CCTV News:Recently, a school in Jiangxi called Yuzhang Academy has attracted much attention. The school claims that it can help problem of juvenile get rid of Internet addiction through Chinese studies, but many students who have studied here claim that the so-called Chinese studies in Yuzhang Academy are actually corporal punishment such as flogging and shutting down a small black room. So what is the truth? Faced with many questions, CCTV reporters contacted many parties, found several students and their parents who had studied here, and interviewed the principal and teachers of Yuzhang Academy, trying to solve the secret of this academy.

　　Establish qualified private training institutions in 2013.

　　A small tile-headed wall with blue bricks and a lattice window hanging in the cloister, these two poems seem to describe the building in front of us. Yuzhang Academy is one of the four major academies in Jiangxi’s history. In May 2013, with the approval of the local education department, this school named Yuzhang Academy was established in Qingshanhu District of Nanchang City. The nature of the school is a private non-academic education and training institution.

　　Students come from all over the country, mostly junior high school students.

　　Although Yuzhang Academy is located in Jiangxi, its students come from all over the country. At most, there are nearly 200 students, most of whom are teenagers in middle and high schools. Why does a private training institution that teaches Chinese studies attract so many children from all over the country to go to school?

　　Xiaowei, who lives in Nanchang, began to study at Yuzhang Academy in September 2013. According to him, he was "kidnapped" from home by several strangers.

　　Xiaowei: "I feel kidnapped. Ask them where this is and where they are taking me."

　　According to Xiaowei, he was "kidnapped" to the school. Another child, Xiao Yao, also said that he was cheated in the name of eating. However, unlike Xiaowei, Xiaoyao vaguely guessed what place he was going to be sent to.

　　Xiaoyao: "At that time, in my home computer, that is, in the history of search, my dad should have glanced at it before deleting it, and I just happened to see such a school. I forgot about almost such a school."

　　Xiaoyao’s family lives in Shangrao, which is more than 200 kilometers away from Nanchang. His father runs a lot of business there. However, since Xiaoyao entered high school, the existing crisis between father and son has become more explosive.

　　Ms. Yin, the parent of another girl in Yuzhang Academy, said that her daughter used to be like this, not only resisting communication with them, but even fighting with them. What worries Ms. Yin even more is that her daughter is crazy about mobile phones, and even in order to secretly buy mobile phones, instead of eating breakfast, she saves several or dozens of pocket money and meals to buy mobile phones.

　　No way, it is the common feeling of these parents, and at this time, Yuzhang Academy in Nanchang, Jiangxi Province entered the sight of these parents.

　　"Helping people with youth crisis to achieve excellent life" is a promise in the agreement signed between Yuzhang Academy and parents. The admission items of this agreement indicate that students can study at any time, and the semester is from six months to one year. The cost for six months is 31,250 yuan, and the cost for one year is 49,750 yuan.

　　Such tuition fees are not cheap for many families, but parents who are willing to spend so much money to send their children in have a common expectation. They believe that through the "characteristic education" of Yuzhang Academy, these children who even their parents can’t discipline will usher in a thoroughly remoulded change after half a year.

　　Why should every freshman be confined for seven days when he first arrives?

　　"Yuzhang Academy" has a meditation room, and every child who has just arrived at the academy has to be kept alone in the meditation room for seven days and seven nights. The headmaster gave his own opinion about this practice.

　

　　This "boredom relief room" is also called the meditation room in Yuzhang Academy, but for many students, it is a dark room that restricts their freedom. As soon as each student enters Yuzhang Academy, he will be kept here alone for seven days and seven nights.

　　Xiaoyao: "I said how I could be sent to a place like this, but I didn’t tell me anything clearly. I wanted to see my parents or something, so they quarreled with me. After I scolded them, they started to fight. I started to fight with their two instructors. I am sure I can’t beat them. Then they beat me up and they left. "

　　JovesongThere is a hole under the bed, and then I know what they do? That is to deliberately make a hole to scare you, that is, mosquitoes, mice and ants, and mice can climb in through this hole. "

　　Except for a few books, no mobile phone and no computer, it is extremely difficult for Calvin and Xiaoyao, who are only teenagers, to stay in this empty room.

　　The headmaster explained that this was Morita therapy.

　　Why do students have to be kept alone for seven days when they first enter school? The headmaster of Yuzhang Academy does not deny the question of "closing a small black room". He explained that this is actually a kind of psychotherapy called Morita therapy.

　　Ren Weiqiang, president of Yuzhang Academy, said: "The child may have some antagonism and reluctance when he comes at first, so we will let him get rid of this emotion through a relatively mild method,/because this teenager’s simple language communication will not be effective when he is in such an emotional state, and some even directly attack our teacher."

　　After seven days, the students became quiet but said they learned to pretend.

　　After seven days, the students released from the meditation room were really quiet and less grumpy. However, according to Xiaoyao, these were all produced by them.

　　Whether it is camouflage or Morita therapy, President Ren Weiqiang believes that after seven days of tempering, it is very helpful for students to study in the academy next.

　　Violating the "rules" will be punished by the "dragon whip"

　　At the end of the seven-day confinement, the formal school life began. During the day, there was a culture class, and at night, there was a course called Calder, which many students still couldn’t get over.

　　In Calder class, the culture teacher first summarizes the students’ day’s study, and then the instructor punishes the students who violate the so-called "school rules". This punishment is not just talk, but the use of a ruler and a whip, which is also called a dragon whip.

