[Aika Auto Domestic New Car Original]

　　On September 17th, 2023, Geely Automobile officially announced the prices of two new models of the Star Yue L in Xi ‘an Black Light Factory, namely the Yun Qi version with a guide price of 157,700 yuan and the Skyline version with a guide price of 168,700 yuan. As new models, Yun Qi version and Skyline version have added exclusive design on the basis of Star Yue L, and are equipped with the latest vehicle system of Galaxy OS 2.0. While announcing the selling price, Geely Automobile also announced the car purchase courtesy including financial gift, rejuvenation gift, quality gift, maintenance gift and flow gift. At the same time, Geely Automobile also announced that it will push the Galaxy OS 2.0 car system for all old users OTA of Xingyue L for free.

　　The exclusive designs for these two models include the far-Dai matte gray car paint and the ink-splashing environment-friendly suede interior. Among them, the official guide price of Yuandai frosted gray car paint is 6,000 yuan, and the official guide price of splash-ink environment-friendly suede interior is 3,000 yuan, while the Sky Edition will come standard with splash-ink environment-friendly suede interior. The environment-friendly chamois interior is covered with a large area of environment-friendly chamois. The covering rate of the seat surface is 68.8%, the ceiling is 100%, and the door panel and instrument panel are all covered with chamois. Not only has the touch been improved, but the sense of advanced has also been filled. In addition, the Galaxy OS 2.0 car system has a brand-new UI design, which is more fashionable and beautiful. The voice wake-up speed reaches millisecond level, and the whole scene can be seen. At the same time, a custom desktop that is more in line with the operating habits of the mobile terminal is adopted to create a more intelligent and non-inductive interactive experience for users.

　　A quick look at the highlights of new cars

　　·　Newly added exclusive designs, including Yuan Dai matte gray car paint and splash-ink environment-friendly suede interior.

　　·　Equipped with the latest Galaxy OS 2.0 car system.

　　·　2.0T+8AT

　　New car introduction

　　In terms of appearance, Geely Xingyue L adopts the family-style design language of Geely Automobile 4.0 generation products, and continues to maintain the high value of atmospheric dynamics. In terms of details, the front face of Xingyue L adopts the iconic straight waterfall air intake grille, and the black middle net is decorated with chrome trim, which makes the front face look very delicate and dynamic. The headlight with full LED light source energy matrix is very sharp in shape, and the two-stage design is highly recognizable. A chrome-plated decorative strip is added to the front enclosure that runs through the design, which is perfectly integrated with the L-shaped chrome-plated decorative strips on both sides.

　　Viewed from the side, Xingyue L adopts a muscular line design, which, together with the burly body size, makes the side look very atmospheric. In terms of body size, the L length/width/height of Xingyue is 4770*1895*1689mm, and the wheelbase is 2845 mm.. The rear of the car continues the family’s atmospheric and steady design style. The biggest highlight is the adoption of the popular through taillights, and the interior adopts the "aurora dot matrix" design, which is full of scientific and technological sense.

　　As for the interior, Xingyue L has adopted a brand-new design concept of "Symphony of Time and Space", and all designs have demonstrated the people-oriented design idea. High-grade suede fabric is widely used in the interior, and the exquisite pearl stitching is used. With the special suede seat with the ultimate skin-friendly touch, the exquisite, elegant and unique car interior is created for the vehicle. In addition, three large 12.3-inch screens are also a highlight of the interior. The 12.3-inch central control screen uses Qualcomm Snapdragon 8155 chip, while the 12.3-inch screen in front of the driver integrates rich functions such as watching videos, listening to songs, games, Tik Tok and karaoke.

　　In the power part, the two new models are equipped with the high-power version of the Drive-E series 2.0TD engine, with a maximum power of 175kW(238 HP) and a peak torque of 350Nm. The transmission is equipped with the 8AT gearbox from Aisin.

　　Editor’s point of view: Up to today, the cumulative sales volume of China Star Series has exceeded 730,000 vehicles, among which the cumulative sales volume of Xingyue L has exceeded 300,000 vehicles, with an average monthly sales volume of over 10,000 vehicles. It is worth mentioning that in August, the sales volume was 17,169 vehicles, with the monthly sales exceeding 15,000 vehicles for three consecutive months. In the past five months, the sales volume of high-equipped 8AT products accounted for over 65%. The addition of the two new models not only brings a more exclusive design, but also brings a richer choice of models for consumers who are concerned about Xingyue L.

　　Wonderful content review:

　　The release of Geely Panda Knight is expected to be launched in early September.

　　Geely Panda mini "Asian Games Bear" has been listed for 29,900 times.

　　Geely Panda mini is officially listed at a price of 39,900 yuan.

In the retail circle, the membership system has been iterative, so we might as well look at the membership logic from Amazon, Nike, Sephora, Starbucks and Xiaomi.

This article comes from WeChat WeChat official account:Retail Watch (ID: On Retail), author: Wang Ziwei

For retailers, the membership system is basically unavoidable. Let’s take a look at what the most mainstream membership system in the e-commerce era is like.

From a global perspective, there are seven most common forms:

1. Integral-hierarchy system

2. Service subscription system

3. Entity subscription system

4. Charity system

5. Sharing cooperation system

6. Community system

7. TOKEN system

I. Integral-Hierarchy System

This is almost the simplest one. In short, every time you spend X yuan, you get Y points. The more you spend, the higher the score.The only variable seems to be that there may be reward points at different times and through different channels, such as 5 times points for in-store consumption during the celebration period and 10 times points for e-commerce consumption during the Black Five/double 11 period.

Let’s take a foreign example, that is, the clothing brand "North"（North Face）",its integral system is called" VIPeak ".

For consumers, understanding this system is also very simple, that is, for every dollar spent, they get 10 points-whether online or offline, if they spend at outlets, they get 5 points for every dollar.

These points can be used in future consumption. To this end, North Face allows users to manage their accounts, buy goods, see points and redeem rewards through the App.

This is the simplest point system, through which consumers are willing to continue to shop. North Face is a typical single-level membership system.

Based on this logic, there will be a multi-level membership system, generally and periodically.(e.g. 1 year)The consumption amount or points are positively related.The characteristic of hierarchical system is that the higher consumers spend, the more rewards they get.

This level itself is also a gamification system, which links consumption with "playing". In the United States, a classic case is the beauty brand e.l.f

Consumers with 0-100 points are at the first level, consumers with 101-400 points are at the second level, and those with 401 points or above are at the highest level-the more membership points, the more unique the rewards.The uniqueness of the highest level is an important factor that urges consumers to buy more goods.

From the point of view of points, the first-level consumers get 2 points for spending 1 dollar, the second-level consumers get 4 points for spending 1 dollar, and the third-level consumers get 6 points for spending 1 dollar, and consumers can get corresponding services by using points.

Similarly, Starbucks in the United States also has this hierarchical system, which is divided into green card levels.（Green Level）And gold card level（Gold Level）.

When the user has less than 299 stars, it is a green card level, and will enjoy the privileges of getting 2 stars for every $1 spent, birthday gifts, mobile payment, placing orders in advance, and free refills in the store; When the number of stars reaches 300 or above, the user will be upgraded to the gold card level. At this time, he will not only enjoy all the green card level permissions, but also double the star accumulation day every month, get a gold card membership card with his name printed on it, and exchange free food or coffee every 125 stars.

In addition to getting stars through consumption, there are also some activities in Starbucks APP, such as going to the store for consumption at a specific time, getting extra stars, and buying specific goods to get extra star rewards.

Second, the paid subscription system-service category

In the payment system, consumers need to pay a monthly fee or an annual fee to become a VIP. Generally speaking, there must be a solid consumer base.After all, it is difficult for you to make a new user become a paying member with little contact with you, so this payment system is basically used to maintain experienced users.

In addition, this payment system must have membership benefits, otherwise users don’t have to pay you in vain.

The most classic case is Amazon. Now Prime with an annual fee of $119 only needs $79 at the earliest, but only one problem was solved in that year, that is, it was guaranteed to be delivered free of charge within 2 days. This was the biggest problem of e-commerce in that year, otherwise a product would only be available in 2-3 weeks, and even if the price was superior, it could not wait.

Later, many functions were added to Prime for free, such as Amazon music, Amazon photos (unlimited storage of photos) and Amazon videos.(Watch all kinds of movies, dramas and original dramas at will)Wait a minute. In 2018, according to data from investment bank JP Morgan, the annual membership fee of $119 is worth about $784, which can be said to be over-valued.

The extreme, even extreme, is Costco.After covering the cost of goods, personnel and management expenses, the income generated by its goods is almost used up, so that its final profit returned to shareholders and membership fees are almost equal.

Third, the paid subscription system-commodity category

Another logic of the payment system is, "subscription box.（Subscription Box）Type ",that is, the subscription of physical items such as products/commodities.

The goods in the "subscription box" generally need to be purchased repeatedly. Take Bean Box as an example, it is the subscription of coffee-normal purchase is the normal price, but if you subscribe, you can always receive coffee on schedule within a cycle, and you can enjoy a discount.The essence is a behavior of directly locking consumers and locking demand, and then it may be the reverse supply chain.

Another advantage of this subscription is that it can increase the lifetime value of customers-from the case of Bean Box, can it be the same if you let consumers buy once and realize repeated service for six months, and let consumers buy for one month and one month?

Amazon has a similar service, and some products can be "subscribed" directly on the purchase page-usually with a discount of about 5%.

Fourth, the charity system

Discount can be a component of the membership system, but it is not necessary.

Therefore,The logic of the charity system is that you are attracting consumers with your own values, thus establishing a stronger relationship.The more common way is that enterprises donate a percentage of their income to charity, such as donating the money to charities, disease research institutions, animal protection organizations and so on.

A small evolutionary version here is that the enterprise will give you several optional donor institutions, and you can choose the one you are willing to donate. This is the case with The Body Shop in America, which introduced animal welfare into its membership system.

In addition to receiving rewards and VIP treatment, consumers can also choose to donate a percentage of their spending to Born Free USA, an animal welfare institution. This is also because The Body Shop has always emphasized environmental responsibility.

This logic lies in that the communication with consumers is not only the exchange of goods and services, but also the integration of values, which in turn makes the loyalty of consumers come to a different and uncontested field.It can be said to be a "blue ocean strategy of values".

V. Sharing cooperation system

A consumer will not only have a membership card, so the demand is also diverse. It can be said that consumers’ spending time is very idle, and the core is whether businesses from different formats can "cut leeks" together-buy electronic products from you, shoes from me and snacks from him.

Therefore, consumers will also want more flexibility in rewards. At this time, what is needed is cross-industry cooperation, which is equivalent to consumer sharing. After all, every enterprise has private domain traffic and data is single-segmented. If(Where permitted by law)Realize the docking of data, then almost draw the whole life of consumers.

