Messi wrote his own legend in Barcelona.

In the early morning of January 31st, Beijing time, Barcelona beat Leganés 5-0 in the fourth round of the King’s Cup, and Messi scored twice for his 500th victory in Barcelona. The team’s full firepower seemed to send a signal to the outside world: even if no striker was introduced in the winter window, Barcelona could still score.

When Messi came out of power, his old rival Cristiano Ronaldo had to face embarrassment. According to a online celebrity analysis website, although there are as many as 200 million Portuguese social network fans, as many as 25% of them belong to "zombie fans".

Before the winter transfer in Europe was closed, some important players decided on their next homes one after another, including Manchester United official bruno fernandez, whose highest transfer price is expected to reach 80 million euros. In addition, Paco’s joining Villarreal also broke the transfer record in team history.

Messi has left more and more names on Barcelona’s record list.

King’s Cup Barcelona 5-0, Messi 500 wins milestone?

In the early morning of 31st, the fourth round of the Spanish King’s Cup in 2019-2020 was contested at Camp Nou. Barcelona beat Leganés 5-0 at home and Messi scored twice.

In the face of Leganés, who ranked second to last in the league, Barcelona fought a bloody battle. Gleizman, Langlais and Artur all scored goals. Messi himself scored two goals in the 59th and 89th minutes. Although the victory was easy, it was a milestone for Messi. This victory was his 500th victory for Barcelona. Since winning for Barcelona for the first time on October 16th, 2004, Messi has never stopped.

Messi has won the most games in the history of Barcelona, followed by Harvey, with 476 games. In addition, Messi has won 86 teams, including as many as 29 victories against Seville.

In this campaign, Setien, the coach of Barcelona, changed his formation back to 433, which Barcelona used to be used to. After the game, the new coach also gave an answer to the lack of signings in Barcelona’s winter window. "Dembele will be back soon in these weeks. He has special abilities and we will try our best to let him find his best state. (Not signing) Maybe there will be some risks when a player is injured, but I believe in my players."

Interestingly, L ‘Equipe revealed that Bakambu, a foreign aid who played for Beijing Guoan, had already entered Barcelona’s signing list. Guoan even received an offer from Barcelona, and Guoan, who was preparing for the pre-season in South Korea, decided to release him. The problem was that when Bakambu arrived in Hong Kong to transfer to Spain, he received a phone call from Abidar, director of Barcelona, and was told that Barcelona finally decided to withdraw his offer, so the player had to fly back to South Korea. Afterwards, Bakambu posted a passage on social media, in which he said with a little ridicule, "Please add’ Almost Joining Barcelona’ to my transfer history in Transfer Market. No matter what happens, I believe in the fate process, thank God. Gleizman, let’s meet again sometime. "

Among C Ronaldo’s social network fans, there are a large number of "suspicious accounts".

C Ronaldo also has zombie fans?

Not long ago, Cristiano Ronaldo’s Ins fans reached an astonishing 200 million, and he even published an Ins status celebration. However, a online celebrity analysis website named HypeAuditor found that 72% of Cristiano Ronaldo’s 200 million fans were real people, 2.1% were online celebrity, another 18.7% were "suspicious accounts", and the remaining 6.4% were "automatically following fans"-that is, the number of followers exceeded.

"Ins robots" are classified as suspicious accounts. They are used to handle likes or comments and also play a role in buying powder. Therefore, 25%-about 50 million fans are not real people. It is worth mentioning that as early as 2015, the Daily Sports Daily broke the news that as many as 64% of Cristiano Ronaldo’s Twitter followers were "zombie fans". The media said that as many as 21 million Cristiano Ronaldo’s Twitter followers were behind him, their Twitter accounts were inactive. Of course, all this may have nothing to do with Cristiano Ronaldo himself. Celebrity social accounts will be run by related teams, and it is reasonable to "buy powder". In fact, another research and analysis in November last year showed that 51% of Cristiano Ronaldo’s former teammate Cross’s fans are "zombie fans", which is the highest among Ins users.

This time, HypeAuditor also analyzed the composition of C Ronaldo’s fans. 49% fans are not interested in sports, but pay more attention to music and even fashion. In addition, 72% of C Ronaldo’s fans are men and 28% are women. There are more fans from India than other places, with 22% fans from India; The second place is Iran, with 15%; There are 3% fans from Madrid, the city where Cristiano Ronaldo’s old club Real Madrid is located. In terms of language use, 44% are English users, 9% are Persian and 9% are Arabic.

Manchester United need to pay up to 80 million euros for Fernandez.

Manchester United officially announced bruno fernandez.

In the early morning of the 31st, Manchester United officially announced that bruno fernandez had joined the club. It is reported that the two parties signed a contract for five and a half years, and there is a one-year renewal option.

In fact, 24 hours ago, Manchester United reached an agreement with Portuguese Sports on the transfer of Fernandez. According to the figures released by Portuguese Sports, Manchester United needs to pay him a maximum of 80 million euros, including 55 million fixed transfer fee plus 25 million floating amount. According to the relevant provisions, 5 million euros is related to the number of appearances, and another 5 million euros depends on whether Manchester United can qualify for the Champions League. In addition, 15 million euros depends on Fernandez’s personal achievements in Manchester United in the future. It is reported that if Fernandez switches to another team in the future, Portuguese sports can still reap 10% income from the transfer fee.

During his two and a half seasons in Portuguese sports, Fernandez played excellent data, with 16 goals and 20 assists in 2017-18 and 32 goals and 18 assists in 2018-19. He has scored 15 goals and 14 assists in the middle of this season. According to the outside world, his joining will inject vitality into Manchester United’s frontcourt attack. Head coach Oleskjaer also said in an interview: "We have been paying attention to Fernandez for several months, and he.

I wonder if Paco can reproduce his previous style in Villarreal.

Paco joined Villarreal, and the transfer fee broke the team history record.

A few days ago, Villarreal officially announced the signing of Spanish striker Paco Alcácer from Dortmund for five and a half years.

According to the previous report of Kicker, the transfer fee of Dortmund striker Paco to Villarreal totaled about 30 million euros, while the version of AS newspaper was 23 million euros, while Dortmund originally signed Paco from Barcelona at a cost of 23 million euros. In any case, Paco’s transfer fee broke the record of "Yellow Submarine" when 20 million euros signed Gerard Moreno two seasons ago.

Last season, Paco scored 18 goals in 26 Bundesliga games, but this season he only played 11 Bundesliga games and contributed 5 goals and 1 assist. With the arrival of Harland, his position has been gradually marginalized. Paco came from Valencia youth training. At the age of 18, he scored 28 goals in 27 games in a single season. He played for the first team of Bat Corps for 3 seasons, scoring 43 goals and assisting 17 times in 124 appearances. In the 2016/17 season, Barcelona signed him for 30 million euros. He played for Barcelona for one and a half seasons, made 50 appearances, scored 15 goals and made 8 assists, won the league championship and the King’s Cup on behalf of Barcelona, and then landed in the Bundesliga … Now Villarreal has introduced Paco with a record transfer fee, so I naturally hope that he will regain his previous style.

Deschamps is very dissatisfied with being labeled as "discrimination".

Deschamps took cantona to court.

A few days ago, according to the news of French media RMC, the case of French team coach Deschamps suing cantona will be officially opened in Paris at the end of February.

The contradiction between them stems from cantona’s inappropriate comments on Deschamps’ selection of players in 2016. At that time, cantona thought that Deschamps’ national team discriminated against players with North African descent, which made them have an issue. Although it has been three years, Deschamps decided to resort to the law.

In an interview with the Guardian before the 2016 European Cup, cantona said: "Benzema is a great player, and so is Ben Alpha, but Deschamps has a real French name. He may be the only person in France who really has a French name. No one in his family has been combined with people of other descent, so I am not surprised when he did not take Benzema to the European Cup. Ben Alpha may be the best player in France.

