According to the latest data released by China National Intellectual Property Administration recently, from 2019 to 2021, the number of cases of patent infringement disputes settled by intellectual property systems across the country increased by 16.3% annually, and the average period of handling cases after making administrative rulings was reduced by one third compared with the statutory time limit. The intensity of handling patent administrative rulings has been continuously increased, and the efficiency of handling cases has been continuously improved, effectively giving play to the advantages of quick and efficient administrative protection of intellectual property rights and diversified solutions to contradictions and disputes, and effectively safeguarding the legitimate rights and interests of innovative subjects and their enthusiasm for innovation and creation.

"As one of the important ways of patent administrative protection, administrative adjudication of patent infringement disputes has the characteristics of high efficiency, low cost and strong professionalism, and plays an important role in ensuring the’ fast, accurate and practical’ patent protection." The relevant person in charge of China National Intellectual Property Administration Intellectual Property Protection Department said. In recent years, the top-level design of administrative adjudication has been continuously strengthened at the national level, and the administrative adjudication system has taken root in intellectual property protection. China National Intellectual Property Administration organized and promoted the local intellectual property system to actively carry out the practice of administrative adjudication of patent infringement disputes, and a number of useful experiences that can be used for reference, copied and popularized emerged.

Perfecting the system and doing practical things

Constructing and perfecting the rapid response mechanism for handling patent infringement disputes and solving the problem of "long cycle" of patent infringement disputes are important starting points for promoting the quality and efficiency of intellectual property protection and effectively optimizing the business environment. An outstanding advantage of the administrative adjudication system is to resolve conflicts and disputes quickly and efficiently through diversified means.

In order to give full play to the advantages of "quick protection" of administrative adjudication of patent infringement disputes, various localities have been exploring and improving the construction of administrative adjudication system based on their own work practice, focusing on consolidating the work foundation, strengthening process control, putting standards and norms first, and strengthening cooperation. For example, Shandong Province, guided by the Implementation Opinions on Continuously and Deeply Optimizing the Business Environment, has implemented smooth acceptance channels and accepted cases according to law. Tighten all links and strengthen institutional constraints; Take the initiative to investigate and collect evidence; Through the implementation of entrusted law enforcement mechanism, integrate law enforcement forces; Establish a long-term mechanism for business guidance and other measures to comprehensively improve the efficiency of handling patent administrative rulings.

"The main function of administrative adjudication is to solve civil disputes closely related to administrative activities. According to the principle of administrative handling first, the administrative adjudication of patent infringement disputes can not only solve the illegality in the process of law enforcement, but also find the omissions in patent management, identify the crux of the dispute, and then sum up the problems, prevent the delay, and achieve better protection for innovation and creation. " Cheng Xiezhong, a professor at the Law School of China University of Political Science and Law, said.

The system of "notification before cutting-guidance after cutting" established in Sichuan is just an example. Post-adjudication guidance mechanism refers to providing extended adjudication services to guide the claimant to improve intellectual property protection measures and reduce the risk of infringement; Directing the requested party to enhance their awareness of intellectual property protection, establish a working system for intellectual property protection, promote technical improvement and upgrading, and avoid the recurrence of infringement, which fully reflects the effectiveness of the whole chain protection of intellectual property management departments.

Innovating mechanism and making practical moves

As an important part of building an efficient implementation system of the rule of law, administrative adjudication plays the role of a "diverter valve" to resolve civil disputes. "How to realize the benign interaction and organic connection between administrative and judicial dispute resolution modes, unify the implementation standards of administrative, judicial and arbitration procedures, and achieve the protection efficiency of coordination in depth and breadth is the basic practical problem faced by the administrative adjudication of patent infringement disputes." Cheng Xiezhong said.

In this regard, there are many explorations of innovative working mechanisms in local practice. For example, Shanghai innovatively implements the judicial confirmation system of administrative mediation agreements, that is, through the judicial confirmation mechanism, the formal certainty and compulsory execution of administrative mediation agreements for intellectual property disputes are enhanced. Since the intellectual property management department has no enforcement power on the administrative mediation agreement, if one party refuses to perform or fails to perform the mediation agreement in full, the other party may apply to the people’s court for enforcement according to this system. This greatly strengthens the enforcement effect of administrative mediation agreement, extends the depth of administrative protection of intellectual property rights, and strengthens the organic connection between administrative protection and judicial protection.

Beijing took the lead in adopting the trial mode of "first refuting and requesting separately", that is, if the patent right involved is declared invalid by China National Intellectual Property Administration, the petitioner in the administrative adjudication case of patent infringement disputes can be informed to withdraw the case. If the petitioner insists on not withdrawing the case, the request can be rejected first, but it can be stated in the award that if the patent right remains valid after judicial review, the petitioner has the right to request another ruling. This trial mode strengthens the connection between patent infringement administrative adjudication and patent confirmation procedure, which can not only improve the efficiency of administrative adjudication, but also reflect the consistency of administrative protection and judicial protection standards, and has certain guidance.

Strengthen support and see actual results

"Professional people do professional things" is the endogenous advantage of administrative adjudication of patent infringement disputes. Most cases of patent infringement disputes are professional and technical, involving a large number of legal issues and a large number of technical facts to be identified. Giving full play to the professional advantages of patent administrative organs, various localities have continuously consolidated their support and strengthened law enforcement guidance by implementing the system of technical investigators, which has steadily demonstrated "professionalism" in administrative law enforcement activities at different levels.

For example, the Guangdong Intellectual Property Office signed a cooperation agreement with the Guangdong Center for Patent Examination and Cooperation of China National Intellectual Property Administration Patent Office to jointly build a technical support mechanism for patent infringement judgment, making full use of Patent examiners’s technical resources and professional advantages to provide consulting services and technical support for the province’s handling of patent disputes. The Bureau promoted the Guangdong Patent Agency Association to set up an intellectual property dispute mediation center and an intellectual property rights protection assistance center to provide auxiliary services for administrative rulings. During the on-site inquest and trial of the case, the patent administrative adjudication department invited Patent examiners and others as technical investigation experts to give opinions on patent infringement judgment and assist in dealing with relevant technical issues.

In addition, Jiangsu, Hubei, Zhejiang and other places also actively use digital means to build an online case handling system for administrative adjudication and strengthen the informatization construction of the administrative adjudication work system. For example, Hubei Intellectual Property Office has organized and developed a unified "Hubei Patent Infringement Dispute Administrative Adjudication System" in the whole province, which realizes "node-style" standardization and management of the case-handling process, and has the functions of automatic introduction of party information, unified management of the case-handling process, automatic generation of case documents, automatic verification of important information, online handling of the whole case, traceability of the whole case-handling behavior, seamless connection with the data of the existing China National Intellectual Property Administration case analysis and reporting system, data rights protection and big data judgment. (Reporter Li Yangfang)

Departments (bureaus) of human resources and social security of all provinces, autonomous regions and municipalities directly under the Central Government, Health Bureau (Health and Family Planning Commission), Civil Service Bureau, Human Resources and Social Security Bureau and Health Bureau of Xinjiang Production and Construction Corps, and personnel (cadre) departments of various ministries and commissions in the State Council:

In accordance with the requirements of the circular issued by the former Ministry of Health (Wei Tong [2012] No.23) on eight recommended health industry standards, such as the Quality Index of Routine Clinical Biochemical Examination, the Ministry of Human Resources and Social Security and the Health and Family Planning Commission have organized medical experts to revise the relevant contents of the Operation Manual for Civil Servant Employment Physical Examination (for Trial Implementation), which are hereby printed and distributed to you. This notice shall be implemented as of September 1, 2013. In the specific work, in case of problems, please timely feedback to the central civil service authorities and health (health and family planning) administrative departments.

Ministry of Human Resources and Social Security Health and Family Planning Commission Civil Service Bureau

August 19, 2013

Operation Manual of Civil Servant’s Employment Physical Examination (Trial).