In the United States, Nike’s membership system is like this. It has cooperated with Apple, Classpass and Headspace. These companies are not randomly selected, but can be linked to sports. They belong to the cooperation of several enterprises with sports as their core values.

At the same time, Nike also has a variety of apps for different sports to help members achieve their exercise goals. Then as long as the consumer’s behavior can be recorded by the App, then you can get a reward.

Japan’s Sakya Bookstore is also this logic, which focuses on life: through the T-card system, the parent company of Sakya Bookstore has opened 887,000 stores in 179 Japanese companies in May 2018, realizing the universality of points, and the profit does not come from the points themselves, but from the big data insight of consumers. Because consumer data is no longer just a single book purchase, eating, shopping, but all the synthesis.

In China, this kind of cross-industry cooperation is also gradually emerging. For example, JD.COM Plus can give you an iQiyi member.It is also the opening of data and traffic sharing between the two parties, which in turn turns traffic into "reservation".

VI. Community system

Beauty cosmetics brand Sephora（Sephora）Beauty Insider, a membership system, must be said. On the one hand, this system can be upgraded to three grades based on consumption, and every dollar spent in each grade can get different grades of points feedback.(1 dollar for 1 point, 1.25 points, 1.5 points respectively)At the same time, there are opportunities to get more exclusive services with the improvement of grades in the traditional "hierarchical system".

Besides,The biggest feature of Sephora’s membership system is the establishment of a community-to communicate with various members, find inspiration, participate in exclusive activities and so on.At this time, members of Sephora come to the brand community, and Sephora can understand the needs of consumers and then optimize its product design.

This logic also exists in China, that is, in Xiaomi’s community, a group of fans gather in the community to communicate with each other and put forward their own needs, and Xiaomi’s product manager can collect relevant information and update the corresponding system: users feel that they are valued, and Xiaomi has obtained consumer demand and met consumer demand, and both sides are happy.

Seven, TOKEN type

The last one is the TOKEN logic in the blockchain, or,Is similar to "asset securitization"（ABS）The idea of "assets token" should be called as a kind of "assets token"（ABT）”。

This kind of logic can be seen in China. At present, it can be simply divided into two types. The first type is "commodity tokenization", which is represented by the second-hand e-commerce enjoyment theory, and the second type is "behavior tokenization". I think the representatives are interesting headlines and today’s headlines. Let’s look at it together:

"Commodity Tokenization"

The problem with second-hand e-commerce is that the seller wants to sell an item that is "emotionally connected with himself", and based on game theory, the buyer will directly regard all second-hand goods as having a problem, forming a "lemon market effect" and paying a very low price, or, no matter how wonderful your price is and how perfect the goods are, I will ask for a 20% discount first and then post it-as long as I have sold something on idle fish once.

This will greatly reduce the efficiency of the transaction, and the seller will usually feel very uncomfortable, and finally there may be problems on the "supply side", which will have a negative effect on the market.

The logic of enjoying things is very interesting, that is, instead of introducing money, users use small red flowers. Users earn small red flowers through various behaviors, such as signing in and sharing, and then "exchange" other people’s goods with their own small red flowers. Because the little red flower is not anchored with the RMB, so,Users will participate in the purchase according to their real needs, rather than the "chopping behavior" caused by "consumerism".As a result, the pressure on both buyers and sellers is reduced, which greatly promotes the circulation efficiency of goods.

This logic actually exists in offline channels, that is, "moon cake tickets", that is, the moon cakes are placed there, and the person who finally gets the tickets goes to a specific place to pick up the goods. As for the intermediate process-the goods are not moving, and the tickets are flying around, which greatly reduces the cost. The logic of this set of freight tickets is "online" and combined with the mode of second-hand e-commerce, which forms the theory of enjoying things.

"Behavior Tokenization"

The second logic is "behavior token", which is the case with interesting headlines.

To put it simply, users can be rewarded for all their behaviors on the APP, including reading gold coins, watching videos, sharing gold coins, and rewarding users with "tokens" in a different way, and then this "token" is every cycle.(The period of interesting headlines is "1 day")Will be cleared, converted into RMB, accumulated to a certain amount, you can withdraw cash-or buy other goods directly in the APP.

The logic is simple,Retaining customers requires costs, so why not give these costs directly to customers as much as possible?And these sources of RMB are also simple, just divide the gross profit of each cycle directly. So now, we will find that many apps have this logic, such as the extreme version of today’s headlines, various headline apps, and various information apps.

Related links:"Integral Incentive System" from the Perspectives of JD.COM, Interesting Headlines and Amaya.

This article comes from WeChat WeChat official account:Retail Watch (ID: On Retail), author: Wang Ziwei

Albinism is a kind of hereditary leukoplakia caused by melanin deficiency or synthesis disorder of skin and accessory organs due to tyrosinase deficiency or functional decline.

According to clinical manifestations, albinism can be divided into three categories: ocular albinism (OA), ocular skin albinism (OCA) and albinism-related syndrome, among which ocular skin albinism (OCA) is the most common and albinism-related syndrome is the rarest.

This paper mainly expounds the clinical manifestations, genetic causes and genetic counseling of OA and OCA.

Clinical manifestations of OA and OCA

Only the eye pigment in OA patients is reduced or lacking, while the eye, skin and hair in OCA patients are obviously reduced or lacking.

1, eye performance

① Iris transillumination defect (TID)-91% ~ 100% albino patients have TID.

② nystagmus

③ Fundus hypopigmentation —— It is caused by the decrease of retinal pigment epithelium and/or choroidal pigmentation, which often leads to obvious choroidal vessels in the posterior pole. It is reported that more than 94% patients with albinism have fundus hypopigmentation.

④ hypoplasia of fovea-characterized by the continuation of the inner layer of retina behind fovea and the decrease of cone photoreceptor specialization.

⑤ optic nerve abnormality

⑥ ametropia

2. Skin manifestations

The skin and hair color of albino patients may change with age.

① Skin and hair pigmentation score

Skin and hair pigmentation scores help to objectively determine the influence of hypopigmentation.

② Skin diseases

Including all albinos, regardless of skin color, the risk of ultraviolet (UV) light-related skin diseases will increase. The most important of these is skin cancer, which includes squamous cell carcinoma, basal cell carcinoma, melanoma and less common Merkel cell carcinoma.

Genetic causes of OA and OCA

The following table summarizes the genes known to be related to nonsyndromic OCA and OA. All nonsyndromic OCA are inherited by autosomal recessive mode. OA (always non-syndrome) is inherited in an x-linked manner.

The following table summarizes the genes known to be related to OCA syndrome:

Genetic counseling

1. Inheritance mode

Nonsyndromic ocular skin albinism (OCA) caused by pathogenic variation in TYR, OCA2, SLC45A2, SLC24A5, LRMDA (C10orf11) or DCT (TYRP1) is inherited in autosomal recessive way.

Ocular albinism (OA) caused by pathogenic variation in GPR143(OA1) is inherited by X linkage.

If an individual suffers from a specific syndrome related to OCA (such as Hermansky-Pudlak syndrome or Chediak-Higashi syndrome), genetic counseling is needed for this disease.

2. Autosomal recessive inheritance-risk to family members

Parents of the proband:

The parents of the affected children are presumed to be heterozygotes causing the pathogenic variation of OCA.

If molecular diagnosis has been established in the proband, it is suggested that the parents of the proband should be tested for molecular genes to confirm that both parents are heterozygotes causing the pathogenic variation of OCA and allow reliable recurrence risk assessment.

If the pathogenic variation is detected only in one parent, and the parental identity test has confirmed biological motherhood and parent-child relationship, one of the pathogenic variations identified in the proband may occur as a newborn event in the proband or as a zygote in the mosaic parent. If the proband seems to have homozygous pathogenic variation (that is, the same two pathogenic variations), other possibilities to be considered include:

The deletion of single exon or multiple exons in the proband was not detected by sequence analysis, which led to artificial homozygosity;

Parental chromosomes and single parent homomorphism of pathogenic variation lead to homozygosity of pathogenic variation among proband.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Siblings of the proband:

If it is known that both parents are heterozygotes of pathogenic variants that cause OCA, each sibling of the affected individual has a 25% chance of being affected at conception, a 50% chance of becoming asymptomatic carriers, and a 25% chance of inheriting any familial pathogenic variants.

Heterozygotes (carriers) are asymptomatic and have no risk of developing the disease.

Descendants of the proband:

The offspring of autosomal recessive OCA individuals are obligate heterozygotes (carriers) that cause the pathogenic variation of OCA.

Other family members:

Every brother and sister of the proband’s parents has a 50% risk of becoming the carrier of OCA’s pathogenic variation.

Carrier detection:

It is necessary to identify the pathogenic variation that causes OCA in the family in advance for carrier detection of at-risk relatives.

3. X-linked inheritance-risk to family members

Parents of male proband:

The father of the affected man will not suffer from this disease, nor will he be a hemizygote of the pathogenic variant GPR143; Therefore, he does not need further evaluation/testing.

In a family with more than one affected individual, the mother of the affected male is an obligate heterozygote. Note: If a woman has more than one affected child and no other affected relatives, and if family pathogenic variation cannot be detected in her white blood cell DNA, she is likely to have germline chimera.

If the male is the only affected family member (i.e., a simple case), the mother may be heterozygote, the affected male may have new pathogenic variation (in this case, the mother is not heterozygote), or the mother may have somatic/germline chimera.

It is suggested that the mother should be tested for molecular genes to confirm her genetic status and make a reliable recurrence risk assessment.

Brothers and sisters of male proband:

The risk of siblings depends on the mother’s genetic status:

If the proband’s mother has the pathogenic variation of GPR143, the chance of transmission in each pregnancy is 50%.

Men with genetic disease variation will be affected;

The female with genetic pathogenic variation will be heterozygote (i.e. carrier). Heterozygotes are usually unaffected, although they can show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

If the proband represents a simplex case and the pathogenic variation cannot be detected in the mother’s leukocyte DNA, it is assumed that the risk of sibs is low, but the risk is higher than that of the general population because of the possibility of maternal lineage mosaic.

Descendants of male proband:

The affected men spread the disease-causing mutation of GPR143 to all their daughters, but not to their sons.

Other family members:

Menstruation and maternal cousins of the male proband may be at risk of GPR143.

Note: Molecular genetic testing may be able to identify family members with new pathogenic mutations, and this information can help determine the genetic risk status of large families.

Heterozygote detection:

To identify female heterozygotes, it is necessary to identify the pathogenic variation of GPR143 in the family in advance.

Note: As carriers of this X-linked disease, women are heterozygotes, which are usually not affected, but they may show iris penetration defects, "mud splash" fundus appearance and fovea hypoplasia.

Source | Metz Medical official website

Write | ｜Anna.An

Original title: Inheritance and Manifestation of Albinism

Read the original text

　　Recently, various provinces and cities have successively disclosed the practical projects of people’s livelihood in 2025 and the provincial budget. According to statistics, up to now, more than ten provinces, including Beijing and Sichuan, have carried out or planned to carry out free vaccination programs for provincial-level female HPV vaccine.