　　Jovesong"I didn’t recite the ancient prose he asked me to recite that day, and then I was beaten with a steel ruler. I think I hit it ten times, but I didn’t feel any pain at all. Why? Because I feel that my heart is dead, just like a walking corpse, disheartened and without any feeling. "

　　Xiaoyao: "Hiding snacks, not eating clean, not eating, boys and girls pass notes, lighter is to beat the ruler, heavier is to beat the dragon whip, anyway, it is all kinds of miscellaneous things, and the instructor can beat you with the ruler if you are unhappy."

　　The two recalled that for some serious mistakes in school regulations, it was not just to beat the ruler, but to use another thing, the whip.

　　Principal: Corporal punishment and non-violence are not half-terror on the Internet.

　　As for corporal punishment, President Ren Weiqiang believes that it is not violence. Before playing the ruler, they sometimes beat themselves a few times to master the strength. For the ruler to quit the whip, President Ren Weiqiang said that it was not as horrible as it was uploaded online.

　　Corporal punishment has clear approval procedures. Instructors specialize in punishment.

　　At the same time, President Ren Weiqiang said that corporal punishment has clear approval procedures and requirements, and their regulations are not so strict, and corporal punishment will not be carried out just because of a trivial matter. Is the situation like what the headmaster said? Our reporter found an instructor who had worked in the academy for a period of time. According to him, the culture teacher would record the students who violated discipline, and the instructor’s job was to punish them.

　　Zhou Wenliang used to be an instructor in Yuzhang Academy.: "The ruler is very common, that is, people basically make mistakes by hitting the ruler, so when boys and girls talk, they communicate with the opposite sex, which means fighting, hitting the teacher or trying to escape. This is very serious."

　　 At present, the police have launched an investigation into whether the behavior of Yuzhang Academy is suspected of breaking the law.

　　The "measures" for the administration of real estate surveying and mapping have been deliberated and adopted by the 31st executive meeting of the Ministry of Construction on October 8, 2000 and the executive meeting of the State Bureau of Surveying and Mapping on October 26, 2000 (the State Bureau of Surveying and Mapping is authorized by the Ministry of Land and Resources), and are hereby promulgated and shall come into force as of May 1, 2001.

　　Chapter I General Provisions

　　Article 1 In order to strengthen the management of real estate surveying and mapping, standardize the behavior of real estate surveying and mapping, and protect the legitimate rights and interests of housing owners, these Measures are formulated in accordance with the Surveying and Mapping Law of People’s Republic of China (PRC) and the Urban Real Estate Management Law of People’s Republic of China (PRC).

　　Article 2 These Measures shall be observed when engaging in real estate surveying and mapping activities and implementing real estate surveying and mapping management in People’s Republic of China (PRC).

　　Third real estate surveying and mapping units shall strictly abide by the relevant laws and regulations of the state, implement the national real estate surveying norms and relevant technical standards and regulations, and be responsible for the quality of their completed real estate surveying and mapping results.

　　Real estate surveying and mapping units shall adopt advanced technology and equipment, improve the level of surveying and mapping technology, and accept the technical guidance and business supervision of the real estate administrative department and the surveying and mapping administrative department.

　　Article 4 Real estate surveying and mapping practitioners shall ensure the completeness and accuracy of surveying and mapping results, and shall not engage in illegal surveying and mapping, practise fraud, or harm the national interests, social public interests and the legitimate rights and interests of others.

　　Fifth the State Council Surveying and mapping administrative departments and the State Council construction administrative departments shall be responsible for the supervision and management of real estate surveying and mapping and the application of the results according to the division of responsibilities determined by the State Council.

　　The surveying and mapping administrative departments of the people’s governments of provinces, autonomous regions and municipalities directly under the Central Government (hereinafter referred to as the provincial surveying and mapping administrative departments) and the construction administrative departments of the people’s governments of provinces and autonomous regions and the real estate administrative departments of the people’s governments of municipalities directly under the Central Government (hereinafter referred to as the provincial real estate administrative departments) are responsible for the supervision and management of real estate surveying and mapping and the application of results according to the division of responsibilities determined by the people’s governments of provinces, autonomous regions and municipalities directly under the Central Government.

　　Chapter II Entrustment of Real Estate Surveying and Mapping

　　Article 6 In any of the following circumstances, the applicant for housing rights, the owner of housing rights or other interested parties shall entrust a real estate surveying and mapping unit to conduct real estate surveying and mapping:

　　(1) Houses applying for initial registration of property rights;

　　(2) Houses whose natural conditions have changed;

　　(three) the housing rights or other interested parties require surveying and mapping houses.

　　Real estate surveying and mapping required in real estate management shall be entrusted by the real estate administrative department to conduct real estate surveying and mapping units.

　　Seventh real estate surveying and mapping results should be consistent with the natural conditions of real estate. When the natural conditions of the real estate change, the real estate change measurement shall be implemented in time.

　　Eighth commissioned by the real estate surveying and mapping, the client and the real estate surveying and mapping unit shall sign a written contract for real estate surveying and mapping.

　　Ninth real estate surveying and mapping units should be independent economic entities, and shall not have an interest in the client.

　　Tenth real estate surveying and mapping costs paid by the client.

　　Real estate surveying and mapping fees in accordance with the relevant provisions of the state.

　　Chapter III Qualification Management

　　Article 11 The State implements the qualification examination and certification system for real estate surveying and mapping units.

