Original Zhao Bei Ten-Point Science

Because of the aging immune system, vaccines are less effective for the elderly. Scientists believe that it is more important and more widely used to develop drugs that can enhance the immune function of the elderly than to develop vaccines for the elderly.

Along with skin aging, there is also the immune system. | Figure worm creativity

Author | Doctor of Immunology, Zhao Bei

Recently, many deaths caused by influenza vaccine in Korea have attracted attention. As of October 31st, the death toll rose to 83, of which 71 were over 70 years old (accounting for 85.5%). In addition to the possible quality problems of the vaccine itself, it also reminds us of the fact that the role of the vaccine for young people and the elderly is different.

This is also a difficult point in the development of COVID19 vaccine.

Increasing age, and aging immune system

As people get older, we experience a series of physical changes, such as hearing loss, skin relaxation, joint injury and so on, and even the vitality of the immune system gradually decreases. This phenomenon is called "immune aging". This is also the reason why the elderly have become the main targets of infection and death in Covid-19.

In the face of the out-of-control epidemic in COVID-19, USA, and the emergence of the second round of epidemic peak in Europe, vaccine research and development is in full swing in various countries, which is expected to be a life-saving straw to reverse the situation.

However, vaccines, a means of "actively mobilizing the human immune system to prevent real virus attacks", are usually far less effective in the elderly population-the immune response of the elderly to vaccines is often weaker. That is, the immune system of the elderly is more difficult to be mobilized by vaccines.

This means that vaccines may not protect those who need protection most.

So, how does the immune system age?

Our bodies are naturally resistant to most pathogens. Although the environment is full of pathogens, we still live well most of the time.

The human immune system is divided into innate immunity and acquired immunity. The former is universal immunity. When the body encounters foreign objects (such as skin and mucous membrane), innate immunity will respond quickly. However, although it responds quickly, its ability is limited and it is often broken. For example, when it meets Covid-19, it can’t hold on.

The latter is the acquired immunity of the body, that is, for some pathogens that have not been seen before, the body must first fight with it and learn from it before it can gain immunity to it. The power of acquired immunity is very powerful. As long as the body can withstand the attack of pathogens in "learning" and meet the same pathogens in the future, it will not be a problem at all. For example, infectious diseases such as smallpox and chickenpox, if you get it once, you will generally not get it again.

When the body is invaded by foreign pathogens, such as viruses, innate immunity and acquired immunity will cooperate to resist.

In the innate immune system, immune cells, such as phagocytes and natural killer cells, will recognize or even devour the virus first, and secrete a large number of cytokines to summon more immune cells with different functions to join the battle. Some of these cells, such as phagocytes and dendritic cells, will also transmit the antigens of these viruses (substances that can cause antibody production) to the subsequent T cells and B cells, which are representatives of acquired immune cells.

T-cells and B-cells (shown here as antibodies produced by B-cells) are representatives of immune cells, and they are named after mature parts. The former is mature in thymus (English) and the latter is mature in bone marrow (English). Both are star immune cells. | Figure worm creativity

These two kinds of cells can not only produce antibodies and cytokines to quickly destroy the virus, but also form specific memory cells, so that they can respond quickly after encountering the same virus again.

When the immune system destroys the virus, immune cells will gather locally in the body, forming redness, swelling and heat pain, which is what we usually call inflammation. Proinflammatory factors secreted during this period, such as interleukin -1 and tumor necrosis factor α, can promote the elimination of pathogenic microorganisms, but excessive inflammation may lead to cytokine storms and even life-threatening. Another kind of anti-inflammatory factor, such as interleukin -10, can prevent excessive inflammation and maintain the balance of the body environment.

These factors together constitute our immunity.

And what will happen to our immune function as we get older? What is the impact on vaccine development?

Compared with young people, the immune aging of the elderly is mainly manifested in two aspects:

The initial number of T cells and B cells decreased. Vaccine mainly stimulates B cells to produce antibodies. Only when there are a large number of B cells with high diversity of receptors in the body, the greater the probability of recognizing antigens, and the targeted (directional) antibodies and memory B cells can be formed. -The decrease of B cells will undoubtedly weaken this effect.

Chronic low-grade inflammation is easy to occur after vaccination. The aging and necrotic cells in the elderly can not be removed in time, which will stimulate the immune system continuously, causing immune cells (such as macrophages) to continuously secrete pro-inflammatory cytokines, and the immune response cannot be terminated. The consequence is that the immune system can’t respond the next time the pathogenic microorganism attacks the human body, that is, immune dysfunction.

These lead to different effects of vaccines in the elderly and young people.

Vaccine research and development under "immune aging";

A special vaccine or an auxiliary drug to reverse aging?

For Covid-19, there are about 50 kinds of vaccines being tested in the world, but scientists are still not sure whether the vaccines are equally effective for the elderly.

One of the vaccines "mRNA-1273" being developed by Moderna, a biological company located in Cambridge, Massachusetts, USA, produced antibody levels similar to those of younger subjects in 40 subjects over the age of 56.

However, Pfizer and BioNTech, pharmaceutical companies located in Mainz, Germany, found in the first phase of the experiment that the antibody level induced by the vaccine "BNT162b2" was only half that of young people. It is certain that the antibody level produced by the elderly after vaccination is higher than that caused by the virus infection of their peers, but this is still not enough to explain whether the antibody induced by "BNT162b2" is enough to protect the elderly from the real virus attack.

Most of the vaccines being developed have elderly subjects, but more than half of the 18 latest candidate vaccines have no elderly subjects in clinical trials, which greatly increases the potential risks of vaccines to the elderly.

Some vaccines are being developed, which may have hidden dangers for the elderly. | Figure worm creativity

Facing the phenomenon of immune aging of the elderly, scientists are also actively looking for strategies.

Mainly includes the following two aspects:

(1) The first is how to enhance the immune response of the elderly induced by vaccines.

According to the experience in the research and development of influenza vaccine, the elderly are usually treated by increasing immune stimulating components (such as adjuvants) or increasing the dose of virus antigen to achieve the expected antibody level.

Other scientists have turned to developing drugs to enhance the immune system function of the elderly, that is, supplementing drugs at the same time of vaccination. This way aims to promote the rejuvenation of the immune system of the elderly, even reverse immune aging, and can also resist the virus more effectively when it is infected.

In the above two schemes, the research on reversing age, especially immune aging, has made some progress. In the past 20 years, scientists have found some key small molecular targets. One kind of anti-aging drugs acts on the protein molecule mTOR in the cell growth regulation pathway. Experiments show that inhibiting the expression of mTOR can prolong the life of Drosophila and even mice.

Joan Mannick, one of the founders of resTORbio, a biotechnology company in Boston, Massachusetts, USA, said that "mTOR participates in many biological regulation mechanisms, especially the process of human aging and organ dysfunction".

During his work at Novartis Institute in Cambridge, Massachusetts, Mannick published a study on mTOR protein in 2018, trying to answer the question "Can reducing the content of mTOR protein in the elderly improve the immune system function of the elderly?". 264 participants in the study received low-dose mTOR inhibitor or placebo respectively, and after six weeks, the infection rate of influenza virus and the effect of influenza vaccine were followed up. It was found that the number of people suffering from influenza in the elderly who received mTOR inhibitors decreased significantly, and the immune response caused by influenza vaccine was stronger.

Another study shows that mTOR inhibitor RTB101 can enhance the immune response of the elderly after coronavirus infection, and the elderly who receive mTOR inhibitor have lower coronavirus load and recover faster. At present, resTORbio is testing the preventive or therapeutic effect of RTB101 on Covid-19 infection in 550 elderly people over 65 years old in nursing homes.

In addition, at least four research teams are studying the therapeutic effect of rapamycin, another more mature mTOR inhibitor, on the elderly over 60 years old infected with COVID-19.

In addition, metformin, a drug for the treatment of type 2 diabetes, also inhibits the activity of mTOR protein. Clinical data from China and the United States show that diabetic or obese patients who take metformin have less symptoms of Covid-19 infection and lower mortality.

Carolyn Bramante, a researcher at the University of Minnesota in the United States, pointed out that people with diabetes and obesity show immune deficiency very similar to that of the elderly. At present, Bramante and his colleagues are conducting a study involving 1,500 people to explore whether taking metformin can prevent Covid-19’s infection or alleviate its symptoms. Although the mechanism is not clear, decades of clinical data show that metformin has high safety, can be used in children and even pregnant women, and the cost is very low, which are the advantages of metformin.

(2) The second key is how to avoid causing or how to terminate chronic inflammatory reaction.

Studies have found that losmapimod, an anti-inflammatory drug used to treat muscular dystrophy, can inhibit chronic inflammatory response and improve the body’s response when viruses or bacteria invade. A biological company in Cambridge, Massachusetts, USA recruited 400 volunteers to verify the therapeutic effect of losmapimod on patients with COVID-19. The drug may be able to treat symptoms such as respiratory failure after Covid-19 infection, thus saving patients’ lives.

Many scientists say that it is more important to develop drugs to enhance the immune function of the elderly than to develop COVID-19 vaccine for the elderly, and the latter is more universal, which can improve the protection effect of influenza vaccine, COVID-19 vaccine and even other vaccines in the future. A deep understanding of immune aging and its regulation mechanism and the development of related drugs will also have far-reaching implications for the treatment of other diseases such as diabetes and cancer.

In short, although there are always difficulties in vaccine development, known or unknown, scientists have been working hard and believe that methods will always be found.

(Editor Gao Peiwen)

Original information:

Cassandra Willyard, Nature vol 586, 15.10.2020

Reference information:

1. Anderson E. J.et al., N. Engl. J. Med., 2020

2. Walsh E. E. etal., Preprint at medRxiv https://doi.org/10.1101/2020.08.17.20176651 (2020)

3. Helfand B. K. I. et al., JAMA Intern. Med., 2020

4. Mannick J. B. et al., Sci. Transl. Med., 2020

5. Luo P. et al., Am. J. Trop. Med. Hyg., 2020

6. Bramante, C. et al., Preprint at medRxiv https://doi.org/10.1101/2020.06.19.20135095(2020)

7. Vukmanovic-Stejic M. et al., J. Allergy Clin. Immunol., 2018

The article was published by "Ten Points of Science" (ID: Science _ 10) WeChat official account, please indicate the source.