Cantona’s meaning is very clear. Because both players are of North African descent, they were abandoned by the head coach, but this statement obviously doesn’t work. Deschamps’ team is a powerful whole composed of players of different colors and bloodlines. In 2016, he won the runner-up in the European Cup and reached the peak in the 2018 World Cup. A large number of black players such as Bogba and Mbappé are still the absolute core. Deschamps has no reason to exclude players with North African descent. In fact, Ben Alfa has already gone from bad to worse, and Benzema can’t make it because of the fierce competition in the front.

Deschamps responded at the first time: "I don’t understand what he is saying at all, and I will never forgive him for slandering me."

In 2017, Deschamps entrusted a lawyer to prepare to sue cantona, but the case did not enter the final judicial procedure until today. It is reported that the court will hold a hearing on February 28th, and judging from the current situation, cantona, who has no secret words, may be overwhelmed.

Ding Junhui continued his ups and downs.

Ding Junhui missed the top 16 in the German Masters.

On January 30th, German snooker master Sai Ding Junhui lost to Scottish Donaldson 4-5 and missed the top 16, which was his second defeat to the same opponent in a week.

Last week’s European master Sai Ding Junhui just met Donaldson, when he lost to his opponent 2-5 in the second round and missed the quarter-finals. Fighting again after a week, Ding Junhui failed to take revenge and add new hatred. Before the game, the two sides were evenly divided in the first four games. Ding Junhui scored 55 points in the third game and Donaldson shot 132 in the fourth game. After the break, Ding Junhui won two games in a row 60-50 and 72-0 to get the match point, but Donaldson chased two games in a row; Although Ding Junhui scored 50 points in the deciding game, it was a pity that Donaldson still scored 52 points in one shot, which was a pity.

It is worth mentioning that Donaldson lost against Ding Junhui three times in a row before these two confrontations. Now the player ranked 24th in the world seems to have found the confidence to beat Ding Junhui. On the other hand, Ding Junhui, after winning the championship in the British Championship at the end of 2019 and ending the shortage of ranking titles for more than two years, was frustrated again in 2020, with a round of snooker masters, a round of European masters and a round of German masters … He was depressed.

1905 movie network news From, to, almost every summer, there will be a national ramble out of the tight encirclement. This year, the first film in the series of painting rivers and lakes — — The curse of the wind. After the trailer was released at Cannes Film Festival in 2014, five years later, The Wind Spell was finally produced and will be shown to the audience on July 13th. Let many fans sigh, and finally wait for you.

In the preview released this time, Xia Lan used the five elements of gold, wood, water, fire and earth to fight fiercely with fierce beasts. According to legend, only the power of wind can compete with it, revealing the meaning of the title "Wind Spell" and setting up a world view full of Chinese style. In the poster released together, the young volley confronted the huge gluttony, revealing a stirring story of the rise of a young hero.

　

The most valuable guoman IP　The Wind Spell permeates the national wind into every detail.

From its first broadcast in 2012 to the present, the painting rivers and lakes have created many high-quality comic dramas, such as Xia Lan, Bad Man, Soul Master, Cup Don’t Stop, and Changed Students, which can be said to be the most cosmopolitan and vital national comic, and also regarded as the most valuable national comic IP in the industry. Therefore, the first movie of painting rivers and lakes was placed high hopes by anime fans to help the rise of the country.

In the preview, the mythical gluttony in this world, Xia Lan uses the power of five elements to compete, and the teenager wants to be a hero when he enters the rivers and lakes … … The setting of the whole world outlook in the Wind Mantra is full of Chinese style. The same is true of the details. Fierce beasts, which are mostly composed of curved designs, and rivers and lakes in noisy streets are trying their best to convey an oriental aesthetics, which conforms to the audience’s imagination of "national ramble". Director Liu Kuo almost "digs" these details to the extreme. "Let the China audience like it first and see it comfortably."

　

Hold back the movie dream for six years and develop the only domestic animation engine.　"grab back" some audiences for Guoman

The completion of the Wind Spell took five years of preparation and three years of production. But the time behind it is far more than that. In the mind of director Liu Kuo, this movie dream has been held back for too long. "Although I had a dream of making movies long ago, I still held back. I want to make myself strong first. Because the country in my heart is made by ourselves. "

With this in mind, director Liu Kuo and the team started to develop a "Datura Engine" for animation. After six years of "darkness before dawn", China’s 3D animation finally has the original ability of the whole process. After tens of thousands of minutes of animation polishing, "Wind Spell" was finally launched. The film is about to be released, and Liu Kuo revealed his hope that "in the case that the China market has been occupied by Hollywood and Japanese animation for a long time, we can win back some audiences for domestic animated films in China"!

　　Cctv newsNine times out of ten, life is not satisfactory, only a little joy.

　　The four children got what they wanted, and they all had their own places after the college entrance examination; Three families bumped into each other, experienced anxiety and pain, and finally gained their own little joy … The hit TV series Little Joy, which has been unhappy all the time, finally ushered in a relatively "satisfactory" ending.

　　Little Tao Hong, who hasn’t taken the role for many years, didn’t expect Little Joy to be so popular. At first, he didn’t want to take the role of "Song Qian". He just joined in with the mentality of helping, and only agreed after turning on the phone, not to make a strong comeback. "I don’t have a play, but I don’t have nothing to do every day. I’m busy." Since he married Xú Zhēng, Tao Hong Jr. has gradually faded out of people’s sight and devoted himself to his wife. After having a daughter in 2008, accompanying her to grow up day by day became the happiest thing for Tao Hong Jr.

　　It’s not easy to tidy up a home. It took 10 years to learn how to be a mother. After returning to the family, Tao Hong Jr. once again attracted attention with the image of such a paranoid mother and became the most discussed mother in Little Joy. The audience remembered that Tao Hong, who had a pair of peach eyes, had interpreted so many classic characters. She has been clever and charming in Black Eyes, Empty Mirror, Sunny Days and Pig with Bright Spring, and she never forgets anything.

　　Interestingly, on the one hand, he became famous too early and left the screen for too long, so that many young viewers didn’t know little Tao Hong at all; On the other hand, the image of "Song Qian", an unlovable but true "Chinese-style" mother, makes people see Tao Hong’s acting again. "I feel great, don’t know me, so I can ‘ Do whatever you want ’ Play more different roles. "

　　Not long ago, Christina’s speech at the FIRST Film Festival calling on directors and producers to give Mesozoic actresses a chance caused a heated discussion. The passive situation that the subject matter is far away, the role is missing, and the older actress has no play is once again put on the table. In "Little Joy", in addition to the formidable young actors, the excellent acting skills of six middle-aged actors are the quality guarantee of the whole play.

　　Tao Hong Jr. thinks that this is not something that a middle-aged actress can’t play in the final analysis, but something that the whole middle-aged women group is not concerned by the society. "Without corresponding attention, there will be no film and television works, and no works will tell them. Who will we play?" Nowadays, Tao Hong Jr. is more relaxed. He never picks up plays at random, and he doesn’t need to prove that he can act. If he has good works, he will come out and perform. With inner satisfaction and family harmony, Tao Hong Jr. no longer "competes" with herself, and the pressure and anxiety of middle-aged actresses do not exist here.

　　Yongmei and George W. Tao Hong are old acquaintances. It’s been 20 years since they first collaborated on Where Dreams Start to Little Joy. In the play, Yongmei’s gentle and intellectual mother "liujing" is not only in sharp contrast with Tao Hong’s tough mother "Song Qian", but also has a special friendship with Song Qian’s daughter "Eiko". Many viewers reported that they were often moved to tears by this unforgettable friendship between liujing and Eiko.

　　Making friends with a child, supporting each other and making progress is also Yongmei’s favorite counterpart. Playing mother is nothing new to Yongmei. In "Little Joy", Yongmei, who has never been a mother, just deduced the most ideal mother in the hearts of countless people, giving this role the most comfortable and appropriate appearance, and his acting skills can be seen.