　　According to the agency, with the successful completion of phase III clinical trials and the release of production capacity of HPV vaccine under research in China, the indications are extended to male population.ChinaThe market scale of HPV vaccine will continue to expand, and it is expected to reach 62.54 billion yuan in 2031.

　　Multi-provincial promotion

　　Since the beginning of this year, many provinces have indicated that they will launch a free vaccination program for HPV vaccine for school-age women.

　　Recently, Sichuan Province disclosed the "Report on the Implementation of the Budget in Sichuan Province in 2024 and the Draft Budget in 2025", which proposed to allocate 4.41 billion yuan for public health services. Improve the financial subsidy standard for basic public health services, support the implementation of "two cancers" free screening for school-age women, support the free vaccination of domestic bivalent HPV vaccine for eligible school-age girls, and increase support for AIDS prevention and treatment.

　　On January 26th, the General Office of the Beijing Municipal People’s Government issued the notice of "Important Livelihood Projects in Beijing in 2025", and Beijing will voluntarily vaccinate human papillomavirus vaccine for new girls in Grade One in 2025.

　　On January 10th, Tianjin Municipal Health and Health Commission formulated 16 measures to serve Tianjin Health and Health Kang Weimin in 2025, and explicitly launched the public welfare vaccination activities of reducing or exempting 450,000 doses of bivalent HPV vaccine for women aged 9-45.

　　In 2025, the work report of Yunnan provincial government put the implementation of "children’s health care and protection""Huimin Project" is listed as one of the 10 practical things to be done in 2025, and it is clearly put forward that domestic HPV vaccine should be vaccinated free of charge for eligible junior one girls in the province according to the principle of informed and voluntary.

　　In January this year, the government work report for 2025 released by Gansu Province made it clear that in 2025, we will continue to make overall arrangements for financial resources and do 10 practical things for the people, one of which is to subsidize HPV vaccination for 100,000 school-age girls on the premise of "knowing, volunteering and subsidizing".

　　In October 2024, National Health Commission held a press conference to disclose that since 2021, 11 provinces including Guangdong, Hainan, Fujian, Jiangsu, Jiangxi, Chongqing, Tibet, Zhejiang, Shandong, Hubei and Guangxi, as well as Zhengzhou,Chengdu and other cities have included HPV vaccination in the government’s practical projects for the people, and provided free HPV vaccination services for school-age girls aged 13-14 in the region through financial purchase services and fixed subsidies. Up to now, the policy of free HPV vaccination has covered about 40% of school-age girls in the country.

　　Speed up research and development

　　On January 8,It was announced that a number of new indications of tetravalent human papillomavirus vaccine (Saccharomyces cerevisiae) (trade name: Jiadaxiu, also known as tetravalent HPV vaccine) have been approved for marketing in National Medical Products Administration, which is suitable for male vaccination aged 9-26. This is the first HPV vaccine approved for male vaccination in China. Subsequently, many places announced the start of male HPV vaccination.

　　HPV infection is one of the most important public health problems in the world. Vaccination is the best way to prevent cervical cancer and other HPV-related cancers. Recently, in order to further respond to WHO’s Global Strategy for Accelerating the Elimination of Cervical Cancer, the International Papillomavirus Society needs to achieve the phased goal of "90-70-90" in 2030, and actively appeals to all countries to adopt a vaccination plan for both men and women as soon as possible, that is, to promote HPV vaccine equally to school-age boys and girls, so as to expand the coverage of vaccination and maximize the immune effect of the group.

　　Research and development of domestic nine-valent human papillomavirus vaccine is accelerated. A few days ago,It is said that the work of the phase III clinical study of the subsidiary Shanghai Zerun nine-valent HPV vaccine continues to advance. At present, the phase III clinical trial comparing the immunogenicity of this vaccine with similar vaccines is in the stage of data statistical analysis and writing clinical research reports. Based on the clinical development plan of nine-valent HPV vaccine products, the company is keeping close communication with National Medical Products Administration Drug Evaluation Center, and actively striving for the best strategy to promote the clinical research on protective efficacy.

　　At the end of August 2024, it was announced that the company’s nine-valent HPV vaccine marketing license application was accepted. After the application for registration of the nine-valent HPV vaccine is accepted, it still needs to go through comprehensive evaluation, on-site verification and other procedures, which will not have a significant impact on the company’s financial situation and operating performance in the short term. After being approved for listing, it will be conducive to the promotion and use of the company’s HPV vaccine, enrich the company’s product line, further enhance the company’s core competitiveness and lay a solid foundation for the company’s sustained and steady development.

　　Many domestic vaccine companies are also competing for the HPV vaccine market for male indications. In November 2024, it was revealed that the nine-valent HPV vaccine for male population was approved for clinical trials. In addition, on February 12, 2025,Ruike biologyIt was disclosed that the application for clinical trial of the new adjuvant recombinant nine-valent HPV vaccine developed by the company for male population was accepted in National Medical Products Administration.

　　It is estimated that its nine-valent HPV vaccine (female indication) will be submitted in China and Indonesia respectively in 2025.License application (BLA), nine-valent HPV vaccine (male indication) is expected to be submitted to BLA in 2027.

　　open-sourceIt is predicted that with the successful completion of the third phase clinical trial of HPV vaccine and the release of its production capacity, its indications will be extended to the male population, and the vaccination awareness of the target population will continue to increase, and the market scale of HPV vaccine in China will continue to expand, which is expected to reach 62.54 billion yuan in 2031.

　　ASEAN countries are located at the intersection of land and sea in the Belt and Road Initiative, and are key areas for high-quality joint construction of the Belt and Road Initiative. In the past 10 years since the Belt and Road Initiative was put forward, from economic and trade exchanges to cultural exchanges, China-ASEAN Expo’s circle of friends has become larger and larger, and its outward attraction has become stronger and stronger.

　　— — — — — — — — — —

　　The 20th China-ASEAN Expo came to an end not long ago, but the vision of China and ASEAN countries meeting challenges together and building a closer China-ASEAN destiny community is inspiring people to move forward.

　　"This year, the Chairman of the Supreme Leader proposed to build a closer China-ASEAN destiny community and jointly build ‘ Belt and Road ’ The 10th anniversary of the initiative is also the 20th anniversary of the founding of China-ASEAN Expo and China-ASEAN Business and Investment Summit (hereinafter referred to as "China-ASEAN Expo" and "Summit" respectively). China — Wei Zhaohui, Secretary-General of the ASEAN Expo Secretariat, said that since China-ASEAN Expo and the Summit were held for 20 years, the bilateral trade volume between China and ASEAN has grown at an average annual rate of more than 13%, which has promoted the two sides to become each other’s largest trading partners and the most active partners in mutual investment, and helped to build a new pattern of China-ASEAN opening up at a higher level.

　　According to Xu Ningning, executive director of the China-ASEAN Business Council, ASEAN countries are located in the land-sea intersection of the "Belt and Road" and are key areas for building the "Belt and Road" with high quality. In the 10 years since the "Belt and Road Initiative" was put forward, China-ASEAN Expo has closely followed China — The needs of the times of ASEAN cooperation, constantly expand the functions of the platform, and promote the implementation of China — A series of consensus documents, joint statements and action plans reached by ASEAN have deepened China’s trade, investment, interconnection and regional cooperation with ASEAN countries, which is also the way to China-ASEAN Expo’s enduring success.

　　Inter-regional complementary resources promote active investment and trade.

　　The theme of the 20th China-ASEAN Expo is "Building a Home with Harmony, Destiny and Common Future — — Push ‘ Belt and Road ’ High-quality development and building an economic growth center. " At the meeting, many exhibitors expressed that they felt the dividends brought by the complementary market resources and factor flow between China and ASEAN. Zhu Qiugen, from Xishuangbanna, Yunnan, talks about tea at the exhibition during the day and packs tea for customers from all over the world in the hotel at night.

　　This year is his second time in China-ASEAN Expo, and he found that many tea lovers used to look at the price but now at the quality. "More and more customers have found me for the fragrance of tea, and people who understand the good products have found it. This change is more gratifying than how much tea I have sold."

　　Zhu Qiugen deals in ancient tea from Laos. The local tea garden employs local people to pick fresh tea and process it into "wool", and then it is transported to Xishuangbanna via China-Laos Railway for further processing to make a series of products such as tea cakes and tea bricks. Zhu Qiugen also founded the brand of "Laos Ancient Rhyme Tea Industry".

　　In recent years, thanks to the convenience of transportation and policies, Zhu Qiugen went deep into the country of origin and built a relatively complete industrial chain from picking, research and development, production and sales. "Let customers drink a cup of ancient tree tea that really comes from the mountains, without middlemen." In this way, the quality and cost have been well controlled.

　　The tea consumption market in China is huge, and the demand for high-quality tea has become a trend. Zhu Qiugen thinks that tea is a gentle lifestyle and a product that pursues quality of life. However, the domestic resources for picking ancient tree tea are limited, and some merchants have false propaganda and shoddy to some extent, which makes many consumers hesitate to buy.

　　In 2015, Zhu Qiugen just arrived in Laos, and he was doing hotel business at that time, but soon the local ancient tree tea fragrance caught his attention. In Laos, the unique and closed natural environment creates the good quality of Laos ancient tree tea, but these teas are mostly sold as agricultural products. "Laos has raw materials, and China has a market, so the connection naturally arises." Zhu Qiugen said.

　　With the opening of China-Laos Railway, Zhu Qiugen’s tea business has more convenient transportation conditions. If the tea is to be sold to Nanning market, Zhu Qiugen will choose to go by sea through Vietnam, which is "more cost-effective".

　　Guangxi is the only land-sea connecting region between China and ASEAN. The coastal, border and riverside areas of China-ASEAN Industrial Cooperation Zone are the frontier and window of Guangxi’s opening to the outside world. Relying on the existing parks in Nanning, Beihai, Fangchenggang, Qinzhou, Yulin, Baise and Chongzuo, Guangxi has integrated the construction of China-ASEAN Industrial Cooperation Zone, creating a development pattern of "one city, one area, one park". At present, many areas in the cooperation zone have achieved seamless traffic connection with ASEAN countries. For example, Chongzuo area is 180 kilometers away from Hanoi and Nanning, the capital of Vietnam, and there are four national first-class ports around it, which is the most convenient land international passage from China to Indo-China Peninsula.

　　"In July this year, Liuzhou Economic and Trade Delegation and 32 key enterprises went to Southeast Asia to carry out economic and trade exchange activities." Yao Fang, deputy director of the Management Committee of Liuzhou Economic and Technological Development Zone, said that the well-known domestic new energy automobile brands with factories in Liuzhou have actively gone abroad, and now they have sales markets in 72 countries and regions around the world.