Original title: "Immune aging that cannot be underestimated: old age may lead to ineffective vaccines"

Read the original text

　　On Tuesday (April 2), Eastern Time, the second quarter of the US stock market seemed to have a bad start. The three major indexes of the US stock market fell across the board overnight. They all fell more than 1% in intraday trading, and the Dow fell nearly 400 points to a two-week low, the biggest daily decline in four weeks with S&P. The expectation of interest rate cuts in the first half of the year was frustrated, and the yield of US bonds rose again, which suppressed the market to some extent. However, the performance of gold is still strong and continues to refresh.

　　At the close, the S&P 500 index fell 0.72% to 5205.81 points; The Dow Jones index fell 1.00% to 39,170.24 points; The Nasdaq index fell 0.95% to 16,240.45.

　　In terms of US bond yield, the 10-year US bond yield once rushed above 4.4% to close at 4.36%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, closed at 4.70%.

　　Since Powell reiterated last week that he was in no hurry to cut interest rates, the market sentiment has not been high. And overnight, internal officials of the Federal Reserve once again consolidated this statement, and market sentiment was once again hit.

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. The former "big hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　It is worth noting that the economic data of the United States even triggered speculation about whether the Fed will cut interest rates three times this year. The data released on Tuesday showed that the number of job vacancies in the United States has not changed much compared with the previous value, or it indicates that the labor demand is still stable at a high level in the high interest rate environment.

　　LPL Financial analysts pointed out that although the Fed does expect to cut interest rates sometime this year, the argument that interest rates will be higher for a longer period of time is playing a role again, so this worries the market. He also explained from another angle why the market will pull back. A healthy market really needs to pull back. The current trend is not necessarily a bad thing. The S&P 500 index has still risen by about 9% so far this year. Therefore, the market outlook still needs to keep a close eye on the US economic data.

　　On the enterprise side, Tesla released the latest car delivery data, which was not as good as the market expectation. The share price fell by 4.9% overnight, and it has fallen by nearly one-third during the year, and its market value has been erased by 260 billion US dollars. The data shows that Tesla’s delivery volume in the first quarter decreased by 8.5% year-on-year to about 386,800 vehicles, which was far lower than the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected in history. During the same period, about 433,400 vehicles were produced, which was also lower than expected.

　　This is also the first time that Tesla has fallen below the 400,000-vehicle mark since the third quarter of 2022, a decrease of over 8.5% compared with the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　In the first quarter, Tesla faced a double blow of reduced demand for electric vehicles and high interest rates. Analysts had previously lowered their expectations for Tesla’s delivery. Some analysts pointed out that Tesla would experience the first year-on-year sales decline since the early days of the epidemic.

　　In addition, Tesla also faced many obstacles in the first quarter, such as the interruption of the supply of spare parts in the Red Sea caused by the attack of Houthi militia and the temporary suspension of production in the German factory. Although the next generation model is the key to growth, the production of this model is not expected to start until late next year, which means that the company may face the risk of slowing down growth before this.

　　[Hot stocks]

　　Among the popular US stocks, Microsoft fell by 0.74%, Google A by 0.60%, NVIDIA by 1.01%, Amazon by 0.16%, Apple by 0.70%, Meta by 1.23%, AMD by 2.53%, Arm Holdings by 2.07% and Netflix by 0.02%.

　　Due to the delivery of Q1 far less than expected, Tesla fell by 4.9%, and has fallen by nearly one-third during the year.

　　Global stock index

　　In the European stock market, the FTSE 100 index in Britain fell slightly by 0.22% to 7935 points. The French CAC40 index fell slightly by 0.92% to 8130 points. Germany’s DAX index fell 1.13% to 18,283 points.

　　In Asian stock markets, the Hang Seng Index rose 2.36% to 16,932 points. The index of state-owned enterprises rose 2.58% to 5961 points. The Nikkei 225 index fell 0.73% to 39,625 points.

　　[China Stock Market]

　　Nasdaq China Jinlong Index closed up 0.32%. In terms of popular Chinese stocks, Pinduoduo fell by 0.77%, TSMC by 0.88%, Weilai by 2.16%, Xpeng Motors by 2.26%, Alibaba by 0.61%, Baidu by 0.08% and Netease by 1.88%.

　　[foreign exchange commodities]

　　The US dollar index rose first and then fell, once standing above the 105 mark in intraday trading, and once fell to an intraday low of 104.67 during the US session, then rebounded and finally closed down by 0.19% to 104.81.

　　Gold futures for June delivery in the New York Mercantile Exchange closed up 1.09% at $2,281.80 an ounce, a record closing high, having risen to $2,297.70 an ounce in intraday trading. May silver futures closed up 3.39% at $25.923 an ounce.

　　Geopolitical risks have enhanced the attractiveness of gold, while traders have avoided the shadow cast by the strong economic data of the United States on the prospect of the Fed raising interest rates.

　　Oil prices continue to rise due to supply concerns. WTI crude oil rushed above $85 in intraday trading, rising more than 2% in the day, and continued to hit a new high since October last year, finally closing up 1.76% to $85.47/barrel; Brent crude oil also hit a new high since October last year, and finally closed up 2.12% to $89.27/barrel.

　　[Highlights]

　　The Fed reiterated that it is not in a hurry to cut interest rates, but it is still possible to start in June?

　　San Francisco Fed President Daley said that three interest rate cuts this year are a baseline forecast and can be increased or decreased if necessary. Regardless of changing the inflation target, the continuous rise in oil prices will become a problem; The former "Great Hawk" and Cleveland Fed President Meister also expect to cut interest rates three times this year, and it is not excluded to cut interest rates in June, and the reasons for cutting interest rates in May are insufficient; Both warned of the risk of cutting interest rates prematurely.

　　Job vacancies in the United States in February were slightly higher than expected

　　The voluntary turnover rate is the lowest since 2020, and the number of layoffs is the highest in nearly a year. The number of JOLTS vacancies in the United States in February was 8.756 million, slightly better than expected, and the value was revised down to 8.748 million before January. The voluntary turnover rate in February was 2.2%, the lowest level since 2020. Due to the increase in layoffs in the leisure and hotel industries, the number of layoffs has risen to the highest level in the past year.

　　Tesla’s quarterly delivery dropped for the first time in nearly four years, and its market value has evaporated by $260 billion in the year.

　　On Tuesday, Tesla Corporation, an American electric vehicle manufacturer, released a report on automobile production and delivery in the first quarter of 2024. According to the specific data, Tesla delivered a total of 386,810 vehicles in the first three months of this year, far below the analyst’s previous average expectation of 449,080 vehicles, which was the biggest worse than expected. This is also the first time that the company has fallen below the 400,000-vehicle mark since the third quarter of 2022, which is over 8.5% lower than the delivery of 422,875 vehicles in the first quarter of last year, recording the first year-on-year decline since the second quarter of 2020.

　　Intel’s report shows that the loss of its foundry business expanded in 2023.

　　In a document submitted by Intel on Tuesday, Intel said that the sales of its new manufacturing division, Intel Foundry, in 2023 were $18.9 billion, down from $27.5 billion in the previous year, and the operating loss increased from $5.2 billion in 2022 to $7 billion. It is estimated that the loss will reach its peak in 2024 and will be realized at the operational level "in the middle of now to the end of 2030". Intel shares fell more than 2% after the report was released. Intel’s entry into outsourcing chip production is one of the biggest transformations in the company’s history. CEO Pat Gelsinge’s recovery plan also includes restoring the company’s once impeccable technological advantage, which the chip giant lost in the years before he took office in 2021.

　　A major breakthrough in AI pharmaceutical! Stanford SyntheMol model develops new antibiotics

　　According to a report by Stanford Medical College on March 28th, researchers from Stanford Medical College and McMaster University have made important progress in this field. They have developed an AI model called SyntheMol, which can synthesize drugs and create formulas for chemists in the laboratory.

　　The model creatively designed six new drugs for drug-resistant bacterial strain Acinetobacter baumannii, which is one of the main pathogens causing antibiotic resistance-related deaths. The model not only created a new drug structure, but also provided a detailed formula for chemical synthesis, enabling chemists to synthesize these drugs in the laboratory.

　　Abbott’s heart valve repair system has been approved by FDA to provide patients with new treatment options.

　　On Tuesday, US medical and health company Abbott announced that its heart valve repair system has been approved by the US Food and Drug Administration (FDA), which is suitable for patients with potentially fatal heart disease. Abbott’s minimally invasive transcatheter TriClip repair system aims to treat tricuspid regurgitation (TR), which is a disease in which the valve between the right ventricle and the right atrium of the heart cannot be closed normally, resulting in blood reflux. Abbott has incorporated TriClip into its so-called "Fab 5" () equipment portfolio, which is expected to promote the company’s sales growth in the next few years, representing Abbott’s technological innovation and market leadership in their respective fields.

　　[financial calendar]

September 21, 2011, my hometown in Feicheng, Shandong. According to the custom in the village, on the third day after marriage, Wang Zhibao took Han Ping to the grave, saying that he wanted his new wife to visit his ancestors.

On March 15th, 2013, Wang Zhibao’s mother was hospitalized due to illness in Feicheng Hospital, Shandong Province. Hearing that his mother was unwell, Wang Zhibao hurried back by coach.

February 9, 2013, my hometown in Feicheng, Shandong. On New Year’s Eve, Wang Zhibao had a New Year’s Eve dinner with relatives and friends, while his wife looked after the crying children.

On December 18, 2015, Jinan, Shandong Province, had to go to work during the day, and Wang Zhibao and his wife followed the intermediary to see the second-hand house at night. There is no light in the top building facing the street, so they have to use their mobile phones for lighting.

　　Photographer Liu Lei recorded the life of rural youth Wang Zhibao and his wife Han Ping for seven years in this 10-square-meter rental house in a village in Jinan. From marriage, having children to their daughter’s going to school, they travel between their hometown and the city, with meager income and light sorrow … …

　　In 1986, Wang Zhibao was born in panzhuang, Feicheng City, Tai ‘an City, Shandong Province. Like other children of similar age in the village, he spent his childhood in the dirt. The experience of helping adults do farm work filled his primary school memory. He became familiar with the agricultural knowledge handed down by his ancestors and knew when to plant and when to harvest.