　　Yongmei has always been the kind of actor whose audience is particularly familiar with but whose name is unknown. Liujing, who is as gentle as jade and generous in understanding, has more or less Yongmei’s own shadow. She often gives people the impression of extraordinary temperament. She speaks slowly and eloquently, and people and voices are very comfortable. It seems that seeing her will make her feel better.

　　After 23 years of debut, Yongmei, a non-trained actress, is not a prolific actress. In the entertainment industry, she is even less eager to achieve success and pursue fame and fortune. At the beginning of the year, it seems that the afterheat of Yongmei’s winning the first Berlin film in the mainland with Wang Xiaoshuai’s film Auld Lang Syne has just dissipated. Little Joy is so gentle that liujing in her bones is once again surrounded by powder, and Yongmei, who has always been low-key, has reached a new high in fans and attention, which has made everyone have new expectations for her.

　　The audience slowly understood her story. She has always maintained a cautious sense of alienation in the entertainment industry. After four years without filming, she once said, "I am waiting for the role that belongs to me. I am not in a hurry, so don’t worry." Yongmei, who is in no hurry, still has a temper when she has an opinion. When there is no filming, there are works to find her, and she can only play some unnecessary wife roles. "How to say, like a shelf without a soul." Yongmei refused.

　　"I also have times when I am not gentle, more stubborn and more individual, and sometimes when I am unreasonable." As long as it’s a good character, dynamic and touching, even if it’s repeated, Yongmei thinks it can be played. It’s not that she doesn’t feel the confusion of middle-aged actresses, especially in domestic scripts, which are always stereotyped and faceless, lacking all kinds of middle-aged female images. Therefore, when he meets a good role and cast, Yongmei cherishes it especially. There are some phenomena that she doesn’t agree with and can’t change, but she believes that the current situation that there is no market for powerful actors is slowly changing. At present, it is most important to be yourself.

　　Sha Yi had only eight episodes in Little Joy, and as a special actor, he was a veritable "supporting role". However, as soon as he appeared, "Qiao Weidong" who opened his mouth "Eiko, open the door, stay" contracted all the jokes of the audience. Sha Yi’s "Qiao Weidong" was originally an out-and-out "love rat" image, dressed in flowery shirts, whiskers and crew cut, and quickly won the title of "rustic old man".

　　You can feel the "greasy" of "Qiao Weidong" through the screen. However, it is such a father who is full of humor, afraid of his wife and loves his daughter, and has become the favorite of the audience among the three fathers. Some people say that just seeing Sha Yi’s face makes him want to laugh, and he is a man with his own jokes. With superb acting skills, Sha Yi has successfully promoted the role of "Qiao Weidong" to one of the important leading roles, and more and more scenes have been played.

　　Sha Yi, who had a childhood filter, frequently searched for Little Joy. The charming Bai Zhantang disappeared completely and was replaced by the good father "Old Joe" who knew, loved and cared for children.

　　Over the years, Sha Yi has never faded out of public view, but it seems that he has only done one thing, being a good father to Angie and Xiaoyu. Although not yet a son, Sha Yi, who relies on his two sons to perform variety shows frequently, teases himself that he has ushered in the second spring of his career, which makes him feel helpless.

　　Time is like killing a pig, getting fat and getting out of the dimple. It is hard for people to think that "Qiao Weidong" and "Bai Zhantang" are the same person in Sha Yi now. Legend of the Wulin is indeed the pinnacle of Sha Yi’s popularity and career, but since then, although he has played some roles intermittently, the audience’s impression of him still stays in "Bai Zhantang". Sha Yi seems to be used to it, too. It is much more difficult for him to be a father to his two sons and accompany them to grow up than to be an actor. He doesn’t mind being a green leaf in the family.

　　It is precisely because every character in the play is so lively and all the actors are acting online that "Little Joy" has left so many viewers wanting more. The actors we knew as children are no longer young or even forgotten by us, but when they appear, they are always warm and bright. Just as the director said, life is like "looking for sugar in glass slag" to "joy", and every grain is precious. (Text/Wang Jiaying)

CCTV News:In Wonsan, the eastern city of North Korea, there is a famous factory that produces leather shoes. The "Yingfengshan" brand leather shoes produced here have excellent workmanship and fashionable styles, which are well received by the Korean people. This factory is Yuanshan Leather Shoes Factory.

At the North Korean National Footwear Exhibition in 2018 and 2019, a leather shoes brand named "Yingfengshan" made a big splash for two consecutive years and won the first prize and the special prize respectively. This brand came from Yuanshan Leather Shoes Factory.

Yuanshan Leather Shoes Factory was founded in 1959 and has a history of 60 years. Kim Jong-un, the current top leader of North Korea, came to Yuanshan Leather Shoes Factory five times since 2014, and it was from 2014 that the development of Yuanshan Leather Shoes Factory entered the fast lane.

CCTV reporter Dong Haitao:This pair of shoes on the exhibition platform was produced in 2007, while this pair of shoes on this side was produced in 2017. It can be seen that there are great differences in texture, design and workmanship between them in the past ten years.

Independent research and development, independent manufacturing and self-reliance

According to the factory commentator, the entire production system of the factory is independently developed by North Korea, and the raw materials for shoemaking are also independently produced by North Korea, while the electricity is provided by national power stations such as Yuanshan Military and Civilian Power Station. They are at the forefront of North Korea’s footwear industry in implementing national policies and realizing self-reliant production, and factory employees are particularly proud.

Zhao Mingshi, head of technical department of Yuanshan Leather Shoes Factory:We received many favorable comments and won the special prize at this spring national footwear exhibition in North Korea.

Cui Hua, a female worker in Yuanshan Leather Shoes Factory:I am a shoe-maker, and I like the ladies’ sandals produced by our factory best. Sandals are women’s favorite footwear products in summer, and we have successfully controlled the weight of women’s sandals within 250 grams.

Nowadays, the vast majority of shoemaking employees in the factory have more than 5 years of shoemaking experience, and the factory will arrange different kinds of leather shoes production plans according to the season, personnel arrangement and product demand.

CCTV reporter Dong Haitao:I’m at the end of the production line of Yuanshan Leather Shoes Factory, where all kinds of leather shoes are displayed. I’m going to have a try now. Let’s try on this pair of pointed leather shoes first. They look very fashionable. The sole is solid and powerful, and it walks steadily. It is a good pair of shoes.

Leather shoes factory is looking forward to expanding production.

Since 2014, the quality of "Yingfengshan" brand leather shoes has been continuously improved, but the price is very close to the people. Take the pair of leather shoes that I just tried on as an example. The ex-factory price is only 25,000 yuan, which is equivalent to about 20 yuan, which is quite good and cheap. The factory commentator told me that the supply of factory products to the Korean people is already in short supply, and they hope to expand production in the future and strive to make "Yingfengshan" brand leather shoes go global.

With the popularization of HPV vaccine knowledge, many people want to be vaccinated with HPV vaccine. But how much do you know about HPV vaccine? What is the difference in the applicable population of HPV vaccines with different "prices"? In this regard, Chen Shouzhen, deputy director of the Obstetrics and Gynecology Hospital affiliated to Fudan University, summed up ten common questions and answered them to the majority of netizens.

What is HPV virus?

Human papillomavirus (HPV) is a small double-stranded DNA virus, so it is called human papillomavirus because it only infects humans. There are more than 200 subtypes of HPV, which can be divided into high-risk type and low-risk type according to whether they are carcinogenic or not.

Low-risk type usually infects the skin and causes warts, commonly known as boils. Most of them can naturally subside in 3-5 years, and some may need laser, freezing and other methods to remove them.

