On Tuesday (April 2), Eastern Time, the second quarter of the US stock market seemed to have a bad start. The three major indexes of the US stock market fell across the board overnight. They all fell more than 1% in intraday trading, and the Dow fell nearly 400 points to a two-week low, the biggest daily decline in four weeks with S&P. The expectation of interest rate cuts in the first half of the year was frustrated, and the yield of US bonds rose again, which suppressed the market to some extent. However, the performance of gold is still strong and continues to refresh.

　　At the close, the S&P 500 index fell 0.72% to 5205.81 points; The Dow Jones index fell 1.00% to 39,170.24 points; The Nasdaq index fell 0.95% to 16,240.45.

　　In terms of US bond yield, the 10-year US bond yield once rushed above 4.4% to close at 4.36%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, closed at 4.70%.

　　Since Powell reiterated last week that he was in no hurry to cut interest rates, the market sentiment has not been high. And overnight, internal officials of the Federal Reserve once again consolidated this statement, and market sentiment was once again hit.

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. The former "big hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　It is worth noting that the economic data of the United States even triggered speculation about whether the Fed will cut interest rates three times this year. The data released on Tuesday showed that the number of job vacancies in the United States has not changed much compared with the previous value, or it indicates that the labor demand is still stable at a high level in the high interest rate environment.

　　LPL Financial analysts pointed out that although the Fed does expect to cut interest rates sometime this year, the argument that interest rates will be higher for a longer period of time is playing a role again, so this worries the market. He also explained from another angle why the market will pull back. A healthy market really needs to pull back. The current trend is not necessarily a bad thing. The S&P 500 index has still risen by about 9% so far this year. Therefore, the market outlook still needs to keep a close eye on the US economic data.

　　On the enterprise side, Tesla released the latest car delivery data, which was not as good as the market expectation. The share price fell by 4.9% overnight, and it has fallen by nearly one-third during the year, and its market value has been erased by 260 billion US dollars. The data shows that Tesla’s delivery volume in the first quarter decreased by 8.5% year-on-year to about 386,800 vehicles, which was far lower than the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected in history. During the same period, about 433,400 vehicles were produced, which was also lower than expected.

　　This is also the first time that Tesla has fallen below the 400,000-vehicle mark since the third quarter of 2022, a decrease of over 8.5% compared with the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　In the first quarter, Tesla faced a double blow of reduced demand for electric vehicles and high interest rates. Analysts had previously lowered their expectations for Tesla’s delivery. Some analysts pointed out that Tesla would experience the first year-on-year sales decline since the early days of the epidemic.

　　In addition, Tesla also faced many obstacles in the first quarter, such as the interruption of the supply of spare parts in the Red Sea caused by the attack of Houthi militia and the temporary suspension of production in the German factory. Although the next generation model is the key to growth, the production of this model is not expected to start until late next year, which means that the company may face the risk of slowing down growth before this.

　　[Hot stocks]

　　Among the popular US stocks, Microsoft fell by 0.74%, Google A by 0.60%, NVIDIA by 1.01%, Amazon by 0.16%, Apple by 0.70%, Meta by 1.23%, AMD by 2.53%, Arm Holdings by 2.07% and Netflix by 0.02%.

　　Due to the delivery of Q1 far less than expected, Tesla fell by 4.9%, and has fallen by nearly one-third during the year.

　　Global stock index

　　In the European stock market, the FTSE 100 index in Britain fell slightly by 0.22% to 7935 points. The French CAC40 index fell slightly by 0.92% to 8130 points. Germany’s DAX index fell 1.13% to 18,283 points.

　　In Asian stock markets, the Hang Seng Index rose 2.36% to 16,932 points. The index of state-owned enterprises rose 2.58% to 5961 points. The Nikkei 225 index fell 0.73% to 39,625 points.

　　[China Stock Market]

　　Nasdaq China Jinlong Index closed up 0.32%. In terms of popular Chinese stocks, Pinduoduo fell by 0.77%, TSMC by 0.88%, Weilai by 2.16%, Xpeng Motors by 2.26%, Alibaba by 0.61%, Baidu by 0.08% and Netease by 1.88%.

　　[foreign exchange commodities]

　　The US dollar index rose first and then fell, once standing above the 105 mark in intraday trading, and once fell to an intraday low of 104.67 during the US session, then rebounded and finally closed down by 0.19% to 104.81.

　　Gold futures for June delivery in the New York Mercantile Exchange closed up 1.09% at $2,281.80 an ounce, a record closing high, having risen to $2,297.70 an ounce in intraday trading. May silver futures closed up 3.39% at $25.923 an ounce.

　　Geopolitical risks have enhanced the attractiveness of gold, while traders have avoided the shadow cast by the strong economic data of the United States on the prospect of the Fed raising interest rates.

　　Oil prices continue to rise due to supply concerns. WTI crude oil rushed above $85 in intraday trading, rising more than 2% in the day, and continued to hit a new high since October last year, finally closing up 1.76% to $85.47/barrel; Brent crude oil also hit a new high since October last year, and finally closed up 2.12% to $89.27/barrel.

　　[Highlights]

　　The Fed reiterated that it is not in a hurry to cut interest rates, but it is still possible to start in June?

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. Regardless of changing the inflation target, the continuous rise in oil prices will become a problem; The former "Great Hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　Job vacancies in the United States in February were slightly higher than expected

　　The voluntary turnover rate is the lowest since 2020, and the number of layoffs is the highest in nearly a year. The number of JOLTS vacancies in the United States in February was 8.756 million, slightly better than expected, and the value was revised down to 8.748 million before January. The voluntary turnover rate in February was 2.2%, the lowest level since 2020. Due to the increase in layoffs in the leisure and hotel industries, the number of layoffs has risen to the highest level in the past year.

　　Tesla’s quarterly delivery dropped for the first time in nearly four years, and its market value has evaporated by $260 billion in the year.

　　On Tuesday, Tesla Corporation, an American electric vehicle manufacturer, released a report on automobile production and delivery in the first quarter of 2024. According to the specific data, Tesla delivered a total of 386,810 vehicles in the first three months of this year, far below the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected. This is also the first time that the company has fallen below the 400,000-vehicle mark since the third quarter of 2022, which is over 8.5% lower than the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　Intel’s report shows that the loss of its foundry business expanded in 2023.

　　In a document submitted by Intel on Tuesday, Intel said that the sales of its new manufacturing division, Intel Foundry, in 2023 were $18.9 billion, down from $27.5 billion in the previous year, and the operating loss increased from $5.2 billion in 2022 to $7 billion. It is estimated that the loss will reach its peak in 2024 and will be realized at the operational level "in the middle of now to the end of 2030". Intel shares fell more than 2% after the report was released. Intel’s entry into outsourcing chip production is one of the biggest transformations in the company’s history. CEO Pat Gelsinge’s recovery plan also includes restoring the company’s once impeccable technological advantage, which the chip giant lost in the years before he took office in 2021.

　　A major breakthrough in AI pharmaceutical! Stanford SyntheMol model develops new antibiotics

　　According to a report by Stanford Medical College on March 28th, researchers from Stanford Medical College and McMaster University have made important progress in this field. They have developed an AI model called SyntheMol, which can synthesize drugs and create formulas for chemists in the laboratory.

　　The model creatively designed six new drugs for drug-resistant bacterial strain Acinetobacter baumannii, which is one of the main pathogens causing antibiotic resistance-related deaths. The model not only created a new drug structure, but also provided a detailed formula for chemical synthesis, enabling chemists to synthesize these drugs in the laboratory.

　　Abbott’s heart valve repair system has been approved by FDA to provide patients with new treatment options.

　　On Tuesday, US medical and health company Abbott announced that its heart valve repair system has been approved by the US Food and Drug Administration (FDA), which is suitable for patients with potentially fatal heart disease. Abbott’s minimally invasive transcatheter TriClip repair system aims to treat tricuspid regurgitation (TR), which is a disease in which the valve between the right ventricle and the right atrium of the heart cannot be closed normally, resulting in blood reflux. Abbott has incorporated TriClip into its so-called "Fab 5" () equipment portfolio, which is expected to promote the company’s sales growth in the next few years, representing Abbott’s technological innovation and market leadership in their respective fields.