　　Twelfth real estate surveying and mapping units shall, in accordance with the "People’s Republic of China (PRC) Surveying and Mapping Law" and the provisions of these measures, obtain the "Surveying and Mapping Qualification Certificate" issued by the surveying and mapping administrative department of the people’s government at or above the provincial level, which specifies the real estate surveying and mapping business.

　　Thirteenth unless otherwise stipulated in these measures, the qualification examination, grading standards, operation limits and annual inspection of real estate surveying and mapping shall be implemented in accordance with the relevant provisions of the state.

　　Fourteenth units applying for the qualification of real estate surveying and mapping shall submit a written application to the local provincial administrative department of surveying and mapping, and submit relevant materials in accordance with the requirements of surveying and mapping qualification examination and management.

　　The provincial administrative department of Surveying and mapping shall, within 5 days from the date of acceptance, transfer it to the provincial administrative department of real estate for preliminary examination. Provincial real estate administrative departments shall, within 15 days, put forward written preliminary opinions and feedback to the provincial administrative departments of Surveying and mapping; Among them, the preliminary examination opinions on applying for the qualification of Grade A real estate surveying and mapping shall be submitted to the construction administrative department of the State Council for the record.

　　To apply for the qualification of Grade A real estate surveying and mapping, the provincial administrative department of surveying and mapping shall report to the administrative department of surveying and mapping of the State Council for approval and certification; Those who apply for the qualification of real estate surveying and mapping below Grade B shall be examined and approved by the provincial administrative department of surveying and mapping.

　　Units that have obtained Grade A real estate surveying and mapping qualifications shall be jointly announced to the public by the administrative departments of surveying and mapping in the State Council and construction in the State Council. Units that have obtained the qualification of real estate surveying and mapping below Grade B shall be jointly announced to the public by the provincial administrative department of surveying and mapping and the provincial administrative department of real estate.

　　Fifteenth "Surveying and mapping qualification certificate" is valid for 5 years, 3 months before the expiration, the holder shall submit it for review, and the issuing authority shall be responsible for the review and replacement. For real estate surveying and mapping projects, the issuing authority shall solicit the opinions of the real estate administrative department at the same level when reviewing and replacing the certificate.

　　Within the validity period of the "Surveying and Mapping Qualification Certificate", the qualification of real estate surveying and mapping shall be inspected by the administrative department of surveying and mapping. During the annual inspection, the surveying and mapping administrative department shall solicit the opinions of the real estate administrative department at the same level. Units that have been demoted or disqualified from real estate surveying and mapping in the annual inspection shall be jointly announced to the public by the surveying and mapping administrative department of the annual inspection and the real estate administrative department at the same level.

　　Apply for upgrading the qualification of real estate surveying and mapping within the validity period of the "Surveying and mapping qualification certificate", and re-apply for qualification examination procedures in accordance with the provisions of Article 14 of these Measures.

　　Chapter IV Results Management

　　Sixteenth real estate surveying and mapping results include: real estate books, real estate data and real estate atlas.

　　Seventeenth parties have objections to the results of real estate surveying and mapping, you can entrust a nationally recognized appraisal agency for real estate surveying and mapping results.

　　Article 18 The real estate administrative department shall examine and verify the qualifications of the surveying and mapping unit, the applicability of the surveying and mapping results, the accuracy of the boundary points, the basis and method of area measurement, etc. for the results of real estate surveying and mapping used for real estate management such as housing ownership registration. After the audit of real estate surveying and mapping results into the unified management of real estate files.

　　Article 19. Providing, giving away and selling unpublished data of real estate surveying and mapping achievements to organizations and individuals outside the country (territory), and entrusting institutions outside the country (territory) to print real estate surveying and mapping maps shall be handled in accordance with the People’s Republic of China (PRC) Surveying and Mapping Law, the Regulations on the Administration of Surveying and Mapping Achievements in People’s Republic of China (PRC) and the relevant provisions of national security and confidentiality.

　　Chapter V Legal Liability

　　Article 20 Whoever engages in real estate surveying and mapping business without obtaining the Surveying and Mapping Qualification Certificate which specifies the real estate surveying and mapping business and undertakes the real estate surveying and mapping task beyond the business scope and operation limit of real estate surveying and mapping stipulated in the Surveying and mapping Qualification Certificate shall be punished in accordance with the provisions of the People’s Republic of China (PRC) Surveying and Mapping Law and the Administrative Provisions on Surveying and Mapping Qualification Examination and Certification.

　　Twenty-first real estate surveying and mapping units in any of the following circumstances, the real estate administrative departments of the people’s governments at or above the county level shall give a warning and order it to make corrections within a time limit, and may impose a fine of not less than 10 thousand yuan but not more than 30 thousand yuan; If the circumstances are serious, the issuing authority shall demote or cancel its qualification for real estate surveying and mapping:

　　(a) the national standards, norms and regulations are not implemented in the calculation of real estate area;

　　(two) in the calculation of real estate area, fraud, deception of housing rights;

　　(three) the calculation of the real estate area is wrong, causing great losses.

　　Twenty-second in violation of the provisions of article nineteenth of these measures, according to the "People’s Republic of China (PRC) Surveying and Mapping Law", "People’s Republic of China (PRC) Surveying and Mapping Achievements Management Regulations" and the provisions of national security and confidentiality laws and regulations.

　　Twenty-third real estate surveying and mapping management personnel, staff dereliction of duty, abuse of power, corruption, shall be given administrative sanctions; If a crime is constituted, criminal responsibility shall be investigated according to law.

　　Chapter VI Supplementary Provisions

　　Twenty-fourth provincial real estate administrative departments and surveying and mapping administrative departments may formulate detailed rules for implementation according to these measures.