Relevant revision contents

I "Article 2 Physical Examination Items and Operating Procedures 6.1 Blood Routine" is revised as:

6.1 Blood routine

It can provide clues for the diagnosis of hematological diseases. Among them, red blood cells, white blood cells and platelets are counted by instrument or microscope, and hemoglobin is counted by instrument or photoelectric colorimetry. Must check the project includes the following five items:

6.1.1 Total number of red blood cells (RBC)

[Reference value] Male: (4.3 ~ 5.8) × 1012/L; Female: (3.8 ~ 5.1) × 1012/L.

Erythropenia is more common in all kinds of anemia, such as acute or chronic aplastic anemia and iron deficiency anemia. Polycythemia is common in hypoxia, blood concentration, polycythemia vera and secondary polycythemia.

6.1.2 Hemoglobin (HGB)

[Reference value] Male: 130 ~ 175 g/L; Female: 115 ~ 150 g/L.

The clinical significance of decreasing or increasing hemoglobin is basically the same as the total number of red blood cells.

6.1.3 Total white blood cell count (WBC)

[Reference value] (3.5 ~ 9.5) × 109/L.

Physiological leukocytosis is common in strenuous exercise, after eating, pregnancy and so on. In addition, different blood collection sites can also make the number of white blood cells different, such as the average number of white blood cells in earlobe blood is higher than that in finger blood.

Pathological leukocytosis is common in acute suppurative infection, uremia, leukemia, tissue injury, acute bleeding and so on.

Pathological leukopenia is common in aplastic anemia, some infectious diseases, liver cirrhosis, hypersplenism, radiotherapy, chemotherapy, taking some drugs and so on.

6.1.4 Differential white blood cell count (DC)

[Reference value]

Neutrophils: (1.8 ~ 6.3) × 109/L (40% ~ 75%).

Eosinophil: (0.02 ~ 0.52) × 109/L (0.4% ~ 8%).

Basophil: (0.00 ~ 0.06) × 109/L (0 ~ 1%).

Lymphocyte: (1.1 ~ 3.2) × 109/L (20% ~ 50%).

Monocyte: (0.1 ~ 0.6) × 109/L (3% ~ 10%).

Neutrophilia is common in acute suppurative infection, massive hemorrhage, serious tissue injury, chronic myeloid leukemia, sleeping pill poisoning, etc. Reduce common viral infections, aplastic anemia, agranulocytosis, etc.

Eosinophilia is common in psoriasis, pemphigus, eczema, bronchial asthma, allergies, some hematological diseases and tumors, such as chronic myeloid leukemia, nasopharyngeal carcinoma, lung cancer and cervical cancer. Decrease is common in the early stage of typhoid fever and paratyphoid fever and after long-term use of adrenocortical hormone.

Basophilia is common in chronic myeloid leukemia with bone marrow fibrosis, chronic hemolysis and splenectomy. Reduction is generally of no clinical significance.

Lymphocytosis is common in infectious mononucleosis, tuberculosis, malaria, chronic lymphocytic leukemia, whooping cough, some viral infections, etc. Decrease is common in some leukemia or excessive destruction, such as long-term chemotherapy, X-ray irradiation and immune deficiency.

Monocytosis is common in monocytic leukemia, active tuberculosis, typhoid fever, malaria, etc. Reducing the clinical significance is not significant.

6.1.5 platelet count (PLT)

[reference value] (125 ~ 350) × 109/L.

Increased platelet count is more common in thrombocytosis, after splenectomy, acute infection, hemolysis, fracture, etc. Decrease is more common in aplastic anemia, acute leukemia, acute radiation sickness, primary or secondary thrombocytopenic purpura, hypersplenism, uremia, after taking some drugs, etc.

Two, the "second physical examination items and operating procedures 6.3 blood biochemistry" is revised as follows:

6.3 blood biochemistry

6.3.1 Diagnostic index of blood glucose (GLU) diabetes. Glucose oxidase method and automatic or semi-automatic biochemical analyzer should be used, and blood should be detected as soon as possible after blood collection.

[reference value] 3.9 ~ 6.1 mmol/L.

The blood glucose concentration of blood taken on an empty stomach for more than 8 hours is ≥7.0 mmol/L, or the blood glucose concentration of blood taken at any time of the day is ≥11.1 mmol/L, and it still reaches or exceeds this value after reexamination, so as to diagnose diabetes; The fasting blood glucose concentration is between 5.6 and 6.9 mmol/L, and further diagnosis should be made by oral glucose tolerance test (OGTT). If the 2-hour blood glucose concentration of OGTT is ≥11.1 mmol/L, diabetes is diagnosed.

6.3.2 Liver biochemical indexes of alanine aminotransferase (ALT) can be detected by automatic or semi-automatic biochemical analyzer by enzymatic method, which can be used for early diagnosis of hepatobiliary diseases such as viral hepatitis and help to judge the degree and prognosis of the disease.

[reference value] male: 9 ~ 50 u/l, female: 7 ~ 40 u/l.

6.3.3 Liver biochemical indexes of aspartate aminotransferase (AST), and the detection method and significance are the same as those of ALT.

[reference value] male: 15 ~ 40 u/l, female: 13 ~ 35 u/l.

ALT and AST are sensitive indicators reflecting the damage of liver cells, which can be increased in the incubation period and early onset of hepatitis, so it is helpful for early detection of hepatitis. ALT mainly exists in the cytoplasm of hepatocytes, while AST is distributed in the mitochondria of hepatocytes in addition to the cytoplasm. ALT and AST levels can be increased when liver cells are damaged by various liver diseases (such as viral hepatitis, drug-induced liver damage, fatty liver, cirrhosis, etc.) and some extrahepatic diseases.

When liver damage is mild, only ALT and AST in cytoplasm are released into blood, so the increase of ALT is greater than AST. It is generally believed that serum ALT exceeds the upper limit of reference value by more than 2 times, indicating that liver cells have inflammation, necrosis and liver damage. When severe liver injury occurs, mitochondria are destroyed, and a large amount of AST is released into the blood, resulting in a higher serum AST level than ALT. AST/ALT ratio > 1 can indicate the progress of hepatitis with significant hepatocyte necrosis. Therefore, measuring AST/ALT ratio is helpful to judge the severity of liver injury. The increase of single AST should also consider the pathological changes of myocardium and bones, especially the ratio of AST／ALT in myocardial infarction is often greater than 3, accompanied by corresponding clinical manifestations, so it is not difficult to diagnose.

In addition to the liver, other tissues such as heart, brain, kidney and muscle also contain ALT and AST, and the pathological changes of these organs can also cause the increase of serum ALT and AST. Changes in some physiological conditions can also cause the elevation of ALT and AST. For example, strenuous physical activity may cause a temporary slight elevation of ALT. Because there are various reasons for the increase of serum ALT and AST, it is necessary to make a clear diagnosis according to the specific situation and combined with other necessary examination methods.

6.3.4 Blood urea nitrogen (BUN) Blood urea nitrogen is the product of protein metabolism. The purpose of determining blood urea nitrogen is to judge the excretion ability of protein metabolites by the kidney, so the value of blood urea nitrogen can be used as an index to judge glomerular filtration function. However, blood urea nitrogen is easily influenced by diet, urine volume and other factors, so although it can be used as an index to judge glomerular function, it is not as accurate as blood creatinine. Blood urea nitrogen was detected by urease method.

[reference value] 2.8 ~ 7.2 mmol/L.

6.3.5 Serum creatinine (CR) is the product of human muscle metabolism, which is not easily influenced by diet and urine volume, and can reflect renal function more sensitively, and is an important indicator for diagnosing renal failure, and its level is directly proportional to the degree of renal function damage. Serum creatinine was detected by picric acid method or enzymatic method.

[Reference value] Picric acid method: 44 ~ 133 μ mol/L for male and 70 ~ 106 μ mol/L for female. Enzymatic method: 53 ~ 97 μ mol/L for male and 44 ~ 80 μ mol/L for female.