　　The knowledge in books is more difficult to learn than farm work, and Wang Zhibao’s academic performance is always bad. In his own words, the academic performance at that time belonged to the level of "idiot", and the teachers were too lazy to take care of him. But he is optimistic about this — — There are several other "idiots" in the same village: Er Dan in the south of the village, Yandong &hellip in the west of the village; … They naturally became good friends. Although more than ten years have passed, he can still quickly and accurately list the "idiot" students who were connected with the same life at any time, and these students, like his current state, are doing some temporary work in a city and running between the city and the countryside.

　　Wang Zhibao said that people who have never studied in their ancestors for generations seem to need genetic inheritance to read good books. Moreover, the older generation in the village always warned the younger generation that there would be no great promise in farming. Before the second day of junior high school, Wang Zhibao left the village, went to the county to be an apprentice, and began to work.

　　The hardened asphalt road in the county is smoother than the dirt road in the village. Wang Zhibao, who came to the city, felt relieved. Away from my mother’s nagging, I seem to be an independent and mature man in an instant.

　　Later, 17-year-old Wang Zhibao came to Jinan, the provincial capital. He worked as a cable worker, cleaner, hotel room cleaner and chess room attendant. At the age of 22, Wang Zhibao entered the stone renovation industry to do odd jobs, which continues to this day. Wages rose from 70 yuan at that time to 150 yuan now, and sometimes you can earn 200 yuan one lucky day, but you have to wait for the foreman’s phone call to recruit.

　　After some ignorant and failed contacts, he met his wife Han Ping through a friend’s introduction. She came to work in Jinan from Heze rural area with a low education level, but she has a good personality, which can tolerate Wang Zhibao’s natural rebellious temper and does not dislike his meager income. Wang Zhibao also feels that Han Ping is "the kind of person who lives a down-to-earth life". At the end of 2005, Han Ping moved into a 10-square-meter hut he rented near Xishilihe Street in Jinan.

　　In 2011, Wang Zhibao married Han Ping back to his hometown of Feicheng panzhuang. Han Ping was four months pregnant when she stood at the wedding scene in a wedding dress. In order to make up enough months for the unit to pay medical insurance for itself, Han Ping insisted on going to work normally in the shopping mall with a big belly. Wang Zhibao said that this can get maternity leave wages, plus maternity insurance can earn a lot of money.

　　The cost of Jinan hospital is large, and the cost of caesarean section alone is more than 8 thousand yuan, as well as nutrition and other expenses. It’s far from home. If relatives come to take care of Han Ping, their food, drink and accommodation will be another expense, so Wang Zhibao took his wife to his hometown hospital with relatively poor conditions to give birth.

　　In 2012, my daughter fell to the ground. The fortune teller said that his daughter, LMNT, had little soil. After calling many people for advice, he added the word "Yu" to her name.

　　Wang Zhibao’s family of three has rented a 10-square-meter cabin in the village of Jinan, and the house price in the nearby community doubled in 2017 compared with that in 2013. Wang Zhibao had the idea of buying a second-hand house. At the end of 2015, at the instigation of his younger brother, he took a fancy to a street-facing old-top building with an area of 40 square meters and a selling price of 280,000 yuan. After calculation, they still feel that they can’t stand the pressure of paying a down payment of 80,000 yuan and a monthly loan of more than 1,000 yuan, and finally give up. But in just one year, the price of the same type of house has risen to about 400,000 yuan.

　　Without their own house, there is no shortage of happiness in the life of a family of three. The small home is full of her daughter’s snacks and toys, with her paintings and awards on the walls, and photos of a family of three. The aisle at the door was neatly covered with Han Ping’s laundry. On weekends, Wang Zhibao will take his wife and daughter to the park to play. Seeing his daughter running with other children, he wanted to lie on the lawn and have a good sleep.

　　Wang Zhibao said that he likes the freedom and vastness of the city, but his mother who is alone in his hometown is deeply concerned. My father died 10 years ago, and my 70-year-old mother is in poor health, but it is difficult to adapt to the life in the city. He and his younger brother, who also work in Jinan, had to take turns to visit.

　　The villagers said that their family is a real person. Wang Zhibao looks forward to working in the city every day, and works sincerely. Even if his income is meager, his worries drift lightly, and he turns back and forth between his hometown and rented house, year after year. Their daughter will go to primary school next year. According to Jinan’s policy, migrant children must meet the condition that both parents pay social security for one year. There is nothing wrong with Han Ping’s social security. However, Wang Zhibao worked in Jinan for 15 years, but never paid social security … …

　　I don’t know how his sorrow fell this time.

Southeast Network is the official news portal of Fujian, which is headed by the Propaganda Department of Fujian Provincial Committee of the Communist Party of China and sponsored by Fujian Daily Newspaper Group.

recent days

Website of the State Administration of Market Supervision

Announce the latest batch

Motor vehicle recall information

Involving Guangqi Honda and Dongfeng Honda

Land Rover, Mercedes-Benz, Volvo, etc.

↓↓↓

Guangqi Honda Automobile Co., Ltd.

Dongfeng Honda automobile co., ltd

Recall some domestic hybrid electric vehicles

Recently, Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall, and decided to recall the following vehicles from now on.

I Guangqi Honda Automobile Co., Ltd.

A total of 87,092 domestic hybrid BREEZE and plug-in hybrid BREEZE cars produced between January 4, 2019 and December 29, 2022 were recalled.

Second, Dongfeng Honda Automobile Co., Ltd.

A total of 169,000 domestic hybrid cars (CR-V) and plug-in hybrid cars (CR-V) produced between June 8, 2017 and August 17, 2022 were recalled.

For the vehicles within the scope of this recall, due to the layout problem of the battery positive wiring harness, when the left front part of the front of the car collides at a specific angle, the battery positive wiring harness may be damaged, and there is a risk of short circuit and fire.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will replace the improved battery positive wire harness for vehicles within the recall range free of charge to eliminate potential safety hazards.

Guangqi Honda Automobile Co., Ltd. and Dongfeng Honda Automobile Co., Ltd. will notify the relevant users of the recall by registered mail, and take the initiative to contact the users through authorized special sales service stores to make an appointment to arrange the recall and maintenance. Users of Guangqi Honda can call the service hotlines: 800-830-8999 (fixed-line users only), 400-830-8999 and the hotlines of special sales service stores for consultation, or visit Guangqi Honda’s website for recall information. Users of Dongfeng Honda can call the service hotlines: 800-880-9899 and 400-880-6622 (by mobile phone) for consultation, or visit the website of Dongfeng Honda for recall information. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Jaguar Land Rover (China) has limited investment.

The company recalled some imports.

Land Rover Range Rover Sport Series Cars

A few days ago, Jaguar Land Rover (China) Investment Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From March 29th, 2024, some imported 2023 Land Rover Range Rover Sport cars produced from July 4th, 2022 to November 30th, 2022 were recalled, totaling 1,987 vehicles.

Due to the factory assembly, the right taillight of the vehicles within the scope of this recall may get water and fail during use, which can not provide effective signals for the rear vehicles, increasing the risk of vehicle collision and posing potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will replace the taillights on the right side of the tailgate and the right side of the car body for vehicles within the recall range free of charge to eliminate potential safety hazards.

Jaguar Land Rover (China) Investment Co., Ltd. will notify relevant users of this recall by registered mail. Users can call the Land Rover brand customer service hotline: 400-820-0187 through landline or mobile phone for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Mercedes-Benz (China)

Automobile sales co., ltd. recalled

Some imported GLE SUV cars

A few days ago, Mercedes-Benz (China) Automobile Sales Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. From now on, a total of 118 imported GLE SUV vehicles with production dates from February 9, 2021 to November 18, 2021 will be recalled.

Some vehicles within the scope of this recall are not properly fixed with the grounding fixing bolts of the 12V battery grounding wire, resulting in an increase in the resistance of the fixed area and a large current passing through it, which may lead to an abnormal temperature rise in this area and a fire risk.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will inspect and retighten the grounding wire fixing bolts for vehicles within the recalled scope free of charge through Mercedes-Benz authorized dealers, and replace the grounding wire if it is damaged, so as to eliminate potential safety hazards.

Mercedes-Benz (China) Automobile Sales Co., Ltd. will notify the relevant owners of the recall by registered mail. Users can call the service hotline: 400-818-1188 through landline or mobile phone for consultation (service time is 24 hours a day from Monday to Sunday). In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Volvo automobile sales (Shanghai)

Co., ltd. recalled some imports

XC90 automobile

A few days ago, Volvo Car Sales (Shanghai) Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some imported XC90 cars from 2015 to 2024, which were produced between December 1, 2014 and September 23, 2023, with a total of 1,200 vehicles.

The fixing bolts of the seat belts in the second row of some vehicles within the scope of this recall are not tightened according to the regulations. When a vehicle collides, the fixing bolts of the seat belts may be loose, which will affect the restraint effect of the seat belts, increase the risk of passengers being injured, and pose potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will tighten the seat belt fixing bolts according to the specified torque for the vehicles within the recall range free of charge through authorized dealers of Volvo Cars to eliminate potential safety hazards.

Volvo Car Sales (Shanghai) Co., Ltd. will notify relevant users by registered mail. Authorized dealers of Volvo Cars will also take the initiative to contact the relevant car owners to arrange the recall. Users can call the Volvo car after-sales service hotline: 10108666 for consultation through mobile phones and fixed telephones. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

China Heavy Duty Truck Group Jinan Truck Co., Ltd.

Recall part of limited company

Haowo brand traction car

Recently, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures for the Regulations on the Management of Defective Automobile Product Recall. It is decided to recall some Hauwo brand traction vehicles produced from April 23, 2020 to November 29, 2020, totaling 37 vehicles.

Due to manufacturing problems, the rear position lights on both sides of the top of the cab were not installed in the vehicles within the scope of this recall. At night or under poor road lighting conditions, the outline of the vehicle may not be displayed, which may pose a safety hazard.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will replenish the rear position light assemblies on both sides of the rear top of the cab free of charge for vehicles within the scope of recall, so as to eliminate potential safety hazards.