　　[financial calendar]

　　Recently, Hu Yue, associate professor and doctoral supervisor of Huazhong University of Science and Technology, has caused a heated discussion because he published 60 SCI papers in five years.

　　According to the teacher’s personal homepage of Huazhong University of Science and Technology, Hu Yue received a bachelor’s degree in applied chemistry from East China University of Science and Technology in 2012 and a doctorate in chemistry from Edinburgh University in 2016.

　　In the same year, she joined Wuhan Photoelectric National Research Center of Huazhong University of Science and Technology, and has been engaged in theoretical and experimental research of photovoltaic materials for solar cells for a long time.

　　In self-introduction, Hu Yue mentioned that in the past five years, she has published more than 60 SCI papers, including 21 papers by the first correspondent, including 1 paper by Science, 1 paper by Joule and 1 paper by Advanced Materials. At present, there are 2 highly cited papers on ESI.

　　Nine groups of journalists found that in the statistical table of journal impact factors released in June this year, the impact factor of Science was 47.728, that of Joule was 41.248, and that of Advanced Materials was 30.849. Impact factor refers to the frequency with which articles in a periodical are cited in a specific year or period. Generally speaking, the higher the impact factor, the greater the influence of the journal.

　　Some netizens said that before Hu Yue joined Huazhong University of Science and Technology, there were only four papers by the first author, and one paper was output on average one month after joining the company, and his paper was suspected of "irrigation".

　　"Our teacher didn’t do anything wrong, but the mistake was too much exposure." On the afternoon of December 13th, han hongwei, the leader of Hu Yue’s research group and professor of Huazhong University of Science and Technology, responded to the reporter.

　　"Our research group has a large number of people and published many articles, which has caused some misunderstandings." Han hongwei said.

　　The leader of the research group responded: The mistake is that there is too much exposure.

　　"We didn’t expect the heat to be so high, and this matter was misinterpreted." Han hongwei said.

　　His office is next door to Hu Yue. On December 13th, he answered the phone all afternoon and walked in a hurry. Referring to Hu Yue, he said angrily, "Our teacher didn’t do anything wrong, but the mistake was too much exposure."

　　On December 8th, a post-90s doctoral supervisor was often recognized as a "teacher elder sister"! The introduction is very eye-catching! The article was reprinted by many media, allowing Hu Wei to enter the public eye. While gaining praise, Hu Yue’s resume also sparked heated discussion.

　　In the article, Hu Yue said that her grandfather graduated from Zhejiang University with a bachelor’s degree and a master’s degree, and she has been engaged in chemical-related work. Her interest in scientific research was enlightened by her grandfather. In 2008, Hu Yue was admitted to the School of Chemistry and Molecular Engineering of East China University of Science and Technology. In 2009, she joined the team of Academician Tian He and participated in the national innovative experimental program for college students to carry out research on "dye-sensitized solar cells". Therefore, some netizens speculated that Hu Yue relied on his grandfather to obtain academic resources.

　　On December 14th, Hu Yue responded in an interview with China Science News that his grandfather was a retired engineer of former Wuhan Chemical Industry Bureau, not an academician of Internet communication. According to public reports, Hu Yue scored 626 points in the college entrance examination that year, ranking first among Hubei candidates admitted by East China University of Science and Technology. With such good grades, she joined the Department of Science and Technology Excellence of East China University of Science and Technology, and had the opportunity to choose Professor Tian He as her tutor.

　　On the teacher’s personal homepage of Huazhong University of Science and Technology, Hu Yue briefly mentioned that in the past five years, she has published more than 60 SCI papers, including 21 first/correspondent papers. Including 1 science, 1 Joule, 1 advanced materials, 2 advanced energy materials, 2 advanced functional materials, 1 ACS energy letter and 1 energy & environmental science. At present, Google Scholar has cited more than 1,800 times, with an H index of 24, and 2 papers have been selected as highly cited papers in ESI.

　　Hu Yue’s research field. Network screenshot

　　Han hongwei explained why the number of Hu Yue’s articles is as high as 60: "As a teacher of the research group, we will collectively take a group of students to give guidance from different angles and different professional backgrounds. If the teacher contributes, we will write his name in." He added that apart from the first author, co-first author and correspondent, other teachers are only participants, and their contribution may be only 1% or 10%, and they are not responsible for the article.

　　According to WeChat official account, the official of Huazhong University of Science and Technology, at present, Hu Yue and Professor han hongwei have jointly trained five doctoral students and five master students independently. Three master students have graduated, two have entered Huawei and one has gone to Zhejiang University for further study.

　　"Our research group has a large number of people and published many articles, which has caused some misunderstandings." Han hongwei said.

　　He was promoted to associate professor in two years and became a doctoral supervisor in three years.

　　"Young" and "excellent" are Hu Yue’s most conspicuous labels. The short film "Chasing the Light — — In Hu Yue, Hu Yue said: "I am an associate professor and doctoral supervisor born in the 1990s. When I first returned to China, many students were even older than me."

　　During the undergraduate course, she studied with Professor Hua Jianli of East China University of Science and Technology and Academician Tian He. In the representative papers listed by Professor Hua Jianli in official website, East China University of Science and Technology, Hu Yue’s name appeared in the author list of six papers, and the publishing time was from 2014 to 2017.

　　In 2012, after graduating from Hu Yue University, he applied for a full scholarship with excellent results and entered the University of Edinburgh to continue solar cell research. In 2016, Hu Yue received his Ph.D. and joined Huazhong University of Science and Technology through the postdoctoral talent introduction program.

　　According to the upstream news report, there are four papers published by Hu Yue in 2016, which are neither the first author nor the correspondent author, and of these four papers, only one is more valuable, but it is not the top publication. Therefore, some netizens think: "At this level, if the postdoctoral experience is not gilded, it is difficult to get a teaching position in a school like Huake."

　　In this regard, Hu Yue said in an interview with China Science News that during her doctoral period, she published more than 10 papers, among which 6 were first authors or co-first authors. After graduating from Ph.D., she first entered Huazhong University of Science and Technology as a postdoctoral fellow and stayed at school after leaving the station.

　　Official website of Huazhong University of Science and Technology shows that Hu Yue went to Oxford University, London Imperial College London and Lausanne Federal Institute of Technology for cooperation and exchange for one or three months during his doctoral studies.

　　After entering Huazhong University of Science and Technology, the number of articles published by Hu Yue increased significantly. The reporter found in Google Academic Search that Hu Yue published 13 papers in 2017.

　　In 2018, she and associate professor Rong Guangguang of Huazhong University of Science and Technology and Dr. Mei Anyi published a paper as the co-first author, which was published in Science magazine, and the project also won the support of major research plan integration projects and key projects of the National Natural Science Foundation.

　　In the same year, Hu Yue was promoted to associate professor and became a doctoral supervisor in 2019.

　　The office door is covered with cartoon images.

　　At five o’clock on the afternoon of December 13th, the building of Wuhan Optoelectronic National Research Center in the east campus of Huazhong University of Science and Technology was full of busy students.

　　In the corridor, five students around the round table discussed the group work fiercely. A black boy wearing headphones came out of the laboratory and stared blankly out of the window. There were four graduate students at the corner of the stairs to define the division of labor for the next project presentation.

　　Hu Yue works on the eighth floor. In a row of offices, hers is the most special. The gray door is covered with the image of opening, an orange cat sticker is stuck by the door, and the stills of Naruto are skewed in the center, with two molecular formulas sandwiched between them.

　　Hu Yue’s office. Figure/Nine School News Ma Jieying

　　The reporter found that Hu Yue had only one project practice class recently.

　　Liu Yilin (pseudonym), a graduate student at the School of Optoelectronic and Information, Huazhong University of Science and Technology, said that Hu Yue spends most of her time in the laboratory, but recently, because of her graduation thesis defense, she rarely appears in this building. "I am not here these days." Liu Yilin said.