When both blood urea nitrogen and blood creatinine are "mmol/ L", the reference value of the ratio of blood urea nitrogen to creatinine is 25 ~ 40. When the ratio is less than 25, protein’s insufficient intake and acute tubular necrosis are considered; > 40, considering the cause of prerenal.

Because the measured values of blood urea nitrogen and creatinine are easily influenced by hemolysis, bilirubin and drugs, it is of diagnostic significance to increase them at the same time. The degree of blood urea nitrogen increase is more obvious than that of blood creatinine in renal parenchymal lesions.

Iii. Amend the detailed rules for the implementation of Article 3 "General Standards for Physical Examination of Civil Servants (for Trial Implementation)" 3. About Hematological Diseases as follows:

Article 3 the blood system disease, unqualified. Simple iron deficiency anemia, with hemoglobin higher than 90 g/L in men and 80 g/L in women, is qualified.

3.1 Interpretation of Articles

The blood system consists of blood and hematopoietic organs, which include bone marrow, spleen, lymph nodes, lymphoid tissues scattered all over the body and mononuclear-phagocytic cell system. Hematological diseases refer to diseases that originate from and mainly involve blood and hematopoietic organs (the former is leukemia and the latter is iron deficiency anemia), commonly known as hematological diseases. Those who suffer from other systemic diseases and have blood changes can only be called hematological manifestations of systemic diseases, not real hematological diseases.

Hematological diseases can generally be divided into red blood cell diseases, white blood cell diseases, hemorrhagic diseases, hematopoietic stem cell diseases, etc. Clinically, they can be manifested as lymphadenopathy, hepatosplenomegaly, etc. caused by anemia, hemorrhage, fever or malignant cell infiltration, and different diseases have their own characteristics. Now only some common diseases are briefly described.

3.1.1 Anemia means that the hemoglobin content per unit volume of blood is lower than the lower limit of the reference value, and it is often accompanied by a decrease in the number of red blood cells and hematocrit in different degrees. It is generally believed that in plain areas, anemia can be diagnosed when the hemoglobin content of adult males is less than 130 g/L and females are less than 115 g/L. Anemia can be primary to hematopoietic organ diseases, or secondary to some systemic diseases (such as chronic kidney disease, chronic liver disease, chronic infection caused by various pathogens, malignant tumors, etc.). The etiological judgment of anemia is very important, with different causes and different prognosis. Except for iron deficiency anemia caused by some reasons, it is often difficult to completely cure and it is unqualified in physical examination. Common anemia has the following types:

1) Iron deficiency anemia: It is the most common anemia, which is caused by the lack of iron necessary for the synthesis of hemoglobin in the body. It is characterized by small cell hypochromic anemia. Common causes include chronic blood loss (such as menorrhagia, hemorrhoid bleeding, ulcer disease, hookworm disease, etc.) and iron malabsorption (such as after subtotal gastrectomy, long-term diarrhea, lack of stomach acid, hobby of strong tea, etc.). The prognosis depends on whether the etiology can be eliminated. If the etiology can be eliminated, anemia can be corrected quickly. The so-called simple iron deficiency anemia also refers to anemia caused by bad eating habits, menorrhagia, hemorrhoid bleeding, etc. When the hemoglobin content of this kind of anemia is not less than 90 g/L for men and 80 g/L for women, the symptoms are not obvious, and the cause is easy to eliminate, which has little impact on the body. After the cause is eliminated, the hemoglobin content is easy to return to normal and the prognosis is good, so it can be treated as qualified.

2) Aplastic anemia: referred to as aplastic anemia, is a syndrome characterized by pancytopenia caused by bone marrow failure caused by various causes. The common causes are drugs, chemical poisons, ionizing radiation, virus infection and so on. Aplastic anemia can be divided into acute type and chronic type. Acute type has an acute onset and rapid progress, and its main clinical manifestations are bleeding (such as gastrointestinal bleeding, hematuria, fundus hemorrhage and intracranial hemorrhage, etc.), which is easy to be complicated with infection and has a high mortality rate. The onset of chronic type is slow, and anemia is the main manifestation. The course of disease is long, and remission and attack can alternate repeatedly, and it will not heal for many years. Once the disease is diagnosed, it is concluded that it is unqualified.

3) megaloblastic anemia: anemia caused by DNA synthesis disorder caused by folic acid and/or vitamin B12 deficiency. It is characterized by an increase in the volume of hematopoietic cells, involving red blood cells, granulocytes and megakaryocytes. Clinically, it often shows pancytopenia with gastrointestinal symptoms. The common reasons are long-term vegetarian diet, partial eclipse, improper cooking of vegetables, improper dieting, malabsorption caused by gastrointestinal diseases, taking drugs that interfere with the absorption of folic acid and/or vitamin B12, etc. Once the disease is diagnosed, it is concluded that it is unqualified.

4) Tumor anemia: anemia caused by blood tumor (such as leukemia, lymphoma and myeloma) or solid tumor infiltrating into bone marrow or abnormal bone marrow hyperplasia (such as myelodysplastic syndrome). Once the disease is diagnosed, it is concluded that it is unqualified.

5) Hemolytic anemia: It is caused by the accelerated destruction of red blood cells, which exceeds the compensatory ability of hematopoietic function of bone marrow. Its main features are anemia, jaundice, splenomegaly, reticulocytosis and myeloerythropoiesis. The causes of hemolysis can be caused by genetic defects of red blood cells such as structural and functional defects of red blood cell membrane and enzyme defects, and can also be caused by acquired factors such as infection, drugs, physics and chemistry, immunity and metabolism. According to the main sites of red blood cell destruction, it can be divided into intravascular hemolysis and extravascular hemolysis. Both of them are unqualified conclusions.

3.1.2 Polycythemia refers to the fact that the number of red blood cells, hemoglobin content and hematocrit per unit volume of blood are significantly higher than the reference value. Usually, polycythemia can be diagnosed by hemoglobin ≥180 g/L, red blood cell number ≥6.0×1012/L or hematocrit ≥0.55. There are many causes, which can be relative polycythemia caused by decreased plasma volume, secondary polycythemia caused by tissue hypoxia, and true polycythemia (also known as primary polycythemia) with unknown reasons. Whether the patient with secondary polycythemia is qualified or not depends on the etiology. If the hemoglobin content and red blood cell count caused by temporary dehydration slightly exceed the reference value and can be corrected by normal drinking water, a qualified conclusion can be made; For those caused by other causes, the unqualified conclusion should be made according to the nature of the primary disease.

1) Secondary polycythemia: Tissue hypoxia caused by various reasons can lead to compensatory erythrocytic proliferation, that is, secondary polycythemia. The common causes are excessive smoking, high altitude polycythemia, cyanotic congenital heart disease, chronic obstructive pulmonary disease, tumor, kidney disease, obesity-pulmonary ventilation syndrome and so on.

2) polycythemia vera: it is a chronic myeloproliferative disease with abnormal proliferation of erythroid cells, with slow onset, characterized by dark red skin and mucous membrane, splenomegaly, increased red blood cell count and blood volume with pancytocytosis, and often nervous system and blood circulation dysfunction, thrombosis, heart failure, etc. Once the disease is diagnosed, the conclusion is unqualified.

3.1.3 Leukocyte diseases include all kinds of leukopenia and hyperplasia diseases.

1) Leukopenia and agranulocytosis: Leukopenia refers to peripheral blood white blood cell count < 3.5×109/L, in which neutropenia accounts for the vast majority. When the total number of neutrophils is < 0.5×109/L, it is called agranulocytosis. The causes of both are roughly the same. The most common causes are drug reactions (anti-tumor drugs, immunosuppressive drugs, antibiotics, antithyroid drugs, antiarrhythmic drugs, antihistamines and sedatives, etc.), radiation and chemical damage, immune-mediated bone marrow damage, bone marrow infiltration by abnormal cells (such as tumor cells), some bacterial and viral infections, and granulocyte maturation disorders (such as folic acid and vitamin B12 deficiency). In addition, abnormal distribution in blood pool, increased demand and accelerated consumption and destruction can also cause this disease.