This recall was carried out under the condition that the State Administration of Market Supervision initiated a defect investigation. Affected by the investigation, China National Heavy Duty Truck Group Jinan Truck Co., Ltd. decided to take recall measures to eliminate potential safety hazards.

China National Heavy Duty Truck Group Jinan Truck Co., Ltd. will notify relevant users by registered mail or telephone through dealers, and arrange for free recall and maintenance. Users can also call the 24-hour service hotline: 4001888666 for consultation. In addition, you can also visit the website www.dpac.org.cn for more information and reflect the defect clues.

Original title: "A large number of recalls! Check yourself quickly! Your family may also have it.

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(full) name gender Ticket number Examination department Apply for a position graduated institutions remarks Lu Yitong man 2013010100104 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Li Jiangbo man 2013010100109 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Zhou yongchao man 2013010100122 Provincial Commission for Discipline Inspection 201123773 First-level director and below Chinese people’s public security university Zhang Yu man 2013010100222 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Chai yuze man 2013010100229 Provincial Commission for Discipline Inspection 201123773 First-level director and below Fuzhou University Qiu Han man 2013010100409 Provincial Commission for Discipline Inspection 201123773 First-level director and below China University of Political Science and Law (CUPL) Qin wenjie man 2013010100417 Provincial Commission for Discipline Inspection 201123773 First-level director and below Longdong college Lei Yu man 2013010100502 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Wujiabo man 2013010100602 Provincial Commission for Discipline Inspection 201123773 First-level director and below Huazhong University of Science and Technology Li long man 2013010100617 Provincial Commission for Discipline Inspection 201123773 First-level director and below Hu’ nan Institute of Technology Chen Zhiwen man 2013010100618 Provincial Commission for Discipline Inspection 201123773 First-level director and below Northwest university of political science and law Sun Peng man 2013010100623 Provincial Commission for Discipline Inspection 201123773 First-level director and below Renmin University of China Pinghao man 2013010100702 Provincial Commission for Discipline Inspection 201123773 First-level director and below China University of Political Science and Law (CUPL) Wu shuaihong man 2013010101322 Provincial Commission for Discipline Inspection 201123774 First-level director and below Zhejiang University Zhang yang man 2013010101727 Provincial Commission for Discipline Inspection 201123774 First-level director and below Chang’an University Zhu Baoyuan man 2013010102323 Provincial Commission for Discipline Inspection 201123774 First-level director and below the central institute for correctional police Jamolan woman 2013010102411 Provincial Commission for Discipline Inspection 201123774 First-level director and below Beijing Jiaotong University Chang Jing woman 2013010102718 Provincial Commission for Discipline Inspection 201123774 First-level director and below China University of Political Science and Law (CUPL) Li Jin man 2013010103116 Provincial Commission for Discipline Inspection 201123774 First-level director and below Qingdao university Dangqiao woman 2013010103624 Provincial Commission for Discipline Inspection 201123774 First-level director and below Northwest A&F University Shang Jiaxin man 2013010103820 General office of provincial party Committee 201133775, the fourth-level director of the organ Xi’an University of Technology Sun zhenglong man 2013010103828 General office of provincial party Committee 201133776 Director of the fourth level of the organ Northwest university of political science and law Yang ruoyu woman 2013010103910 General office of provincial party Committee 201133777 Director of the fourth level of the organ Lanzhou Jiaotong University He Jing man 2013010104003 General office of provincial party Committee 201133778, the fourth-level director of the organ Shaanxi Normal University Xiong Yao woman 2013010104111 General office of provincial party Committee 201133779 Director, Level 4, Secrecy Office of Provincial Party Committee Xiamen University Qu dangping man 2013010104201 General office of provincial party Committee 201133780 Director of the Secrecy Office of the Provincial Party Committee Northwest University Law School Zhang bochao man 2013010104202 General office of provincial party Committee 201133780 Director of the Secrecy Office of the Provincial Party Committee Northwest university of political science and law Daisy woman 2013010104226 Propaganda department of provincial party Committee 201143781 Director of the Propaganda Department of the Provincial Party Committee Shenyang Aerospace University Luo beijuan woman 2013010104525 Propaganda department of provincial party Committee 201143782 Director of the Propaganda Department of the Provincial Party Committee Communication University of China Liu jieqiong woman 2013010104605 United Front Work Department of Provincial Party Committee 201153783, the first-level director of the Ministry and below Lanzhou university of technology Feng xinxing man 2013010104615 United Front Work Department of Provincial Party Committee 201153784, the first-level director of the Ministry and below China University of Political Science and Law (CUPL) Liu ruizhu woman 2013010104628 United Front Work Department of Provincial Party Committee 201153785, the first-level director of the Ministry and below Renmin University of China Zhang Chenchen man 2013010104723 United Front Work Department of Provincial Party Committee 201153786, the first-level director of the Ministry and below Shanghai University Dang Qiuxia woman 2013010104804 United Front Work Department of Provincial Party Committee 201153787 First-level director of the provincial party committee of the Agricultural Workers’ Party and below Shanxi University Han Jie man 2013010104818 United Front Work Department of Provincial Party Committee 201153788 First-level director and below of the Provincial Committee of Jiu San Society Lanzhou University Wang wenmiao man 2013010104905 United Front Work Department of Provincial Party Committee 201153789 Provincial Federation of Industry and Commerce, first-level director and below Baoji university of arts and sciences Mao chuhao man 2013010104906 Office of Foreign Affairs Working Committee of Provincial Party Committee 201163790 First-level director and below Beijing Foreign Languages University Yuan Wenting woman 2013010104922 Office of Foreign Affairs Working Committee of Provincial Party Committee 201163791 Provincial People’s Association for Friendship with Foreign Countries First-level Chief Staff and below Xi ‘ an international studies university Li yang man 2013010105004 Provincial Party Committee Organization Establishment Committee Office 201173792, the fourth-level director of the office. Chinese people’s public security university Saki Liu woman 2013010105015 Provincial Party Committee directly under the authority Workers’ Committee 201183793 First-level director and below yan’an university Zhou Zhendong man 2013010105022 Provincial Party Committee directly under the authority Workers’ Committee 201183793 First-level director and below CPC Shaanxi Provincial Party School Tian zhuowen woman 2013010105107 Provincial bureau of retired veteran cadres 201193794 [Civil Servant] First-level Chief Clerk and below Xi ‘ an international studies university Jiawei Zhang man 2013010105401 Provincial bureau of retired veteran cadres 201193795 [Civil Servant] First-level Chief Clerk and below xian university of science and technology high tech college John Chang man 2013010105425 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below yan’an university Wang Kaixuan man 2013010105426 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below yan’an university Liu Yitong woman 2013010105429 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Beijing Normal University Wang zhangzhang man 2013010105502 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Jilin University Huan Wang woman 2013010105511 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below Wuhan University Zhang jiapei woman 2013010105512 Provincial Party History Research Office 201203796 [Reference Management] First-level Chief Clerk and below China West Normal University Louise Yang woman 2013010105527 Provincial archives 201213797 Department [Reference Management] Level 4 Chief Clerk and below Tibet University for Nationalities Long xiuping woman 2013010105627 Provincial archives 201213798 Department [Reference Management] Level 4 Chief Clerk and below Xidian University Antong man 2013010105805 Provincial archives 201213799 Post-warehouse Management Office [Reference Management] Level 4 Chief Clerk and below North China University of Technology Ai Jing woman 2013010105819 Provincial People’s Congress Standing Committee 201223800, the fourth-level director of the organ Southwest Politics and Law University Zhao Xiaoyu woman 2013010105912 Provincial People’s Congress Standing Committee 201223801, the fourth-level director of the organ Northwest university of political science and law Zhang Haodong man 2013010105915 Provincial People’s Congress Standing Committee 201223802, the fourth-level director of the organ Australian National University Fu Hui woman 2013010106010 Provincial People’s Congress Standing Committee 201223803 Director of the fourth level of the organ The University of Hong Kong aftereffect woman 2013010106106 Provincial Higher People’s Court 201233805 The second-level director of the agency and below South China Normal University Yaoyujing woman 2013010106119 Sheng women’s Federation 201243806, the fourth-level director of the organ university of leicester Wang mei woman 2013010106202 Provincial Red Cross Society 201253807 [Reference Management] First-level Chief Clerk and below Northwest University Geng liming man 2013010106301 Provincial Education Committee, Provincial Education Department 201263808, the fourth-level director of the organ Xi’an Jiaotong University Bai Peng man 2013010106306 Provincial Education Committee, Provincial Education Department 201263808, the fourth-level director of the organ yan’an university Hao wenzhuo woman 2013010106401 Provincial Education Committee, Provincial Education Department 201263809, the fourth-level director of the organ South China Normal University Huqi woman 2013010106519 Provincial Education Committee, Provincial Education Department 201263809, the fourth-level director of the organ University of Warwick, UK Xue Xiaoqiang man 2013010106529 Provincial Education Committee, Provincial Education Department 201263810 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Shaanxi Normal University Liu rennan woman 2013010106616 Provincial Education Committee, Provincial Education Department 201263811 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Southwest University Panjiali man 2013010106622 Provincial Education Committee, Provincial Education Department 201263812 Provincial Education Examinations Institute [Reference Management] Level 4 Chief Clerk Yunnan University He Yueyang woman 2013010106624 Provincial department of science and technology 201273814 First-level director and below Xi’an Jiaotong University Li Wenbo man 2013010106801 Provincial civil affairs department 201283816 The second-level director of the agency and below Qinghai University for Nationalities Qiao Fangyu man 2013010106925 Provincial finance department 201293819 Second-level chief clerk and below in government offices Lanzhou university of finance and economics Wang yinzhe man 2013010106928 Provincial finance department 201293819 Second-level chief clerk and below in government offices Xi’an University of Technology Gao Jiaxing woman 2013010107022 Provincial finance department 201293820 Second-level chief clerk and below in government offices The Central University Of Finance and Economics Yang Jingyan woman 2013010107102 Provincial finance department 201293820 Second-level chief clerk and below in government offices Northwest University Sun guangyan man 2013010107407 Provincial finance department 201293821 Second-level chief clerk and below in government offices Southwestern University of Finance and Economics Zhou Nan man 2013010107415 Provincial finance department 201293821 Second-level chief clerk and below in government offices North University of China Liu Jimei woman 2013010107514 Provincial finance department 201293822 Second-level chief clerk and below in government offices yan’an university Ma Rong woman 2013010107520 Provincial finance department 201293822 Second-level chief clerk and below in government offices Xi’an Jiaotong University Cao Jinbao man 2013010107606 Provincial finance department 201293823 Second-level chief clerk and below in government offices Shaanxi Normal University Cui qinqin woman 2013010107702 Provincial finance department 201293824 Second-level chief clerk and below in government offices Xidian University Wang Jiayue woman 2013010107725 Provincial department of natural resources 201303825 First-level chief clerk of Xixian