: Guo Liang was the pioneer of Hunan workers’ movement. Anyuan in Jiangxi, Shuikoushan in Hunan, Changsha, Guangdong, Han and Zhuping in Hunan, Hubei and Jiangxi provinces, these local workers and other industrial professional workers all organized struggles under his direct and indirect guidance.

"Heroes have never bowed their heads since ancient times."

"Xiang water stirs up the hatred of the river, and the sword breaks the water and flows more. Although good and evil are reversed, heroes have never bowed their heads since ancient times. " This poem was sung by Guo Liang on the way to Wuchang after he was arrested by the enemy. It not only expressed his resentment of "the inversion of good and evil", but also showed his heroic spirit of being fearless and dying. In July, 1924, after Guo Liang was elected as the chairman of Hunan Anti-Imperialism Alliance, he wrote a lot of campaign articles. Under the careful organization of Guo Liang, Hunan once again set off an anti-imperialist climax. Guo Liang, who was at the forefront of the struggle, was wanted several times by Zhao Hengti, the warlord of Hunan at that time. In the face of the wanted notice, Guo Liang laughed it off without fear, and wrote a doggerel: "Zhao thief is persistent, a man looks like a wolf, killing with one hand and burning incense with the other, shouting autonomy and secretly communicating with the powers. If this cub is not removed, the people will suffer, and they will get a dog’s head and a pair of copper coins. Advise the police, don’t be fooled, help the tiger eat, and it will come to no good end. The notice is integrated, so remember to be detailed. " This limerick exposes the ugly face of reactionaries in laughing and cursing, and also points out the direction of struggle for the people in plain language. Under the leadership of Guo Liang and other comrades, anti-imperialist and patriotic activities in Hunan have become increasingly frequent and powerful. Facing the great revolutionary situation, Guo Liang and his comrade-in-arms Xia Minghan touched the scene and recited poems. Guo Liang recited: "One sword hangs on the bedside, and the GREAT GHOST kid comes in." Xia Minghan replied, "Kill all demons and level the world, and the mountains, rivers, the sun and the moon will be rearranged." The two revolutionary heroes expressed their aspirations with poems, and their determination to fight to the end jumped to the page.

In January 1928, dispatched by the CPC Central Committee, Guo Liang served as the secretary of the special committee of Hunan, Hubei and Jiangxi. Under the leadership of his organization, the party organizations in the border areas of Hunan, Hubei and Jiangxi provinces have been restored and developed. On March 27th, Guo Liang was arrested in Yueyang because of a traitor’s informer, and was executed secretly by the reactionary authorities in the early morning of 29th. Before his execution, he wrote a cone-shaped suicide note to his wife, who is also a native of communist party: "Can Ying, my love: Bright running around, homeless and stateless. I’m done. Hope to be kind and caress my son to follow my ambition. This is awkward. " This touching suicide note not only expresses deep attachment to family members, but also expresses infinite expectations for future generations to continue their struggle.

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With its well-designed profile, Pentium pony shows a unique sense of movement and stability. The body size is 3000mm*1510mm*1630mm, and the wheelbase is 1953mm, which ensures spacious interior space and good driving stability. The front and rear wheel tracks are 1290mm, which provides a balanced handling performance for the vehicle. It is worth mentioning that it is equipped with 145/70 R12 tires, with simple and fashionable rim design, which not only improves the overall visual effect, but also provides a comfortable driving experience for drivers.

The interior design of Pentium pony fully embodies the simple and practical style. The steering wheel is made of plastic, which is not full of advanced feeling, but it ensures the portability and durability of operation. The center console is equipped with a concise control panel, integrated with an easy-to-operate multimedia screen, and provided with USB interfaces, including one in the front row, which is convenient for drivers and passengers to connect electronic devices. The seat is made of fabric, which makes it comfortable to sit. The main seat supports front and rear adjustment and backrest adjustment, and the co-pilot seat is also equipped with front and rear and backrest adjustment functions to meet the needs of different drivers. The rear seats support the proportional tilting, which provides greater flexibility for the interior space, and is convenient for loading goods or meeting the needs of family travel. On the whole, the interior design of Pentium pony pays attention to practicality and humanized configuration.