Because most of the causes are acquired factors, the unqualified conclusion is made before the causes are eliminated and the total number of white blood cells or neutrophils is not restored to normal and stable.

2) neutropenia: refers to the number of neutrophils in peripheral blood > 7.0× 109/L. The main causes are acute infection, tissue necrosis, severe burns, poisoning, drug reaction, myeloproliferative diseases (chronic myeloid leukemia, polycythemia vera, primary thrombocytosis, myelofibrosis), and some malignant tumors. It can also occur due to physiological reasons such as pregnancy, emotional excitement, strenuous exercise, etc. Whether the disease is qualified or not depends on the etiology. For those who may be caused by mild inflammation, exercise or emotional factors, white blood cells are slightly elevated and can return to normal after reexamination, a qualified conclusion can be made.

3.1.4 Malignant lymphoma refers to a malignant tumor originating in the immune system (lymph nodes or extra-nodal lymphoid tissues), which is characterized by a large number of proliferation of lymphocytes and/or histiocytes. Clinically, it often shows painless and progressive lymphadenopathy, fever, hepatosplenomegaly, cachexia and anemia in the late stage. Once the disease is diagnosed, the conclusion is unqualified.

3.1.5 Multiple myeloma is one of the most common malignant plasma cell diseases, which is characterized by the tumor proliferation of monoclonal plasma cells, thus destroying bone tissue. The main clinical manifestations are bone pain, pathological fracture, anemia, hypercalcemia, renal function damage and easy infection. Once the disease is diagnosed, the conclusion is unqualified.

3.1.6 Hypersplenism is a syndrome, which can be caused by a variety of primary or secondary causes, such as infection, congestion (heart failure, liver cirrhosis, portal vein or splenic vein obstruction, etc.), abnormal immune response, myeloproliferative diseases, etc. The clinical feature is splenomegaly with decrease of red blood cells, white blood cells and platelets alone or simultaneously. Once the disease is diagnosed, the conclusion is unqualified.

3.1.7 The normal hemostasis mechanism of hemorrhagic disease is accomplished by the synergistic effect of blood vessels, platelets and coagulation mechanism. Obstacles in any one aspect can lead to abnormal bleeding, that is, excessive bleeding, which is called hemorrhagic disease.

1) Thrombocytopenia means that the platelet count in peripheral blood is less than 100× 109/L.. When the platelet count is lower than 50×109/L, there may be bleeding, and when it is lower than 20×109/L, the bleeding symptoms will be aggravated, such as skin and mucous membrane bleeding (diameter < ＜2 mm), purpura (diameter 3 ~ 5 mm) or ecchymosis (diameter > 5 mm), gingival bleeding, nosebleed, and even visceral bleeding, such as blood in stool and urine. There are many and complicated causes of thrombocytopenia, which are difficult to correct in most cases. As a physical examination, there is no need to make etiological diagnosis. Once thrombocytopenia is diagnosed, it is generally concluded that it is unqualified. If it can be confirmed that there is a temporary slight decrease in platelets caused by virus infection, drug factors, etc., and there is no bleeding tendency, those whose platelet count can return to normal level after eliminating the above factors can be treated as qualified.

2) Thrombocytopenic purpura: It belongs to a type of thrombocytopenia, including idiopathic, secondary and thrombotic thrombocytopenic purpura, and its common feature is bleeding with thrombocytopenia. It is not difficult to diagnose the disease according to the clinical manifestations and laboratory examination. As a physical examination, there is no need to make a classified diagnosis. Once diagnosed, make an unqualified conclusion.

3) Henoch-Schonlein purpura (Henoch-Schonlein purpura) is a common allergic hemorrhagic disease, which is mainly caused by the increase of capillary wall permeability and brittleness due to the allergic reaction of the body to certain substances, leading to exudative bleeding. The main causes are infection, drugs, food and other factors. According to the clinical manifestations, it can be divided into simple type, abdominal type, joint type, renal type and mixed type. Once the disease is diagnosed, the conclusion is unqualified.

4) Hemophilia: It is a group of hemorrhagic diseases caused by hereditary thromboplastin production disorder, characterized by positive family history, childhood onset, spontaneous or mild traumatic bleeding, hematoma formation and joint bleeding. This disease is a lifelong disease, and there is no radical cure. Once diagnosed, it is unqualified.

3.1.8 Leukemia is a malignant tumor of hematopoietic system, accounting for about 5% of the total cancer incidence. It is characterized by the tumor proliferation of a certain type of leukemia cells in bone marrow or other hematopoietic tissues, and infiltration into other organs and tissues in the body, which inhibits normal hematopoiesis and produces corresponding symptoms and signs. Anemia, fever, infection, bleeding and swelling of liver, spleen and lymph nodes in different degrees are common in clinic. Once the disease is diagnosed, the conclusion is unqualified.

3.2 Diagnostic points

3.2.1 Iron deficiency anemia

1) Key points of medical history inquiry: whether there is a history of chronic blood loss (such as menorrhagia, ulcer bleeding, hemorrhoid bleeding, etc.) and primary diseases that cause iron absorption disorders (such as subtotal gastrectomy, atrophic gastritis, long-term diarrhea, etc.), and pay attention to finding etiological evidence of anemia; Whether there are symptoms of anemia, such as dizziness, fatigue, palpitation and shortness of breath after activities.

2) Physical examination points: Pale skin mucosa is the main sign of anemia, and it is generally reliable to observe nail bed, palm skin wrinkles, oral mucosa and eyelid conjunctiva. Pay attention to other signs such as angular stomatitis, glossitis, and increased heart rate.

3) Auxiliary inspection points:

Blood routine: it is the main basis for diagnosis of anemia, which can be analyzed by automatic blood cell analyzer. Iron deficiency anemia is characterized by small cell hypopigmentation anemia. Generally, the diagnosis can be confirmed by routine blood examination combined with medical history and signs.

Reticulocyte count: It should be used as a routine supplementary examination in anemia patients. The reticulocyte count of patients with iron deficiency anemia is mostly normal.

When the nature of anemia cannot be determined, further testing items can be selected according to local conditions, such as determination of serum ferritin, serum iron, total iron binding capacity, etc., to determine whether it is iron deficiency anemia, and to further find out the cause of iron deficiency, so as to make a qualified conclusion.

3.2.2 Aplastic anemia

1) Key points of medical history inquiry: Pay attention to inquire about possible causes (virus infection, taking drugs, working environment exposed to radiation, toxins or chemicals, etc.), onset time, anemia symptoms (fatigue, dizziness, palpitation, shortness of breath, etc.), susceptibility to infection (frequent fever) and bleeding history (nosebleed, gingival bleeding, conjunctival bleeding, hematemesis, hemoptysis, hematochezia, etc.).

2) Physical examination points: Pay attention to whether the skin and mucosa are pale, bleeding, ecchymosis, hematoma, fever, infection, etc.

3) Auxiliary inspection points:

Blood routine: the main manifestation is the decrease of whole blood cells (red blood cells, white blood cells and platelets). If only red blood cells decrease, it is pure red blood cell aplastic anemia. Aplastic anemia is characterized by positive pigment cell anemia.

Reticulocyte count: significantly reduced.

As far as the physical examination of civil servants is concerned, as long as it is found to be pancytopenia, it is concluded that it is unqualified, and it is generally unnecessary to make an etiological diagnosis of pancytopenia.

3.2.3 Megaloblastic Anemia

1) main points of medical history inquiry: whether there are common causes of folic acid and vitamin B12 deficiency (such as long cooking and heating time, partial eclipse, complete vegetarian diet, chronic gastrointestinal diseases, taking drugs that interfere with folic acid and vitamin B12 absorption, etc.), anemia symptoms (fatigue, dizziness, palpitation, shortness of breath, etc.) and accompanying digestive tract symptoms (such as loss of appetite, nausea, diarrhea, etc.).