New Area Natural Resources Bureau and below. Xi’an University of Architecture and Technology Tang Qi woman 2013010107820 Provincial water resources department 201313827 Provincial Water Conservancy Engineering Quality and Safety Center, Level 4 Chief Clerk Institutes Of Technology Of Changsha Deng Peng man 2013010107825 Provincial water resources department 201313828 Director of Level 4 of Provincial Water Conservancy Engineering Quality and Safety Center Hohai University Yang peina woman 2013010107917 Provincial Department of Agriculture and Rural Affairs 201323829 Third-level chief clerk and below in government offices. Chang’an University Chen Xue woman 2013010108009 Provincial Department of Agriculture and Rural Affairs 201323830 Provincial Rural Cooperative Economic Workstation [Reference Management] Level 4 Chief Clerk and below Southwestern University of Finance and Economics Yu Zhou man 2013010108021 Provincial Department of Agriculture and Rural Affairs 201323830 Provincial Rural Cooperative Economic Workstation [Reference Management] Level 4 Chief Clerk and below Northwest A&F University Yi Cai woman 2013010108118 Provincial Health and Wellness Commission 201333831 Director, Level 4, Provincial Health Supervision Center China Shiyou University (Beijing) Dan Li woman 2013010108122 Provincial Health and Wellness Commission 201333831 Director, Level 4, Provincial Health Supervision Center Xi’an University of Technology Wang Wen woman 2013010108210 Provincial Health and Wellness Commission 201333832 Director, Level 4, Provincial Health Supervision Center Beijing University of Chinese Medicine Changyibo man 2013010108501 Provincial Health and Wellness Commission 201333833 First-level Staff of Provincial Health Supervision Center shanxi medical university jinci college Luoganggang man 2013010108823 Provincial emergency management department 201343834 First-level Chief of the Comprehensive Coordination Department of Work Safety and below Beijing University of Chemical Technology Li yujia woman 2013010312510 Provincial emergency management department 201343835 First-level Chief of Science and Technology and Information Technology Division and below Peking University Qiao Shuyue woman 2013010109019 Provincial emergency management department 201343836 Provincial Flood Control and Drought Relief Security Center [Reference Management] First-level Chief Clerk and below china institute of water resources and hydropower research Max Zhang man 2013010109024 Provincial emergency management department 201343836 Provincial Flood Control and Drought Relief Security Center [Reference Management] First-level Chief Clerk and below Wuhan University Liu Jianwei man 2013010109130 Provincial audit office 201353837 First-level chief clerk and below in government offices Beijing National Accounting Institute Xi min woman 2013010109225 Provincial audit office 201353837 First-level chief clerk and below in government offices Chongqing University Huo xiaonan woman 2013010109322 Provincial audit office 201353838 First-level chief clerk and below in government offices Xi’an University of Architecture and Technology Villi woman 2013010109423 Provincial audit office 201353838 First-level chief clerk and below in government offices Chang’an University Jasmine Zhang woman 2013010109707 Provincial audit office 201353839 First-level chief clerk and below in government offices Xi ‘ an institute of finance and economics Liu Min woman 2013010109815 Provincial audit office 201353839 First-level chief clerk and below in government offices Xi’an Jiaotong University Gaohang man 2013010110027 Provincial audit office 201353840 First-level chief clerk and below in government offices Xidian University Yue Lu woman 2013010110014 Provincial audit office 201353840 First-level chief clerk and below in government offices Xi’an Technological University fill the vacancies in the proper order Anlang man 2013010110126 Provincial audit office 201353841 First-level chief clerk and below in government offices. Chang’an University Li Xin man 2013010110307 Provincial audit office 201353841 First-level chief clerk and below in government offices. Chang’an University Yang qiujun woman 2013010110316 Provincial Forestry Bureau 201363842 First-level Chief Clerk of Regulation Science and Technology Department and below Party School of the CPC Central Committee Derek lv woman 2013010110417 Provincial Forestry Bureau 201363843 First-level Director of Public Service Department and below Northwest A&F University Zhang Bin man 2013010110616 Provincial Forestry Bureau 201363844 First-level Chief Clerk of Provincial Forest Resources Administration and below southwest forestry university Liang yunpeng man 2013010110619 Provincial Forestry Bureau 201363845 First-level Chief Clerk of Provincial Forest Resources Administration and below Yunnan University Vencent Yang man 2013010110620 Provincial Forestry Bureau 201363845 First-level Chief Clerk of Provincial Forest Resources Administration and below Lanzhou University Wei qiuming woman 2013010110623 Provincial Forestry Bureau 201363846 First-level Chief Clerk of Provincial Forest Resources Administration and below Beijing Forestry University Su min woman 2013010110712 Provincial Forestry Bureau 201363847 First-level Chief Clerk of Provincial Forest Resources Administration and below Shaanxi Normal University Luo Ruijuan woman 2013010110723 Provincial Forestry Bureau 201363848 First-level Chief Staff of Provincial Forest Resources Administration and below Leeds University Huang Xiao woman 2013010110801 Provincial Forestry Bureau 201363850 First-level Chief Staff of Provincial Forest Resources Administration and below Chang’an University Li Jin woman 2013010110805 Provincial Forestry Bureau 201363850 First-level Chief Staff of Provincial Forest Resources Administration and below Xidian University Zhao shanling woman 2013010110821 Provincial radio and television bureau 201373851 Director of the Fourth Department of Provincial Radio and Television Bureau Southwest Politics and Law University Lei Jingxiang man 2013010110921 Provincial radio and television bureau 201373852 Director of the Fourth Department of Provincial Radio and Television Bureau Chang’an University Lawrence Wang man 2013010110924 Provincial radio and television bureau 201373852 Director of the Fourth Department of Provincial Radio and Television Bureau Xidian University Cao Yong man 2013010111001 Provincial statistics bureau 201383853 Third-level chief clerk of business office and below Tibet University for Nationalities Zheng Bo woman 2013010111004 Provincial statistics bureau 201383854 Third-level chief clerk of comprehensive office and below Hebei University Lv bingheng man 2013010111005 Provincial statistics bureau 201383855 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Queen’s University of Canada Jia Bei woman 2013010111014 Provincial statistics bureau 201383856 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Hebei University Zhang Chenyu woman 2013010111026 Provincial statistics bureau 201383857 Provincial Local Socio-economic Survey Center [Reference Management] Third-level Chief Clerk and below Korea Korea University Wang Jingyuan man 2013010111123 Provincial bureau of cultural relics 201393858 First-level director and below Shaanxi Normal University Tongkewei woman 2013010111201 Provincial bureau of cultural relics 201393859 First-level director and below xi’an shiyou university Chen yanru woman 2013010111212 Provincial poverty alleviation office 201403861 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below The Central University Of Finance and Economics Yin Hailei man 2013010111309 Provincial poverty alleviation office 201403862 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northeast university of finance and economics Chen Yuanyuan woman 2013010111408 Provincial poverty alleviation office 201403863 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northwest university of political science and law Zhao Peng man 2013010111415 Provincial poverty alleviation office 201403864 Provincial Poverty Alleviation Monitoring Center [Reference Management] First-level Director and below Northwest university of political science and law Ai Xinhua woman 2013010111505 Provincial local financial supervision and management bureau 201413865 Second-level chief clerk and below in government offices Xi’an Jiaotong University Yin yixuan woman 2013010111714 Provincial Grain and Material Reserve Bureau 201423867 Second-level Director and below Xidian University Wang herui woman 2013010111803 Provincial organ affairs service center 201433869 Personnel Department (Retiree Service Management Office) Level II Chief Staff and below University of Newcastle, UK Xu shuoqi man 2013010111808 Provincial organ affairs service center 201433870 Second-level Chief of the Commission for Discipline Inspection and below Shaanxi Normal University Wang jiao woman 2013010111814 Provincial organ affairs service center 201433871 Second-level Chief of Housing Management Office and below Qinghai University for Nationalities Feng yuru woman 2013010111828 Provincial organ affairs service center 201433872 Second-level Chief of Real Estate Management Office and below Northwest University Wang kaibo man 2013010111921 Provincial organ affairs service center 201433873 Second-level Chief of Energy Conservation Management Office of public institutions and below brunel university Jet Chao man 2013010111923 Provincial organ affairs service center 201433874 Second-level Chief Staff of Security Department and below Xi ‘ an university of posts and telecommunications Sun Xiaoqian woman 2013010111928 Provincial organ affairs service center 201433875 Director II of Infrastructure Engineering Management Office and below Xi’an University of Architecture and Technology Ma Lin woman 2013010112002 Provincial organ affairs service center 201433876 Director II of Infrastructure Engineering Management Office and below Chang’an University Huiyu woman 2013010112006 Provincial organ affairs service center 201433877 The second-level director of Fengcheng Management Center of provincial organs and below Xi ‘ an university of science and technology He Lu woman 2013010112011 Provincial organ affairs service center 201433879 The second-level director of Xingqing Veteran Cadres Service Management Office of provincial organs and below. Chinese Marine University Li Jiaojie woman 2013010112015 Provincial organ affairs service center 201433880 The second-level director of Xiaozhai Veteran Cadres Service Management Office of provincial organs and below Xi’an University of Technology Li Ning woman 2013010112018 Provincial organ affairs service center 201433882 Second-level Chief of the Office of the Provincial Committee for the Care of the Next Generation and below Xi’an Jiaotong University Shimin woman 2013010112023 Sheng supply and marketing cooperatives head office 201443883 Department Office [Reference Management] Level 4 Chief Clerk The Central University Of Finance and Economics Li jingman woman 2013010200103 Sheng supply and marketing cooperatives head office 201443884 Department Office [Reference Management] Level 4 Chief Clerk Xi ‘ an university of science and technology Zhang daiyue woman 2013010200109 Sheng supply and marketing cooperatives head office 201443885 Department Office [Reference Management] Level 4 Chief Clerk Northwest university of political science and law Zhang ningyi woman 2013010200121 Provincial court system 201453886 Assistant Judge of Xi ‘an Railway Transportation Intermediate Court Xi’an Jiaotong University Rui Hu woman 2013010200207 Provincial court system 201453887 Assistant Judge of Xi ‘an Railway Transport Court Renmin University of China slowly woman 2013010200221 Provincial court system 201453887 Assistant Judge of Xi ‘an Railway Transport Court Lanzhou University Pan Lei man 2013010200306 Provincial court system 201453888 Assistant Judge of Xi ‘an Railway Transport Court Tongji University Longdihui man 2013010200309 Provincial court system 201453888 Assistant Judge of Xi ‘an Railway Transport Court Southwest Politics and Law University Hu Juan woman 2013010200315 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court Northwest university of political science and law Min Feng woman 2013010200407 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court Northwest university of political science and law Liu Xiaoqian woman 2013010200410 Provincial court system 201453889 Assistant Judge of Ankang Railway Transport Court sichuan police college Chen Ruixiang man 2013010200421 Provincial court system 201453890 Assistant Judge of Ankang Railway Transport Court Xi’an Polytechnic University Xiong cheng man 2013010200424 Provincial court system 201453890 Assistant Judge of Ankang Railway Transport Court Chang’an University Li Yinxia woman 2013010200506 Provincial procuratorate system 201463891 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Guangdong Polytechnic Normal University He Qian woman 2013010200511 Provincial procuratorate system 201463892 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law Zhao Xuesong woman 2013010200604 Provincial procuratorate system 201463893 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law Zhang liqian woman 2013010200626 Provincial procuratorate system 201463893 Assistant Prosecutor of Xi ‘an Railway Transport Procuratorate Northwest university of political science and law