For the Pentium Pony, the engine is excellent in power performance, and the maximum power reaches 20 kW, which provides strong power support for the vehicle. At the same time, its torque output is 85 Nm, which can ensure smooth and flexible handling during daily driving and light load. This configuration ensures that the Pentium pony meets the driver’s needs while taking into account fuel economy and driving pleasure.

In the eyes of car home car owners, the uniqueness of Pentium pony lies in its unique appearance design, especially the eye-catching headlights and unique rear window shape. Although some people may question its face value, for Zhan Wang, these characteristics are the reason why he chose Pentium pony. They not only make the vehicle stand out among many models, but also enhance the driver’s self-expression. Generally speaking, with its unique charm, Pentium Pony won the recognition of the owner @ Call Me Work Soul Warrior.

The third week of May every year is "National Nutrition Week", and this year’s theme is "Whole grain, nutrition+,opening a new era of nutritious and healthy grains". In the new version of Dietary Guidelines for China Residents (2016), the first core recommendation mentions cereals: there are various foods, and cereals are the main ones. What does the grain include? Where is the whole grain? How much grain should we eat every day? Today, Xiaobian will give you a "past lives" of grain.

What is whole grain?

Whole grain refers to the whole grain and its natural nutrients that have not been refined (or processed by grinding and crushing). Compared with refined grains, whole grains contain more B vitamins, minerals, dietary fiber, phytochemicals, tannins, carotenoids, phytic acid, lignin and lignans. Common varieties are grain amaranth, barley, buckwheat and so on. "Whole grain" retains all kinds of nutrients and active ingredients in the grain to the maximum extent, and its health effects in preventing chronic diseases and other fields are remarkable.

How much grain do you want to eat every day?

Dietary Guidelines for China Residents (2016) suggests that healthy adults should consume 250g-400g of cereals and potatoes every day, which is equivalent to 1 small bowl of rice or 1 medium-sized steamed bread per meal. The whole grain and miscellaneous beans are not less than one third (50-150g).

What are the benefits of eating whole grains often?

According to the data of the Whole Grains Council of the United States, eating whole grains regularly can effectively reduce the risk of some chronic diseases, such as type 2 diabetes by 21-30%, cardiovascular disease by 25-28% and stroke by 30-36%. It can also reduce the risk of obesity, colorectal cancer, asthma and inflammatory diseases, maintain normal blood pressure, reduce gum disease and prevent tooth loss.

How to select whole grains

1. According to the suggestion of USDA, firstly, check whether there is the word "whole" in the ingredient list, such as whole oats, whole wheat flour, whole grain corn and whole rye.

2. Even if some foods are marked with "multi-grain", "100% wheat", "high-fiber" and "whole wheat", in fact, they are only added with bran, lacking germ, and do not belong to whole grains, so they need to be carefully recognized when purchasing.

3. When choosing oatmeal, try to choose "pure oatmeal" instead of "nutritious oatmeal" with various ingredients, such as white sugar and vegetable oil powder. "Pure oatmeal" contains higher nutrients, such as dietary fiber, and more sugar and fat in "nutritious oatmeal" is not conducive to cardiovascular health.

Content source: Beijing Nutrition Society

On August 3rd, Netease Cloud Music and Tik Tok officially announced a cooperation to jointly build a "music+short video" content ecosystem. The two sides will strengthen the support and promotion of musicians and music works, explore the diversity of music, help more outstanding musicians and works out of the circle, and effectively increase the income of musicians.

Netease Cloud Music and Tik Tok will explore musicians’ support, music announcement, music copyright, music IP and other aspects, focusing on issues that musicians care about, such as creation, exposure, income, and work management, and give full play to the superior resources of their online music platforms and short video platforms.