　　Liu Yilin’s impression of Hu Yue is "tenderness". Because they are not in the same research group, there is not much communication. The only communication between him and Hu Yue was when he defended his graduation thesis last year. At that time, as soon as he showed the results of his paper, Hu Yue asked a question about energy management, but Liu Yilin’s research direction was different from this. He didn’t answer it. "I was very nervous at that time, but the teacher was very gentle and didn’t answer it."

　　Opposite Hu Yue’s office is the student office, where several graduate students work. The computer screen of the girl sitting at the door is covered with experimental pictures, and there are unfinished English papers in the document.

　　A student from other research groups told reporters that she had read online queries and hoped not to interview Mr. Hu. "Teacher Hu is usually very kind to us."

Southeast Network is the official news portal of Fujian, which is headed by the Propaganda Department of Fujian Provincial Committee of the Communist Party of China and sponsored by Fujian Daily Newspaper Group.

recent days

Website of the State Administration of Market Supervision

Announce the latest batch

Motor vehicle recall information

Involving Guangqi Honda and Dongfeng Honda

Land Rover, Mercedes-Benz, Volvo, etc.

↓↓↓

Guangqi Honda Automobile Co., Ltd.

Dongfeng Honda automobile co., ltd

Recall some domestic hybrid electric vehicles

Recently, Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall, and decided to recall the following vehicles from now on.

I Guangqi Honda Automobile Co., Ltd.

A total of 87,092 domestic hybrid BREEZE and plug-in hybrid BREEZE cars produced between January 4, 2019 and December 29, 2022 were recalled.

Second, Dongfeng Honda Automobile Co., Ltd.

A total of 169,000 domestic hybrid cars (CR-V) and plug-in hybrid cars (CR-V) produced between June 8, 2017 and August 17, 2022 were recalled.

For the vehicles within the scope of this recall, due to the layout problem of the battery positive wiring harness, when the left front part of the front of the car collides at a specific angle, the battery positive wiring harness may be damaged, and there is a risk of short circuit and fire.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will replace the improved battery positive wire harness for vehicles within the recall range free of charge to eliminate potential safety hazards.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will notify the relevant users of the recall by registered mail, and take the initiative to contact the users through authorized special sales service stores to make an appointment to arrange the recall and maintenance. Users of Guangqi Honda can call the service hotlines: 800-830-8999 (fixed-line users only), 400-830-8999 and the hotlines of special sales service stores for consultation, or visit Guangqi Honda’s website for recall information. Users of Dongfeng Honda can call the service hotlines: 800-880-9899 and 400-880-6622 (by mobile phone) for consultation, or visit the website of Dongfeng Honda for recall information. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Jaguar Land Rover (China) has limited investment.

The company recalled some imports.

Land Rover Range Rover Sport Series Cars

A few days ago, Jaguar Land Rover (China) Investment Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From March 29th, 2024, some imported 2023 Land Rover Range Rover Sport cars produced from July 4th, 2022 to November 30th, 2022 were recalled, totaling 1,987 vehicles.

Due to the factory assembly, the right taillight of the vehicles within the scope of this recall may get water and fail during use, which can not provide effective signals for the rear vehicles, increasing the risk of vehicle collision and posing potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will replace the taillights on the right side of the tailgate and the right side of the car body for vehicles within the recall range free of charge to eliminate potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will notify relevant users of this recall by registered mail. Users can call the Land Rover brand customer service hotline: 400-820-0187 through landline or mobile phone for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Mercedes-Benz (China)

Automobile sales co., ltd. recalled

Some imported GLE SUV cars

A few days ago, Mercedes-Benz (China) Automobile Sales Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From now on, a total of 118 imported GLE SUV vehicles with production dates from February 9, 2021 to November 18, 2021 will be recalled.

Some vehicles within the scope of this recall are not properly fixed with the grounding fixing bolts of the 12V battery grounding wire, resulting in an increase in the resistance of the fixed area and a large current passing through it, which may lead to an abnormal temperature rise in this area and a fire risk.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will inspect and retighten the grounding wire fixing bolts for vehicles within the recalled scope free of charge through Mercedes-Benz authorized dealers, and replace the grounding wire if it is damaged, so as to eliminate potential safety hazards.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will notify the relevant owners of the recall by registered mail. Users can call the service hotline: 400-818-1188 through landline or mobile phone for consultation (service time is 24 hours a day from Monday to Sunday). In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Volvo automobile sales (Shanghai)

Co., ltd. recalled some imports

XC90 automobile

A few days ago, Volvo Car Sales (Shanghai) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some imported XC90 cars from 2015 to 2024, which were produced between December 1, 2014 and September 23, 2023, with a total of 1,200 vehicles.

The fixing bolts of the seat belts in the second row of some vehicles within the scope of this recall are not tightened according to the regulations. When a vehicle collides, the fixing bolts of the seat belts may be loose, which will affect the restraint effect of the seat belts, increase the risk of passengers being injured, and pose potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will tighten the seat belt fixing bolts according to the specified torque for the vehicles within the recall range free of charge through authorized dealers of Volvo Cars to eliminate potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will notify relevant users by registered mail. Authorized dealers of Volvo Cars will also take the initiative to contact the relevant car owners to arrange the recall. Users can call the Volvo car after-sales service hotline: 10108666 for consultation through mobile phones and fixed telephones. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

China Heavy Duty Truck Group Jinan Truck Co., Ltd.

Recall part of limited company

Haowo brand traction car

Recently, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some Hauwo brand traction vehicles produced from April 23, 2020 to November 29, 2020, totaling 37 vehicles.

Due to manufacturing problems, the rear position lights on both sides of the top of the cab were not installed in the vehicles within the scope of this recall. At night or under poor road lighting conditions, the outline of the vehicle may not be displayed, which may pose a safety hazard.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will replenish the rear position light assemblies on both sides of the rear top of the cab free of charge for vehicles within the scope of recall, so as to eliminate potential safety hazards.

This recall was carried out under the condition that the State Administration of Market Supervision initiated a defect investigation. Affected by the investigation, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. decided to take recall measures to eliminate potential safety hazards.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will notify relevant users by registered mail or telephone through dealers, and arrange for free recall and maintenance. Users can also call the 24-hour service hotline: 4001888666 for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Original title: "A large number of recalls! Check yourself quickly! Your family may also have it.

Read the original text

Foreword

Influenza virus can cause seasonal influenza, and may even cause a pandemic outbreak. Influenza virus is a negative-strand RNA virus with complex classification, numerous subtypes and easy mutation. At present, it is recognized that the best way to prevent influenza is vaccination. In order to ensure the effectiveness of the vaccine, the World Health Organization (WHO) updates the composition of the vaccine strain every year.

Changes of influenza vaccine strains in the northern hemisphere in 2024-2025

In order to keep the vaccine effective, it is necessary to update the components of influenza virus vaccine regularly. After analyzing the global influenza virus epidemiology, etiology and vaccine serology, WHO announced the recommendation of influenza vaccine components in the northern hemisphere from 2024 to 2025 on February 23, 2024.

?

Trivalent chicken embryo culture vaccine

an A/Victoria/4897/2022 (H1N1)pdm09-like virus

an A/Thailand/8/2022 (H3N2) -like virus

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus

?

Trivalent cell culture or recombinant protein vaccine

an A/Wisconsin/67/2022 (H1N1)pdm09-like virus

an A/Massachusetts/18/2022 (H3N2)-like virus

a B/Austria/1359417/2021 (B/Victoria lineage)-like virus

?

Tetravalent chicken embryo and cell culture or recombinant protein vaccine

The following components are added on the basis of trivalent vaccine

a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus

Since March 2020, the naturally occurring B/Yamagata virus has not been confirmed. WHO thinks that it is not necessary to use B/Yamagata virus as a component of influenza vaccine, and it should be removed from the component of influenza vaccine. Where tetravalent vaccine is still used, the composition of B/Yamagata line is consistent with the previous recommendation.