There are about 15 HPV subtypes (HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 and 82) that can cause malignant tumors such as cervical cancer, vaginal cancer and oropharyngeal cancer, so they are called high-risk HPV. Among them, HPV16/18 has the highest risk of cancer. About 70% of cervical cancer in the world is caused by high-risk HPV16 and 18, and 20% is caused by HPV31, 33, 45, 52 and 58. HPV16 types 16 and 18 are also associated with oropharyngeal cancer, vulvar cancer, vaginal cancer, penile cancer and anal cancer.

Will HPV infection definitely lead to cancer?

Persistent infection of high-risk HPV will lead to cancer. More than 90% of HPV infections usually subside naturally within 2 years. If carcinogenic HPV infection lasts for more than 1 year, the possibility of precancerous or cancerous lesions will increase, but not all persistent infections will progress. Only less than 1% of infections will develop into cancer after 5 to 10 years of precancerous lesions. Therefore, even if there is HPV infection, it will not necessarily become cancer, but we should pay attention to the corresponding screening.

At present, there is no specific drug to treat HPV. Through regular screening, we can observe the situation of HPV infection, so that we can treat it at an appropriate time and reduce the risk of cancer.

Personal life is very healthy, how can you be infected with HPV?

HPV virus spreads in various ways.

It can be widely spread among people through skin contact, and more than 80% of women have been infected with HPV at least once in their lives. Sexual life is the main reason why HPV spreads around the anus and genitals. Sticking to the correct use of condoms can reduce the risk of HPV infection.

Generally speaking, there are many ways of HPV infection. At present, there is no good way to prevent HPV infection, but healthy living habits, such as quitting smoking and drinking, and wiping separately after going to the toilet may reduce the probability of HPV infection. Even if you are infected with HPV, you don’t have to be nervous, because most HPV infections can be monitored regularly after infection, and generally will naturally fade away soon.

How to prevent HPV transmission?

Vaccination with HPV vaccine can safely prevent cancer caused by persistent HPV infection.

Vaccination with tetravalent or nonavalent HPV vaccine can also prevent condyloma acuminatum, which is a benign disease, but the treatment failure rate is relatively high, affecting physical and mental health. Therefore, for the majority of women, it is very necessary to vaccinate HPV vaccine.

How to choose HPV vaccine?

At present, three different vaccines have been developed, which are divided into bivalent, tetravalent and nonavalent vaccines according to the number of HPV subtypes they target. Simply put, bivalent HPV vaccine is aimed at HPV types 16 and 18; The tetravalent HPV vaccine is aimed at HPV6, 11, 16 and 18; The nine-valent HPV vaccine not only targets the same HPV subtype as the four-valent vaccine, but also targets types 31, 33, 45, 52 and 58. At present, HPV vaccines are all preventive vaccines, aiming at preventing initial HPV infection and subsequent HPV-related diseases.

At present, many hospitals, from community medical service centers to tertiary hospitals, have HPV vaccines, and these HPV vaccines can be safely vaccinated. Because of limited resources, the queue time of nine-valent vaccine will be longer. If resources and funds are not a problem, it is recommended to vaccinate the nine-valent HPV vaccine. If there is no nine-valent HPV vaccine, tetravalent HPV vaccine and bivalent HPV vaccine are also good choices, because both vaccines cover the most dangerous types 16 and 18. Generally speaking, you should try to use the same vaccine preparation to complete vaccination. However, if you don’t know the original HPV vaccine dosage form, you can also use another HPV vaccine preparation to complete the subsequent vaccination.

At what age is it appropriate to get HPV vaccine?

At present, the recommended age of HPV vaccination in China is 9-45 years old. Most countries in the world recommend routine HPV vaccination at the age of 11-12, and some suggest starting from the age of 9. For teenagers and adults aged 13-26, replanting is also recommended if they have not been vaccinated with HPV vaccine or have not completed a series of vaccines.

Why don’t foreign countries recommend routine replanting for adults over 27 years old? This is because with the increase of age, the possibility of infection with subtypes covered by HPV vaccine is gradually increasing. For older people, the benefit and cost performance of HPV vaccination are low. However, research shows that there are two peaks of high-risk infection among women in China: 17-24 years old and 40-44 years old, and single HPV infection is the main infection. Considering the characteristics of female infection and the low coverage rate of cervical cancer screening, experts suggest that women aged 9-26 should be vaccinated with HPV, and women aged 27-45 should be vaccinated when conditions permit. Women over the age of 45 don’t have to worry. At this stage, the HPV vaccine is low in cost performance, and the standardized HPV screening is enough to prevent cancer.

In the recommended age range, the best time for HPV vaccination is before the first sexual intercourse, because HPV vaccine immunization is the most effective for individuals who are not infected with HPV. That is to say, the younger you are when you are vaccinated with HPV, the more the incidence of cervical cancer decreases.

Are there any side effects of vaccination?

Vaccination of HPV vaccine, like other vaccines, may have pain, swelling and erythema at the inoculation site. A few people may have syncope or dizziness, and there are some rare other side effects, which may be related to the adjuvant in the vaccine, so you can rest assured to vaccinate. In addition, HPV vaccine can be safely inoculated in different parts with other vaccines at the same time. At present, there is evidence that inoculation of tetanus, acellular pertussis, diphtheria and inactivated polio vaccine at the same time with HPV vaccine does not damage the immune effect of the body against HPV vaccine or other vaccines at the same time.

Because there is no relevant evidence, it is generally not recommended to vaccinate HPV during pregnancy. However, with the increase of the number of people vaccinated, more and more data about unintentional vaccination after pregnancy show that vaccination during pregnancy has no effect on the safety of mother and child. Nevertheless, the remaining vaccination should be postponed, and it is best for vaccinated women to get pregnant two months after the vaccination is completed. Vaccine does not affect the safety of breastfeeding, but at present, such data are limited, so it is necessary to carefully consider HPV vaccination for lactating women.

I have been infected with HPV before, can I still be vaccinated?

There is no need to evaluate whether you have been infected with HPV before vaccination. A history of abnormal cervical cancer screening, genital warts and HPV infection is not a taboo for HPV immunization. Because these conditions all suggest that HPV was infected in the past, but it is not necessarily HPV subtype infection covered by HPV vaccine. For people who have a history of HPV infection but are still within the recommended age range, vaccination is still recommended because it still has a protective effect on the uninfected vaccine strain HPV virus. However, for people who have been infected with the subtype covered by HPV vaccine, the benefits of immunization are small.

What if we miss the seeds? I have been vaccinated with bivalent or tetravalent HPV vaccine before. Do I need to replant with nine-valent HPV vaccine?

Missing seeds means that immunization is not carried out according to the schedule. At present, the evidence shows that no matter how long the series vaccination is interrupted, it can continue to vaccinate without restarting the series vaccination.

Now it is found that HPV vaccine has a long-lasting protective effect against HPV-related diseases, and there is no need for multiple cropping. For women who have already completed bivalent or tetravalent HPV vaccination, the benefit of using nine-valent vaccine for multiple inoculation may not be obvious, so it is not recommended.

After vaccination with HPV vaccine, can I avoid regular screening?

At present, HPV vaccine can only prevent infection. After vaccination, existing HPV infection, genital warts or precancerous lesions cannot be eliminated, and the vaccine can only prevent cervical cancer caused by seven subtypes at most. After injection of HPV vaccine, other subtypes of HPV may still be infected, which may lead to cancer. Therefore, cervical cancer screening is still needed after HPV vaccination.

On February 28th, in Zhongxing Village, Guanshi Town, Hengyang County, Hengyang City, Hunan Province, the agricultural machinery hand drove the agricultural machinery to work in the field. Photo by Cao Zhengping (Zhongjing Vision)

　　Doing a good job in spring ploughing production and winning a bumper harvest in agriculture is of great significance to winning the battle against poverty and building a well-off society in an all-round way. The reporter learned that due to the epidemic, the current agricultural production faces some outstanding difficulties. But the more complicated the situation, the more we must stabilize agriculture. Moreover, there are still many favorable conditions for stabilizing agricultural production.