　　ASEAN countries are located at the intersection of land and sea in the Belt and Road Initiative, and are key areas for high-quality joint construction of the Belt and Road Initiative. In the past 10 years since the Belt and Road Initiative was put forward, from economic and trade exchanges to cultural exchanges, China-ASEAN Expo’s circle of friends has become larger and larger, and its outward attraction has become stronger and stronger.

　　— — — — — — — — — —

　　The 20th China-ASEAN Expo came to an end not long ago, but the vision of China and ASEAN countries meeting challenges together and building a closer China-ASEAN destiny community is inspiring people to move forward.

　　"This year, the Chairman of the Supreme Leader proposed to build a closer China-ASEAN destiny community and jointly build ‘ Belt and Road ’ The 10th anniversary of the initiative is also the 20th anniversary of the founding of China-ASEAN Expo and China-ASEAN Business and Investment Summit (hereinafter referred to as "China-ASEAN Expo" and "Summit" respectively). China — Wei Zhaohui, Secretary-General of the ASEAN Expo Secretariat, said that since China-ASEAN Expo and the Summit were held for 20 years, the bilateral trade volume between China and ASEAN has grown at an average annual rate of more than 13%, which has promoted the two sides to become each other’s largest trading partners and the most active partners in mutual investment, and helped to build a new pattern of China-ASEAN opening up at a higher level.

　　According to Xu Ningning, executive director of the China-ASEAN Business Council, ASEAN countries are located in the land-sea intersection of the "Belt and Road" and are key areas for building the "Belt and Road" with high quality. In the 10 years since the "Belt and Road Initiative" was put forward, China-ASEAN Expo has closely followed China — The needs of the times of ASEAN cooperation, constantly expand the functions of the platform, and promote the implementation of China — A series of consensus documents, joint statements and action plans reached by ASEAN have deepened China’s trade, investment, interconnection and regional cooperation with ASEAN countries, which is also the way to China-ASEAN Expo’s enduring success.

　　Inter-regional complementary resources promote active investment and trade.

　　The theme of the 20th China-ASEAN Expo is "Building a Home with Harmony, Destiny and Common Future — — Push ‘ Belt and Road ’ High-quality development and building an economic growth center. " At the meeting, many exhibitors expressed that they felt the dividends brought by the complementary market resources and factor flow between China and ASEAN. Zhu Qiugen, from Xishuangbanna, Yunnan, talks about tea at the exhibition during the day and packs tea for customers from all over the world in the hotel at night.

　　This year is his second time in China-ASEAN Expo, and he found that many tea lovers used to look at the price but now at the quality. "More and more customers have found me for the fragrance of tea, and people who understand the good products have found it. This change is more gratifying than how much tea I have sold."

　　Zhu Qiugen deals in ancient tea from Laos. The local tea garden employs local people to pick fresh tea and process it into "wool", and then it is transported to Xishuangbanna via China-Laos Railway for further processing to make a series of products such as tea cakes and tea bricks. Zhu Qiugen also founded the brand of "Laos Ancient Rhyme Tea Industry".

　　In recent years, thanks to the convenience of transportation and policies, Zhu Qiugen went deep into the country of origin and built a relatively complete industrial chain from picking, research and development, production and sales. "Let customers drink a cup of ancient tree tea that really comes from the mountains, without middlemen." In this way, the quality and cost have been well controlled.

　　The tea consumption market in China is huge, and the demand for high-quality tea has become a trend. Zhu Qiugen thinks that tea is a gentle lifestyle and a product that pursues quality of life. However, the domestic resources for picking ancient tree tea are limited, and some merchants have false propaganda and shoddy to some extent, which makes many consumers hesitate to buy.

　　In 2015, Zhu Qiugen just arrived in Laos, and he was doing hotel business at that time, but soon the local ancient tree tea fragrance caught his attention. In Laos, the unique and closed natural environment creates the good quality of Laos ancient tree tea, but these teas are mostly sold as agricultural products. "Laos has raw materials, and China has a market, so the connection naturally arises." Zhu Qiugen said.

　　With the opening of China-Laos Railway, Zhu Qiugen’s tea business has more convenient transportation conditions. If the tea is to be sold to Nanning market, Zhu Qiugen will choose to go by sea through Vietnam, which is "more cost-effective".

　　Guangxi is the only land-sea connecting region between China and ASEAN. The coastal, border and riverside areas of China-ASEAN Industrial Cooperation Zone are the frontier and window of Guangxi’s opening to the outside world. Relying on the existing parks in Nanning, Beihai, Fangchenggang, Qinzhou, Yulin, Baise and Chongzuo, Guangxi has integrated the construction of China-ASEAN Industrial Cooperation Zone, creating a development pattern of "one city, one area, one park". At present, many areas in the cooperation zone have achieved seamless traffic connection with ASEAN countries. For example, Chongzuo area is 180 kilometers away from Hanoi and Nanning, the capital of Vietnam, and there are four national first-class ports around it, which is the most convenient land international passage from China to Indo-China Peninsula.

　　"In July this year, Liuzhou Economic and Trade Delegation and 32 key enterprises went to Southeast Asia to carry out economic and trade exchange activities." Yao Fang, deputy director of the Management Committee of Liuzhou Economic and Technological Development Zone, said that the well-known domestic new energy automobile brands with factories in Liuzhou have actively gone abroad, and now they have sales markets in 72 countries and regions around the world.

　　The vigorous market demand drives the pace of transportation infrastructure construction. Sima Zhe, senior economist of the Asian Infrastructure Investment Bank and head of the ecosystem of the Ministry of Economic Affairs, said that in 2021, the AIIB provided 300 million US dollars to support the improvement project of border connectivity in Chongzuo, Guangxi, which improved the efficiency of cross-border connectivity around Shuolong Port and strengthened the economic and trade activities between China and Viet Nam.

　　In terms of commodity trading, the exchanges between Guangxi and ASEAN have become increasingly close. Guangxi is rich in commodity resources, with the output of white sugar, wood and raw silk ranking first in the country, and the output of alumina, pigs, pulp, Chinese herbal medicines and non-ferrous metals ranking first in the country. At the same time, Guangxi is also an important import port for ASEAN-specific commodities such as wood, non-ferrous metals, oil and gas, coal and fruits.

　　Li Kaizhou, deputy director of the local financial supervision bureau of Guangxi Zhuang Autonomous Region, said that in recent years, Guangxi has seized green opportunities, deepened cooperation with ASEAN, built a pilot free trade zone with high quality, and actively created a convenient place for domestic and international dual-cycle markets. The construction of new land and sea channels in the west has been accelerating. From January to July this year, Guangxi’s import and export to ASEAN was 188.08 billion yuan, a year-on-year increase of 71.6%.

　　Adhere to joint business and win-win sharing.

　　Wei Zhaohui, Secretary-General of China-ASEAN Expo Secretariat, said that since the China-ASEAN Expo and China-ASEAN Investment Summit were held 20 years ago, 196 Chinese and foreign leaders, more than 4,100 ministerial-level VIPs and heads of international organizations attended, which was accompanied by friendly relations between China and ASEAN and grew together with the construction of China-ASEAN Free Trade Area.

　　"China-ASEAN Expo has been successfully held for 20 years in a row, thanks to the unique exhibition mode. This is the successful password for China-ASEAN Expo to do something new and better." Wei Zhaohui introduced.

　　Adhere to business cooperation and win-win sharing, adhere to the principle of not making profits for ASEAN countries, respect ASEAN’s opinions on major issues, and give priority to meeting ASEAN’s needs in terms of booth arrangement. In this China-ASEAN Expo, the scale and proportion of ASEAN exhibitions remain the largest in China International Exhibition, and seven countries including Indonesia, Malaysia and Viet Nam have resumed their pavilions and restored ASEAN’s "Charming City" exhibition area.

　　Wei Zhaohui introduced that in all aspects of exhibition preparation, we should respect the ASEAN way, take care of ASEAN wishes, and always adhere to the value concept of "10+1>11". The ministers of economy and trade of China and 10 ASEAN governments and the ASEAN Secretary-General will serve as co-directors of the organizing committee, the directors of departments in charge of various countries will serve as deputy secretaries-general, and the directors will serve as liaison officers. Major issues will be discussed by the organizing committee meetings and senior officials meetings.