2) Physical examination points: Pay attention to whether there are signs of nervous system such as pale skin and mucous membrane (same as iron deficiency anemia), atrophy or disappearance of tongue nipple, abnormal muscle strength and walking disorder.

3) Auxiliary inspection points:

Blood routine: it is characterized by large cell anemia, and white blood cells and platelets are often reduced.

If the nature of anemia cannot be determined, further tests can be selected according to local conditions, such as the determination of serum vitamin B12, folic acid and erythrocyte folic acid, so as to establish the diagnosis and conclusion.

3.2.4 Bone marrow disease anemia

1) Key points of medical history inquiry: whether there is a history of primary diseases (acute and chronic leukemia, lymphoma, multiple myeloma, malignant histiocytosis and metastatic cancer, etc.) causing myelopathic anemia, and whether there is a history of bone pain and fracture.

2) Physical examination points: Pay attention to anemia, hepatosplenomegaly and related signs of primary diseases.

3) Key points of auxiliary examination: Routine blood examination showed normal cellular anemia.

For anemia, bone pain with unexplained hepatosplenomegaly and other suspicious cases, consultation can be organized or done if necessary.

Step-by-step examination, such as whether there is bone destruction on bone X-ray film, whether there are tumor cells on bone marrow film, and whether there is hemogram of young erythrocytes, etc., to make a clear diagnosis.

3.2.5 Hemolytic anemia

1) Key points of medical history inquiry: intravascular hemolysis is acute, mostly serious, and rare in physical examination; If the disease is found in physical examination, it is mostly caused by chronic extravascular hemolysis, and the onset time of pallor and fatigue should be asked. Congenital patients often have the disease since childhood, and acquired patients should be asked if they have blood transfusion, taking special drugs or food and related primary diseases.

2) Physical examination points: Pay attention to signs such as pale skin and mucosa, increased heart rate, yellow sclera, hepatosplenomegaly, etc.

3) Auxiliary inspection points:

Blood routine: normal cellular anemia.

Reticulocyte count: more elevated.

Generally, anemia can be diagnosed according to the characteristics of anemia and jaundice, splenomegaly and elevated reticulocyte. Suspicious cases can be further examined, such as serum bilirubin (the characteristic of this disease is mainly indirect bilirubin increase), free hemoglobin, hemoglobinuria, hemosiderosis, etc., in order to further diagnose.

3.2.6 Polycythemia

1) Key points of medical history inquiry: whether there are chronic hypoxic diseases (such as pulmonary heart disease, congenital heart disease, severe sleep apnea syndrome, etc.), plateau living history, physiological dehydration history, etc.

2) Physical examination points: pay attention to the presence of bloody appearance such as red and purple face, signs such as splenomegaly and hypertension.

3) Key points of auxiliary examination: Hemoglobin ≥180 g/L, red blood cell count ≥6.0×1012/L, white blood cells and platelets are also increased.

3.2.7 Leukopenia and agranulocytosis

1) Key points of medical history inquiry: whether there is the cause of the disease (such as drugs, poisoning, infection, lack of some nutrients, etc.) and the history of secondary infection.

2) Key points of physical examination: The disease generally has no positive signs, and it is mainly diagnosed by medical history and blood test.

3) Key points of auxiliary examination: The white blood cell count of routine blood examination is lower than the lower limit of reference value, and red blood cells and platelets are generally normal. According to the degree of leukopenia, the diagnosis is leukopenia or agranulocytosis.

3.2.8 Neutrophilia

1) Key points of medical history inquiry: Are there any causes of neutropenia, such as acute infection, tissue necrosis, severe burns, poisoning, drug reaction, myeloproliferative diseases (chronic myeloid leukemia, polycythemia vera, primary thrombocytosis, myelofibrosis), and some malignant tumors.

2) Physical examination points: focus on checking whether there are related signs of primary diseases.

3) Key points of auxiliary examination: The diagnosis can be made when the absolute value of neutrophils in routine blood examination is more than 7.0× 109/L..

3.2.9 Malignant lymphoma

1) Key points of medical history inquiry: whether there is a history of lymphoma in the past, and those with signs of superficial lymphadenopathy should focus on the progress of lymphadenopathy and whether there are symptoms such as pain and fever.

2) Physical examination points: whether there is superficial lymphadenopathy in the whole body, and if there is, pay attention to its hardness, activity and fusion; Whether there is hepatosplenomegaly.

3) Auxiliary inspection points:

Blood routine: anemia and increased number of lymphocytes may occur.

Chest x-ray: the mediastinal shadow is widened and hilar lymph nodes are enlarged.

Abdominal B-ultrasound: In addition to hepatosplenomegaly, retroperitoneal lymphadenopathy can be seen.

If lymph node enlargement is the main manifestation, lymph node biopsy can be taken if necessary to further confirm the diagnosis.

3.2.10 Multiple myeloma

1) Key points of medical history inquiry: The clinical manifestations of multiple myeloma are varied, and the early manifestations are mainly bone pain and easy fracture, so attention should be paid to medical history inquiry.

2) Key points of physical examination: The signs of this disease are generally not obvious, sometimes anemia can be seen, and the diagnosis mainly depends on medical history and targeted auxiliary examination.

3) Auxiliary examination points: For suspicious cases such as bone pain or pathological fracture, anemia, recurrent fever, etc., consultation or further examination can be organized when necessary, and diagnosis can be made according to whether bone X-ray film has osteolysis and bone destruction, whether bone marrow film has abnormal plasma cell increase, whether urine protein is positive, and whether plasma protein electrophoresis has M component.

3.2.11 Hypersplenism

1) Key points of medical history inquiry: Have you ever had a history of chronic hepatitis, schistosomiasis and other diseases, and pay attention to finding clues about the primary diseases.

2) Key points of physical examination: The physical examination shows splenomegaly and related signs of primary diseases.

3) Auxiliary inspection points:

Blood routine: pancytopenia or leukopenia and thrombocytopenia.

Abdominal B-ultrasound showed splenomegaly.

Generally, the diagnosis can be made according to the characteristics of blood examination, B-ultrasound examination and comprehensive judgment of the primary disease.

3.2.12 Thrombocytopenia

1) Key points of medical history inquiry: Do you have a history of recurrent skin and mucous membrane bleeding (such as nosebleed or gingival bleeding)?

2) Physical examination points: Pay attention to the nature and location of bleeding, whether there are purpura, bleeding spots on gums, bloody blisters on oral mucosa, and whether there are swelling of liver, spleen and lymph nodes.

3) Key points of auxiliary examination: When the platelet count of routine blood examination is lower than the lower limit of reference value, diagnosis can be made.

3.2.13 Thrombocytopenic Purpura

1) Key points of medical history inquiry: Do you have a history of repeated skin and mucous membrane bleeding, such as nosebleed or gingival bleeding, and do you have a family history of bleeding?

2) Physical examination points: Pay attention to whether there are purpura, bleeding spots on gums, bloody blisters on oral mucosa, and swelling of liver, spleen and lymph nodes.

3) Key points of auxiliary examination: The platelet count of routine blood examination is lower than the lower limit of reference value.

It can be diagnosed if there are bleeding symptoms accompanied by thrombocytopenia.

3.2.14 Allergic Purpura

1) Key points of medical history inquiry: whether there is spontaneous skin purpura, especially recurrent skin purpura in both lower limbs, and whether the treatment of purpura can spontaneously subside; Whether there are other types of purpura related symptoms such as abdominal pain, joint pain, hematuria, etc.

2) Key points of physical examination: Purpura simplex is only manifested in the skin. Purpura is characterized by being distributed in limbs and buttocks, mostly in the extended side, mostly symmetrical, and rashes appear in batches, which can be higher than the skin with itching; Other types of purpura may show corresponding signs before or after the occurrence of cutaneous purpura. For example, abdominal purpura may have tenderness around the abdomen, joint purpura may show joint redness, tenderness and dysfunction, and renal purpura may have edema and increased blood pressure. Combined with the characteristics of purpura, it is generally easy to diagnose.