　　The vigorous market demand drives the pace of transportation infrastructure construction. Sima Zhe, senior economist of the Asian Infrastructure Investment Bank and head of the ecosystem of the Ministry of Economic Affairs, said that in 2021, the AIIB provided 300 million US dollars to support the improvement project of border connectivity in Chongzuo, Guangxi, which improved the efficiency of cross-border connectivity around Shuolong Port and strengthened the economic and trade activities between China and Viet Nam.

　　In terms of commodity trading, the exchanges between Guangxi and ASEAN have become increasingly close. Guangxi is rich in commodity resources, with the output of white sugar, wood and raw silk ranking first in the country, and the output of alumina, pigs, pulp, Chinese herbal medicines and non-ferrous metals ranking first in the country. At the same time, Guangxi is also an important import port for ASEAN-specific commodities such as wood, non-ferrous metals, oil and gas, coal and fruits.

　　Li Kaizhou, deputy director of the local financial supervision bureau of Guangxi Zhuang Autonomous Region, said that in recent years, Guangxi has seized green opportunities, deepened cooperation with ASEAN, built a pilot free trade zone with high quality, and actively created a convenient place for domestic and international dual-cycle markets. The construction of new land and sea channels in the west has been accelerating. From January to July this year, Guangxi’s import and export to ASEAN was 188.08 billion yuan, a year-on-year increase of 71.6%.

　　Adhere to joint business and win-win sharing.

　　Wei Zhaohui, Secretary-General of China-ASEAN Expo Secretariat, said that since the China-ASEAN Expo and China-ASEAN Investment Summit were held 20 years ago, 196 Chinese and foreign leaders, more than 4,100 ministerial-level VIPs and heads of international organizations attended, which was accompanied by friendly relations between China and ASEAN and grew together with the construction of China-ASEAN Free Trade Area.

　　"China-ASEAN Expo has been successfully held for 20 years in a row, thanks to the unique exhibition mode. This is the successful password for China-ASEAN Expo to do something new and better." Wei Zhaohui introduced.

　　Adhere to business cooperation and win-win sharing, adhere to the principle of not making profits for ASEAN countries, respect ASEAN’s opinions on major issues, and give priority to meeting ASEAN’s needs in terms of booth arrangement. In this China-ASEAN Expo, the scale and proportion of ASEAN exhibitions remain the largest in China International Exhibition, and seven countries including Indonesia, Malaysia and Viet Nam have resumed their pavilions and restored ASEAN’s "Charming City" exhibition area.

　　Wei Zhaohui introduced that in all aspects of exhibition preparation, we should respect the ASEAN way, take care of ASEAN wishes, and always adhere to the value concept of "10+1>11". The ministers of economy and trade of China and 10 ASEAN governments and the ASEAN Secretary-General will serve as co-directors of the organizing committee, the directors of departments in charge of various countries will serve as deputy secretaries-general, and the directors will serve as liaison officers. Major issues will be discussed by the organizing committee meetings and senior officials meetings.

　　"International Friendship City Entering Dongbo" is also a highlight of the exhibition in recent years. According to the data of Foreign Affairs Office of Guangxi Zhuang Autonomous Region, at present, Guangxi has concluded 128 pairs of international sister cities with 39 countries, ranking fourth in the country. During this visit to China-ASEAN Expo, more than 30 sister cities from nearly 20 countries participated in the exhibition with their own special products.

　　"Before, our market was mainly concentrated in Jiangsu, Zhejiang and Shanghai. I never thought that the products could radiate to the inland of China and even ASEAN countries." Hong Yongwang, representing Zaragoza, Spain, said that Zaragoza and Yulin, Guangxi Zhuang Autonomous Region are international sister cities. Entrusted by the Zaragoza municipal government, Hong Yongwang brought more than 160 products including red wine, ham and olive oil to the site in China-ASEAN Expo.

　　Last year, the double-deck sinking square of Nahong Interchange Station of Nanning Metro, designed and built jointly by Nanning and Crema, Italy — — Friendship City Metro Plaza was officially completed, becoming the first subway station space in China that was fully decorated and designed by International Friendship City. At this year’s China-ASEAN Expo, exhibitor Zhang Xiaowei brought a painting entitled "Table Culture" to the scene to explain the Italian wine culture to the audience, and the author of this painting, Marilisa Leon, is the designer of the subway station space. Stephania Bonaldi, mayor of Crema, Italy, commented: "The design of the square is closely related to the theme of the Silk Road, which has brought the cultural ties between China and Italy closer and the two countries and peoples closer."

　　Institutional opening stimulates new kinetic energy of cooperation

　　From economic and trade exchanges to cultural exchanges, China-ASEAN Expo’s circle of friends is getting bigger and bigger, and its outward attraction is getting stronger and stronger. In the process of cooperation between China and ASEAN countries, many institutional and mechanistic modes of cooperation and dialogue have gradually taken shape.

　　During this year’s China-ASEAN Expo, a side event on the theme of "Institutional Opening: A New Pattern of Regional Economic Development" was held for the first time, and the "ASEAN National Standardization Cooperation and Exchange Center" was officially unveiled. The ASEAN cross-border e-commerce digital intelligence service platform and the e-commerce exchange center of the digital economy industrial park were announced to be open.

　　According to customs statistics, from January to August this year, the total import and export value of China to countries that jointly built the Belt and Road Initiative reached 12.62 trillion yuan, up 3.6% year-on-year, of which food trade reached 553.82 billion yuan, up 10.4% compared with the same period of last year and 162% compared with the same period of 2013. On the eve of the opening of China-ASEAN Expo, the Nanning Declaration on Customs Food Safety Cooperation on the Belt and Road was issued, and all parties signed the articles of association of the cooperation mechanism.

　　The perfection of the mechanism and articles of association aims at more convenient, long-term and stable factor flow. It is the consensus of many enterprises that "there is vitality when there is mobility, and there is market when there is mobility".

　　Last year, Guangxi Xinzhong Industrial Investment Co., Ltd. cooperated with the secretariat of China-ASEAN Expo to build a China-ASEAN special commodity gathering center. He Yan, the company’s deputy general manager, hopes that after participating in China-ASEAN Expo, economic and trade activities will continue for a long time through 17 offline pavilions and online platforms, and continuous economic and trade exchanges will take place with ASEAN countries in 365 days.

　　The international situation is complex and changeable, but the potential of the ASEAN market is constantly being released. "The number of ASEAN regional offices has grown particularly fast, exceeding our growth rate in China." Through this detail, Bo Yu, managing partner of PricewaterhouseCoopers Consulting (Shenzhen) Co., Ltd., found that the ASEAN market is being regarded as a growth point in the future, both in China and the world.

　　Bo Yu further analyzed that people value the population and future growth of ASEAN, and the population structure is relatively young. He believed that Guangxi should make good use of the role of "bridgehead".

　　As an Indonesian enterprise, Jinguang Group has been rooted in China for more than 30 years. Zhai Jingli, vice president of Jinguang Paper (China) Investment Co., Ltd., a subsidiary of Jinguang Group, believes that enterprises can make use of the cumulative rule of regional origin of RCEP and the advantage of the shortest and most convenient industrial supporting distance between Guangxi and ASEAN to expand the ASEAN market and play a good "ASEAN brand".

　　At present, some ASEAN countries have many environmental problems, such as soil degradation, water shortage and air pollution, which have affected local agricultural production and tourism and damaged local economic development to some extent. With the increasing demand for environmental protection in ASEAN countries, China’s environmental protection industry has gradually entered the ASEAN market. Hong Tao, director and professor of business economics research at Beijing Technology and Business University, pointed out in the China-ASEAN Forum on Innovation and Development of Commodity Trading that the effective implementation of RCEP has provided new impetus and cooperation foundation for promoting green recovery of regional economy, low-carbon development and global economic recovery, and reduced the cost of environmental protection industry in China.

　　In the past 20 years, the cooperation between China and ASEAN in the field of energy and electricity has been equally fruitful. By the end of August this year, China Southern Power Grid had been connected with the power grids of ASEAN countries through more than 10 circuits of 110 kV and above, achieving a total cross-border two-way power trade of nearly 70 billion kWh, of which clean energy accounted for over 90%. Hu Tianxiang of China-ASEAN Expo and china huadian Guangxi Company introduced that china huadian has invested in 9 projects under construction in ASEAN, with an installed capacity of 4.66 million kilowatts. In Cambodia, china huadian is the largest foreign power generation operator in Cambodia with an installed capacity of 1.038 million kilowatts under construction.

　　RCEP has entered a new stage of full entry into force and implementation, constantly releasing the strategic potential of economy and trade. Zhou Shi, a researcher and deputy director of the Research Office of the Market and Price Research Institute of the National Development and Reform Commission, believes that the import and export of Hunan and ASEAN countries in China increased by more than 70% in the year when RCEP was implemented, and the import and export of Guangxi to ASEAN countries also increased by 71.6% from January to July this year.

　　In the face of the current complicated and changeable international situation, many exhibitors realized that China and ASEAN are opportunities for mutual development and have great potential for cooperation. China was the first big country to sign and join the Treaty of Amity and Cooperation in Southeast Asia. In 2021, China and ASEAN upgraded their bilateral relations to a comprehensive strategic partnership.

　　Jiangsu Furen Group’s booth area in the 20th China-ASEAN Expo was not large, but the personnel in charge of market, operation and technology all came to the scene in order to better understand the ASEAN market and enterprises. In 2014, Jiangsu Furen Group held Jiangsu Xuzhou Forging Machine Group Co., Ltd., and two years later, it successfully acquired German EBU Forming Technology Co., Ltd. "This also marks that China Press has begun to rank among the world’s advanced manufacturing." Li Wei, deputy general manager of Xuforging Group, said that due to the rapid development of Thailand’s automobile industry in recent years, many internationally renowned automobile companies have invested and built factories in Thailand, and the export of intelligent forging equipment of Xuforging Group to Thailand has also increased by 20%-30%.

　　"The ASEAN market is becoming a new strategic growth point, especially in terms of labor structure, operating costs and market potential. The implementation of RCEP has also provided us with a stable and efficient supply chain network." Li Wei is full of expectations for the development of enterprises in the ASEAN market and the prospect of international cooperation. "We will also continue to enhance the technological breakthrough capability of intelligent manufacturing and better go abroad." (Zhongqing Daily Zhongqing Net Trainee Reporter Wang Junli Reporter Xie Yang Intern Zheng Quan)

　　Recently, the Central Network Information Office, the Ministry of Agriculture and Rural Affairs, the National Development and Reform Commission, the Ministry of Industry and Information Technology, and the National Rural Revitalization Bureau jointly issued the Key Points of Digital Rural Development in 2022 (hereinafter referred to as the Key Points). The circular calls for adhering to the guidance of the Supreme Leader’s Socialism with Chinese characteristics Thought in the New Era, fully implementing the spirit of the 19th National Congress of the Communist Party of China and the previous plenary sessions of the 19th National Congress, thoroughly implementing the spirit of the Central Economic Work Conference and the Central Rural Work Conference, and conscientiously implementing the Opinions of the Central Committee of the Communist Party of China and the State Council on Doing a Good Job in Comprehensively Promoting Rural Revitalization in 2022, the Strategic Outline for the Development of Digital Villages, and the National Informatization Plan for the 14th Five-Year Plan. Give full play to the driving and empowering role of informatization in rural revitalization, accelerate the construction of a digital economic system that leads rural industrial revitalization, build a digital governance system that adapts to the development of urban-rural integration, constantly promote new progress in rural revitalization, and push the construction of digital China to a new step.