　　"International Friendship City Entering Dongbo" is also a highlight of the exhibition in recent years. According to the data of Foreign Affairs Office of Guangxi Zhuang Autonomous Region, at present, Guangxi has concluded 128 pairs of international sister cities with 39 countries, ranking fourth in the country. During this visit to China-ASEAN Expo, more than 30 sister cities from nearly 20 countries participated in the exhibition with their own special products.

　　"Before, our market was mainly concentrated in Jiangsu, Zhejiang and Shanghai. I never thought that the products could radiate to the inland of China and even ASEAN countries." Hong Yongwang, representing Zaragoza, Spain, said that Zaragoza and Yulin, Guangxi Zhuang Autonomous Region are international sister cities. Entrusted by the Zaragoza municipal government, Hong Yongwang brought more than 160 products including red wine, ham and olive oil to the site in China-ASEAN Expo.

　　Last year, the double-deck sinking square of Nahong Interchange Station of Nanning Metro, designed and built jointly by Nanning and Crema, Italy — — Friendship City Metro Plaza was officially completed, becoming the first subway station space in China that was fully decorated and designed by International Friendship City. At this year’s China-ASEAN Expo, exhibitor Zhang Xiaowei brought a painting entitled "Table Culture" to the scene to explain the Italian wine culture to the audience, and the author of this painting, Marilisa Leon, is the designer of the subway station space. Stephania Bonaldi, mayor of Crema, Italy, commented: "The design of the square is closely related to the theme of the Silk Road, which has brought the cultural ties between China and Italy closer and the two countries and peoples closer."

　　Institutional opening stimulates new kinetic energy of cooperation

　　From economic and trade exchanges to cultural exchanges, China-ASEAN Expo’s circle of friends is getting bigger and bigger, and its outward attraction is getting stronger and stronger. In the process of cooperation between China and ASEAN countries, many institutional and mechanistic modes of cooperation and dialogue have gradually taken shape.

　　During this year’s China-ASEAN Expo, a side event on the theme of "Institutional Opening: A New Pattern of Regional Economic Development" was held for the first time, and the "ASEAN National Standardization Cooperation and Exchange Center" was officially unveiled. The ASEAN cross-border e-commerce digital intelligence service platform and the e-commerce exchange center of the digital economy industrial park were announced to be open.

　　According to customs statistics, from January to August this year, the total import and export value of China to countries that jointly built the Belt and Road Initiative reached 12.62 trillion yuan, up 3.6% year-on-year, of which food trade reached 553.82 billion yuan, up 10.4% compared with the same period of last year and 162% compared with the same period of 2013. On the eve of the opening of China-ASEAN Expo, the Nanning Declaration on Customs Food Safety Cooperation on the Belt and Road was issued, and all parties signed the articles of association of the cooperation mechanism.

　　The perfection of the mechanism and articles of association aims at more convenient, long-term and stable factor flow. It is the consensus of many enterprises that "there is vitality when there is mobility, and there is market when there is mobility".

　　Last year, Guangxi Xinzhong Industrial Investment Co., Ltd. cooperated with the secretariat of China-ASEAN Expo to build a China-ASEAN special commodity gathering center. He Yan, the company’s deputy general manager, hopes that after participating in China-ASEAN Expo, economic and trade activities will continue for a long time through 17 offline pavilions and online platforms, and continuous economic and trade exchanges will take place with ASEAN countries in 365 days.

　　The international situation is complex and changeable, but the potential of the ASEAN market is constantly being released. "The number of ASEAN regional offices has grown particularly fast, exceeding our growth rate in China." Through this detail, Bo Yu, managing partner of PricewaterhouseCoopers Consulting (Shenzhen) Co., Ltd., found that the ASEAN market is being regarded as a growth point in the future, both in China and the world.

　　Bo Yu further analyzed that people value the population and future growth of ASEAN, and the population structure is relatively young. He believed that Guangxi should make good use of the role of "bridgehead".

　　As an Indonesian enterprise, Jinguang Group has been rooted in China for more than 30 years. Zhai Jingli, vice president of Jinguang Paper (China) Investment Co., Ltd., a subsidiary of Jinguang Group, believes that enterprises can make use of the cumulative rule of regional origin of RCEP and the advantage of the shortest and most convenient industrial supporting distance between Guangxi and ASEAN to expand the ASEAN market and play a good "ASEAN brand".

　　At present, some ASEAN countries have many environmental problems, such as soil degradation, water shortage and air pollution, which have affected local agricultural production and tourism and damaged local economic development to some extent. With the increasing demand for environmental protection in ASEAN countries, China’s environmental protection industry has gradually entered the ASEAN market. Hong Tao, director and professor of business economics research at Beijing Technology and Business University, pointed out in the China-ASEAN Forum on Innovation and Development of Commodity Trading that the effective implementation of RCEP has provided new impetus and cooperation foundation for promoting green recovery of regional economy, low-carbon development and global economic recovery, and reduced the cost of environmental protection industry in China.

　　In the past 20 years, the cooperation between China and ASEAN in the field of energy and electricity has been equally fruitful. By the end of August this year, China Southern Power Grid had been connected with the power grids of ASEAN countries through more than 10 circuits of 110 kV and above, achieving a total cross-border two-way power trade of nearly 70 billion kWh, of which clean energy accounted for over 90%. Hu Tianxiang of China-ASEAN Expo and china huadian Guangxi Company introduced that china huadian has invested in 9 projects under construction in ASEAN, with an installed capacity of 4.66 million kilowatts. In Cambodia, china huadian is the largest foreign power generation operator in Cambodia with an installed capacity of 1.038 million kilowatts under construction.

　　RCEP has entered a new stage of full entry into force and implementation, constantly releasing the strategic potential of economy and trade. Zhou Shi, a researcher and deputy director of the Research Office of the Market and Price Research Institute of the National Development and Reform Commission, believes that the import and export of Hunan and ASEAN countries in China increased by more than 70% in the year when RCEP was implemented, and the import and export of Guangxi to ASEAN countries also increased by 71.6% from January to July this year.

　　In the face of the current complicated and changeable international situation, many exhibitors realized that China and ASEAN are opportunities for mutual development and have great potential for cooperation. China was the first big country to sign and join the Treaty of Amity and Cooperation in Southeast Asia. In 2021, China and ASEAN upgraded their bilateral relations to a comprehensive strategic partnership.

　　Jiangsu Furen Group’s booth area in the 20th China-ASEAN Expo was not large, but the personnel in charge of market, operation and technology all came to the scene in order to better understand the ASEAN market and enterprises. In 2014, Jiangsu Furen Group held Jiangsu Xuzhou Forging Machine Group Co., Ltd., and two years later, it successfully acquired German EBU Forming Technology Co., Ltd. "This also marks that China Press has begun to rank among the world’s advanced manufacturing." Li Wei, deputy general manager of Xuforging Group, said that due to the rapid development of Thailand’s automobile industry in recent years, many internationally renowned automobile companies have invested and built factories in Thailand, and the export of intelligent forging equipment of Xuforging Group to Thailand has also increased by 20%-30%.

　　"The ASEAN market is becoming a new strategic growth point, especially in terms of labor structure, operating costs and market potential. The implementation of RCEP has also provided us with a stable and efficient supply chain network." Li Wei is full of expectations for the development of enterprises in the ASEAN market and the prospect of international cooperation. "We will also continue to enhance the technological breakthrough capability of intelligent manufacturing and better go abroad." (Zhongqing Daily Zhongqing Net Trainee Reporter Wang Junli Reporter Xie Yang Intern Zheng Quan)

　　On April 25th, 2024, the 18th auto china will officially open in Shunyi Pavilion of China International Exhibition Center. At that time, BYD will land at booth W106 in Hall W1, in which the lineup of Ocean Network will be exposed, and a number of brand-new models, such as Seal 06DM-i, Sea Lion 07EV and concept car OCEAN-M, will be unveiled hand in hand.

　　The new medium-sized car, Seal 06DM-i will be equipped with the latest technology.

　　Seal 06DM-i is a brand-new medium-sized car under BYD Ocean Network, which is positioned between destroyer 05 and seal DM-i.. It is reported that Seal 06DM-i will be equipped with BYD’s latest technology, and the chassis quality and safety control will be greatly improved. The sword refers to the joint venture fuel medium-sized car market.

　　Seal 06DM-i continues the marine aesthetic design, with a body size of 4830*1875*1495mm and a wheelbase of 2790mm, reaching the level of mainstream medium-sized cars; In terms of power, Seal 06DM-i will adopt a 1.5L engine and provide 120kW and 160kW motors.

　　Ocean Net’s first medium-sized pure electric SUV, Sea Lion 07EV is equipped with "Eye of God" high-order intelligent driving.

　　BYD Haishi 07EV is positioned as a "medium-sized urban smart electric SUV", which is based on BYD’s latest pure electric platform technology. It is the first medium-sized pure electric SUV of Ocean Net and the first model of Ocean Net’s brand-new Haishi IP. Sea lion 07EV combines the latest pure electric platform technology and forward-looking aesthetic thought, and integrates face value, safety, comfort, intelligence, performance and efficiency. At the same time, based on the advanced electronic and electrical architecture, Sea Lion 07EV adopts the advanced version of intelligent cockpit -DiLink 100 and the advanced intelligent driving assistance system of Eye of God -DiPilot 100, which brings users a full-scale intelligent travel experience.

　　BYD Sea Lion 07EV will further expand the product matrix of Ocean Net, strengthen the layout of Ocean Net in the field of high-value products, and meet the yearning and pursuit of more young consumers for high-quality driving life.

　　The industry’s first hatchback rear-drive pure electric steel gun, the world’s first show of OCEAN-M concept car.

　　The brand-new concept car OCEAN-M will also make its world debut. As the first rear-drive pure electric steel gun model in the industry, it has a brand-new advanced aesthetic design and is equipped with a brand-new pure electric platform. It is another masterpiece of BYD Ocean, which focuses on the promotion and popularization of new energy vehicles, and deserves continuous attention.

　　Summary:

　　BYD Ocean Network brought a number of brand-new models to the Beijing Auto Show. Seal 06DM-i and Sea Lion 07EV will form a brand-new "Gemini", which will empower new experiences with the latest technology and become the most anticipated new energy vehicle at this Beijing Auto Show. OCEAN-M concept car will show the future charm of Ocean Network with the posture of seeing the future now. On April 25th, auto china BYD booth, let’s pay attention together!