3) Auxiliary inspection points:

Blood routine: Platelet count is normal.

Urine routine: Nephrotic purpura can have microscopic hematuria and positive urine protein.

3.2.15 Hemophilia

1) Key points of medical history inquiry: whether there is a family history, whether there is a history of spontaneous bleeding of skin and mucosa or bleeding after minor injuries, or a history of menorrhagia, trauma or abnormal bleeding during surgery, etc.

2) Physical examination points: There may be signs such as joint swelling and tenderness during the attack.

3) Key points of auxiliary examination: The diagnosis of this disease is mainly based on the medical history. If necessary, the diagnosis can be further made by hematological examination such as coagulation time and partial thromboplastin time.

3.2.16 Leukemia

1) Key points of medical history inquiry: whether there are related symptoms such as fever, bleeding and anemia.

2) Physical examination points: check whether there are bleeding spots and ecchymosis on the skin and mucosa, whether there is anemia, and whether there are signs such as liver, spleen, lymph node enlargement and sternal tenderness.

3) Key points of auxiliary examination: the total number of white blood cells can be increased by routine blood examination, and white blood cells at various stages can be seen by classification; Most of them are normal cell anemia.

Suspicious cases should be consulted by hematology department in time, and bone marrow examination should be made if necessary to make a clear diagnosis.

3.3 Precautions

3.3.1 There are many kinds of hematological diseases, and their clinical manifestations are varied. In the physical examination, we should ask and record the medical history in detail as far as possible (I should truthfully reflect it) in order to find clues about the primary diseases; Physical examination should be serious and comprehensive to avoid missing important signs; In addition to routine blood tests, auxiliary laboratory tests can be added when necessary. It is necessary to comprehensively analyze the results of medical history inquiry, physical examination and auxiliary examination to avoid missed diagnosis as much as possible.

3.3.2 Hematological diseases are mostly systemic and refractory diseases, which have serious effects on health, so they are all treated as unqualified in principle. However, some hematological diseases, whose causes are clear (such as virus infection, drug reaction, inflammation, etc.) and easy to correct, have little impact on health (such as only causing transient slight decrease or increase of platelets or leukocytes, mild iron deficiency anemia, etc.), can quickly return to normal after eliminating the causes and can be treated as qualified.

3.3.3 The etiology of hematological diseases is complex, some of which are difficult to be clear in physical examination, and the purpose of physical examination is not to find a treatment for the cause, so we should pay attention to the diagnosis of the disease and make a conclusion on whether it is qualified or not. In addition to anemia, it is not necessary to go into the etiological diagnosis and disease name diagnosis of other blood diseases, such as thrombocytopenia and purpura, and make unqualified conclusions on this basis, without making the diagnosis of thrombocytopenia and purpura.

Fast silver and Fung Wong-Nui.

　 　 1905 movie network news　"What are you going to do during the Dragon Boat Festival? Go out to play? The weather is hot and there are many scenic spots. I have a good suggestion. It is better to invite friends and family to the cinema! "

　 　 This suggestion was given to you by "cute" fast silver evan peters and Fung Wong-Nui "three idiots" sophie turner. In the special video of Dragon Boat Festival released by the film today, Kuaiyin and Fung Wong-Nui are still very funny. They take China’s zongzi and wish everyone a happy Dragon Boat Festival. Kuaiyin also asks, "Is this edible? I want to bring one for my dad Wan Ciwang! " Fung Wong-Nui also quickly said, "Then I’ll bring one for Professor X."

　 　 X-Men: Apocalypse, a Hollywood superhero blockbuster, has been released all over the country. This movie is the final chapter of the prequel trilogy, and it is well received all over the world.

　

Sophie turner plays Fung Wong-Nui in the X-Men.

Fast silver looks up

　 　The story of X-Men: Apocalypse took place in the 1980s, that is, the last decade. In 1983, Apocalypse, the first mutant in history, woke up in Egypt. He wanted to rule and change the world, so there was the mutant war.

　 　 Many fans said that this is probably the X-Men movie that is most loyal to comics. The background of these mutants, such as Storm, Nightcrawler, Angel, Psylocke, Laser Eye, etc., is very clear. It doesn’t look like an ending with pure fighting, but like the beginning of a movie series, and it seems that there is a bigger story being built. In the film, Fung Wong-Nui first meets the laser eye and Wolverine, and Wan Ciwang is still an important role, explaining what happened to Wan Ciwang 10 years after X-Men: Days of Future Past, and why he became one of the four knights who helped the apocalypse. What story will happen between him and his son, Kuaiyin, and "old friend" Professor X becomes more suspenseful.

Fung Wong-Nui, Laser Eye and Nightcrawler

Quick silver saves the magic girl

　

　 　 　 　Many viewers said that they cried, not only because the film was wonderful, but also because this series was accompanied by their own experiences. The friendship between Professor X and Wan Ciwang in the film was particularly strong. Even if they were not together and had different positions, they still understood each other’s perspectives.

　 　 　　The theme of the X-Men series is how to face discrimination and oppression. Professor X, Wan Ciwang, Magic Woman and the Apocalypse of this episode are all looking for their own beliefs and fighting for them. Therefore, every character in this series of movies has supporters.

　 　 　 　Dragon Boat Festival is one of the most important traditional festivals in China. Let’s go to the cinema to watch X-Men: Apocalypse, which is being shown, and have a pleasant holiday.

　　1. From 17 to 19, there was a rare heavy rain and snow weather in the central and eastern regions during the same period in history.

　　Since November 17th, there has been a large range of heavy rain and snow in the central and eastern regions of China, which has a wide range of influence and strong intensity, and is rare in the same period in history.

　　According to the monitoring data, as of the morning of the 19th, there were heavy blizzards in parts of southeastern Heilongjiang, northwestern Jilin, central and southeastern Inner Mongolia, and heavy blizzards in Mudanjiang, Heilongjiang, Tongliao and Chifeng, Inner Mongolia (snowfall 20 ~ 43mm); Heavy rains occurred in southeastern Jilin, eastern Liaoning, Shandong, central and eastern Henan, central and northern Jiangsu, central and northern Anhui, southwestern and eastern Hubei, northern Chongqing, northeastern Sichuan and other places, and heavy rains occurred in Dandong, Liaoning and northern Chongqing (rainfall 100 ~ 141 mm); The depth of snow in southeastern Heilongjiang, western Jilin and central and eastern Inner Mongolia is 5-10 cm, and the local area is 15-25 cm.

　　According to statistics, the daily precipitation of 243 national meteorological observatories in Liaoning, Jilin, Inner Mongolia, Shandong, Henan and other places has exceeded the historical extreme in November since meteorological records were recorded.

　　On the morning of the 19th, the heavy rain and snow process was still not over, and the Central Meteorological Observatory issued a yellow warning of blizzard: It is expected that there will be heavy snowstorms in parts of central and eastern Heilongjiang and central and northern Jilin in the next 24 hours, among which there will be heavy snowstorms in the eastern part of Heilongjiang (20 ~ 23 mm); The depth of newly added snow in the above areas is 5 ~ 10 cm, and the local area is more than 15 cm.

　　2. A new round of rain, snow and cooling weather struck from 20th to 22nd.

　　It is expected that there will be a large-scale rain and snow cooling weather again in the central and eastern regions from the 20th to the 22nd. The specific forecast is as follows:

　　Rain and snow forecast: From 20th to 22nd, there will be small to medium snow or sleet in the eastern part of northwest China, northern Sichuan Plateau, north China, northern Huanghuai and south-central part of northeast China, and there will be heavy snow or blizzard in the southeast of Qinghai, southern Gansu, north-central Shaanxi, Shanxi and northwest Hebei, with 1-5 cm of newly added snow and 8-10 cm of local area. There are small to moderate rains in the eastern part of Southwest China, southern Huanghuai, Jianghan, Jianghuai, Jiangnan and South China, and heavy rains in Chongqing, northwestern Hunan, Hubei and central Anhui.