　　The "Key Points of Work" defines the work goal: by the end of 2022, new and greater progress will be made in the construction of digital villages. Digital technology has strongly supported the foundation of agriculture to be more stable, and the results of poverty alleviation have been further consolidated. The construction of rural digital infrastructure continued to advance, and 5G networks covered key towns and some key administrative villages. The Internet penetration rate in rural areas exceeded 60%. The rural digital economy has accelerated, the level of agricultural production informatization has steadily improved, and the retail sales of agricultural products e-commerce network has exceeded 430 billion yuan. The rural digital governance system has been continuously improved, the information service for the benefit of the people has been continuously deepened, farmers’ digital literacy and skills have been effectively improved, and the pilot construction of digital villages has achieved initial results.

　　The "Work Points" deployed 30 key tasks in 10 aspects. The first is to build a digital barrier to food security, including strengthening the monitoring of information on stable agricultural production and supply, and improving the digital level of farmland construction management. Second, continue to consolidate and improve the effectiveness of network assistance, including strengthening dynamic monitoring and assistance to prevent poverty, and optimizing and improving network assistance measures. The third is to speed up the filling of the shortcomings of digital infrastructure, including continuously promoting the construction of rural network infrastructure and promoting the digital transformation and upgrading of rural infrastructure. Fourth, vigorously promote the construction of smart agriculture, including consolidating the foundation of smart agriculture development, accelerating the digital transformation of agriculture, strengthening the supply of agricultural science and technology innovation, and improving the digital level of agricultural product quality and safety traceability. The fifth is to cultivate new formats of rural digital economy, including deepening the development of agricultural products e-commerce, cultivating and developing new formats of rural areas, strengthening rural digital financial services, and strengthening the information management of rural resource elements. Sixth, the prosperity and development of rural digital culture, including strengthening the construction of rural network culture positions and promoting the digitalization of outstanding rural cultural resources. The seventh is to improve the efficiency of rural digital governance, including promoting the intelligentization of rural party building and village management, improving the digitalization level of rural social governance, promoting the intelligentization of rural emergency management, and using digital technology to help rural epidemic prevention and control. Eighth, expand the digital service space for benefiting the people, including developing "Internet+education", "Internet+medical health", improving social security information services, deepening employment and entrepreneurship information services, and promoting rural consumption upgrading.The ninth is to speed up the construction of smart green villages, including improving the monitoring level of rural natural resources and ecological environment and strengthening the digital governance of rural human settlements. The tenth is to promote the construction of digital villages as a whole, including strengthening overall coordination and pilot construction, strengthening policy guarantee and financial services, and strengthening the construction of digital rural talents.

　　Key points of digital rural development in 2022

　　The year 2022 is a crucial year for comprehensively promoting rural revitalization and accelerating agricultural and rural modernization during the Tenth Five-Year Plan period. It is of special significance to stabilize the basic agricultural sector and do a good job in "agriculture, countryside and farmers". The development of digital villages should adhere to the guidance of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, fully implement the spirit of the 19th National Congress of the Communist Party of China and the previous plenary sessions of the 19th National Congress, thoroughly implement the spirit of the Central Economic Work Conference and the Central Rural Work Conference, and conscientiously implement the Opinions of the Central Committee of the Communist Party of China and the State Council on Doing a Good Job in Comprehensively Promoting Rural Revitalization in 2022, the Strategic Outline of Digital Village Development and the National Informatization Plan of the 14th Five-Year Plan. Give full play to the driving and empowering role of informatization in rural revitalization, accelerate the construction of a digital economic system that leads rural industrial revitalization, build a digital governance system that adapts to the development of urban-rural integration, constantly promote new progress in rural revitalization, and push the construction of digital China to a new step.

　　I. Work objectives

　　By the end of 2022, new and greater progress will be made in the construction of digital villages. Digital technology has strongly supported the foundation of agriculture to be more stable, and the results of poverty alleviation have been further consolidated. The construction of rural digital infrastructure continued to advance, and 5G networks covered key towns and some key administrative villages. The Internet penetration rate in rural areas exceeded 60%. The rural digital economy has accelerated, the level of agricultural production informatization has steadily improved, and the retail sales of agricultural products e-commerce network has exceeded 430 billion yuan. The rural digital governance system has been continuously improved, the information service for the benefit of the people has been continuously deepened, farmers’ digital literacy and skills have been effectively improved, and the pilot construction of digital villages has achieved initial results.

　　Second, the key tasks

　　(A) to build a digital barrier to food security

　　1. Strengthen information monitoring of stable agricultural production and supply. Strengthen digital supervision in the field of grain purchase and sale, and speed up the construction of a digital supervision system with full coverage, whole chain and whole process of central and local governments. Establish and improve the market monitoring and early warning system of important agricultural products, and strengthen regulation and emergency support by classification and variety. Upgrade and improve the integrated platform of national and provincial agrometeorological services, promote the application of meteorological monitoring technologies such as satellite remote sensing and soil moisture data fusion, carry out refined agrometeorological disaster forecasting and early warning, and improve the ability of food safety meteorological services.

　　2. Improve the digital level of farmland construction management. Accelerate the establishment of a national comprehensive monitoring and supervision platform for farmland construction, improve the permanent basic farmland database, and build a "one map" of farmland construction in the country. Comprehensive use of satellite remote sensing and other monitoring technologies to strengthen the whole process monitoring and accurate management of high-standard farmland. We will further promote the national black soil protection project and explore the use of remote sensing monitoring and information management to supervise the quality of black soil cultivated land. Using satellite remote sensing images and information technology, we will strengthen the dynamic monitoring of "non-agricultural" and "non-grain" of cultivated land and permanent basic farmland throughout the country.

　　(2) Continue to consolidate and improve the effectiveness of network assistance.

　　3. Strengthen dynamic monitoring and assistance to prevent poverty. Improve and optimize the monitoring information system to prevent poverty, and include farmers who are at risk of returning to poverty and suddenly have serious difficulties in the monitoring scope. In view of the emerging problems found due to disasters, causes and epidemics, timely implement social assistance, medical security and other assistance measures. Promote the construction of dynamic monitoring information platform for low-income population, and strengthen the active discovery mechanism, dynamic monitoring and hierarchical classification assistance for rural low-income population.

　　4. Optimize and improve the network assistance measures. Increase support for the upgrading and transformation of broadband networks in poverty-stricken areas, especially in key counties for national rural revitalization. Continue to carry out accurate fee reduction for poverty-stricken households. Continue to promote the construction of key radio and television projects that benefit the people. Comprehensively improve the operational service level of agricultural and sideline products online sales platform in poverty-stricken areas and expand the sales scale of agricultural products in poverty-stricken areas. Using the new generation of information technology to consolidate and expand the achievements of ecological poverty alleviation. Encourage central enterprises to actively develop digital rural projects in poverty-stricken areas in combination with fixed-point assistance work, and strengthen infrastructure construction, innovation of operation mode and coverage of interest linkage. Relying on the action of "making every enterprise prosper every village", we will guide private enterprises to support the construction of digital villages in poverty-stricken areas. Give full play to the advantages of online letter enterprises and continue to carry out public welfare projects of digital village cohesion action.

　　(C) to speed up the completion of digital infrastructure shortcomings

　　5. Continue to promote the construction of rural network infrastructure. Continue to deepen the universal service of telecommunications and promote the breadth and depth coverage of rural optical fiber and 4G networks. Facing rural and remote areas with conditions and needs, we will gradually promote the construction of Gigabit optical fiber networks and accelerate the use of low frequencies to carry out rural 5G network coverage. Fill in the shortcomings of communication network facilities in border areas, and comprehensively use satellite communication and other access means to provide users with broadband network access services. Implement smart radio and television rural projects and continue to promote the special action of smart radio and television to serve rural revitalization.

　　6. Promote the digital transformation and upgrading of rural infrastructure. Further improve the digital management mechanism of rural roads and strengthen the construction of basic data statistics, collection and sharing mechanisms. Vigorously promote the construction of smart water conservancy, and continue to carry out digital twin basins and digital twin water conservancy projects. Accelerate the improvement of water conservancy infrastructure system in rural areas and promote the intelligent transformation of water conservancy infrastructure. Continue to implement rural power grid consolidation and upgrading projects to improve rural power supply reliability and power supply support capacity. Support business circulation, postal service and express delivery enterprises to strengthen the infrastructure construction of cold chain logistics in agricultural products producing areas and actively promote the informationization of cold chain logistics.

　　(D) Vigorously promote the construction of smart agriculture

　　7. Consolidate the foundation for the development of smart agriculture. Continue to promote the application of high-scoring satellite data in agricultural remote sensing. Actively promote the coverage of mobile Internet of Things in rural areas and increase the deployment of narrowband Internet of Things (NB-IoT) in agricultural production scenarios. Accelerate the construction and application of agricultural and rural big data, focus on building a national agricultural and rural big data platform, establish and improve the agricultural and rural data resource system, and build a "one map" of national agricultural and rural big data. Relying on the national seed industry big data platform, the database of agricultural germplasm resources was constructed. Further promote the construction of big data in the whole industry chain of single varieties of important agricultural products.

　　8. Accelerate the digital transformation of agriculture. Vigorously promote the application of digital breeding technology, build a digital breeding service platform, accelerate the transformation from "experience breeding" to "precision breeding", and gradually develop design breeding. Accelerate the application of information technology in agricultural production and operation, and improve the efficiency of agricultural production and operation. Strengthen the digital coordination of the whole grain industry chain, and promote the whole chain of grain production, purchase, storage and marketing. Improve the function of the national grain trading platform and develop mobile transactions. Accelerate the digital transformation of supply and marketing service outlets and build a comprehensive platform for "digital supply and marketing" to serve agriculture. Continue to do a good job in promoting the implementation, supervision and management of digital agriculture and rural projects, and further give play to the demonstration and leading role of agricultural and rural informatization demonstration bases.