Video shooting/video editing: Liang Xuhao

Luo Zhengxiang, reporter Liang Yihao, photo

[Guangdong famous doctor who has been a doctor for 70 years]

Jinyang. com reporter Feng Xixi correspondent Yue Weixin Zhang Lanxi Zhang Lingling Yuting

Professor Luo Zhengxiang, 93, is a famous expert in cardiothoracic and vascular surgery in China. He used to be the president of Guangdong Provincial People’s Hospital and the director of Guangdong Institute of Cardiovascular Diseases. From a handsome young boy to a white-haired old man today, years have left traces, but he can never change the "passion" in his heart-"saving lives" is his lifelong pursuit.

Under his leadership, Guangdong took the lead in establishing the Institute of Cardiovascular Diseases in China, and its reputation is still far-reaching. This famous cardiovascular expert also won the honor of "Outstanding Contribution Award of China Cardiothoracic Surgery".

The "best student" was admitted to medical college.

Luo Zhengxiang, 93, has gray hair, but his figure is straight. He is still a handsome elder in a suit. His thinking is very clear. When he is free, he watches movies and listens to classical music. When he goes out, he takes a mobile phone and "scans the code to pay" like a young man. He is a "grandfather". This "post-90 s" grandfather has made outstanding contributions to the development of cardiovascular disease in China.

In 1947, Luo Zhengxiang did not study business or economics as expected by his father. "When I was a child, I loved reading history books and wanted to be a hero. At that time, the best students could be admitted to medical school, so I went after the hardest." With an indomitable spirit, he successfully passed the West China University of Medical Sciences.

In 1954, Luo Zhengxiang came to work in Guangdong Provincial People’s Hospital, and chose the most difficult and complicated major in the medical field at that time-cardiac surgery. Since then, he has embarked on a journey of "heart" for more than half a century.

Cardiac surgery was difficult to start in China at that time. But Luo Zhengxiang never gave up his research on heart disease-heart surgery is extremely demanding, starting with the most basic hemostasis practice. The great blood vessel was accidentally broken and the blood was shocking. Luo Zhengxiang looked at the shadowless lamp, pressed it, pressed it, pinched it, and stitched the wound with a big curved needle. He was calm and calm for a few times: OK. The valves are stitched one by one, and repeated actions are done over and over again, which is simple and boring. 1 hour, 2 hours … Some doctors have been standing on their legs and looking at them, but Luo Zhengxiang is staring, unhurried and meticulously crafted.

"I used to have surgery and the conditions were very bad. Eating a dollar at noon is simple; There is no air conditioning in the operating room. Everyone is sweating after the operation and can only drink more water after the operation. " Luo Zhengxiang said that although the conditions are difficult, everyone can work together with Qi Xin. "The director of the department takes the lead in suffering, and the doctors and nurses will follow suit. This is a kind of atmosphere and a kind of culture."

The first generation of artificial biological heart valve in China has been developed.

In 1974, after visiting Beijing, Shanghai and Guangzhou, Argentine cardiovascular experts decided to invite Guangdong experts to study cardiovascular technology in Argentina. On March 16th, 1974, a technical team organized by the Ministry of Health, mainly from Guangdong Provincial People’s Hospital (Xiang Xiangyao, Luo Zhengxiang, Chen Chuanrong, Wei Wanchang, Chen Zhiming, Wang Tailai and Jin Si Lan from the First Affiliated Hospital of Sun Yat-sen Medical College) went to Argentina for a one-year medical investigation. This year’s study was fruitful, and Luo Zhengxiang and his party brought back advanced valve technology. In 1977, Luo Zhengxiang and Cai Zengxin went to an Italian hospital in Argentina again to study heart valve technology. In 1975, the first domestic aortic valve replacement was successfully implemented, and the first domestic pediatric valve replacement was successfully implemented in the same year …