　　Twenty-fifth approach by the administrative department of construction in the State Council and the administrative department of Surveying and mapping in the State Council jointly explained.

　　Twenty-sixth the implementation since May 1, 2001.

On the morning of March 7, the Jiangsu delegation of the Second Session of the 14th National People’s Congress held a plenary meeting, at which the topic of how to protect, utilize and innovate the intangible cultural heritage in Jiangsu in the new era was discussed. In recent years, by strengthening protection, cultivating talent teams and innovating artistic expressions, Jiangsu has made Kunqu Opera, one of the world’s intangible cultural heritages, constantly glow with new charm.

Intangible protection

Ancient Kunqu opera reappears the glory of the times

Kunqu Opera is one of the oldest existing operas in China, and it is called "the father and teacher of hundreds of operas". In May 2001, Kunqu Opera was awarded the title of "masterpiece of oral and intangible heritage of mankind" by UNESCO. Kunqu opera has both cultural heritage and cultural products. Its protection and inheritance will help to enhance people’s awareness of traditional culture and group identity, and promote social cultural prosperity and development.

Kunshan, Jiangsu Province is the birthplace of Kunqu Opera. In recent years, Kunshan regards the protection of Kunqu Opera as an important part of exploring new experiences in building the modern civilization of the Chinese nation, strengthens cultural self-confidence, highlights the spirit of the city, shows the characteristics of the city, and thoroughly implements the three-year action plan for promoting the brand of Kunqu Opera. At the same time, it holds brand activities such as "Beautiful Days and Elegant Collection", "Kunqu Opera Home" and "Chongyang Music Festival", and at the same time, it strengthens the creation of excellent Kunqu Opera, promotes the tour of excellent Kunqu Opera, and promotes it with multiple subjects, types and channels.

Since 2022, the "New Three Years, New Hundred Operas" program has been launched in the Grand Festival of Traditional Opera (Kunshan), focusing on the selection and training of leading opera talents, the support of endangered operas and the construction of China opera heritage base, actively exploring new modes such as "Opera+Tourism", "Opera+Fashion" and "Opera+Industry", which has effectively promoted the protection and development of China operas.

One stage will be Kyushu, and one city will watch hundreds of plays. Since the opening of the Hundred Drama (Kunshan) Festival in 2023, 40 opera troupes across the country have given 26 wonderful performances, with over 15,000 people watching live performances, over 70 million people watching online performances, and nearly 300 million people in five sessions. Sina Weibo has read 400 million people and over 1.6 billion people in five sessions. The Tik Tok has been broadcast for 300 million people, with the cumulative number exceeding 1.2 billion people in five sessions, which fully shows the enduring vitality and colorful weather of Chinese opera.

personnel training

"Xiao Kun Ban" blooms the flower of inheritance

The performance of Kunqu Opera lasted for 400 to 500 years, and there were strict norms for oral instruction. Besides, cultural elites have been involved in the refinement process of Kunqu Opera for a long time since the Ming and Qing Dynasties, so it was inherited in an orderly manner and left us a valuable cultural heritage. Inheritance is the soul of Kunqu Opera’s eternal life. Only by getting more young people to participate in the creation and appreciation of Kunqu Opera can we store endogenous power for the sustainable development of Kunqu Opera.

In 1921, the establishment of Kunqu Opera Studio opened the prelude to the inheritance and development of Kunqu Opera since the 20th century. In April, 1992, the first small Kunqu class in China was formally established in Kunshan No.1 Central Primary School, marking the entrance of Kunqu culture into the campus. By 2023, Kunshan had successively set up 22 small Kunqu classes in primary and secondary schools in the city, and trained more than 5,000 Kunqu students. More than 100 students were selected for further study in professional colleges, and nearly 20 students have become national excellent Kunqu actors.

The establishment of Kunshan Contemporary Kunqu Opera Theatre has also created a platform for outstanding Kunqu students to dream of Kunqu Opera. Many young actors who had the experience of learning opera in Xiaokun class have grown up and matured on the stage of Kunqu Opera Theatre, contributing to the inheritance and promotion of Kunqu Opera culture. At the same time, in the Kunqu Opera Talent Training Class of the Opera School affiliated to Shanghai Theatre Academy, there are also students from Xiaokun Class, who are moving towards the growth of professional actors and waiting for six years to stand on the stage of Kunqu Opera Theatre.

innovative development

Traditional culture realizes cross-border integration.

Under the background of the integration of literature and tourism in the new era, more and more people began to know and like Kunqu opera, and even fell in love with this kind of intangible culture. On the stage, masterpieces of famous rookies such as Peony Pavilion, White Snake and Gu Yanwu continue; In the theater, there are more and more young audiences, which makes people feel that the ancient Kunqu opera art is rejuvenating.

"Immersion" performance is one of the most effective and popular performances of Kunqu Opera. Compared with the past, Kunqu Opera not only exists in professional academies, folk music clubs and inheritance institutions, but also generally appears in various tourist sites and experience projects. Kunqu Opera performances went out of the theater and into the gardens and halls. A series of immersive Kunqu Opera performances were launched, which integrated the appreciation of landscape gardens and listening to operas, making the audience more immersive.

In addition, Kunqu opera is also combined with modern science and technology, relying on technologies such as the Internet and Metauniverse to innovate artistic expression forms. In August, 2022, the Kunqu Opera "Huansha Ji" was performed simultaneously in the Grand Theatre of Kunshan Culture and Art Center and Dayuwan Square through the 5G holographic live broadcast technology, realizing the stage performance "time travel".