　　Temperature forecast: From 19th to 23rd, affected by two cold air streams, the temperature in the central and eastern regions will continue to drop, with the temperature dropping by 8 ~ 12℃ in most areas, with the temperature dropping by more than 14℃ in parts of the south of the Yangtze River and northern South China. After the cold air passes, the lowest temperature 0℃ line will be pressed to the south-central part of Huanghuai on the morning of 23rd or 24th, in which the lowest temperature in north and northeast China is-12 ~-8℃ and the lowest temperature in south China and Huanghuai is-4 ~ 0℃. There are 4 ~ 6 northerly winds and 7 ~ 8 gusts in the north of the Yangtze River and the west of the south of the Yangtze River.

　　Meteorologists reminded that the public should guard against the adverse effects of snow and ice on roads caused by rain and snow and low visibility weather on travel traffic; Under the continuous suppression of cold air, the temperature in the south of the Yangtze River and the north will continue to drop in the next few days. Please ask the public to increase their clothes in time, take measures to prevent cold and wind, and beware of catching a cold.

　　(Editor: Su Jessie)

On February 15th, DuckDuckGo browser announced a cross-platform password sharing function yesterday.

It is reported that DuckDuckGo browser originally supported users to import bookmarks and passwords from other browsers into DuckDuckGo, but the newly added "password synchronization function" allows users to freely synchronize bookmarks and passwords of DuckDuckGo browsers on various platforms without logging in to an account.

IT House inquired about the official press release of DuckDuckGo, and learned that DuckDuckGo claimed that although competitors such as Google also provided similar cross-platform password sharing functions, while users enjoyed cross-platform password sharing, relevant private information would be quietly obtained by Google.

The advantage of DuckDuckGo is that users only need to scan the QR code to synchronize bookmarks and passwords. After the synchronization is completed, users can manually store the backup "Recovery PDF" file in a safe place. If the user’s device is lost or damaged, they can use "Recovery PDF" to recover their passwords and bookmark data.

Yin Liqing, a V-certified user in Weibo, published "The News of double 11 Sales Data Falsification of Taobao from 2009 to 2018", which caused a heated discussion on the Internet. On this matter, "Tan Jing is charging" interviewed the doctor of applied mathematics of Chinese Academy of Sciences. He pointed out a small problem that the cubic regression curve is not a "linear formula".

Yin Liqing mentioned in the article that "the production data are almost perfectly distributed on the cubic regression curve, and the fitting degree is over 99.94%." "The data is too perfect" and "the linear formula set as expected" and so on, the conclusion points to "Taobao double 11 scam". Alibaba Taobao did not respond accordingly.

On this matter, "Tan Jing is charging" interviewed the doctor of applied mathematics of Chinese Academy of Sciences. He pointed out a small problem that the cubic regression curve is not a "linear formula".

In fact, the technological development curve behind double 11 is more worthy of attention than the sales growth curve. The problem of "perfect fit", a small probability event, may be found from the business point of view. For example, corporate marketing activities will have their own market objectives and budgets. Once the plan is made, the executive team will definitely complete the performance KPI through various marketing means.

If (please re-read here) when making the activity budget, the expectation of market growth is planned according to a certain curve, it is not surprising that it can be "perfectly fitted". Of course, if there is such a situation, we have to ask Alibaba to reply.

(The researcher added, because I haven’t seen the original data, the conclusion is not rigorous, and it only represents my personal opinion. )

　　CCTV News:Yesterday (August 27th), at the media briefing of "Financial Knowledge Popularization Month" in 2021, China Banking and Insurance Regulatory Commission focused on the popularization of financial knowledge such as reasonable borrowing and rational consumption for young consumers such as teenagers and school students. At the same time, focus on popularizing the concept of rational investment for the elderly, improve their anti-fraud awareness and self-protection ability, and require that banking and insurance institutions should not force the elderly to use bank cards, and should not force and violate regulations to handle business through self-service smart devices instead of the elderly.

　　Cctv newsAccording to "Shanghai released" Weibo news, from 20: 00 on September 1, Shanghai started 12&mdash; 14-year-old people register for vaccination. Parents (guardians) can make an APPointment online through the "Healthy Cloud" app. After the appointment is successful, the child, accompanied by parents (guardians), will go to the appointed inoculation point for vaccination according to the appointment time. From September 3, the vaccination work will be carried out in an all-round way.

　　At present, the vaccinated vaccines are Covid-19 inactivated vaccine from Sinopharm Zhongsheng Beijing Institute and Kexing Zhongxin Crown Virus inactivated vaccine, with two doses in the whole process.

　　If you have any questions about vaccination in COVID-19, you can call the Shanghai Health Hotline at 12320.

　　Hot Questions and Answers on Appointment Vaccination of COVID-19 Vaccine among People Aged 12-17

　　1. Why should people aged 12-17 be vaccinated with COVID-19 vaccine?

　　Vaccination with Covid-19 vaccine can obtain corresponding immunity, thus effectively reducing the risk of onset, severe illness and death; At the same time, children and adolescents will spread to the people around them after infection. Vaccination with Covid-19 vaccine is of great significance to strengthen the immune barrier of the population and block the epidemic in COVID-19.

　　2. Is it safe to vaccinate people aged 12-17 with COVID-19 vaccine?

　　According to the press conference of the State Council Joint Prevention and Control Mechanism, the Covid-19 inactivated vaccine produced by Sinopharm China Institute of Biological Products and Beijing Kexing Zhongwei Biotechnology Co., Ltd. has carried out relevant clinical trials on children and adolescents aged 3-17. After evaluation and demonstration, it is fully proved that it is safe to use in people aged 3-17.

　　3. What kind of Covid-19 vaccine was given to people aged 12-17?

　　Relevant state departments have approved the emergency use of Covid-19 inactivated vaccine produced by China Institute of Biological Products of Sinopharm Group and Beijing Kexing Zhongwei Biotechnology Co., Ltd. among people aged 12-17. There are 2 doses of basic immunization, with an interval of 3-8 weeks. Inoculation route is intramuscular injection, and the best part is deltoid muscle outside the upper arm.

　　4. How to register an appointment?

　　You can download the "Healthy Cloud" App or enter the "Covid-19 Vaccination Service" area through the "Healthy Cloud Pro" WeChat applet, the "Follow the Bid" mobile terminal, the "Shanghai Release" and the "Shanghai CDC", select "Minors Registration", and parents (guardians) will make registration and appointment according to the operation steps.

　　For families without mobile phones, they can bring their ID cards to the health post in the street to print the vaccination bar code themselves, and then choose the designated vaccination point nearby to vaccinate themselves.

　　5. Where can I get the Covid-19 vaccine? The school and the place of residence are not in the same district. How to choose the inoculation point?

　　Parents (guardians) can choose an inoculation point near the school or the district where they live to make an appointment for their children. After registering through the "With the bid" and "Healthy Cloud" apps, they will see all the information of the inoculation points that can be reserved.

　　6. What are the contraindications for vaccination?

　　Inoculation contraindications for people aged 12-17 are the same as those for adults aged 18 and above. According to the Technical Guide for Vaccination in Covid-19 (First Edition), the usual taboos for vaccination include:

　　(1) those who are allergic to the active ingredients of the vaccine, any kind of inactive ingredients, substances used in the production process, or those who have been allergic to similar vaccines before;

　　(2) Those who have had severe allergic reactions to vaccines in the past (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.);

　　(3) Patients with uncontrolled epilepsy and other serious nervous system diseases (such as transverse myelitis, guillain-barre syndrome, demyelinating diseases, etc.);

　　(4) People who are suffering from fever, acute diseases, acute attacks of chronic diseases, or uncontrolled patients with severe chronic diseases;

　　(5) Other taboos listed in the manual.

　　7. I have just received other vaccines recently, such as rabies vaccine and HPV vaccine. Can I get Covid-19 vaccine?

　　If you have been vaccinated with other vaccines, it is recommended to vaccinate Covid-19 vaccine every 14 days.