　　At present, in the Huang-Huai-Hai Plain, winter wheat has turned green, and spring field management has begun; In Jiangnan, rape flowers are about to bloom one after another; In South China and Southwest China, some crops have begun to be sown in spring; In the northeast, some places are planning to prepare soil for farming. In the vast vegetable greenhouses and livestock pens, the pace of agricultural production in spring has never stopped.

　　The more complicated the situation, the more we should stabilize agriculture. "This year is a special year. Doing a good job in spring ploughing and winning a bumper harvest in agriculture is of great significance to winning the battle against poverty and building a well-off society in an all-round way." Han Changfu, Minister of Agriculture and Rural Affairs, said that it is necessary to adhere to the "two mistakes" in epidemic prevention and control and agricultural production, ensure the normal and orderly agricultural production in spring, resolutely fight the tough battle of agricultural harvest in the year of preventing epidemic and winning a well-off life, and ensure that the key tasks of agricultural and rural development are completed as scheduled.

　　Play the agricultural card well and stabilize the basic disk

　　In the past few days, agricultural machinery has roared in the farmland of Zhenqingmei Planting Professional Cooperative in Dongshan Village, Penggao Town, Shangli County, Pingxiang City, Jiangxi Province, and agricultural hand Hu Ruhai has driven the cultivator to shuttle through the fields, and a piece of farmland has become flat. The farmers on the side took advantage of the fine weather to clear the land that had been finished by the machine out of the ditch and sort it into pieces. Li Haijun, chairman of the cooperative, said that the cooperative has 116 mu of farmland, and it is planned to arrange all the farmland in one week without delaying the next planting plan.

　　A year’s plan starts with spring. Liu Changquan, director of the Industrial Economics Office of the Institute of Rural Development of China Academy of Social Sciences, believes that doing a good job in agricultural production is the material basis for coordinating the prevention and control of epidemic situation and economic and social development. Different from industrial production, the object of agricultural production is living organisms, which has its natural laws, and the farming time is urgent and can not be delayed. Agricultural production in spring involves many varieties and a wide range. The area of spring sown grain accounts for more than half of the whole year, and the output of summer grain accounts for about a quarter of the whole year; Spring is the peak season for livestock and poultry to replenish livestock and poultry, and the protection of meat, eggs and milk cannot be separated from the spring.

　　The reporter learned that due to the epidemic, the current agricultural production faces some outstanding difficulties. In some areas, it is difficult for agricultural materials to reach the village, and it is difficult for farmers to go to the fields, which has affected food production to some extent. In some areas, the circulation of important agricultural products such as "vegetable basket" is blocked, vegetables and fruits are unsalable in some areas, live poultry transportation is prohibited in some places, and the normal supply, transportation, slaughter and sales channels of poultry are blocked. In some provinces, it is difficult to sell milk and fish, especially for new agricultural subjects such as family farms, farmers’ cooperatives and leading agricultural enterprises, which are generally faced with difficulties in employment and expensive employment, and encounter difficulties in production and operation.

　　But at the same time, the reporter found that there are still many favorable conditions for stabilizing agricultural production. On the one hand, the policy has support. The central government has continued to support grain production. China has maintained the minimum purchase price of rice and wheat, and the subsidy policy for corn and soybean producers has been generally stable. The purchase subsidy for agricultural machinery has increased, which is conducive to mobilizing farmers’ enthusiasm for farming. Recently, the Ministry of Agriculture and Rural Affairs has put forward a series of policies and measures on the stable production and supply of "vegetable basket" products, spring ploughing and preparation for ploughing, the resumption of aquaculture and the connection between production and marketing of agricultural products. On the other hand, agricultural resources are guaranteed. It is estimated that the demand for hybrid corn and hybrid rice seeds in China this year will be 1.06 billion and 210 million kilograms respectively, and the available seeds will be 1.64 billion and 400 million kilograms respectively. The supply of pesticides and fertilizers is generally guaranteed. It is estimated that more than 22 million sets of various agricultural machinery can be put into use nationwide, and the mechanized tillage rate and mechanized sowing rate of grain and oil crops are over 90% and 55% respectively.

　　Develop planting industry and keep the "rice bag"

　　The latest agricultural situation dispatch of the Ministry of Agriculture and Rural Affairs shows that the crops in the field are growing well in the country. The area of winter wheat is basically stable, with 11 major winter wheat producing provinces accounting for 83.4%, an increase of 2.7 percentage points over the same period of last year, and the growth of seedlings is better than that of last year. At present, winter wheat in most parts of the north is still in the wintering period. The area of winter rape is more than 92 million mu, up by 2.7 million mu year-on-year. The first-and second-class seedlings in the main producing areas account for 83.3%, up by 1.3 percentage points year-on-year. At present, winter rape in the Yangtze River basin has entered the bud stage.

　　Heilongjiang is the largest province in grain production. At this time, the black land gradually broke the silence. "The crop planting area in the province is expected to remain above 220 million mu, including more than 210 million mu of grain crops." Wang Yongkang, deputy governor of Heilongjiang Province, introduced that Heilongjiang has opened a green channel for agricultural materials, and adopted measures such as special person in charge, special car transportation, special line driving and special person pick-up and drop-off to ensure smooth transportation. Using new media such as Yinong Information Agency and Agricultural Big Data Platform, we will adopt new methods of preparing for farming such as online guidance, ordering, training and loans, so as to prevent and control the epidemic situation and prepare for farming. At present, spring ploughing seeds, pesticides and diesel oil have been put in place, 75% of chemical fertilizers have arrived, and 80% of funds have been raised.

　　Shandong is a major province of wheat production, and 58.6 million mu of wheat is the key period of field management in spring. "At present, the seedling situation in Shandong Province is generally good, and the first and second types of seedlings account for 83% of the total area. In order to stabilize the development of grain production, last year, the province took the stability of grain production as an important indicator, incorporated it into the rural revitalization assessment system, and gradually compacted the responsibility for food security. " Yu Guoan, vice governor of Shandong Province, said that this year, the assessment indicators of grain production will be improved, the assessment efforts will be intensified, and the enthusiasm of grass-roots governments for attaching importance to agriculture and grasping grain will be mobilized. At the same time, we will study and issue implementation opinions on effectively strengthening the construction of high-standard farmland and improving the national food security guarantee capacity, and carry out the green, high-quality and efficient creation of grain in the whole system to continuously improve the level of grain production.

　　Farming time waits for no one, so we should pay close attention to preparing for spring ploughing. Pan Wenbo, director of the Planting Department of the Ministry of Agriculture and Rural Affairs, said that it is necessary to effectively stabilize the grain planting area, promote the introduction of temporary subsidy measures, guide the southern region to resume double-cropping rice, and strive to ensure that the area of early rice is not lower than last year. This year’s structural adjustment will not reduce the grain area, corn should be stabilized, the pilot project of crop rotation and fallow will be adjusted appropriately, and grain feeding will mainly support the farming-pastoral ecotone in the north. Affected by the epidemic, the production and operation of seeds, fertilizers, pesticides, etc. are blocked. It is necessary to promote agricultural production enterprises to speed up the resumption of production, open stores as soon as possible, and establish a "green channel" for point-to-point supply and transportation to ensure that they can reach the village before spring ploughing. Strengthen the assistance and guidance for large-scale business entities and promote "one-stop" production custody services.