This exhibition is an innovation in the way of traditional Chinese opera communication. Holographic projection technology has broken the limit of the number of people and venues in the theater, and made the traditional Chinese opera art really "go out of the theater and approach the public". The first show of "Opera+Science and Technology" has aroused enthusiastic response, which is a new way to promote the spread of opera art to people’s lives. At the same time, the digital guidance of Kunqu opera has also promoted the transformation, application and development of digital resources of traditional culture.

(Zhang Wenwen)

Editor: Tang Xinci

Editor: Hu Su Xiaoling

Audit: Yuan Xianglin

Editor: Cheng Juren Editor: Hu Su, Xiao Ling Audit: Yuan Xianglin

"Love Excellence" Yao Chen and Chen rushed to the Chinese clothes

　　　　　　　 Directed by Chinese-American director Alexi Tan and starring Yao Chen, Liu Ye and Chen Chong, the fashion love movie "Love Outstanding" will soon be released to meet the general audience. Apart from the dazzling star lineup, the presence of international famous brands such as Hermes, Versace, Cartier and Diesel has made the film more pure in fashion among many domestic fashion movies.

International brands strive to blow "Chinese style"

　　　　　　　 Whether the four major brands get together in the film Love Outstanding, or the two leading actors Yao Chen and Liu Ye in the film become the first spokespersons of world-renowned brands in China respectively, the trend of increasingly close relationship between international brands and China’s cultural industry is highlighted. Selecting the most popular and appealing first-line stars and excellent film and television works to work together is not only an effective way for international brands to actively explore the China market and improve brand awareness, but also a good way for China actors or film and television works to stand on the world stage and integrate with the international mainstream.

　　　　　　　 The most intuitive change is that when we walk into the makeup area of department stores, the blonde western faces have been quietly replaced by the well-known China actresses. At that time, those English brands that sound a little awkward and unfamiliar seem to have become a lot more friendly. Even if we don’t know which products we are suitable for, people can know a little about the brand style by looking at the product endorsements. Through these endorsements, foreign advertising companies or film and television production companies have learned more about China stars. Through the penetration of these brands, they will be subtly influenced in the future global strategy formulation, and more China actors and film and television works will have the opportunity to stand on the world stage.

Yao Chen logo smiles into a world business card

　　　　　　　 More and more pictures of fashion street shooting, magazine cover blockbusters and attending brand activities have witnessed the changes of Yao Chen in the past year or two — — Her increasingly international fashion temperament comes from the popularity and praise accumulated by excellent film and television works and the self-confidence after being recognized by more and more world-renowned brands. In June, 2010, Yao Chen signed a contract with an internationally renowned high-end cosmetic brand, becoming the first female spokesperson of the brand in China. "Her true and natural personality, energetic smile, conquered everyone. These are from the heart and cannot be concealed. This is also the idea that biotherm wants to express, which is true, modern and energetic. We hope that through cooperation with Yao Chen, we can be closer to customers in China and provide better life enjoyment for modern women. " Lamy, the general manager of the brand in China, expressed his attitude, and Yao Chen’s iconic BigSmile left a deep impression on the French head office.

　　2019In, the whole province focused on catching up and surpassing and the requirements of "five solidities" to overcome various adverse effects, and with the help of vigorously improving the business environment, the total output value of the construction industry was realized throughout the year.7883.88100 million yuan, a year-on-year increase10.7%The growth rate of output value ranks twelfth in the country. The comprehensive strength of construction enterprises has been greatly improved, the industrial structure of enterprises has become increasingly reasonable, and the added value of construction industry accounts for the whole province.GDPSpecific gravity reached9.6%The position of the construction industry as a pillar industry has been continuously consolidated.

　

　　First, the overall production and operation of construction enterprises in the province is improving.

　

　　oneThe output value of enterprises has increased steadily.

　

　　2019In, the construction enterprises in the whole province (note: the following construction enterprises refer to general contracting and professional contracting enterprises) completed the total output value of the construction industry.7883.88100 million yuan, a year-on-year increase10.7%, down from the same period last year.3.6Percentage points. In which: the output value of construction project is completed.6910.58100 million yuan, a year-on-year increase10.9%, down from the same period last year.1.4Percentage points. Completion of installation project output value665.65100 million yuan, a year-on-year increase11.4%, down from the same period last year.12.5Percentage points. Other output value307.65100 million yuan, a year-on-year increase6.0%, down from the same period last year.40.9Percentage points.

　

　

　　2The amount of new contracts signed this year has increased significantly.

　

　　2019The total amount of contracts signed by construction enterprises in the province in.17973.34100 million yuan, a year-on-year increase17.7%, higher than the same period of last year.8.7Percentage points. In which: Contract amount carried forward from the previous year8275.77100 million yuan, a year-on-year increase16.0%, down from the same period last year.13.5Percentage points. New contract amount signed this year9697.57100 million yuan, a year-on-year increase19.2%, higher than the same period of last year.23.5Percentage points. The effective growth of newly signed contracts has provided effective support for the steady growth of construction production in our province throughout the year.

　

　　threeThe growth rate of enterprise construction area has accelerated.

　

　　2019In, the construction enterprises in the whole province realized the building construction area.35276.4610,000 square meters, a year-on-year increase.19.0%, higher than last year.ninePercentage points. Due to the unsaturated workload of some enterprises in this year’s construction, the growth of new construction area this year is weak, falling year-on-year4.3%.