　　9. Strengthen the supply of agricultural science and technology innovation. Strengthen the R&D and manufacturing of high-end intelligent agricultural machinery and equipment, and implement the national key R&D plan "Key technologies and intelligent agricultural machinery and equipment in factory farming" and "R&D and integrated application of common key technologies in rural industries". Using special support to adapt to a number of agricultural machinery and equipment such as rice planting machinery in southern hilly areas. Implement the subsidy policy for agricultural machinery purchase and application, and promote the application of Beidou intelligent terminal in agricultural production. Accelerate the preparation of the national agricultural machinery and equipment industry measurement and testing center. Build an information management service system for science and technology commissioners to improve their service efficiency.

　　10 to improve the quality and safety of agricultural products traceability digital level. Improve the national agricultural product quality and safety traceability management information platform. Continuously improve the traceability information system for organic product certification, and further optimize the public inquiry service of the certification information system for food and agricultural products. Guide leading grain processing enterprises and "China Good Grain and Oil" demonstration enterprises to carry out quality traceability. Accelerate the application of traceability platform for agricultural materials quality and safety in China, and build and improve the national cotton industry information platform.

　　(E) Cultivate new formats of rural digital economy

　　11. Deepen the development of agricultural products e-commerce. Further promote the project of "internet plus" agricultural products leaving the village and entering the city. We will continue to deepen the concept of "developing agriculture with a number of merchants", cultivate and promote online brands of agricultural products, carry out certification, funding and promotion of characteristic agricultural products, and promote the development of characteristic industries with branding. We will promote the work of postal express service for agricultural special products from villages to cities, cultivate modern agricultural demonstration projects for express service, build a demonstration zone for the coordinated development of rural e-commerce express delivery, and continue to promote the integrated development of transportation and postal express delivery. In-depth implementation of the youth rural e-commerce cultivation project, the formation of "Qingyun China" live broadcast to help agriculture alliance, and extensive "Qingyun China" live broadcast to help agriculture activities. We will continue to develop "women’s e-commerce" and cultivate industries that support women’s advantages and characteristics.

　　12. Cultivate and develop new rural formats. Strengthen the brand building of key villages and towns in rural tourism, and increase the online promotion of rural tourism brands. Improve the rural tourism monitoring system. Continue to hold the Yangtze River Delta Rural Cultural Travel Maker Conference to promote the effective combination of entrepreneurial innovation and rural revitalization. Promote the development of new Internet-based formats such as leisure agriculture, creative agriculture and adoption agriculture. Relying on China National Geographical Names Information Database, we will deepen the promotion of rural geographical names information service.

　　13. Strengthen rural digital financial services. Continue to promote the development of rural digital inclusive finance, and actively and steadily carry out the construction of inclusive finance Reform Experimental Zone. Increase the application and promotion of financial technology in rural areas, and accelerate the research and development of financial products suitable for the needs of farmers and new agricultural business entities. We will further promote the construction of rural credit system and continuously improve the coverage of credit. We will continue to promote the construction of rural payment service environment, promote online processing channels and fund collection services for central bank account business of rural financial institutions, and promote the sinking of mobile payment convenience services to rural areas in counties.

　　14. Strengthen the information management of rural resource elements. Improve the national, provincial, city, county and other interconnected rural land contract information application platforms, and steadily carry out online signing of rural land contract. Guide all localities to improve the online signing system of rural contracted land management rights transfer contracts, and improve the standardization and information management level of rural contracted land management rights transfer. Encourage all localities to establish a network trading platform for the transfer of rural contracted land management rights, and standardize services such as policy consultation, information release, contract signing, transaction verification, rights evaluation, financing guarantee, and file management. Explore the construction of rural homestead database and management information system.

　　(VI) Prospering and developing rural digital culture.

　　15. Strengthen the construction of rural network culture positions. We will continue to deepen the construction of county-level media integration centers and expand the coverage of public welfare projects for East-West cooperation and exchange in county-level media integration centers. Increase support for online audio-visual programs on the theme of agriculture, rural areas and farmers, and enhance the supply of high-quality content resources. Standardize the Internet religious information service, strengthen the supervision and disposal of harmful information on the Internet in rural areas, and vigorously publicize the party’s religious work theory, principles and policies. We will continue to carry out various special actions such as "Clean Net" and "Clear Lang" to create a safe and healthy network environment for children in rural areas.

　　16. Promote the digitalization of outstanding cultural resources in rural areas. We will strengthen the excavation and protection of outstanding traditional cultural resources in rural areas, further promote the key projects of the 14 th Five-Year Plan for the inheritance and development of Chinese outstanding traditional culture, and continue to promote the implementation of the national cultural digitalization strategy. We will continue to improve the construction of digital museums of famous historical and cultural towns and villages and traditional villages in China, and promote the implementation of ethnic village projects in Yunshang. Relying on the rural digital cultural relics resource library and digital exhibition, we will promote the digital permanent preservation and open utilization of rural cultural relics resources.

　　(7) Improve the efficiency of rural digital governance.

　　17. Promote the wisdom of rural party building and village management. Optimize and upgrade the modern distance education system for cadres in party member, and constantly improve the informationization and scientific level of rural grassroots party building work. Accelerate the full coverage of online government services at the provincial, city, county, township (town, street) and village (community) levels, strengthen the construction of city and county government service platforms, and provide accurate and refined government services for rural residents. Implement the village-level comprehensive service upgrading project to improve the informationization and intelligence level of village-level comprehensive services. Accelerate the construction of a comprehensive information management platform for rural housing, and improve the informatization level of rural housing construction management and service.

　　18. Improve the digital level of rural social governance. Explore and promote the new model of digital rural governance and expand the digital application scenarios of rural governance. Carry out standardization construction of grid service management, and deepen the construction of Zhi ‘an community and safe countryside. Continue to strengthen the networking application of video image system construction in rural public areas, and actively promote the in-depth application of video image resources in epidemic prevention and control, disaster prevention and mitigation, emergency management and other industries and fields. Continue to carry out the activities of "rural revitalization and rule of law", further promote the construction of public legal service platform, further strengthen the popularization and application of mobile intelligent mediation system, and accelerate the construction of a modern public legal service system covering urban and rural areas, which is convenient, efficient, equal and inclusive.

　　19. Promote the wisdom of rural emergency management. Improve the intelligent digital grid forecasting technology system, promote the accurate early warning signals of heavy rain and sudden strong convection in local areas to townships (towns and streets), and build an extreme weather monitoring and early warning service system. Relying on the integrated monitoring system of air, space and earth, strengthen disaster risk monitoring in rural disaster-prone areas. We will implement projects such as informatization of natural disaster monitoring and early warning, rapid reporting and early warning of national earthquake intensity, and strengthen early warning information services for remote rural areas, pastoral areas and mountainous areas. Continue to carry out publicity and education on disaster prevention and mitigation in rural areas.

　　20. Use digital technology to help rural epidemic prevention and control. Strengthen the monitoring of rural epidemic information, upgrade the communication big data platform, support the accurate prevention and control of rural normalized epidemic situation and the emergency response of local epidemic situation, and improve the accuracy and timeliness of regional investigation data. Promote national mutual recognition of health codes and one code communication. Make full use of the Internet, emergency broadcast terminals and other information means to carry out vaccination, epidemic prevention and control and other aspects of policy measures and knowledge popularization and publicity.

　　(8) Expanding the service space of digital benefiting the people.

　　21. Develop "Internet+Education". Accelerate the construction of new educational infrastructure, continuously improve the network construction of rural primary and secondary schools, and improve the network carrying capacity and service quality of primary and secondary schools. Through satellite TV and broadband network, high-quality educational resources are delivered to weak schools and teaching points in rural areas. Constantly improve the national public service system of digital education resources, strengthen the function of the national smart education platform for primary and secondary schools, and promote the cooperation between digital resources and the East. Continue to carry out special training and donation activities on educational informatization, and improve the educational informatization literacy of teachers and students in rural areas. We will continue to research and develop digital national common language learning resources, and continue to carry out research and development of national language informatization.

　　22. Develop "Internet+medical health". Build an authoritative, unified and interconnected national health information platform, and promote all kinds of medical and health institutions at all levels to be included in the regional national health information platform. Steadily promote the intensive cloud deployment of information systems in medical institutions. Promote the "Internet+Medical Health" and "Five Ones" service actions, continue to strengthen the construction of telemedicine service networks, and promote the sinking of quality medical resources. Guide local governments to explore the construction of grassroots digital health communities. Continue to promote the application service of electronic license and promote the joint office of "one thing is born". We will further promote the service of "internet plus Traditional Chinese Medicine" and deepen the popularization and application of the health information platform of the Chinese Medicine Museum. Accelerate the application of a unified national medical security information platform, and gradually establish an information sharing mechanism for medical expenses of patients. Before the end of 2022, at least one designated medical institution in each county will realize the direct settlement of medical expenses including outpatient expenses across provinces.

　　23. Improve social security information services. We will continue to improve the construction of a unified national social insurance public service platform, establish a "one-card" service for residents with social security cards as the carrier, further optimize rural grassroots social security services, and continuously expand the scope of services. Accelerate the popularization and application of the national social assistance system and promote the extension of social assistance services to the mobile terminal. We will broaden the service mode of "cross-provincial general office" for two subsidies for the disabled and promote the realization of "full-course network office". Increase the supervision function of the national information system of two subsidies for the disabled, and improve the accuracy of subsidies. Carry out the aging and barrier-free transformation of Internet websites and apps, and formulate the aging and barrier-free transformation plan for localized Internet applications.

　　24. Deepen employment and entrepreneurship information services. We will continue to improve the construction of employment information platform and strengthen the employment monitoring and analysis of poverty-stricken population, migrant workers, rural youth and other groups. Make full use of the internet platform to collect job information, and broaden the channels for farmers to go out for employment and find jobs nearby. Carry out vocational skills training for groups such as rural migrant workers and returning migrant workers, and support and help them find jobs and start businesses. Promote Internet enterprises to carry out Internet-assisted agricultural projects in rural areas, and open up new channels for farmers to increase their income.

　　25. Promote the upgrading of rural consumption. We will continue to implement county-level commercial construction, expand the coverage of rural e-commerce, improve the three-level logistics distribution system in counties and villages, and promote the expansion, upgrading and upgrading of rural consumption. Support large-scale commercial circulation enterprises, e-commerce platforms and other service enterprises to extend to rural areas, and accelerate brand consumption and quality consumption into rural areas. Accelerate the construction of rural delivery logistics system, promote the "express delivery into the village" project by classification, and promote the joint distribution of rural delivery logistics. Promote universal postal coverage in border villages. Guide traditional business circulation and postal enterprises to strengthen data-driven, promote digital product innovation, intelligent operation management and accurate service for agriculture, and support enterprises to accelerate digital and chain transformation and upgrading.

　　(9) Accelerate the construction of smart green villages.