　　After vaccination with Covid-19 vaccine, it is suggested that the interval between vaccination and other vaccines should be at least 14 days. However, in case of dog bite or trauma, it is unnecessary to consider this interval when emergency vaccination with rabies vaccine, tetanus vaccine or immunoglobulin is needed.

　　8. Can I get vaccinated if I feel uncomfortable on the day of the appointment?

　　If you have fever, cough, diarrhea and other unwell symptoms on the day of scheduled vaccination, it is recommended to suspend vaccination and make an appointment after recovery.

　　9. What should I pay attention to before vaccination? What materials do I need to carry when I am vaccinated?

　　Be careful not to have an empty stomach before vaccination, wear loose clothes to facilitate vaccination, carry necessary identification documents and other materials, and wear masks throughout the vaccination clinic.

　　If you take antipyretics, antiviral drugs and antibiotics before inoculation, please inform the doctor at the inoculation point.

　　Parents (guardians) are required to accompany the vaccinator, bring the vaccinator’s ID card or household registration book, and go to the appointed inoculation point for vaccination. Show the "vaccination barcode" at the scene, sign the "informed consent form" voluntarily, and vaccinate according to the staff’s instructions.

　　10. Are there any precautions after vaccination?

　　After inoculation, you can live, study and play normally, and you should pay attention to rest and avoid being too tired. Pay attention to a healthy and light diet and eat less seafood and other foods that are easy to induce allergies. Drink plenty of water on the day of inoculation, keep the local skin clean and avoid scratching the inoculation site with your hands. It is recommended not to do strenuous exercise within one week after inoculation. After vaccination, it is still necessary to take protective measures such as wearing masks, washing hands frequently and keeping social distance.

　　11. Do you need to avoid eating after vaccination?

　　After vaccination, doctors usually remind people not to eat irritating foods such as peppers and seafood such as fish and shrimp to reduce the discomfort and possible allergies caused by these foods. If you don’t have a history of allergies such as seafood and have eating habits such as peppers, you can eat them normally according to your usual eating habits. After vaccination, you can eat normally.

　　12. What are the possible adverse reactions of Covid-19 vaccination?

　　According to the results of clinical trials of Covid-19 vaccine and the information collected during its use, the common adverse reactions of Covid-19 vaccine are basically similar to those of other vaccines that have been widely used. Mainly for the inoculation site redness, induration, pain, etc., but also fever, fatigue, nausea, headache, muscle pain and so on. Generally, there is no need for special treatment. If necessary, contact the inoculation point, which will give disposal guidance.

"How to build a good car for users?" This problem runs through the development of Geely all the time, and has a profound impact on Geely’s strategic layout and product innovation.

On December 6th, Geely Automobile held a 7 # listing conference in Taizhou, Zhejiang. Taizhou is the place where Geely Automobile started, so during the media interview after the listing conference, Yan Jiayu, CEO of Geely Automobile Group, began to talk to the media about Geely Automobile’s concept of making cars.

Gan Jiayue said: Since the first car rolled off the assembly line on August 8, 1998, Geely has a 27-year history of building cars, and up to now it has accumulated 16 million users, ranking first in the number of independent brands in China. However, Geely Automobile’s concept of building a car remains unchanged, that is, to build a good car for users and ordinary people.

Constant values: building a good car for the people

Geely’s "unchanged" can be summed up as a simple and profound mission: "building a good car for the people." This concept has been established since the establishment of Geely, and has been accompanied by the development of the enterprise.

Yan Jiayue mentioned that Geely’s initial goal was to "build a car that ordinary people can afford". With the gradual development of the company, this goal was further deepened into "building a good car that ordinary people can afford" and now "building the safest, most energy-saving and most intelligent new energy vehicle". What remains unchanged is that Geely has never forgotten its original intention, that is, to meet the needs of mass consumers through cost-effective products.

Take Galaxy as an example. The main mission of Galaxy is to be a "high-value" new energy product. Gan Jiayu explained: High value means leading from technology, leading from quality and leading from the value of products, which is what Geely often talks about internally.

This "high-value" car-making concept also ensures Geely’s success. In 2024, the competition in China’s automobile market is becoming increasingly fierce, and many automobile companies have experienced double sales and profits, while Geely stands out in the market with its excellent "price-to-product ratio" and good user experience. Whether it is listed in August or Geely listed in October, it has become a market explosion.

Changing factors: technological progress and product innovation

Although Geely has always adhered to the concept of "building a good car for ordinary people", with the rapid development of the automobile industry, especially the rapid progress of intelligent and new energy technologies, Geely Automobile should continue to maintain the advantage of "price ratio" of its products, or return to the market and understand what products users need from the market perspective. Take the Milky Way as an example, which is manifested in the following aspects.

The first is the core technology. Yan Jiayu believes that if the technology is not continuously leading, the product will not be recognized by the market.

According to the introduction, in recent years, Geely Automobile has practiced the strategy of "one network and three systems" in technology, that is, an "intelligent Geely technology ecological network" and three systems composed of "intelligent energy, intelligent manufacturing and intelligent services".

Gan Jiayu believes that in the "one network and three systems", the most important thing for Galaxy is the intelligent energy system. To this end, Geely has built a Aegis short knife battery and an 11-in-1 channel platform. This system has ensured the best endurance achievement rate and safety of the same level for Geely Galaxy, and the power consumption and energy consumption of the products have also been well optimized, thus ensuring that the products get higher customer satisfaction.

Secondly, in terms of intelligence, Geely has accelerated the upgrading of intelligent manufacturing by implementing the "Smart Geely 2025" strategy.

Yan Jiayue mentioned that from 2021 to now, Geely has continuously strengthened its independent research and development capabilities, from the chip to the self-research of the operating system, which is constantly breaking down technical barriers and bringing better driving experience to consumers.

Take the Flyme Auto system as an example. This system is an AI intelligent system jointly developed by Geely and Meizu, which can optimize the intelligent operation in the car in real time according to the needs of users. This technology not only improves the operating experience in the car, but also helps the vehicle to achieve better performance in fuel consumption through the application of AI agents. For example, Starship 7 has better fuel consumption performance than many similar hybrid vehicles with the help of AI agents.

Such a technological breakthrough not only makes Geely stand out in the market, but also creates a leading technical image for the brand.

In addition, Geely has spared no effort in quality control. Gan Jiayu emphasized that "quality is the bottom line, the lifeline and the red line of Geely". While improving product technology, Geely always insists on maintaining high standards in quality management. This strict quality control not only ensures the safety and durability of vehicles, but also makes consumers feel more at ease when choosing Geely brand.

Balance between Change and Invariance: User Experience First

Geely’s success lies not only in technological breakthroughs, but also in how to transform these technologies into product values that users can actually feel.

Yan Jiayue emphasized that Geely does not need to show off its skills, but brings consumers a more real experience through practical technology. This "user-centered" design concept runs through every model of Geely, especially in the field of new energy vehicles, and Galaxy series is the concrete embodiment of this concept.

As a pure electric SUV, Yinhe E5 has been widely welcomed for its excellent intelligent system and extreme driving experience. Through the all-round fuel consumption optimization of AI agent, Galaxy Starship 7 achieved the best fuel consumption performance among similar new energy vehicles, which not only reduced the use cost of the owner, but also improved the overall driving experience. In addition, the addition of Flyme Auto system not only improves the convenience of the owner’s operation in the car, but also makes the intelligent interaction in the car more humanized, thus providing users with a higher value experience.

Conclusion: Geely’s "change" and "unchanged" are the core of its continuous success. On the basis of adhering to the initial goal of "building a good car for the common people", Geely has gradually realized the transformation from a China brand to a global brand through technological innovation, quality improvement and product experience optimization. It can be predicted that Geely in the future will continue to promote the continuous progress of the automobile industry with the initial intention of "building a good car for users" and achieve more high-value products with international competitiveness.