Comparing the composition of influenza vaccine in the northern hemisphere from 2023 to 2024, it was found that the change of composition was mainly due to the difference of H3N2 virus strains:

Vaccine types

2023-2024

2024-2025

Trivalent chicken embryo culture vaccine

A/Darwin/9/2021 (H3N2)-like virus

A/Thailand/8/2022 (H3N2) -like virus

Trivalent cell culture or recombinant protein vaccine

A/Darwin/9/2021 (H3N2)-like virus

A/Massachusetts/18/2022 (H3N2)-like virus

Recombinant antigen is the key material for vaccine research.

In influenza virus-related vaccines, drugs and even diagnostic reagents, key target antigens have played an important role. In the following table, we have sorted out the information of HA, NA and NP proteins.

albumen

function

app; application

HA

(hemagglutinin)

The sialic acid receptor on the host cell membrane binds to help the virus envelope fuse with the host cell membrane; Coagulation

Basic research on influenza

Influenza vaccine research and development

Development of anti-hemagglutinin antibody

Study on virus detection reagent

NA

(neuraminidase)

Hydrolyze sialic acid receptor to promote the release of mature virus particles

Research and development of antiviral drugs

Basic research on influenza

Influenza vaccine research and development

Antibody development

Study on virus detection reagent

NP

(nuclear protein)

Combine with influenza genetic material and participate in virus gene replication, transcription and translation; Maintain the stability of virus gene

Research and development of antiviral drugs

Basic research on influenza

Antibody development

Diagnostic product development

The recombinant antigen of influenza vaccine strain can be used in all aspects of vaccine development, such as vaccine content detection, vaccine biological titer detection and toxicological experimental research. Using recombinant antigen for ELISA detection, we can analyze the levels of serum total antibody and neutralizing antibody after vaccination, and use recombinant protein as control to detect the vaccine content.

The results of detecting the serum antibody level of mice immunized with vaccine by recombinant influenza HA protein (image from Andersen, et al.)

Influenza vaccine strain-related antigens are available in stock.

Yiqiao Shenzhou continues to pay attention to the research progress of influenza vaccine, and has built a relatively complete influenza virus research reagent library. It has been online to recombine some proteins of HA, NA and NP of the northern hemisphere influenza vaccine strain in 2024-2025, and it is available from stock. Order it now!

Consultation is polite!

After checking the information correctly, you can get a 35 yuan Luckin Coffee voucher.

Scanning code to understand the recombinant antigens related to components of influenza vaccine strains from 2024 to 2025;

references

[1]https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2024-2025-northern-hemisphere-influenza-season

[2] Andersen, et al. Pandemic Preparedness Against Influenza: DNA Vaccine for Rapid Relief.[J]. Frontiers in Immunology.2021.747032.

[3] Bangaru S , et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface[J]. Cell, 2019.

[4] Kim M, et al. Inhibition of infection virus internalization by (-)-Epigallocatechin-3-gallate. [J]. Antiviral Research, 2013,100 (2): 460-472. Continue to slide to see the next one.