　　26. Improve the monitoring level of rural natural resources and ecological environment. We will continue to organize the investigation and monitoring of natural resources, the construction of real-life three-dimensional China, and expand the construction of three-dimensional "one map" of natural resources, the basic information platform of land and space, and the application system of natural resources supervision and decision-making. Explore and promote the construction of national ecological monitoring, evaluation and early warning system, including rural areas. Accelerate the construction and application of forest and grass ecological network perception system, and promote the "real use and real connection" and "interconnection" of all related business systems of the perception platform. Promote the selection of national forestry and grass information demonstration zones.

　　27. Strengthen the digital governance of rural human settlements. Establish an online acceptance mechanism for rural human settlements, and guide rural residents to participate in the online supervision of human settlements through APP and small programs. Constantly improve the rural environmental monitoring system, and continuously strengthen the monitoring of environmental factors and key regulatory targets. Improve the monitoring capacity of water environment and water ecology in rural areas. Continue to strengthen the information management of rural domestic garbage collection, transportation and disposal, and improve the level of sewage and garbage treatment in villages and towns. Carry out the demonstration work of high-scoring satellite in the monitoring and application of rural human settlements.

　　(ten) to promote the construction of digital villages as a whole.

　　28. Strengthen overall coordination and pilot construction. Guide local governments to establish and improve the overall coordination mechanism for digital rural development, and promote the implementation of the Digital Rural Development Action Plan (2022-2025). Study and formulate the evaluation index system of digital rural development and carry out the evaluation of digital rural development. We will issue guidelines for the implementation of the digital village standard system and strengthen the standardization of digital villages. Continuously improve the guidelines for the construction of digital villages. Complete the summary and evaluation of the first batch of national digital village pilots, and encourage local governments to carry out regional digital village pilots. Make full use of the media, live broadcast platform, network audio-visual programs and other channels to tell the story of rural revitalization, sum up and promote typical experiences, and create a good social atmosphere.

　　29. Strengthen policy guarantee and financial services. Increase financial investment and guidance, make overall use of existing agriculture-related policies and funding channels in accordance with regulations, and support the construction of key digital rural projects. Strengthen financial institutions’ credit and financing support for key digital rural construction projects and high-quality agriculture-related enterprises, new agricultural business entities and rural employment and entrepreneurship groups. We will continue to increase the supply of rural finance and improve the adaptability of county credit funds throughout the country. Create a demonstration zone of financial services for rural revitalization and innovation according to local conditions. Continue to promote the demonstration project of financial technology to empower rural revitalization. Encourage local governments to explore the construction of a digital rural service resource pool and guide social forces to participate in the construction of digital villages in an orderly manner.

　　30. Strengthen the construction of digital rural talent team. Continue to carry out the training of farmers’ mobile phone application skills, organize network security education and training, and enhance the digital literacy and personal information protection awareness of rural population. We will continue to send strong staff to make good use of the first resident secretary and team, and strengthen the education and training on the application of modern information technology to rural party member cadres. Continue to strengthen the construction of new rural development research institutes in colleges and universities, and increase the supply of vocational education in areas where talents are urgently needed, such as agriculture and rural areas. Vigorously carry out information training for rural tourism talents, young talents in agriculture and rural science and technology, and compound talents.

With the popularization of HPV vaccine knowledge, many people want to be vaccinated with HPV vaccine. But how much do you know about HPV vaccine? What is the difference in the applicable population of HPV vaccines with different "prices"? In this regard, Chen Shouzhen, deputy director of the Obstetrics and Gynecology Hospital affiliated to Fudan University, summed up ten common questions and answered them to the majority of netizens.

What is HPV virus?

Human papillomavirus (HPV) is a small double-stranded DNA virus, so it is called human papillomavirus because it only infects humans. There are more than 200 subtypes of HPV, which can be divided into high-risk type and low-risk type according to whether they are carcinogenic or not.

Low-risk type usually infects the skin and causes warts, commonly known as boils. Most of them can naturally subside in 3-5 years, and some may need laser, freezing and other methods to remove them.

There are about 15 HPV subtypes (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82) that can cause malignant tumors such as cervical cancer, vaginal cancer and oropharyngeal cancer, so they are called high-risk HPV. Among them, HPV16/18 has the highest risk of cancer. About 70% of cervical cancer in the world is caused by high-risk HPV16 and 18, and 20% is caused by HPV31, 33, 45, 52 and 58. HPV16 types 16 and 18 are also associated with oropharyngeal cancer, vulvar cancer, vaginal cancer, penile cancer and anal cancer.

Will HPV infection definitely lead to cancer?

Persistent infection of high-risk HPV will lead to cancer. More than 90% of HPV infections usually subside naturally within 2 years. If carcinogenic HPV infection lasts for more than 1 year, the possibility of precancerous or cancerous lesions will increase, but not all persistent infections will progress. Only less than 1% of infections will develop into cancer after 5 to 10 years of precancerous lesions. Therefore, even if there is HPV infection, it will not necessarily become cancer, but we should pay attention to the corresponding screening.

At present, there is no specific drug to treat HPV. Through regular screening, we can observe the situation of HPV infection, so that we can treat it at an appropriate time and reduce the risk of cancer.

Personal life is very healthy, how can you be infected with HPV?

HPV virus spreads in various ways.

It can be widely spread among people through skin contact, and more than 80% of women have been infected with HPV at least once in their lives. Sexual life is the main reason why HPV spreads around the anus and genitals. Sticking to the correct use of condoms can reduce the risk of HPV infection.

Generally speaking, there are many ways of HPV infection. At present, there is no good way to prevent HPV infection, but healthy living habits, such as quitting smoking and drinking, and wiping separately after going to the toilet may reduce the probability of HPV infection. Even if you are infected with HPV, you don’t have to be nervous, because most HPV infections can be monitored regularly after infection, and generally will naturally fade away soon.

How to prevent HPV transmission?

Vaccination with HPV vaccine can safely prevent cancer caused by persistent HPV infection.

Vaccination with tetravalent or nonavalent HPV vaccine can also prevent condyloma acuminatum, which is a benign disease, but the treatment failure rate is relatively high, affecting physical and mental health. Therefore, for the majority of women, it is very necessary to vaccinate HPV vaccine.

How to choose HPV vaccine?

At present, three different vaccines have been developed, which are divided into bivalent, tetravalent and nonavalent vaccines according to the number of HPV subtypes they target. Simply put, bivalent HPV vaccine is aimed at HPV types 16 and 18; The tetravalent HPV vaccine is aimed at HPV6, 11, 16 and 18; The nine-valent HPV vaccine not only targets the same HPV subtype as the four-valent vaccine, but also targets types 31, 33, 45, 52 and 58. At present, HPV vaccines are all preventive vaccines, aiming at preventing initial HPV infection and subsequent HPV-related diseases.

At present, many hospitals, from community medical service centers to tertiary hospitals, have HPV vaccines, and these HPV vaccines can be safely vaccinated. Because of limited resources, the queue time of nine-valent vaccine will be longer. If resources and funds are not a problem, it is recommended to vaccinate the nine-valent HPV vaccine. If there is no nine-valent HPV vaccine, tetravalent HPV vaccine and bivalent HPV vaccine are also good choices, because both vaccines cover the most dangerous types 16 and 18. Generally speaking, you should try to use the same vaccine preparation to complete vaccination. However, if you don’t know the original HPV vaccine dosage form, you can also use another HPV vaccine preparation to complete the subsequent vaccination.

At what age is it appropriate to get HPV vaccine?

At present, the recommended age of HPV vaccination in China is 9-45 years old. Most countries in the world recommend routine HPV vaccination at the age of 11-12, and some suggest starting from the age of 9. For teenagers and adults aged 13-26, replanting is also recommended if they have not been vaccinated with HPV vaccine or have not completed a series of vaccines.

Why don’t foreign countries recommend routine replanting for adults over 27 years old? This is because with the increase of age, the possibility of infection with subtypes covered by HPV vaccine is gradually increasing. For older people, the benefit and cost performance of HPV vaccination are low. However, research shows that there are two peaks of high-risk infection among women in China: 17-24 years old and 40-44 years old, and single HPV infection is the main infection. Considering the characteristics of female infection and the low coverage rate of cervical cancer screening, experts suggest that women aged 9-26 should be vaccinated with HPV, and women aged 27-45 should be vaccinated when conditions permit. Women over the age of 45 don’t have to worry. At this stage, the HPV vaccine is low in cost performance, and the standardized HPV screening is enough to prevent cancer.

In the recommended age range, the best time for HPV vaccination is before the first sexual intercourse, because HPV vaccine immunization is the most effective for individuals who are not infected with HPV. That is to say, the younger you are when you are vaccinated with HPV, the more the incidence of cervical cancer decreases.

Are there any side effects of vaccination?

Vaccination of HPV vaccine, like other vaccines, may have pain, swelling and erythema at the inoculation site. A few people may have syncope or dizziness, and there are some rare other side effects, which may be related to the adjuvant in the vaccine, so you can rest assured to vaccinate. In addition, HPV vaccine can be safely inoculated in different parts with other vaccines at the same time. At present, there is evidence that inoculation of tetanus, acellular pertussis, diphtheria and inactivated polio vaccine at the same time with HPV vaccine does not damage the immune effect of the body against HPV vaccine or other vaccines at the same time.

Because there is no relevant evidence, it is generally not recommended to vaccinate HPV during pregnancy. However, with the increase of the number of people vaccinated, more and more data about unintentional vaccination after pregnancy show that vaccination during pregnancy has no effect on the safety of mother and child. Nevertheless, the remaining vaccination should be postponed, and it is best for vaccinated women to get pregnant two months after the vaccination is completed. Vaccine does not affect the safety of breastfeeding, but at present, such data are limited, so it is necessary to carefully consider HPV vaccination for lactating women.

I have been infected with HPV before, can I still be vaccinated?

There is no need to evaluate whether you have been infected with HPV before vaccination. A history of abnormal cervical cancer screening, genital warts and HPV infection is not a taboo for HPV immunization. Because these conditions all suggest that HPV was infected in the past, but it is not necessarily HPV subtype infection covered by HPV vaccine. For people who have a history of HPV infection but are still within the recommended age range, vaccination is still recommended because it still has a protective effect on the uninfected vaccine strain HPV virus. However, for people who have been infected with the subtype covered by HPV vaccine, the benefits of immunization are small.

What if we miss the seeds? I have been vaccinated with bivalent or tetravalent HPV vaccine before. Do I need to replant with nine-valent HPV vaccine?

Missing seeds means that immunization is not carried out according to the schedule. At present, the evidence shows that no matter how long the series vaccination is interrupted, it can continue to vaccinate without restarting the series vaccination.

Now it is found that HPV vaccine has a long-lasting protective effect against HPV-related diseases, and there is no need for multiple cropping. For women who have already completed bivalent or tetravalent HPV vaccination, the benefit of using nine-valent vaccine for multiple inoculation may not be obvious, so it is not recommended.

After vaccination with HPV vaccine, can I avoid regular screening?