In the 1970s, rheumatic heart disease and rheumatic fever prevailed in southern China, but for these patients who need valve replacement, heart valves need to be imported, which is expensive and few people can afford it. Luo Zhengxiang and his colleagues are determined to make Chinese’s own heart valve. In 1976, Guangdong Institute of Cardiovascular Diseases set up a research room for artificial heart biological valves, and then cooperated with Australian medical expert Dr. Zhang Renqian to set up Pacific Biological Products Company in Huangpu District of Guangzhou with full reference to international standards to develop and produce artificial heart valves. In 1977, the first generation of artificial biological heart valve in China, Guangdong Type I, was developed and applied in clinic, taking the lead in the perioperative management of cardiac surgery and the application of intra-aortic balloon counterpulsation in critical heart surgery. In 1987, Guangdong II artificial heart biological valve was successfully developed, and in 1988, the artificial mechanical heart valve was successfully developed in cooperation with Australian experts and applied in clinic. Domestic valves greatly reduce the cost of patients’ surgery and shorten the gap between cardiothoracic surgery in China and advanced countries in the world.

3. Lead the Institute of Mind Research to break through difficulties and create brilliance.

In 1958, Guangdong Provincial Institute of Thoracic Diseases was established in Guangdong Provincial People’s Hospital. For various reasons, the development of the institute was quite tortuous. On August 7th, 1978, Guangdong Provincial Party Committee agreed to rename Guangdong Thoracic Disease Research Institute as "Guangdong Cardiovascular Disease Research Institute", and the Ministry of Health listed Guangdong Cardiovascular Disease Research Institute as one of the three key cardiovascular disease research institutes in China (Beijing, Shanghai and Guangdong).

In this way, the Guangdong Institute of Cardiovascular Diseases was established, but how to go next is a problem that Luo Zhengxiang has to face. Now, 93-year-old Luo Zhengxiang goes back to the Institute every day to see this old place where he has been "cultivating" for decades. Every time he walks past the entrance of Dongchuan Road, Guangzhou, he will think of the difficulties of that year: "The Institute had no funds at first, and we ran to the cement factory to find the cement. I wear leather shoes to the construction site every day to supervise the work. After that, I change my clothes and go back to the operating room for surgery. " In this way, with the concerted efforts of everyone’s Qi Xin, the Institute of Mind Research has grown up slowly.

Today, it has gone through 61 years. Over the past 61 years, the Institute has trained a large number of experts for the country, treated tens of thousands of patients and laid the foundation for the prevention of cardiovascular diseases. Created countless national firsts, first cases, and even world firsts.

Young doctors love to chat with Luo Zhengxiang, and he is also willing to communicate with young people. He said that he likes to chat with patients when he sees a doctor, and it is easier to build trust when he gets familiar with each other. "When you are a doctor, you must be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am saving with my heart. Whether the doctor is careful or not can be seen by patients and their families. "

[famous doctor said]

When you are a doctor, you should devote yourself to the patients.

When you are a doctor, you should be dedicated to the patient and do everything for the patient; I have been a doctor for decades, and some patients have not been saved, but no one has ever made trouble, because they all know that I am trying to save them.

Recently, we obtained the latest spy photos of the M8, which indicates that this new model is expected to meet the public at the end of this year.

As can be seen from the spy photos, this camouflage car is a 6-seat version, which is different from the previously guessed 5-seat version M9. Although the number of seats has changed, the overall shape and outline are highly similar to the current M9, including the body size, and there is no significant difference. The comparative analysis shows that the front face design of the new car is closer to the boundary M7, which is embodied in the straighter front cabin cover shape and the headlight edge shape similar to the boundary M7.

In addition, the vehicle in the spy photos adopts a short front suspension design, which is conducive to maximizing the utilization of internal space in a slightly reduced body size. In terms of details, the new car seems to have cancelled the roof rack and the roof lidar.

According to the spy photos that flowed out before, it is expected that the M8 will be equipped with taillights of the same style as the M9, and equipped with the same lamp programming function. The exposure of this information has undoubtedly increased the market’s expectation and curiosity about M8.

Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text

　　On October 26th, an exclusive interview with DRIs was held in Beijing.