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(full) name gender Ticket number Examination department Apply for a position graduated institutions remarks Lu Yitong man 2013010100104 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Li Jiangbo man 2013010100109 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Zhou yongchao man 2013010100122 Provincial Commission for Discipline Inspection 201123773 First-level director and below Chinese people’s public security university Zhang Yu man 2013010100222 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Chai yuze man 2013010100229 Provincial Commission for Discipline Inspection 201123773 First-level director and below Fuzhou University Qiu Han man 2013010100409 Provincial Commission for Discipline Inspection 201123773 First-level director and below China University of Political Science and Law (CUPL) Qin wenjie man 2013010100417 Provincial Commission for Discipline Inspection 201123773 First-level director and below Longdong college Lei Yu man 2013010100502 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Wujiabo man 2013010100602 Provincial Commission for Discipline Inspection 201123773 First-level director and below Huazhong University of Science and Technology Li long man 2013010100617 Provincial Commission for Discipline Inspection 201123773 First-level director and below Hu’ nan Institute of Technology Chen Zhiwen man 2013010100618 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Sun Peng man 2013010100623 Provincial Commission for Discipline Inspection 201123773 First-level director and below Renmin University of China Pinghao man 2013010100702 Provincial Commission for Discipline Inspection 201123773 First-level director and below China University of Political Science and Law (CUPL) Wu shuaihong man 2013010101322 Provincial Commission for Discipline Inspection 201123774 First-level director and below Zhejiang University Zhang yang man 2013010101727 Provincial Commission for Discipline Inspection 201123774 First-level director and below Chang’an University Zhu Baoyuan man 2013010102323 Provincial Commission for Discipline Inspection 201123774 First-level director and below the central institute for correctional police Jamolan woman 2013010102411 Provincial Commission for Discipline Inspection 201123774 First-level director and below Beijing Jiaotong University Chang Jing woman 2013010102718 Provincial Commission for Discipline Inspection 201123774 First-level director and below China University of Political Science and Law (CUPL) Li Jin man 2013010103116 Provincial Commission for Discipline Inspection 201123774 First-level director and below Qingdao university Dangqiao woman 2013010103624 Provincial Commission for Discipline Inspection 201123774 First-level director and below Northwest A&F University Shang Jiaxin man 2013010103820 General office of provincial party Committee 201133775, the fourth-level director of the organ Xi’an University of Technology Sun zhenglong man 2013010103828 General office of provincial party Committee 201133776 Director of the fourth level of the organ Northwest university of political science and law Yang ruoyu woman 2013010103910 General office of provincial party Committee 201133777 Director of the fourth level of the organ Lanzhou Jiaotong University He Jing man 2013010104003 General office of provincial party Committee 201133778, the fourth-level director of the organ Shaanxi Normal University Xiong Yao woman 2013010104111 General office of provincial party Committee 201133779 Director, Level 4, Secrecy Office of Provincial Party Committee Xiamen University Qu dangping man 2013010104201 General office of provincial party Committee 201133780 Director of the Secrecy Office of the Provincial Party Committee Northwest University Law School Zhang bochao man 2013010104202 General office of provincial party Committee 201133780 Director of the Secrecy Office of the Provincial Party Committee Northwest university of political science and law Daisy woman 2013010104226 Propaganda department of provincial party Committee 201143781 Director of the Propaganda Department of the Provincial Party Committee Shenyang Aerospace University Luo beijuan woman 2013010104525 Propaganda department of provincial party Committee 201143782 Director of the Propaganda Department of the Provincial Party Committee Communication University of China Liu jieqiong woman 2013010104605 United Front Work Department of Provincial Party Committee 201153783, the first-level director of the Ministry and below Lanzhou university of technology Feng xinxing man 2013010104615 United Front Work Department of Provincial Party Committee 201153784, the first-level director of the Ministry and below China University of Political Science and Law (CUPL) Liu ruizhu woman 2013010104628 United Front Work Department of Provincial Party Committee 201153785, the first-level director of the Ministry and below Renmin University of China Zhang Chenchen man 2013010104723 United Front Work Department of Provincial Party Committee 201153786, the first-level director of the Ministry and below Shanghai University Dang Qiuxia woman 2013010104804 United Front Work Department of Provincial Party Committee 201153787 First-level director of the provincial party committee of the Agricultural Workers’ Party and below Shanxi University Han Jie man 2013010104818 United Front Work Department of Provincial Party Committee 201153788 First-level director and below of the Provincial Committee of Jiu San Society Lanzhou University Wang wenmiao man 2013010104905 United Front Work Department of Provincial Party Committee 201153789 Provincial Federation of Industry and Commerce, first-level director and below Baoji university of arts and sciences Mao chuhao man 2013010104906 Office of Foreign Affairs Working Committee of Provincial Party Committee 201163790 First-level director and below Beijing Foreign Languages University Yuan Wenting woman 2013010104922 Office of Foreign Affairs Working Committee of Provincial Party Committee 201163791 Provincial People’s Association for Friendship with Foreign Countries First-level Chief Staff and below Xi ‘ an international studies university Li yang man 2013010105004 Provincial Party Committee Organization Establishment Committee Office 201173792, the fourth-level director of the office. Chinese people’s public security university Saki Liu woman 2013010105015 Provincial Party Committee directly under the authority Workers’ Committee 201183793 First-level director and below yan’an university Zhou Zhendong man 2013010105022 Provincial Party Committee directly under the authority Workers’ Committee 201183793 First-level director and below CPC Shaanxi Provincial Party School Tian zhuowen woman 2013010105107 Provincial bureau of retired veteran cadres 201193794 [Civil Servant] First-level Chief Clerk and below Xi ‘ an international studies university Jiawei Zhang man 2013010105401 Provincial bureau of retired veteran cadres 201193795 [Civil Servant] First-level Chief Clerk and below xian university of science and technology high tech college John Chang man 2013010105425 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below yan’an university Wang Kaixuan man 2013010105426 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below yan’an university Liu Yitong woman 2013010105429 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Beijing Normal University Wang zhangzhang man 2013010105502 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Jilin University Huan Wang woman 2013010105511 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Wuhan University Zhang jiapei woman 2013010105512 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below China West Normal University Louise Yang woman 2013010105527 Provincial archives 201213797 Department [Reference Management] Level 4 Chief Clerk and below Tibet University for Nationalities Long xiuping woman 2013010105627 Provincial archives 201213798 Department [Reference Management] Level 4 Chief Clerk and below Xidian University Antong man 2013010105805 Provincial archives 201213799 Post-warehouse Management Office [Reference Management] Level 4 Chief Clerk and below North China University of Technology Ai Jing woman 2013010105819 Provincial People’s Congress Standing Committee 201223800, the fourth-level director of the organ Southwest Politics and Law University Zhao Xiaoyu woman 2013010105912 Provincial People’s Congress Standing Committee 201223801, the fourth-level director of the organ Northwest university of political science and law Zhang Haodong man 2013010105915 Provincial People’s Congress Standing Committee 201223802, the fourth-level director of the organ Australian National University Fu Hui woman 2013010106010 Provincial People’s Congress Standing Committee 201223803 Director of the fourth level of the organ The University of Hong Kong aftereffect woman 2013010106106 Provincial Higher People’s Court 201233805 The second-level director of the agency and below South China Normal University Yaoyujing woman 2013010106119 Sheng women’s Federation 201243806, the fourth-level director of the organ university of leicester Wang mei woman 2013010106202 Provincial Red Cross Society 201253807 [Reference Management] First-level Chief Clerk and below Northwest University Geng liming man 2013010106301 Provincial Education Committee, Provincial Education Department 201263808, the fourth-level director of the organ Xi’an Jiaotong University Bai Peng man 2013010106306 Provincial Education Committee, Provincial Education Department 201263808, the fourth-level director of the organ yan’an university Hao wenzhuo woman 2013010106401 Provincial Education Committee, Provincial Education Department 201263809, the fourth-level director of the organ South China Normal University Huqi woman 2013010106519 Provincial Education Committee, Provincial Education Department 201263809, the fourth-level director of the organ University of Warwick, UK Xue Xiaoqiang man 2013010106529 Provincial Education Committee, Provincial Education Department 201263810 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Shaanxi Normal University Liu rennan woman 2013010106616 Provincial Education Committee, Provincial Education Department 201263811 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Southwest University Panjiali man 2013010106622 Provincial Education Committee, Provincial Education Department 201263812 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Yunnan University He Yueyang woman 2013010106624 Provincial department of science and technology 201273814 First-level director and below Xi’an Jiaotong University Li Wenbo man 2013010106801 Provincial civil affairs department 201283816 The second-level director of the agency and below Qinghai University for Nationalities Qiao Fangyu man 2013010106925 Provincial finance department 201293819 Second-level chief clerk and below in government offices Lanzhou university of finance and economics Wang yinzhe man 2013010106928 Provincial finance department 201293819 Second-level chief clerk and below in government offices Xi’an University of Technology Gao Jiaxing woman 2013010107022 Provincial finance department 201293820 Second-level chief clerk and below in government offices The Central University Of Finance and Economics Yang Jingyan woman 2013010107102 Provincial finance department 201293820 Second-level chief clerk and below in government offices Northwest University Sun guangyan man 2013010107407 Provincial finance department 201293821 Second-level chief clerk and below in government offices Southwestern University of Finance and Economics Zhou Nan man 2013010107415 Provincial finance department 201293821 Second-level chief clerk and below in government offices North University of China Liu Jimei woman 2013010107514 Provincial finance department 201293822 Second-level chief clerk and below in government offices yan’an university Ma Rong woman 2013010107520 Provincial finance department 201293822 Second-level chief clerk and below in government offices Xi’an Jiaotong University Cao Jinbao man 2013010107606 Provincial finance department 201293823 Second-level chief clerk and below in government offices Shaanxi Normal University Cui qinqin woman 2013010107702 Provincial finance department 201293824 Second-level chief clerk and below in government offices Xidian University Wang Jiayue woman 2013010107725 Provincial department of natural resources 201303825 First-level chief clerk of Xixian New Area Natural Resources Bureau and below. Xi’an University of Architecture and Technology Tang Qi woman 2013010107820 Provincial water resources department 201313827 Provincial Water Conservancy Engineering Quality and Safety Center, Level 4 Chief Clerk Institutes Of Technology Of Changsha Deng Peng man 2013010107825 Provincial water resources department 201313828 Director of