　　Stabilize the aquaculture industry and ensure the supply of meat, eggs and milk

　　Meat, eggs and milk are the main products of animal husbandry production, and they are also the focus of the people’s "food basket". Recently, all localities and departments have stepped up efforts to continue to promote the incorporation of breeding land into the management of facility agricultural land and the implementation of commitment filing system in environmental assessment, and to verify the clean-up and rectification of no-breeding areas. At present, the pilot project of mortgage loan for pig breeding has been expanded from four provinces to the whole country, and the scope of discount subsidy for farm households’ loans has been adjusted from more than 5,000 to more than 500 per year. With the expansion of loan scale, more and more farm households have begun to benefit. All localities have also made efforts to solve the difficulties encountered by poultry breeding due to the epidemic situation, and supported farmers to speed up the replenishment of poultry columns to ensure that poultry meat production will continue to increase throughout the year.

　　Sichuan is the largest province for pig production. "In January this year, there were 29 million pigs in the province, including 2.8 million fertile sows, and the production of pigs increased steadily and slightly." Yao Sidan, vice governor of Sichuan Province, said that the provincial finance in Sichuan allocated 300 million yuan to subsidize new fertile sows according to the standard of each 300 yuan. For free-range farmers, we will promote the model of "company+farmers" to help small and medium-sized farmers develop standardized farming. Carry out "peer-to-peer" services to help feed and slaughter enterprises and 504 pig farm projects to speed up the resumption of work and production. At present, the slaughtering enterprises in the province have basically resumed work, and the rate of returning to work for feed enterprises has reached over 85%. Looking at the whole year, the annual task of slaughtering 60 million pigs is expected to be fully completed.

　　Hunan Province actively implemented the "High-quality Hunan Pig" project. The province will reward the newly built, renovated and expanded standardized pig farms according to the new production capacity. If the annual production capacity is 10,000 to 30,000, the subsidy will be 500,000 yuan; More than 30 thousand heads, a subsidy of 800 thousand yuan. Support the expansion of the pilot scope of live pig price insurance, help farmers connect with loan financing institutions, and ease the financial difficulties of farmers. At present, 187 new large-scale aquaculture projects in the province have started to resume work one after another, and it is estimated that the new production capacity will be 9.3 million heads during the year; In January this year, the slaughter of pigs in the province increased by 32.78% month-on-month, and the basic production capacity of farms with an annual slaughter of more than 500 pigs recovered quickly.

　　"Implement policies and measures to every rural household, and follow up the problem solving situation to every enterprise to ensure that the basic production capacity of livestock and poultry breeding industry is not lost." Yang Zhenhai, director of the Animal Husbandry and Veterinary Bureau of the Ministry of Agriculture and Rural Affairs, said that it is necessary to do everything possible to speed up the recovery and development of pig production and actively promote the stable development of poultry and other aquaculture industries. It is necessary to speed up the resource utilization of livestock and poultry breeding waste, ensure the comprehensive utilization rate to reach more than 75%, and the supporting rate of facilities and equipment for large-scale farms to reach more than 95%. It is necessary to support the development of standardized scale farming, promote the comprehensive revitalization of the dairy industry, promote the quality improvement and efficiency improvement of the feed and veterinary drug industry, and promote the transformation and upgrading of the slaughtering industry. (Economic Daily China Economic Net reporter Qiao Jinliang)

On the evening of March 19th, the 2023 performance report was disclosed.

In 2023, the operating income reached 372.6 billion yuan, up 5.0% year-on-year, and the net profit returned to the mother reached 8.2 billion yuan, up 12% year-on-year, achieving double-digit increase for seven consecutive years; The return on net assets reached 5.1%, achieving a good level in recent years; The capital expenditure is 73.9 billion yuan, and the network investment shows an inflection point.

Over the past year, we have focused on the coordinated development of the two main businesses, successfully achieved effective improvement in quality and reasonable growth in quantity, and laid a solid foundation for long-term development. Behind this is always solidly promoting the deepening of the strategic system, focusing on both scale growth and value enhancement.

Responsible for the main business, fruitful business performance has reached a new high.　　

In recent years, with the promotion of national policies,Data application promotion, etc., the number of Internet users continues to expand.,It has promoted emerging forms such as artificial intelligence and big data to continuously empower the development of traditional industries.,The continuous emergence of industrial digital integration application results has promoted the continuous release of data traffic market demand. As a leading enterprise in the field of communication, it has ushered in broad development opportunities.

Under the wave of digital economy development,Actively embrace the strategic opportunities brought by the same frequency resonance between Chinese modernization and the new generation of digital revolution.In 2023, innovation and transformation will continue to deepen. The business of computing network and intelligence realized a revenue of 75.2 billion yuan, which brought more than half of the new income to the company.

Among them, "Unicom Cloud" business continued to grow steadily, achieving a revenue of 51 billion yuan, a year-on-year increase of 41.6%. The sales of cloud resources exceeded one million cores, a year-on-year increase of 186%, and the coverage of cloud resources has exceeded 230 cities. In 2023, innovations were made in technological innovation and ecological co-construction, the level of independent research and development was further improved, and the dual-engine bases of "virtualization" and "cloud native" were continuously optimized. More than 3,300 sets of self-developed operating system CULinux2.2 were deployed.

With the empowerment of 5G technology, the large-scale development of digital intelligence applications has also achieved remarkable results. There are 30,000 application projects in the 5G industry, covering 71 categories of the national economy, serving over 8,500 customers of 5G private networks, and forming a leading edge in key industries such as industrial Internet, digital government and car networking.

In the 2024 work conference, it was pointed out that it is necessary to solidly promote high-level security. In the past year, we focused on key directions such as network security, data security and information security, and strengthened the strategic business layout of big security. Not only did it build the first digital security operation center for super-large cities in China for customers, but it also landed more than 50 benchmark projects, and actively promoted open cooperation in security ecology, supporting the growth of network security income by 120% year-on-year.

Today, the industry share of data services has exceeded 50% for five consecutive years, leading the industry. With the rapid development of the network intelligence service, the network communication service has also made steady progress.

In 2023, the revenue of networked communication business was 244.6 billion yuan, and the scale of connection was further expanded, with more than 1 billion networked communication users, an increase of about 140 million compared with the end of 2022. Among them, the number of mobile users reached 333 million. In 2023, the net increase of users increased by 90% year-on-year, and the penetration rate of 5G package users also increased by 12 percentage points to 78% compared with last year. The "basic disk" was further consolidated.

Scientific and technological innovation speeds up and the dividend level reaches a record high.

This year’s government work report not only clearly puts forward "vigorously developing the digital economy", but also puts forward clear requirements for "accelerating the development of new quality productive forces" and "promoting industrial innovation with scientific and technological innovation". As one of the three major operators, it is timely and timely to develop new quality productivity.

It is said that the field of artificial intelligence has become an important strategic direction. The company is accelerating the layout of emerging industries of artificial intelligence, combining its advantages in computing network infrastructure, rich business scenarios and extensive customer contacts, and making efforts to create a large model development and application paradigm with Unicom characteristics. At the Mobile World Congress, the "Yuanjing" large model system was launched, and multi-parameter versions were arranged according to different functional requirements to promote the large model to better empower the real economy application scenarios. Relevant achievements were selected as "Wu Wenjun Artificial Intelligence Science and Technology Award", and the innovation ability was further enhanced.

At the same time, it is emphasized that the overall layout of satellite communication will be further accelerated in the later period, and the industrialization and systematic development of integrated communication between heaven and earth will be actively promoted.

In 2023, we will actively promote key core technology research, focus on promoting industrial innovation with scientific and technological innovation, and continuously enhance core competitiveness. During the year, 2,287 patents were granted, up 37% year-on-year, and attention was paid to the construction of scientific and technological innovation talents, whose proportion reached 40%. Standing at a new starting point, scientific and technological innovation has been further intensified, and it has actively become a national strategic scientific and technological force and a "vanguard" for developing new quality productive forces.

With the arrival of the computing power era, the long-term prospects of the company are further optimistic by investors. It also actively gives back to the trust and support of investors. The annual report shows that in 2023, the final dividend per share will be 0.0524 yuan (including tax), together with the already distributed interim dividend of 0.0796 yuan per share, and the total annual dividend per share will be 0.132 yuan, up 21.1% year-on-year, significantly higher than the growth of basic earnings per share of 11.5%, and the cash dividend level will reach a record high.