　

　　fourThe per capita labor productivity is increasing year by year.

　

　　2019Construction enterprises with total qualifications in the province in.3255Households, year-on-year growth15.5%, net increase of enterprises this year.438Household; Average number of people in construction industry171.3Ten thousand people, down year-on-year.1.1%, down from the same period of last year.1.83Ten thousand people. With the decrease of the average number of enterprises and the continuous improvement of the level of mechanization in the industry, the per capita labor productivity of construction enterprises in the province has increased.46.09ten thousand yuan/People, an increase over the same period last year.4.96ten thousand yuan/People. The improvement of labor productivity provides a strong guarantee for the market competitiveness of construction enterprises in our province.

　

　　fiveThe enterprise has a high prosperity and is optimistic about the future construction market.

　

　　According to the annual prosperity index survey,2019The annual business climate index is the first quarter respectively.110.1%Second quarter111.6%Third quarter110.9%Fourth quarter112.8%The prosperity index in the fourth quarter was higher than that in the same period of last year.1.4Percentage points.2019The annual enterprise confidence index is the first quarter respectively.114.6%Second quarter115.2%Third quarter113.7%Fourth quarter115.0%The confidence index in the fourth quarter increased compared with the same period of last year.2.7Percentage points.

　

　　Second, the structural characteristics of the province’s construction enterprises

　

　　oneFrom the composition of output value, the output value of construction projects is dominant.

　

　　2019Construction enterprises in the whole province realized the output value of construction projects in.6910.58One hundred million yuan, the proportion of engineering output value to the total output value is87.7%, higher than the same period of last year.0.2Percentage points. Completion of construction and installation project output value665.65One hundred million yuan, construction and installation engineering output value accounted for the proportion of the total output value is8.4%, unchanged from the same period of last year. Completion of other output values307.65One hundred million yuan, the proportion of other output value in the total output value is3.9%, down from the same period last year.0.2Percentage points.

　

　

　　2In terms of industries, the housing construction industry occupies the first place

　

　　2019In the province’s construction enterprises in, the housing construction industry achieved a total output value.4171.55Billion yuan, accounting for the total output value of the construction industry.53.0%, down from the same period last year.0.9Percentage points. The total output value of civil engineering and construction industry is realized.3184.68100 million yuan. Accounting for the total output value of the construction industry40.4%, higher than the same period of last year.2.2Percentage points. Including: railway, road, tunnel and bridge engineering construction industry completed.2488.11100 million yuan, accounting for the output value of all civil engineering industries.78.1%. The construction and installation industry has achieved total output value.367.95Billion yuan, accounting for the total output value of the construction industry.4.6%, down from the same period last year.0.9Percentage points. Building decoration and other construction industries realize total output value.159.70Billion. Accounting for the total output value of the construction industry2.0%, down from the same period last year.0.4Percentage points.

　

　

　　threeIn terms of qualification level, super-grade and first-class enterprises occupy the main market share.

　

　　2019In 2000, the province’s construction enterprises were middle-grade and first-class enterprises.494Home, accounting for all general contracting and professional contracting enterprises.15.2%, realize the construction industry output value.5471.19Billion yuan, accounting for the total output value.69.4%, higher than last year.2.2Percentage points. Secondary enterprise1769Home, accounting for all general contracting and professional contracting enterprises.54.3%, realize the construction industry output value.1847.88Billion yuan, accounting for the total output value.23.4%, down from the same period last year.0.1Percentage points. Level 3 and below enterprises992Home, accounting for all general contracting and professional contracting enterprises.30.5%, realize the construction industry output value.564.81Billion yuan, accounting for the total output value.7.2%, down from the same period last year.2.1Percentage points.

　

　　fourIn terms of regions, Guanzhong is still the main force.

　

　　The industrial structure of Shaanxi construction industry is still dominated by Guanzhong, supplemented by southern Shaanxi and northern Shaanxi.2019In, the construction enterprises in Xi ‘an, Tongchuan, Xianyang, Weinan, Baoji and Yangling in Guanzhong area completed the total output value of the construction industry.6737.55One hundred million yuan, accounting for the proportion of the province.85.5%, higher than the same period of last year.0.6Percentage points. Construction enterprises in Ankang, Hanzhong, Shangluo, Yan ‘an and Yulin in southern Shaanxi and northern Shaanxi have completed the total output value of the construction industry.1146.33One hundred million yuan, accounting for the proportion of the province.14.5%, down from the same period last year.0.6Percentage points. Among them, southern ShaanxithreeShizhan8.2%, northern Shaanxi2Shizhan6.3%. In terms of the total amount and growth rate of cities, Xi’ an has the highest proportion, accounting for the province’s output value57.3%, higher than the same period of last year.2.5Percentage points. Tongchuan has the lowest proportion, accounting for the province’s output value.0.6%, unchanged from the same period of last year. Tongchuan’s growth rate is the fastest21.7%, higher than the whole province.11Percentage points. Shangluo growth rate-12.3%The growth rate is the lowest, lower than that of the whole province.23Percentage points.

　

　　fiveFrom the perspective of domestic and foreign markets, the share of output value of enterprises in our province in other provinces has been continuously improved.

　

　　2019Enterprises in our province completed output value in other provinces in.2539.36100 million yuan, a year-on-year increase19.5%, higher than the same period of last year.9.1Percentage points, accounting for the total output value.32.2%. Investigation shows that enterprises from other provinces have completed their output value in Shaanxi.991.11100 million yuan, down from the same period last year.24%, down from the same period last year.34.4Percentage points.