　　Yang Yuexin, Chairman of China DRIs Revision Expert Committee and Chairman of China Nutrition Society, Ma Aiguo, Deputy Chairman of the Revision Committee and Executive Vice Chairman of China Nutrition Society, Ding Gangqiang, Deputy Chairman of the Revision Committee, Secretary of the Party Committee of China Nutrition Society and Director of the Institute of Nutrition and Health of China CDC, Yang Xiaoguang, Vice Chairman of China Nutrition Society and researcher of the Institute of Nutrition and Health of China Center for Disease Control and Prevention, Peng Xianwu, the supporting unit of DRIs revision and general manager of Amway (China) Science and Technology Innovation Center, attended the interview and interpreted the new revision.

　　Yang Yuexin introduced that the 2023 edition of China DRIs is the ninth edition. The revised expert committee and technical working group composed of nearly 100 nutrition experts lasted for three years. Based on the four basic principles of scientificity, advancement, integrity and continuity, the different reference intakes of 20 age groups including energy, nutrients and other dietary ingredients and pregnant women and lactating mothers totaled more than 70 nutrients and other dietary ingredients, which were revised and confirmed, and were held at the 14th Asian Nutrition Conference in September 2023.

　　The revision of DRIs in 2023 mainly includes four aspects. First, the concepts and procedures have been improved and perfected. Different procedures for determining different reference values of nutrients have been newly formulated, and the technical points of each link of the formulation procedures have been uniformly determined. The concepts and connotations of recommended intake and specific recommended values for reducing the risk of diet-related non-communicable diseases have been further clarified and improved. Secondly, the basic reference values of China population were formulated and revised, including age grouping, representative weight, reference value of breast milk composition, recommended weight gain of pregnant women, PAL of physical activity level, etc. Thirdly, the new research results of nutrients and other dietary components in the past decade at home and abroad in the fields of function, evaluation, requirement, safety and prevention of chronic diseases have been included, and more research results targeting China residents have been included. Fourth, from the writing framework, format and other styles, it highlights the positioning of reference books centered on quantitative values.

　　Peng Xianwu believes that this revision has far-reaching guiding significance for the big health industry, such as the data of newly added plant nutrients such as coenzyme Q10 and Lycium barbarum polysaccharide, and the quantification of nutrients such as proanthocyanidins, which will help Amway and industry to develop products and guide consumers to use them.

　　Peng Xianwu introduced that in 2022, Amway and China Nutrition Society established Nutrilite Special Fund for Plant Functional Components and Health Research, aiming at attracting more research institutions and personnel to participate in the research direction of plant nutrients, opening up production, learning and research, transforming research results into products faster, and making more scientific research results benefit the public.

　　This revision has greatly changed the protein intake of the elderly and the calcium supplement standard for adults. Yang Xiaoguang believes that China has entered an aging society, and the elderly and ordinary people can’t meet the demand for protein, which is easy to lead to sarcopenia. Therefore, it is necessary to improve the dietary structure of the elderly and increase the intake of protein. Yang Xiaoguang introduced: "The 2023 edition of DRIs revised the requirement of protein for the elderly aged 65 and above in China, and its recommended intake increased from 0.98 g/(kg day) to 1.17 g/(kg day), which is an important achievement".

　　Ding Gangqiang said that in recent years, the health awareness of Chinese residents has been continuously strengthened, and dietary nutrition and healthy behaviors have been continuously formed, but chronic diseases related to nutrition are still increasing. It is hoped that the release of the 2023 edition of DRIs will further guide the needs of China residents in all aspects of dietary nutrition, especially how to achieve a reasonable and balanced diet, and complete the objectives of the second largest action of Healthy China Action-Reasonable Diet Action.

　　The revision of DRIs has a wide range of significance and value. First, it has scientific value, which determines the types and quantities of nutrients that each person should consume every day qualitatively and quantitatively. Second, social value is an important basic data support for formulating relevant policies, regulations and standards; The third is the value of technical support, which plays an important guiding role in the dietary design and evaluation of collective feeding units such as schools and nursing homes, the nutrition labeling of prepackaged foods, and the product research and development of food enterprises.