Talking about the key work in 2024, Chairman Chen Zhongyue said that he would persist in striving for progress while maintaining stability, and thoroughly implement the five strategies of strengthening enterprises through science and technology, talents, reform, digital intelligence and brand, and thoroughly implement the nine key action plans of networking communication development, computer network integration development, digital intelligence application development, internationalization development, big data innovation, artificial intelligence innovation, new digital infrastructure, high-quality service and network information security, and accelerate to become. We are confident that we will continue to maintain steady growth in operating income and double-digit growth in total profits.

　　In 2018, a realistic Dying to Survive hit a 3.1 billion summer box office champion. While countless people are sighing and moving, how to make the "sky-high life-saving medicine" accessible to ordinary patients has become a topic of general public concern.

　　The leukemia drug in this film — — Gleevec (imatinib mesylate) is a microcosm of high-priced drugs. This drug developed by Novartis Pharmaceutical entered China in early 2004, and the price of the original drug was as high as.23,500 yuan(120 tablets/box).

　　According to the first financial reporter, in the past decade, more and more manufacturers have entered the market of leukemia treatment drugs, making the price of this "life-saving medicine" drop again and again.

　　According to the data of CHIS kaisi system of Zhongkang Technology, the retail terminal price of Gleevec has been declining in the past three years, and the retail market price in 2022 will be6449.32 yuan. The reporter saw on an e-commerce platform on July 22 that the price of Gleevec’s original drug was mostly1700 yuan ~1800 yuanBetween

　　With the approval of more and more domestic generic drugs, the lowest price of domestic imatinib mesylate tablets has dropped to.144 yuan/boxIt is about 1.2% of the original price of the drug. At present, the sales price of Gleevec on the e-commerce platform is more than 1,700 yuan, which is nearly 90% lower than when Novartis first entered the China market.

　　The price of "life-saving medicine" continues to drop.

　　On July 19th, Hubei Provincial Medical Insurance Bureau posted a Notice on Publicizing the Information about the First to Fifth Batch of Non-selected Varieties in Centralized Drug Purchase by the State Organization, which stated that the first to fifth batches of centralized drug purchase by the State Organization had been carried out with the non-selected varieties under the generic name over-evaluated, the online price adjusted, the online suspension and the handling of complaints. On this basis, the medical insurance payment standard and other related work were drawn up, and a list of non-selected varieties to be online was formed. The publicity date of this list is from July 19 to July 23, 2023.

　　The online price of drugs refers to the published price of drugs on the centralized procurement platform of medical equipment in Hubei Province for the procurement of public medical institutions in the province. According to the regulations, all public medical institutions in Wuhan must purchase the drugs that have been hung on the net through the provincial centralized procurement platform for medical equipment when implementing the online procurement policy, and must not purchase from offline and other non-prescribed channels. The price of drugs hanging on the net is the highest price limit of public medical institutions in the city.

　　The list of the first batch of non-selected varieties to be hung on the net shows that there are6 imatinib mesylateAmong them, in addition to the original research drug Novartis Pharmaceutical, there are also five models, namely Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical, Chongqing Yaoyou and Sinopharm Yixin, all of which have been evaluated.

　　In terms of price, the highest hanging net is still Gleevec.7182 yuan. Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical and Sinopharm are all interested in imatinib mesylate. The online price is only.More than 500Yuan.

　　Even if the net price is 7,182 yuan, the price of the original drug Gleevec has dropped by nearly 40% compared with 23,500 yuan (120 tablets/box) when it first entered the China market.

　　According to the data of CHIS kaisi system of Zhongkang Technology, although the price of Gleevec in the hospital has remained at around 7182 yuan in the past three years, the price of retail terminals has been declining. In 2022, the retail market price will be6449.32 yuan.

　　The reporter’s search for "imatinib mesylate" on an e-commerce platform shows that the price of Gleevec’s original drug is only 0.1g*60 tablets/box as the standard in most pharmacies.1700 yuan ~1800 yuanBetween, and the price of domestic medicine is in500 yuanAbout. For example, the price of Xinwei tablets in Jiangsu Haosen is 430 yuan, the price of Genico capsules in Zhengda Tianqing is 441.88 yuan, and the lowest price is Shengdika tablets produced by Chongqing Shenghuaxi Pharmaceutical Co., Ltd., with an estimated hand price of 144 yuan.

　　nineDomestic companies were approved for production.

　　More and more cheap domestic "life-saving drugs" appeared, which was related to the end of the protection period of the compound patent of imatinib in China in April 2013, and domestic generic drugs began to be produced and listed.

　　From June 2013 to October 2014, three domestic generic drugs of Jiangsu Haosen, Zhengda Tianqing and Shiyao Ouyi obtained production approval. Because the efficacy of generic drugs has not been verified, the original drug of Novartis, Gleevec, still occupied most of the market. According to public data, in 2016, imatinib mesylate tablets sold more than 4 billion US dollars worldwide.

　　The competitiveness of domestic drugs began to improve after 2018. From 2018 to 2020, the above three drugs passed the consistency evaluation successively. On July 5, 2018, Jiangsu Haosen Pharmaceutical Co., Ltd. said that it had received the Approval Document for Supplementary Application of Imatinib, a chemical drug approved and issued by National Medical Products Administration, and the National Drug Testing Center recommended that it pass the consistency evaluation, making it the first enterprise to pass the consistency evaluation of this drug.

　　Overevaluation means that drugs have reached the passing line in quality and efficacy, and generic drugs have become more competitive. In September 2018, Hansen Pharmaceutical (Haosen Pharmaceutical) disclosed the prospectus for listing in Hong Kong, showing that the sales revenue of the core product imatinib mesylate in 2017 was RMB 2.5 billion, up by 7.3% since 2016, and up to June 30, 2018, up by 34.5% compared with the same period of last year.

　　With the entry of imatinib mesylate tablets into the medical insurance catalogue in 2017, more manufacturers entered this field. National Medical Products Administration website shows that the domestic imatinib mesylateNine manufacturers have been approved.Unacon Ouyi Pharmaceutical, Zhengda Tianqing, Qilu Pharmaceutical, Shenzhen Xinlitai Pharmaceutical, Chongqing Yaoyou Pharmaceutical, Lianyungang Runzhong Pharmaceutical, Shanghai Nuochuang Pharmaceutical, Fujian Nanfang Pharmaceutical and Chongqing Shenghuaxi Pharmaceutical, among which Shanghai Nuochuang Pharmaceutical and Fujian Nanfang Pharmaceutical successivelyMay and June this yearJust approved.

　　What followed was that prices kept falling.

　　In 2018, imatinib mesylate tablets of Jiangsu Haosen Pharmaceutical Co., Ltd. won the bid in four municipalities directly under the Central Government, including Beijing, Tianjin, Shanghai and Chongqing, and 11 cities (referred to as "4+7" cities) including Shenyang, Guangzhou, Chengdu and Xi ‘an, with the winning price of 623.82 yuan per box. In 2019, the "4+7" procurement expanded, and Zhengda Tianqing won the bid at a price of 586.39 yuan, further reducing the price of this drug.

　　In August, 2022, Shanghai issued a price adjustment notice, and the adjusted purchase price of imatinib mesylate tablets produced by Shiyao Ouyi has dropped to 180 yuan/box.

　　The lower price of domestic drugs also impacts the price of original drugs.

　　In 2018, the joint bargaining of imported anticancer drugs in 14 provinces including Shaanxi was completed, and 47 anticancer drugs including Gleevec were successfully negotiated. According to the announcement, the bargaining result of Gleevec’s specification of 0.1g*60 tablets was 9998 yuan.