　　　　Related news:　　　From May 1st, the ban on overseas cartoons will be extended by one hour.　　　　

　　　　CCTV.com News: The news broadcast of Guizhou People’s Broadcasting Station ignored the orders of the State Administration of Radio, Film and Television (SARFT), wantonly played up sexual life, sexual experience, sexual experience and sexual organs in several sets of radio programs, and boasted about the function of sexual drugs. Today, it was severely criticized by SARFT, and the illegal programs were stopped and cancelled.

　　　　According to the website of the State Administration of Radio, Film and Television, on September 13, 2007, Guizhou People’s Broadcasting Station broadcasted sexual obscenity and indecent programs on urban and economic frequencies, which was explicitly stopped by the State Administration of Radio, Film and Television. On November 12th, 2007, Guizhou People’s Broadcasting Station changed the name of Jin Tao’s Talk about Sex, which was stopped, to Jin Tao’s Night Talk, and was ordered by the State Administration of Radio, Film and Television to investigate and deal with it again. Since mid-January, 2008, when the whole province of Guizhou is united in fighting against the snowstorm and freezing disaster, the news broadcast of Guizhou People’s Broadcasting Station has continued to broadcast obscene and obscene programs that exaggerate sexual life, sexual experience, sexual experience, sexual organs and sexual medicine functions in the programs of Health Special Line and Healthy World. The informed criticism issued by the State Administration of Radio, Film and Television to Guizhou People’s Broadcasting Station was copied to the CPC Guizhou Provincial Committee and the Guizhou Provincial People’s Government.

　　　　The State Administration of Radio, Film and Television (SARFT) pointed out that since September 2007, radio, film and television administrative departments at all levels in China and radio and television broadcasters have conscientiously implemented the spirit of the Central Committee, and in accordance with the unified arrangements of SARFT, seriously rectified and severely investigated pornographic and obscene programs, and achieved remarkable results, which were fully affirmed by the Central Committee and praised by the broad masses. The fact that Guizhou People’s Broadcasting Station refuses to implement the provisions of the State Administration of Radio, Film and Television, and its programs involving sexual obscenity and obscenity are repeatedly banned fully shows that Guizhou People’s Broadcasting Station is indifferent in orientation and position awareness, lax in political discipline and propaganda discipline, lacking due social responsibility and professional quality, lax in rules and regulations, and weak in propaganda management, which must be dealt with seriously.

　　　　The State Administration of Radio, Film and Television severely criticized Guizhou People’s Broadcasting Station and its principal responsible persons, and informed the whole country.

　　　　The State Administration of Radio, Film and Television ordered the Guizhou Provincial Radio and Television Bureau to immediately stop broadcasting and cancel the sexually obscene and obscene programs such as Health Line and Healthy World of Guizhou People’s Broadcasting Station, seriously rectify Guizhou People’s Broadcasting Station, severely investigate and deal with relevant personnel and persons in charge of Guizhou People’s Broadcasting Station and news broadcasting in strict accordance with relevant regulations, and report the investigation to the State Administration of Radio, Film and Television as soon as possible.

　　　　The State Administration of Radio, Film and Television requires that all provincial, district (city) radio, film and television bureaus should be duty-bound, strictly implement the relevant publicity management regulations of the State Administration of Radio, Film and Television, earnestly perform their publicity management duties, and once again conduct a comprehensive and thorough clean-up and inspection of radio and television broadcasters within their jurisdiction, especially those at prefecture (city) and county levels. It is necessary to take measures to check at all levels, implement responsibilities, and not neglect their duties, perfunctory, and whitewash. To strengthen the work of listening and watching, strict supervision and management, to prevent the resurgence of pornographic programs, and in March 10, 2008, the clean-up inspection will be reported to the State Administration of Radio, Film and Television. The administrative departments of radio, film and television at all levels and radio and television broadcasters should conscientiously organize study, convey and implement the spirit of a series of documents issued by the State Administration of Radio, Film and Television on the thorough rectification of pornographic and obscene programs, strengthen the sense of orientation and position, emphasize social responsibility and post responsibility, improve the censorship system and broadcasting system, be serious about political discipline and propaganda discipline, increase supervision and investigation, and resolutely ban them to ensure the correct orientation of radio and television propaganda.

　　　　The State Administration of Radio, Film and Television emphasizes that radio, film and television administrative departments at all levels and radio and television broadcasters should thoroughly implement the spirit of the 17th Party Congress, vigorously publicize the socialist core value system, adhere to the orientation of advanced socialist culture, firmly grasp the correct direction of public opinion, keep in mind the social responsibility of radio and television, resolutely safeguard the good image of radio and television, always put social benefits first, advocate the concept of harmony, cultivate the spirit of harmony and build a harmonious culture.

　　　　The State Administration of Radio, Film and Television (SARFT) said that it would continue to supervise and inspect the rectification of pornographic and obscene radio and television programs in various places. Anyone who refuses to implement the provisions of the General Administration will be found together and investigated together, and the mechanism of punishment, accountability and withdrawal of radio and television broadcasters will be started in accordance with relevant regulations. At the same time, the audience is welcome to report, and the telephone number of illegal programs of the State Administration of Radio, Film and Television is 010-86095315; The online reporting address is http://www.chinasarft.gov.cn/.　

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Editor: Feng Ye

During the Spring Festival holiday in 2025, the number of traffic trips exceeded 2.3 billion.