Level 4 of Provincial Water Conservancy Engineering Quality and Safety Center Hohai University Yang peina woman 2013010107917 Provincial Department of Agriculture and Rural Affairs 201323829 Third-level chief clerk and below in government offices. Chang’an University Chen Xue woman 2013010108009 Provincial Department of Agriculture and Rural Affairs 201323830 Provincial Rural Cooperative Economic Workstation [Reference Management] Level 4 Chief Clerk and below Southwestern University of Finance and Economics Yu Zhou man 2013010108021 Provincial Department of Agriculture and Rural Affairs 201323830 Provincial Rural Cooperative Economic Workstation [Reference Management] Level 4 Chief Clerk and below Northwest A&F University Yi Cai woman 2013010108118 Provincial Health and Wellness Commission 201333831 Director, Level 4, Provincial Health Supervision Center China Shiyou University (Beijing) Dan Li woman 2013010108122 Provincial Health and Wellness Commission 201333831 Director, Level 4, Provincial Health Supervision Center Xi’an University of Technology Wang Wen woman 2013010108210 Provincial Health and Wellness Commission 201333832 Director, Level 4, Provincial Health Supervision Center Beijing University of Chinese Medicine Changyibo man 2013010108501 Provincial Health and Wellness Commission 201333833 First-level Staff of Provincial Health Supervision Center shanxi medical university jinci college Luoganggang man 2013010108823 Provincial emergency management department 201343834 First-level Chief of the Comprehensive Coordination Department of Work Safety and below Beijing University of Chemical Technology Li yujia woman 2013010312510 Provincial emergency management department 201343835 First-level Chief of Science and Technology and Information Technology Division and below Peking University Qiao Shuyue woman 2013010109019 Provincial emergency management department 201343836 Provincial Flood Control and Drought Relief Security Center [Reference Management] First-level Chief Clerk and below china institute of water resources and hydropower research Max Zhang man 2013010109024 Provincial emergency management department 201343836 Provincial Flood Control and Drought Relief Security Center [Reference Management] First-level Chief Clerk and below Wuhan University Liu Jianwei man 2013010109130 Provincial audit office 201353837 First-level chief clerk and below in government offices Beijing National Accounting Institute Xi min woman 2013010109225 Provincial audit office 201353837 First-level chief clerk and below in government offices Chongqing University Huo xiaonan woman 2013010109322 Provincial audit office 201353838 First-level chief clerk and below in government offices Xi’an University of Architecture and Technology Villi woman 2013010109423 Provincial audit office 201353838 First-level chief clerk and below in government offices Chang’an University Jasmine Zhang woman 2013010109707 Provincial audit office 201353839 First-level chief clerk and below in government offices Xi ‘ an institute of finance and economics Liu Min woman 2013010109815 Provincial audit office 201353839 First-level chief clerk and below in government offices Xi’an Jiaotong University Gaohang man 2013010110027 Provincial audit office 201353840 First-level chief clerk and below in government offices Xidian University Yue Lu woman 2013010110014 Provincial audit office 201353840 First-level chief clerk and below in government offices Xi’an Technological University fill the vacancies in the proper order Anlang man 2013010110126 Provincial audit office 201353841 First-level chief clerk and below in government offices. Chang’an University Li Xin man 2013010110307 Provincial audit office 201353841 First-level chief clerk and below in government offices. Chang’an University Yang qiujun woman 2013010110316 Provincial Forestry Bureau 201363842 First-level Chief Clerk of Regulation Science and Technology Department and below Party School of the CPC Central Committee Derek lv woman 2013010110417 Provincial Forestry Bureau 201363843 First-level Director of Public Service Department and below Northwest A&F University Zhang Bin man 2013010110616 Provincial Forestry Bureau 201363844 First-level Chief Clerk of Provincial Forest Resources Administration and below southwest forestry university Liang yunpeng man 2013010110619 Provincial Forestry Bureau 201363845 First-level Chief Clerk of Provincial Forest Resources Administration and below Yunnan University Vencent Yang man 2013010110620 Provincial Forestry Bureau 201363845 First-level Chief Clerk of Provincial Forest Resources Administration and below Lanzhou University Wei qiuming woman 2013010110623 Provincial Forestry Bureau 201363846 First-level Chief Clerk of Provincial Forest Resources Administration and below Beijing Forestry University Su min woman 2013010110712 Provincial Forestry Bureau 201363847 First-level Chief Clerk of Provincial Forest Resources Administration and below Shaanxi Normal University Luo Ruijuan woman 2013010110723 Provincial Forestry Bureau 201363848 First-level Chief Staff of Provincial Forest Resources Administration and below Leeds University Huang Xiao woman 2013010110801 Provincial Forestry Bureau 201363850 First-level Chief Staff of Provincial Forest Resources Administration and below Chang’an University Li Jin woman 2013010110805 Provincial Forestry Bureau 201363850 First-level Chief Staff of Provincial Forest Resources Administration and below Xidian University Zhao shanling woman 2013010110821 Provincial radio and television bureau 201373851 Director of the Fourth Department of Provincial Radio and Television Bureau Southwest Politics and Law University Lei Jingxiang man 2013010110921 Provincial radio and television bureau 201373852 Director of the Fourth Department of Provincial Radio and Television Bureau Chang’an University Lawrence Wang man 2013010110924 Provincial radio and television bureau 201373852 Director of the Fourth Department of Provincial Radio and Television Bureau Xidian University Cao Yong man 2013010111001 Provincial statistics bureau 201383853 Third-level chief clerk of business office and below Tibet University for Nationalities Zheng Bo woman 2013010111004 Provincial statistics bureau 201383854 Third-level chief clerk of comprehensive office and below Hebei University Lv bingheng man 2013010111005 Provincial statistics bureau 201383855 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Queen’s University of Canada Jia Bei woman 2013010111014 Provincial statistics bureau 201383856 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Hebei University Zhang Chenyu woman 2013010111026 Provincial statistics bureau 201383857 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Korea Korea University Wang Jingyuan man 2013010111123 Provincial bureau of cultural relics 201393858 First-level director and below Shaanxi Normal University Tongkewei woman 2013010111201 Provincial bureau of cultural relics 201393859 First-level director and below xi’an shiyou university Chen yanru woman 2013010111212 Provincial poverty alleviation office 201403861 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below The Central University Of Finance and Economics Yin Hailei man 2013010111309 Provincial poverty alleviation office 201403862 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northeast university of finance and economics Chen Yuanyuan woman 2013010111408 Provincial poverty alleviation office 201403863 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northwest university of political science and law Zhao Peng man 2013010111415 Provincial poverty alleviation office 201403864 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northwest university of political science and law Ai Xinhua woman 2013010111505 Provincial local financial supervision and management bureau 201413865 Second-level chief clerk and below in government offices Xi’an Jiaotong University Yin yixuan woman 2013010111714 Provincial Grain and Material Reserve Bureau 201423867 Second-level Director and below Xidian University Wang herui woman 2013010111803 Provincial organ affairs service center 201433869 Personnel Department (Retiree Service Management Office) Level II Chief Staff and below University of Newcastle, UK Xu shuoqi man 2013010111808 Provincial organ affairs service center 201433870 Second-level Chief of the Commission for Discipline Inspection and below Shaanxi Normal University Wang jiao woman 2013010111814 Provincial organ affairs service center 201433871 Second-level Chief of Housing Management Office and below Qinghai University for Nationalities Feng yuru woman 2013010111828 Provincial organ affairs service center 201433872 Second-level Chief of Real Estate Management Office and below Northwest University Wang kaibo man 2013010111921 Provincial organ affairs service center 201433873 Second-level Chief of Energy Conservation Management Office of public institutions and below brunel university Jet Chao man 2013010111923 Provincial organ affairs service center 201433874 Second-level Chief Staff of Security Department and below Xi ‘ an university of posts and telecommunications Sun Xiaoqian woman 2013010111928 Provincial organ affairs service center 201433875 Director II of Infrastructure Engineering Management Office and below Xi’an University of Architecture and Technology Ma Lin woman 2013010112002 Provincial organ affairs service center 201433876 Director II of Infrastructure Engineering Management Office and below Chang’an University Huiyu woman 2013010112006 Provincial organ affairs service center 201433877 The second-level director of Fengcheng Management Center of provincial organs and below Xi ‘ an university of science and technology He Lu woman 2013010112011 Provincial organ affairs service center 201433879 The second-level director of Xingqing Veteran Cadres Service Management Office of provincial organs and below. Chinese Marine University Li Jiaojie woman 2013010112015 Provincial organ affairs service center 201433880 The second-level director of Xiaozhai Veteran Cadres Service Management Office of provincial organs and below Xi’an University of Technology Li Ning woman 2013010112018 Provincial organ affairs service center 201433882 Second-level Chief of the Office of the Provincial Committee for the Care of the Next Generation and below Xi’an Jiaotong University Shimin woman 2013010112023 Sheng supply and marketing cooperatives head office 201443883 Department Office [Reference Management] Level 4 Chief Clerk The Central University Of Finance and Economics Li jingman woman 2013010200103 Sheng supply and marketing cooperatives head office 201443884 Department Office [Reference Management] Level 4 Chief Clerk Xi ‘ an university of science and technology Zhang daiyue woman 2013010200109 Sheng supply and marketing cooperatives head office 201443885 Department Office [Reference Management] Level 4 Chief Clerk Northwest university of political science and law Zhang ningyi woman 2013010200121 Provincial court system 201453886 Assistant Judge of Xi ‘an Railway Transportation Intermediate Court Xi’an Jiaotong University Rui Hu woman 2013010200207 Provincial court system 201453887 Assistant Judge of Xi ‘an Railway Transport Court Renmin University of China slowly woman 2013010200221 Provincial court system 201453887 Assistant Judge of Xi ‘an Railway Transport Court Lanzhou University Pan Lei man 2013010200306 Provincial court system 201453888 Assistant Judge of Xi ‘an Railway Transport Court Tongji University Longdihui man 2013010200309 Provincial court system 201453888 Assistant Judge of Xi ‘an Railway Transport Court Southwest Politics and Law University Hu Juan woman 2013010200315 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court Northwest university of political science and law Min Feng woman 2013010200407 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court Northwest university of political science and law Liu Xiaoqian woman 2013010200410 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court sichuan police college Chen Ruixiang man 2013010200421 Provincial court system 201453890 Assistant Judge of Ankang Railway Transport Court Xi’an Polytechnic University Xiong cheng man 2013010200424 Provincial court system 201453890 Assistant Judge of Ankang Railway Transport Court Chang’an University Li Yinxia woman 2013010200506 Provincial procuratorate system 201463891 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Guangdong Polytechnic Normal University He Qian woman 2013010200511 Provincial procuratorate system 201463892 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law Zhao Xuesong woman 2013010200604 Provincial procuratorate system 201463893 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law Zhang liqian woman 2013010200626 Provincial procuratorate system 201463893 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law