　　In 2019, according to the previous report of CBN, the price of the original drug Gleevec in Shanghai has dropped to 7182 yuan/box, which is about 30% lower than the market price of around 11,000 yuan at that time.

　　New progress

　　It is worth mentioning that with the increase of drug resistance caused by long-term medication, Gleevec’s R&D iteration has also attracted much attention.

　　The second and third generation BCR-ABL inhibitors have been developed in order to solve the drug resistance problem and improve the safety. Dashatinib from Bristol-Myers Squibb and Nilotinib from Novartis were introduced one after another, which made the second generation BCR-ABL inhibitors gradually occupy an important position in the first-line and second-line treatment of chronic myeloid leukemia. However, the problem of drug resistance still exists during the use of the second generation BCR-ABL inhibitors.

　　In November, 2021, Nilik, known as the "third generation Gleevec" made in China, was approved for marketing in National Medical Products Administration, China, and was used to treat adult patients who were resistant to any tyrosine kinase inhibitor (TKI) and were diagnosed as chronic myeloid leukemia (CML) with T315I mutation in chronic phase (CP) or accelerated phase (AP) by fully verified detection methods.

　　This year, on July 6th, Yasheng Medical Officer Wei announced that Nilik had obtained the clinical trial permission from National Medical Products Administration Drug Evaluation Center, and would carry out a key registered phase III clinical trial of combined chemotherapy compared with imatinib combined chemotherapy in the treatment of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (referred to as "Ph+ALL").

　　At the end of 2022, Novartis decided not to be responsible for the sales promotion of Gleevec in China.

　　The official micro-display of Sinopharm Holdings shows that from January 1, 2023, Sinopharm Holdings officially obtained the commercial promotion right of Novartis Gleevec in China market. Xie Jiong, director of the Drug Shield Public Welfare Fund, said in an interview with the media that for many drugs, it is necessary to adjust the inherent marketing model after a certain development cycle, so as to drive the second peak of sales. This will not only prolong the life cycle of drug sales, but also greatly enhance the accessibility of drugs and benefit a wider range of patients.

　　Our reporter Lin Zhiyin also contributed to this article.

[Global Network Technology Comprehensive Report] On the evening of August 8, Alibaba Group officially announced the brand-new membership plan of "88VIP" at the "88 Member Annual Stars Festival" in Guangzhou, redefining the traditional membership system.

According to reports, "88VIP" is a "all-in-one card" integrating Ali’s new retail ecology and multi-membership status, covering almost all the core services of Alibaba, and also providing a series of compound rights and interests in conjunction with 88 domestic and foreign brands among the 150,000 brands on Tmall. These exclusive discounts run through the whole year, even in double 11, and "88VIP" can be discounted and then discounted.

Users who have spent money on Ali retail platforms such as Taobao and Tmall in the past year will automatically become 88 members, and each member will correspond to different naughty values. If you are a naughty svip with a value of over 1000, you can only use 88 yuan to get this "88VIP" that non-members have to spend 888 yuan to buy. After preliminary calculation, the value of "88VIP" running through Ali’s ecological rights and interests is nearly 2000 yuan.

After becoming "88VIP", not only can you enjoy the annual "credit" of double 11 discount, but also the high-quality goods from Tmall Supermarket, Tmall International Direct Marketing and 88 brands around the world are all 15% off for the whole year; You can also enjoy annual exclusive discounts on imported milk, imported rice and other necessities; What’s even more surprising is that "88VIP" enjoys the exclusive status of "Eat, Drink and Play in One Train" under Ali, and is automatically upgraded to annual card members including Youku, Hungry, Shrimp and Taobao Film. In this way, according to the average user’s consumption level, becoming "88VIP" can save nearly 2000 yuan a year.

Take a bottle of Newsland fresh milk from 49 yuan as an example. "88VIP" can enjoy 72-hour direct fresh milk from New Zealand Ranch for only 19.9 yuan.

Roughly calculate, suppose a white-collar worker with a monthly salary of 5,000 yuan spends 888 yuan to become an "88VIP", and according to the average user consumption level, he can save 1,596 yuan, which is equivalent to getting 708 yuan for nothing. If it happens to be 88 svip, he only needs 88 yuan to get the "88VIP" status, which is equivalent to getting 1,508 yuan for nothing. Suppose a student party with limited pocket money can save its card fee in one month after spending 88 yuan as an "88VIP", and the following 11 months are pure "bonus hunter".

"Naughty value" is still the cornerstone of Alibaba’s membership system and the basis for the classification of Ali members. Naughty value of 1000 is a demarcation point. Those below 1000 are called 88 members, and those above 1000 are 88 svip. Besides enjoying the special price of "88VIP", they have distinguished privileges in daily shopping, payment and entertainment.

Ali’s new retail ecosystem is continuing to add more value and services to its members. Different consumption and life scenes face the same crowd. They not only order take-away food on the top every day, shop in Taobao Tmall, but also listen to shrimp on the way to and from work and watch the World Cup in Youku. They live in the ecology of Ali’s new retail every day. Compared with the traditional membership mechanism focusing on a certain field, "88VIP" has created a brand-new membership system based on Ali Ecology.

Those senior "hands-on parties" who are naughty and worth more than a thousand dollars have increased their sense of identity and belonging to the Ali ecological platform through the opening of the membership system. They are no longer entangled in the opening, renewal and maintenance of individual membership rights. As long as they have an "88VIP" card, those scenes that are frequently used in daily life can communicate with each other, which not only saves worry and money, but also makes the experience smoother.

This highly integrated Alibaba ecosystem is bringing great value to enterprises and promoting them to better carry out brand operation, user management, channel expansion and product development. For a wide range of merchants active in Ali’s new retail platform, the upgrading and opening of membership systems of different platforms can make them more deeply bound with consumers, not only further opening up online and offline, but also greatly expanding the original membership system.

On March 6 th, Wuling Automobile officially announced that Wuling Bingo PLUS, a five-door pure electric SUV, was launched. The new car models are 401km flagship version and 510km flagship version.

Wuling Binguo PLUS claims to be equipped with an efficient and intelligent thermal management system and intelligent energy management, with a battery life of 10.1-10.6km per kilowatt hour, "the cost per 100 kilometers is less than that of 6 yuan".

It adopts large inclination windshield, front air curtain with wind blade, aluminum alloy wind-breaking wheel hub, anti-upturned tail wing, etc. It is said that "the wind resistance of the whole vehicle is optimized by 13% and the endurance is improved by about 20 kilometers".

In the cockpit part, the cockpit adopts 360-degree skin-friendly soft bag design, the main driver’s seat can be electrically adjusted in 6 directions, the rear seat can be laid down independently in 5/5 minutes, and it is equipped with independent headrest.

, and provide a distance of 912mm between two rows of seats, with a knee distance of 89mm. The new car provides up to 23 storage spaces, among which the auxiliary instrument panel adopts floating island double-layer design to increase the storage space in the front row. The rear seats can form a trunk space of 1450L after being laid down as a whole.

, the maximum torque is 180N?m；; The car also has three charging modes, DC fast charging "takes 30-35 minutes from 30%-80%".

Wuling Binguo PLUS is equipped with Ling OS Linxi intelligent network connection system, 8.8-inch instrument+10.1-inch central control screen, automatic wiper/headlight, brand-new electronic shield and so on.

In terms of safety, Wuling Binguo PLUS high-strength steel accounts for 74.8%, and it is equipped with a refined battery, which is known as "no leakage, no lithium precipitation, no fire and no explosion". In addition, the whole vehicle is equipped with four airbags on both sides of the main and auxiliary drivers and the front row, ESC electronic vehicle stability system, automatic parking, ABS anti-lock braking system, uphill auxiliary function and other configurations.

IT house note:. The length, width and height of the car are 3950/1708/1580mm, the wheelbase is 2560mm, the motors are 30kW and 50kW, and the peak torque is 150N?m.