On the 5th, the reporter learned from the 2025 Spring Festival travel rush Comprehensive Transportation Work Class that during the Spring Festival holiday this year (from January 28th to February 4th), the cross-regional personnel flow of the whole society was 2,306.845 million.

Specifically, the passenger traffic by railway is 96.26 million, the passenger flow by road is 2,182.93 million (the passenger travel by non-operating passenger cars on expressways and provincial highways is 1,989.65 million, and the passenger traffic by road is 193.28 million), the passenger traffic by waterway is 9.413 million, and the passenger traffic by civil aviation is 18.2415 million.

Welcome to [car home Puyang Preferential Promotion Channel] to bring you the latest auto market trends. At present, high-profileBenteng ponyThe model is having a grand preferential activity in Puyang area. Car buyers are blessed, because this model has provided a cash profit of up to 0.5 million yuan at the moment, and the minimum starting price has been as low as 19,900 yuan. This is a good opportunity to buy a car. If you want to know more specific car information and preferential policies, just click "Check the car price" in the quotation form, so that we can grasp this attractive preferential moment together and strive for higher car purchase discounts.

With its well-designed profile, Pentium pony shows a unique sense of movement and stability. The body size is 3000mm*1510mm*1630mm, and the wheelbase is 1953mm, which ensures spacious interior space and good driving stability. The front and rear wheel tracks are 1290mm, which provides a balanced handling performance for the vehicle. It is worth mentioning that it is equipped with 145/70 R12 tires, with simple and fashionable rim design, which not only improves the overall visual effect, but also provides a comfortable driving experience for drivers.

The interior design of Pentium pony fully embodies the simple and practical style. The steering wheel is made of plastic, which is not full of advanced feeling, but it ensures the portability and durability of operation. The center console is equipped with a concise control panel, integrated with an easy-to-operate multimedia screen, and provided with USB interfaces, including one in the front row, which is convenient for drivers and passengers to connect electronic devices. The seat is made of fabric, which makes it comfortable to sit. The main seat supports front and rear adjustment and backrest adjustment, and the co-pilot seat is also equipped with front and rear and backrest adjustment functions to meet the needs of different drivers. The rear seats support the proportional tilting, which provides greater flexibility for the interior space, and is convenient for loading goods or meeting the needs of family travel. On the whole, the interior design of Pentium pony pays attention to practicality and humanized configuration.

For the Pentium Pony, the engine is excellent in power performance, and the maximum power reaches 20 kW, which provides strong power support for the vehicle. At the same time, its torque output is 85 Nm, which can ensure smooth and flexible handling during daily driving and light load. This configuration ensures that the Pentium pony meets the driver’s needs while taking into account fuel economy and driving pleasure.

In the eyes of car home car owners, the uniqueness of Pentium pony lies in its unique appearance design, especially the eye-catching headlights and unique rear window shape. Although some people may question its face value, for Zhan Wang, these characteristics are the reason why he chose Pentium pony. They not only make the vehicle stand out among many models, but also enhance the driver’s self-expression. Generally speaking, with its unique charm, Pentium Pony won the recognition of the owner @ Call Me Work Soul Warrior.

The third week of May every year is "National Nutrition Week", and this year’s theme is "Whole grain, nutrition+,opening a new era of nutritious and healthy grains". In the new version of Dietary Guidelines for China Residents (2016), the first core recommendation mentions cereals: there are various foods, and cereals are the main ones. What does the grain include? Where is the whole grain? How much grain should we eat every day? Today, Xiaobian will give you a "past lives" of grain.

What is whole grain?

Whole grain refers to the whole grain and its natural nutrients that have not been refined (or processed by grinding and crushing). Compared with refined grains, whole grains contain more B vitamins, minerals, dietary fiber, phytochemicals, tannins, carotenoids, phytic acid, lignin and lignans. Common varieties are grain amaranth, barley, buckwheat and so on. "Whole grain" retains all kinds of nutrients and active ingredients in the grain to the maximum extent, and its health effects in preventing chronic diseases and other fields are remarkable.

How much grain do you want to eat every day?

Dietary Guidelines for China Residents (2016) suggests that healthy adults should consume 250g-400g of cereals and potatoes every day, which is equivalent to 1 small bowl of rice or 1 medium-sized steamed bread per meal. The whole grain and miscellaneous beans are not less than one third (50-150g).

What are the benefits of eating whole grains often?

According to the data of the Whole Grains Council of the United States, eating whole grains regularly can effectively reduce the risk of some chronic diseases, such as type 2 diabetes by 21-30%, cardiovascular disease by 25-28% and stroke by 30-36%. It can also reduce the risk of obesity, colorectal cancer, asthma and inflammatory diseases, maintain normal blood pressure, reduce gum disease and prevent tooth loss.

How to select whole grains

1. According to the suggestion of USDA, firstly, check whether there is the word "whole" in the ingredient list, such as whole oats, whole wheat flour, whole grain corn and whole rye.

2. Even if some foods are marked with "multi-grain", "100% wheat", "high-fiber" and "whole wheat", in fact, they are only added with bran, lacking germ, and do not belong to whole grains, so they need to be carefully recognized when purchasing.

3. When choosing oatmeal, try to choose "pure oatmeal" instead of "nutritious oatmeal" with various ingredients, such as white sugar and vegetable oil powder. "Pure oatmeal" contains higher nutrients, such as dietary fiber, and more sugar and fat in "nutritious oatmeal" is not conducive to cardiovascular health.

Content source: Beijing Nutrition Society

Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text