1905 movie network news From, to, almost every summer, there will be a national ramble out of the tight encirclement. This year, the first film in the series of painting rivers and lakes — — The curse of the wind. After the trailer was released at Cannes Film Festival in 2014, five years later, The Wind Spell was finally produced and will be shown to the audience on July 13th. Let many fans sigh, and finally wait for you.

In the preview released this time, Xia Lan used the five elements of gold, wood, water, fire and earth to fight fiercely with fierce beasts. According to legend, only the power of wind can compete with it, revealing the meaning of the title "Wind Spell" and setting up a world view full of Chinese style. In the poster released together, the young volley confronted the huge gluttony, revealing a stirring story of the rise of a young hero.

　

The most valuable guoman IP　The Wind Spell permeates the national wind into every detail.

From its first broadcast in 2012 to the present, the painting rivers and lakes have created many high-quality comic dramas, such as Xia Lan, Bad Man, Soul Master, Cup Don’t Stop, and Changed Students, which can be said to be the most cosmopolitan and vital national comic, and also regarded as the most valuable national comic IP in the industry. Therefore, the first movie of painting rivers and lakes was placed high hopes by anime fans to help the rise of the country.

In the preview, the mythical gluttony in this world, Xia Lan uses the power of five elements to compete, and the teenager wants to be a hero when he enters the rivers and lakes … … The setting of the whole world outlook in the Wind Mantra is full of Chinese style. The same is true of the details. Fierce beasts, which are mostly composed of curved designs, and rivers and lakes in noisy streets are trying their best to convey an oriental aesthetics, which conforms to the audience’s imagination of "national ramble". Director Liu Kuo almost "digs" these details to the extreme. "Let the China audience like it first and see it comfortably."

　

Hold back the movie dream for six years and develop the only domestic animation engine.　"grab back" some audiences for Guoman

The completion of the Wind Spell took five years of preparation and three years of production. But the time behind it is far more than that. In the mind of director Liu Kuo, this movie dream has been held back for too long. "Although I had a dream of making movies long ago, I still held back. I want to make myself strong first. Because the country in my heart is made by ourselves. "

With this in mind, director Liu Kuo and the team started to develop a "Datura Engine" for animation. After six years of "darkness before dawn", China’s 3D animation finally has the original ability of the whole process. After tens of thousands of minutes of animation polishing, "Wind Spell" was finally launched. The film is about to be released, and Liu Kuo revealed his hope that "in the case that the China market has been occupied by Hollywood and Japanese animation for a long time, we can win back some audiences for domestic animated films in China"!

Albinism is a kind of hereditary leukoplakia caused by melanin deficiency or synthesis disorder of skin and accessory organs due to tyrosinase deficiency or functional decline.

According to clinical manifestations, albinism can be divided into three categories: ocular albinism (OA), ocular skin albinism (OCA) and albinism-related syndrome, among which ocular skin albinism (OCA) is the most common and albinism-related syndrome is the rarest.

This paper mainly expounds the clinical manifestations, genetic causes and genetic counseling of OA and OCA.

Clinical manifestations of OA and OCA

Only the eye pigment in OA patients is reduced or lacking, while the eye, skin and hair in OCA patients are obviously reduced or lacking.

1, eye performance

① Iris transillumination defect (TID)-91% ~ 100% albino patients have TID.

② nystagmus

③ Fundus hypopigmentation —— It is caused by the decrease of retinal pigment epithelium and/or choroidal pigmentation, which often leads to obvious choroidal vessels in the posterior pole. It is reported that more than 94% patients with albinism have fundus hypopigmentation.

④ hypoplasia of fovea-characterized by the continuation of the inner layer of retina behind fovea and the decrease of cone photoreceptor specialization.

⑤ optic nerve abnormality

⑥ ametropia

2. Skin manifestations

The skin and hair color of albino patients may change with age.

① Skin and hair pigmentation score

Skin and hair pigmentation scores help to objectively determine the influence of hypopigmentation.

② Skin diseases

Including all albinos, regardless of skin color, the risk of ultraviolet (UV) light-related skin diseases will increase. The most important of these is skin cancer, which includes squamous cell carcinoma, basal cell carcinoma, melanoma and less common Merkel cell carcinoma.

Genetic causes of OA and OCA

The following table summarizes the genes known to be related to nonsyndromic OCA and OA. All nonsyndromic OCA are inherited by autosomal recessive mode. OA (always non-syndrome) is inherited in an x-linked manner.

The following table summarizes the genes known to be related to OCA syndrome:

Genetic counseling

1. Inheritance mode

Nonsyndromic ocular skin albinism (OCA) caused by pathogenic variation in TYR, OCA2, SLC45A2, SLC24A5, LRMDA (C10orf11) or DCT (TYRP1) is inherited in autosomal recessive way.

Ocular albinism (OA) caused by pathogenic variation in GPR143(OA1) is inherited by X linkage.

If an individual suffers from a specific syndrome related to OCA (such as Hermansky-Pudlak syndrome or Chediak-Higashi syndrome), genetic counseling is needed for this disease.

2. Autosomal recessive inheritance-risk to family members

Parents of the proband:

The parents of the affected children are presumed to be heterozygotes causing the pathogenic variation of OCA.

If molecular diagnosis has been established in the proband, it is suggested that the parents of the proband should be tested for molecular genes to confirm that both parents are heterozygotes causing the pathogenic variation of OCA and allow reliable recurrence risk assessment.

If the pathogenic variation is detected only in one parent, and the parental identity test has confirmed biological motherhood and parent-child relationship, one of the pathogenic variations identified in the proband may occur as a newborn event in the proband or as a zygote in the mosaic parent. If the proband seems to have homozygous pathogenic variation (that is, the same two pathogenic variations), other possibilities to be considered include:

The deletion of single exon or multiple exons in the proband was not detected by sequence analysis, which led to artificial homozygosity;

Parental chromosomes and single parent homomorphism of pathogenic variation lead to homozygosity of pathogenic variation among proband.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Siblings of the proband:

If it is known that both parents are heterozygotes of pathogenic variants that cause OCA, each sibling of the affected individual has a 25% chance of being affected at conception, a 50% chance of becoming asymptomatic carriers, and a 25% chance of inheriting any familial pathogenic variants.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Descendants of the proband:

The offspring of autosomal recessive OCA individuals are obligate heterozygotes (carriers) that cause the pathogenic variation of OCA.

Other family members:

Every brother and sister of the proband’s parents has a 50% risk of becoming the carrier of OCA’s pathogenic variation.

Carrier detection:

It is necessary to identify the pathogenic variation that causes OCA in the family in advance for carrier detection of at-risk relatives.

3. X-linked inheritance-risk to family members

Parents of male proband:

The father of the affected man will not suffer from this disease, nor will he be a hemizygote of the pathogenic variant GPR143; Therefore, he does not need further evaluation/testing.

In a family with more than one affected individual, the mother of the affected male is an obligate heterozygote. Note: If a woman has more than one affected child and no other affected relatives, and if family pathogenic variation cannot be detected in her white blood cell DNA, she is likely to have germline chimera.

If the male is the only affected family member (i.e., a simple case), the mother may be heterozygote, the affected male may have new pathogenic variation (in this case, the mother is not heterozygote), or the mother may have somatic/germline chimera.

It is suggested that the mother should be tested for molecular genes to confirm her genetic status and make a reliable recurrence risk assessment.

Brothers and sisters of male proband:

The risk of siblings depends on the mother’s genetic status:

If the proband’s mother has the pathogenic variation of GPR143, the chance of transmission in each pregnancy is 50%.