At present, HPV vaccine can only prevent infection. After vaccination, existing HPV infection, genital warts or precancerous lesions cannot be eliminated, and the vaccine can only prevent cervical cancer caused by seven subtypes at most. After injection of HPV vaccine, other subtypes of HPV may still be infected, which may lead to cancer. Therefore, cervical cancer screening is still needed after HPV vaccination.

Domestic Suzuki New Alto appeared in Beijing.

　　Recently, when Sohu netizens went to a 4S shop in Changan Suzuki for maintenance, they found a new Alto parked in the corner of the shop, which had been heated by major media. They walked over and observed it carefully, and found that the whole car was fine in workmanship, and the pink metallic paint was very bright. The teardrop-shaped headlights on the front of the car were the highlights of the whole car, which raised a lot of spirits for this car. The large-mouth grille follows the design idea of big brother Audi, but it has a lovely appearance on Alto’s little face. The Suzuki "S" chrome-plated logo on the big mouth is huge and eye-catching, which plays a finishing touch for this cute and playful little face.

Car side modeling dynamic fashion body length 3500mm.

　　The side shape of the car body feels familiar. The relatively long front door and short rear door are typical design ideas of a five-door mini-car. The lower edge of the window that rises all the way extends from the A-pillar to the C-pillar, which is dynamic and fashionable. However, due to the body length of 3500mm and the narrow rear door design, the rear door window has become a triangle-like shape. However, the domestic Alto of Changan Suzuki version is different from the European version. The rear door window does not use a low-cost negative pressure ventilation window, but is replaced by an electric lifting window to cater to the tastes of Chinese people, which greatly improves the convenience of use. The overall shape of the side of the car body is similar to that of Global Hawk Panda and BYD F0 listed earlier, which is fashionable and full of vigor.

　　The domestic new Alto’s wheelbase of 2340mm belongs to the middle and upper class among mini-cars, which is longer than that of Global Hawk Panda and BYD F0, and similar to that of Changan Benben of 2365mm. The body width of 1600mm is slightly narrower than that of competitors, and the height of 1470mm is basically the same as that of Panda and F0, and slightly shorter than that of Changan Benben.

Unique tail shape

The tailgate opening is slightly narrow and the trunk is shallow.

　　The shape of the rear part of the car body is unique, probably because the bumper is lifted to a higher position to protect the shorter car body, and the whole rear wall occupies about 2/5 of the rear of the car, which is very full. However, this design also brings inconvenience, that is, the opening of the tailgate becomes higher, and the fashionable three-dimensional crystal diamond combined taillights occupy a large area, which makes the opening of the tailgate narrow, the depth of the trunk is shallow, and it is difficult to enlarge something. The overall shape of the tail is avant-garde, and the logo of Changan Suzuki shows its domestic identity. The high-position brake lights are dotted on the small tail behind the roof, which not only attaches importance to safety but also does not lose fashion.

Design of front McPherson independent suspension and rear trailing arm independent suspension plus lateral stabilizer bar

　　In the aspect of suspension, the new Alto adopts the typical small car design of front McPherson independent suspension and rear trailing arm independent suspension plus lateral stabilizer bar, which saves cost and chassis space while ensuring certain comfort.

Alto adopts 155/65 R14 Jinhu tire and 8 aluminum alloy wheels

　　In terms of wheels, the new Alto high-profile model uses 14-inch 8 aluminum alloy wheels, which are fashionable in shape. 155/65 R14 Jinhu tire seems to be not very kind, and its main competitors are almost all 165 treads. The narrower tire reduces handling but has an advantage in fuel consumption.

　　Like domestic cars with the same price, New Alto is equipped with front disc and rear drum brakes, which is enough for cars with less than 1 ton.

　　Open the door and get into the car. Like Swift and SX4, the interior of the new Alto focuses on simple and fashionable routes, with the same color scheme as the mainstream sedan. The steering wheel shape makes people see at a glance that this is a Suzuki model, which is exactly the same as SX4 and Swift. It is made of PVC, but it looks very big in the petite cockpit of Alto, and it should be more harmonious if it can be designed with smaller points. The new Alto dashboard has a distinctive shape. The huge speedometer occupies the front of the driver’s line of sight. Under the orange background light, the automatic gear position is displayed, and all kinds of warning lights are arranged around the speedometer. On the LCD panel below, information such as clock, mileage and fuel gauge is integrated. The cancellation of the water thermometer shows Suzuki’s confidence in the product.

　　The highlight is the new Alto’s tachometer. On the dashboard in front of the driver’s line of sight on the left, a tachometer is independently designed, which is similar to BYD F0’s design, except that the new Alto’s instrument uses a red background light with a scarlet letter on a black background, which is very outstanding in modification style and adds features to the overall interior modeling.

　　Looking at the whole interior, the new Alto, as a joint venture model, has no outstanding advantages in terms of materials and equipment quality. Under the cost control, the overall level is close to that of domestic models. In terms of vehicle configuration, this experience is an automatic top-mounted vehicle. The gear shifting mechanism is the same as that of Swift, and the shape of the gear shifting base and handle is basically the same. Double airbags, ABS brakes, manual air conditioners, electric rearview mirrors, four-door electric windows with central door locks and remote control keys have become standard equipment for high-equipped vehicles, while four-speaker single-disc CD audio and AUX interface cater to the tastes of young people. The seat adopts manual 4-way adjustment, and the material is a combination of gray flannel and light leather material. In design, the front seat uses the integrated design of seat headrest and has the logo of ALTO, which makes it more comfortable to sit on, but the wrapping is not strong. The headrest of the rear seat is detachable, but the backrest is straight, so I’m afraid it’s uncomfortable to sit for a long time. The whole interior is mainly practical, and there are many necessary conveniences and equipment, while others can be saved. The interior made of plastic and flannel is basically in line with the market positioning of Alto, a mini car.

　　In terms of space, as long as the height is not higher than 185cm, the head space is still sufficient, while the leg space is slightly cramped. There is no problem in short-distance transportation in the city. If you are too tall for a long distance, you will feel bad.

　　It is understood that this car is a trial version of the model, and it is still quite different from the model listed later in the interior and engine compartment.

　　When the car is on fire when the sales are not available, I feel that the sound of ignition is fragile and light. During idling, the car vibrates very little. You even suspect that it uses a 3-cylinder engine, giving people the feeling of a high-end car. Suzuki K10B is really a good machine. Listen to the idling noise on the door. If the tachometer doesn’t point to 800 revolutions, I even doubt whether the engine is running. I found the secret of silence when I opened the hood. It turns out that the new Alto is there. On the nameplate below the car body, the engine power is written as 48Kw, and the compression ratio is reduced and adjusted compared with the previously publicized machine with 50Kw compression ratio of 11: 1. In order to adapt domestic Alto to the ration of 93rd gasoline, it is worthwhile to sacrifice some power.

Photo of old and new Alto

　　Due to the small space, I didn’t test drive for a short experience, but I was deeply impressed by the new Alto. Typical urban scooter and automatic transmission models are very suitable for shuttle in cities, and the 1.0L engine has obvious advantages in fuel consumption. In terms of energy saving and styling design, it has won the favor of many people. In September, the new Alto will be listed soon. In the highly competitive car market, the role of price guiding sales is very obvious. The new Alto has already occupied the absolute advantage of brand and reputation. So, can this old car sell well? Let’s wait for the price of the new Alto, and please continue to pay attention to Sohu Auto’s follow-up reports on the new Alto.

　　Copyright statement: This article is the exclusive manuscript of Sohu Auto, and the copyright belongs to Sohu Auto. It may not be reproduced without permission, and will be investigated once it is found.

　　

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　◆ 2011 model:229,800 ~ 369,800 yuan

　　At the Guangzhou Auto Show,The 2011 Subaru Forester was officially launched. The new cars listed this time involve 11 models with 2.0-liter naturally aspirated and 2.5-liter powertrain, and the price range is22.98-36.98 million yuan.The engine of the 2011 Forester has been slightly modified, and the fuel economy has been improved.

　　In terms of power, the 2011 Subaru Forester 2.5T model,It is equipped with Subaru’s brand-new turbocharged 2.5-liter DOHC horizontally opposed four-cylinder engine, with a maximum power of 230 HP and a maximum torque of 330 N m. Although there is not much improvement in power, the fuel economy of the new engine has been improved by 10%, and the fuel consumption per 100 kilometers in official cities/high-speed conditions has reached 11.2/8.7 liters respectively.

　　Listing articles:

　　229,800 yuan has been listed at the 2011 Forester Guangzhou Auto Show.
　　//www.autohome.com.cn/news/201012/161287.html

◆ New/Great Scenery:21.28 ~ 238,800 yuan

　　Renault’s third-generation scenery and grand scenery have been officially listed at the Guangzhou Auto Show. The listing involves a total of three models, and the price range is21.28-23.88 millionYuan. The new landscape series mainly focuses on improving the functionality of the car, while the appearance continues to adhere to the design style of the series.

　　In terms of power, Renault New Scenery/Grand Scenery is equipped with the old 2.0L inline four-cylinder engine, but it has been adjusted, with an increase of 4 horsepower, reaching 140 horsepower, and the transmission has also been upgraded from the original 4-speed automatic manual transmission to the transmission. Like the old models, the new scenery has a lot of storage space. In addition to the storage compartments everywhere in the cabin, the foldable seats also provide a larger place for storing more items.

　　Listing articles:

　　Sell 212,800-238,800 yuan for new scenery/big scenery listing.
　　http://www.autohome.com.cn/news/101220/161662.html

The Beijing News Shell Financial News (Reporter Lin Zi) On April 15th, the Star Era Night and Star Era ET Pre-sale Conference was held. There are two kinds of pure electric versions and extended range versions of ET in this Star Age, namely REEV series: 199,000 yuan for Plus, 219,000 yuan for Pro and 239,000 yuan for Pro, and BEV series: 239,000 yuan for Pro, 249,000 yuan for Pro Four-wheel Drive, 259,000 yuan for Pro City Smart Drive, 289,000 yuan for Max and 329,000 yuan for Ultra32.9

The longest cruising range of Xingjiyuan ET pure electric version is 760km, and the comprehensive cruising range of extended range version is over 1500km.

The extended-range version adopts a special engine with the highest thermal efficiency of 44.5% in industrial mass production developed by Chery, with a rated power of 115kW, achieving 1L oil power generation of 3.65kWh and WLTC feed fuel consumption of 5.2L/100km.

The pure electric version is equipped with Contemporary Amperex Technology Co., Limited Shenxing rechargeable battery, with a peak charging power of 420kW, which can achieve a battery life of 475km for 11.5 minutes. Even in the low temperature environment of-20℃, it only takes 24 minutes for the SOC to change from 20% to 80%. When the SOC is only 20%, the peak output power still reaches 280kW.

Editor Jiang Fan

Proofread Jia Ning