Men with genetic disease variation will be affected;

The female with genetic pathogenic variation will be heterozygote (i.e. carrier). Heterozygotes are usually unaffected, although they can show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

If the proband represents a simplex case and the pathogenic variation cannot be detected in the mother’s leukocyte DNA, it is assumed that the risk of sibs is low, but the risk is higher than that of the general population because of the possibility of maternal lineage mosaic.

Descendants of male proband:

The affected men spread the disease-causing mutation of GPR143 to all their daughters, but not to their sons.

Other family members:

Menstruation and maternal cousins of the male proband may be at risk of GPR143.

Note: Molecular genetic testing may be able to identify family members with new pathogenic mutations, and this information can help determine the genetic risk status of large families.

Heterozygote detection:

To identify female heterozygotes, it is necessary to identify the pathogenic variation of GPR143 in the family in advance.

Note: As carriers of this X-linked disease, women are heterozygotes, which are usually not affected, but they may show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

Source | Metz Medical official website

Write | ｜Anna.An

Original title: Inheritance and Manifestation of Albinism

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[Know how to drive a car] Recently, it was learned that Chery Automobile released the official Chery map. The new car is positioned as a medium-sized and large-sized car, with a brand-new design, equipped with a laser radar, and equipped with a "smart driving" system. The power is equipped with a C-DM plug-in hybrid system. Next, let’s take a look at the product strength of the new car with everyone.

Appearance, Fengyun A9 adopts a brand-new design, which looks very advanced in appearance. There are many ribs on the hood, the headlights are sharp, the inside is LED light source, and in the middle of the front of the hood, it is equipped with Chery LOGO. The grille of the new car is full of stars, the lower grille is trapezoidal air intake grille, and the front lip is relatively flat.

When you come to the side of the car body, it looks very sporty as a whole. The window is a willow window, and the dive waistline makes the whole car look more powerful. The side is also curved in a large number, showing different light and shadow effects under different light. The wheels of the new car are dense-width wheels.

The tail of the car body is equipped with a small tail, and the taillights are the popular through taillights. The taillights are treated with smoked black, and the tail is also multi-lined, which makes the layering of the tail look more obvious. The rear enclosure is decorated with chrome trim+black trim, and a hidden exhaust pipe is used.

In terms of interior, the overall appearance is relatively advanced. The interior is a double-spelling color and double-width steering wheel. There are many buttons on the steering wheel, equipped with a full LCD instrument panel, and a 15.6-inch floating central control screen is also equipped on the center console. Below the central control screen, it is equipped with a mobile phone wireless fast charging and two cup holders.

In terms of configuration, it is equipped with endless atmosphere lights, 23 speakers, intelligent fragrance system, active noise reduction system, high-speed NOA navigation assistance, 8255, HPA memory parking, L2 intelligent driving ability, 540 panoramic image, DMS fatigue detection, high-speed OTA, AI large model smart companion, wireless phone mapping function, etc.

In terms of power, the C-DM plug-in hybrid system will be equipped with a 1.5T hybrid engine with a maximum power of 105kW and a peak torque of 220Nm, and a driving motor with a maximum power of 150kW. At the same time, it is equipped with a 1-speed DHT hybrid special gearbox with the highest mechanical efficiency of 98.5%. Its CLTC pure battery life is 200km+, and its comprehensive battery life is 1500km+.

For suspension, the front double wishbone+rear five-bar independent suspension is adopted, and CDC magnetic suspension is equipped. In other aspects, it will be equipped with intelligent electric four-wheel drive, speed-controlled electric spoiler and 6-piston fixed calipers.

Xiaobian has something to say:

Chery Fengyun A9 brought by Chery this time, the new car will be equipped with many new technologies, and the overall product strength is strong. As a flagship model, the new car is expected to have surprises in pricing this time. For more information about the new car, we will continue to pay attention to knowing how to drive. Everyone wants to know more about new car information and car purchase market. Welcome to leave a message for interaction. Everyone must consume rationally when buying a car. (Photo: Source Chery Automobile; Text: Know how to drive, edited by Li Ling)

General rule

Recently, a doctor in Rizhao City, Shandong Province was arrested for allegedly broadcasting gynecological surgery clips online, which aroused social concern and boarded a hot search. On the evening of 18th, WeChat official account, WeChat of Donggang Branch of Rizhao Public Security Bureau issued a briefing: At about 16: 00 on January 18th, 2022, Donggang Branch of Rizhao Public Security Bureau received a report from the masses that a doctor was suspected of broadcasting a video of gynecological surgery online, so it immediately investigated the relevant personnel of the hospital involved and arrested Li Mou, the doctor involved, at about 18: 00.

In response, bilibili said: After internal verification, the studio was repeatedly warned and cut off during the live broadcast on January 15th, and then it was permanently banned. At present, we have reported to the public security organs and will actively cooperate with the police to carry out investigation and evidence collection.

Coincidentally, on January 17th, some netizens revealed that some users uploaded surveillance videos in bilibili that were suspected to be obtained after cracking cameras in public places.

Judging from the live screen shots, these live images should come from surveillance cameras in public places such as schools and hospitals. Netizens suspect that there are gangs specializing in cracking surveillance videos in schools, hospitals and other public places, which are used for live broadcast to attract traffic and attract users to pay for it.

In view of this situation, bilibili official Weibo issued a handling notice on January 17th: "Today, we received a report from a user that someone suspected of using illegal means to crack the camera and upload a video surveillance screen to bilibili. We organized the investigation for the first time and removed the relevant content. "

Bilibili said that this kind of behavior is a serious violation of personal privacy, which is illegal. Once found, it will be dealt with seriously according to law. If users find such content, please contact online customer service immediately.

In this regard, netizens questioned the effectiveness of bilibili’s audit mechanism. Why do users need to find problems and bilibili will deal with them? A live broadcast of a problem like a doctor’s live broadcast of gynecological surgery, when discovered by users, has actually caused privacy leakage and spread of problems. Is it necessary for bilibili to do this kind of thing all the time?

Upstream Xiaobian consulted bilibili customer service about the standards and principles of live audit, but did not receive a response.

In this regard, some people in the industry said that because the live content belongs to real-time streaming media, the platform can’t review the "content that hasn’t happened". Therefore, before the broadcast of the anchor, the anchor is generally required to sign a live broadcast specification agreement. "In fact, it is the responsibility to move forward and tell the anchor what content is illegal and can’t be broadcast, and the punishment that will be faced after the live broadcast is illegal. As long as the anchor broadcasts, it means recognition and consent." The source said that at present, the live broadcast industry adopts this method, so whether the live broadcast content is illegal or not can basically only rely on the anchor’s consciousness. What the platform can do is only to conduct audit and supervision during the live broadcast.

The above-mentioned person further introduced that at present, the audit in live broadcast mainly adopts the combination of AI audit and manual audit.

AI audit is to take screenshots of live pictures at regular intervals, and then intelligently identify the pictures. "AI audit can’t accurately understand the live content, and the recognition accuracy of illegal pictures will be different according to the AI ? ? engine used." The source said that the higher the recognition rate and the faster the recognition speed, the higher the AI deployment cost, which puts higher demands on the funds of the live broadcast platform, and it is difficult for some small platforms to bear high technical costs.

The upstream Xiaobian search "AI Audit" found that many companies in China have developed related software and platforms. Some of these platforms clearly stated in the introduction to the live AI audit that "screenshots are supported".

"To accurately identify whether the live content is illegal, manual review is the most reliable." The above-mentioned people said that bilibili had always been famous for its strict auditing, because it was rumored in the industry that bilibili was fully audited manually. "But the biggest drawback of manual auditing is its slow speed." He explained that the mainstream live broadcast platform has thousands of live broadcast rooms at the same time, but it is impossible for the platform to be equipped with so many auditors. Therefore, when the manual audit finds problems, the illegal live broadcast content may have been broadcast for some time. "This is why bilibili encourages users to report, which is equivalent to asking users to be free auditors." The person said.

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