　　In 2018, a realistic Dying to Survive hit a 3.1 billion summer box office champion. While countless people are sighing and moving, how to make the "sky-high life-saving medicine" accessible to ordinary patients has become a topic of general public concern.

　　The leukemia drug in this film — — Gleevec (imatinib mesylate) is a microcosm of high-priced drugs. This drug developed by Novartis Pharmaceutical entered China in early 2004, and the price of the original drug was as high as.23,500 yuan(120 tablets/box).

　　According to the first financial reporter, in the past decade, more and more manufacturers have entered the market of leukemia treatment drugs, making the price of this "life-saving medicine" drop again and again.

　　According to the data of CHIS kaisi system of Zhongkang Technology, the retail terminal price of Gleevec has been declining in the past three years, and the retail market price in 2022 will be6449.32 yuan. The reporter saw on an e-commerce platform on July 22 that the price of Gleevec’s original drug was mostly1700 yuan ~1800 yuanBetween

　　With the approval of more and more domestic generic drugs, the lowest price of domestic imatinib mesylate tablets has dropped to.144 yuan/boxIt is about 1.2% of the original price of the drug. At present, the sales price of Gleevec on the e-commerce platform is more than 1,700 yuan, which is nearly 90% lower than when Novartis first entered the China market.

　　The price of "life-saving medicine" continues to drop.

　　On July 19th, Hubei Provincial Medical Insurance Bureau posted a Notice on Publicizing the Information about the First to Fifth Batch of Non-selected Varieties in Centralized Drug Purchase by the State Organization, which stated that the first to fifth batches of centralized drug purchase by the State Organization had been carried out with the non-selected varieties under the generic name over-evaluated, the online price adjusted, the online suspension and the handling of complaints. On this basis, the medical insurance payment standard and other related work were drawn up, and a list of non-selected varieties to be online was formed. The publicity date of this list is from July 19 to July 23, 2023.

　　The online price of drugs refers to the published price of drugs on the centralized procurement platform of medical equipment in Hubei Province for the procurement of public medical institutions in the province. According to the regulations, all public medical institutions in Wuhan must purchase the drugs that have been hung on the net through the provincial centralized procurement platform for medical equipment when implementing the online procurement policy, and must not purchase from offline and other non-prescribed channels. The price of drugs hanging on the net is the highest price limit of public medical institutions in the city.

　　The list of the first batch of non-selected varieties to be hung on the net shows that there are6 imatinib mesylateAmong them, in addition to the original research drug Novartis Pharmaceutical, there are also five models, namely Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical, Chongqing Yaoyou and Sinopharm Yixin, all of which have been evaluated.

　　In terms of price, the highest hanging net is still Gleevec.7182 yuan. Zhengda Tianqing, Jiangsu Haosen, Qilu Pharmaceutical and Sinopharm are all interested in imatinib mesylate. The online price is only.More than 500Yuan.

　　Even if the net price is 7,182 yuan, the price of the original drug Gleevec has dropped by nearly 40% compared with 23,500 yuan (120 tablets/box) when it first entered the China market.

　　According to the data of CHIS kaisi system of Zhongkang Technology, although the price of Gleevec in the hospital has remained at around 7182 yuan in the past three years, the price of retail terminals has been declining. In 2022, the retail market price will be6449.32 yuan.

　　The reporter’s search for "imatinib mesylate" on an e-commerce platform shows that the price of Gleevec’s original drug is only 0.1g*60 tablets/box as the standard in most pharmacies.1700 yuan ~1800 yuanBetween, and the price of domestic medicine is in500 yuanAbout. For example, the price of Xinwei tablets in Jiangsu Haosen is 430 yuan, the price of Genico capsules in Zhengda Tianqing is 441.88 yuan, and the lowest price is Shengdika tablets produced by Chongqing Shenghuaxi Pharmaceutical Co., Ltd., with an estimated hand price of 144 yuan.

　　nineDomestic companies were approved for production.

　　More and more cheap domestic "life-saving drugs" appeared, which was related to the end of the protection period of the compound patent of imatinib in China in April 2013, and domestic generic drugs began to be produced and listed.

　　From June 2013 to October 2014, three domestic generic drugs of Jiangsu Haosen, Zhengda Tianqing and Shiyao Ouyi obtained production approval. Because the efficacy of generic drugs has not been verified, the original drug of Novartis, Gleevec, still occupied most of the market. According to public data, in 2016, imatinib mesylate tablets sold more than 4 billion US dollars worldwide.

　　The competitiveness of domestic drugs began to improve after 2018. From 2018 to 2020, the above three drugs passed the consistency evaluation successively. On July 5, 2018, Jiangsu Haosen Pharmaceutical Co., Ltd. said that it had received the Approval Document for Supplementary Application of Imatinib, a chemical drug approved and issued by National Medical Products Administration, and the National Drug Testing Center recommended that it pass the consistency evaluation, making it the first enterprise to pass the consistency evaluation of this drug.

　　Overevaluation means that drugs have reached the passing line in quality and efficacy, and generic drugs have become more competitive. In September 2018, Hansen Pharmaceutical (Haosen Pharmaceutical) disclosed the prospectus for listing in Hong Kong, showing that the sales revenue of the core product imatinib mesylate in 2017 was RMB 2.5 billion, up by 7.3% since 2016, and up to June 30, 2018, up by 34.5% compared with the same period of last year.

　　With the entry of imatinib mesylate tablets into the medical insurance catalogue in 2017, more manufacturers entered this field. National Medical Products Administration website shows that the domestic imatinib mesylateNine manufacturers have been approved.Unacon Ouyi Pharmaceutical, Zhengda Tianqing, Qilu Pharmaceutical, Shenzhen Xinlitai Pharmaceutical, Chongqing Yaoyou Pharmaceutical, Lianyungang Runzhong Pharmaceutical, Shanghai Nuochuang Pharmaceutical, Fujian Nanfang Pharmaceutical and Chongqing Shenghuaxi Pharmaceutical, among which Shanghai Nuochuang Pharmaceutical and Fujian Nanfang Pharmaceutical successivelyMay and June this yearJust approved.

　　What followed was that prices kept falling.

　　In 2018, imatinib mesylate tablets of Jiangsu Haosen Pharmaceutical Co., Ltd. won the bid in four municipalities directly under the Central Government, including Beijing, Tianjin, Shanghai and Chongqing, and 11 cities (referred to as "4+7" cities) including Shenyang, Guangzhou, Chengdu and Xi ‘an, with the winning price of 623.82 yuan per box. In 2019, the "4+7" procurement expanded, and Zhengda Tianqing won the bid at a price of 586.39 yuan, further reducing the price of this drug.

　　In August, 2022, Shanghai issued a price adjustment notice, and the adjusted purchase price of imatinib mesylate tablets produced by Shiyao Ouyi has dropped to 180 yuan/box.

　　The lower price of domestic drugs also impacts the price of original drugs.

　　In 2018, the joint bargaining of imported anticancer drugs in 14 provinces including Shaanxi was completed, and 47 anticancer drugs including Gleevec were successfully negotiated. According to the announcement, the bargaining result of Gleevec’s specification of 0.1g*60 tablets was 9998 yuan.

　　In 2019, according to the previous report of CBN, the price of the original drug Gleevec in Shanghai has dropped to 7182 yuan/box, which is about 30% lower than the market price of around 11,000 yuan at that time.

　　New progress

　　It is worth mentioning that with the increase of drug resistance caused by long-term medication, Gleevec’s R&D iteration has also attracted much attention.

　　The second and third generation BCR-ABL inhibitors have been developed in order to solve the drug resistance problem and improve the safety. Dashatinib from Bristol-Myers Squibb and Nilotinib from Novartis were introduced one after another, which made the second generation BCR-ABL inhibitors gradually occupy an important position in the first-line and second-line treatment of chronic myeloid leukemia. However, the problem of drug resistance still exists during the use of the second generation BCR-ABL inhibitors.

　　In November, 2021, Nilik, known as the "third generation Gleevec" made in China, was approved for marketing in National Medical Products Administration, China, and was used to treat adult patients who were resistant to any tyrosine kinase inhibitor (TKI) and were diagnosed as chronic myeloid leukemia (CML) with T315I mutation in chronic phase (CP) or accelerated phase (AP) by fully verified detection methods.

　　This year, on July 6th, Yasheng Medical Officer Wei announced that Nilik had obtained the clinical trial permission from National Medical Products Administration Drug Evaluation Center, and would carry out a key registered phase III clinical trial of combined chemotherapy compared with imatinib combined chemotherapy in the treatment of newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (referred to as "Ph+ALL").

　　At the end of 2022, Novartis decided not to be responsible for the sales promotion of Gleevec in China.

　　The official micro-display of Sinopharm Holdings shows that from January 1, 2023, Sinopharm Holdings officially obtained the commercial promotion right of Novartis Gleevec in China market. Xie Jiong, director of the Drug Shield Public Welfare Fund, said in an interview with the media that for many drugs, it is necessary to adjust the inherent marketing model after a certain development cycle, so as to drive the second peak of sales. This will not only prolong the life cycle of drug sales, but also greatly enhance the accessibility of drugs and benefit a wider range of patients.

　　Our reporter Lin Zhiyin also contributed to this article.

CCTV News:The Paris Olympic Games is in full swing, and the spirit of Olympic athletes’ tenacious struggle and self-breakthrough in the Olympic Games is inspiring. The TV programs of the Paris Olympic Games of the Central Radio and Television General Station were broadcast live in more than 800 cinemas across the country, attracting many viewers to watch the games.

On the evening of August 4th, Beijing time, the men’s singles table tennis final of the Paris Olympic Games began, and China’s Fan Zhendong played against Sweden. In a movie theater on BeijingRoad, Guangzhou, the audience cheered for China’s Fan Zhendong.

There is a strong atmosphere in the cinema to watch the Olympic Games. When the games enter a stalemate, the audience hold their breath and say hello. When the China athletes scored a point, the audience cheered loudly and waved flags to cheer.

In the end, Fan Zhendong won 4-1, winning the third gold medal for the China table tennis team. When the national flag was raised and the national anthem was played, all the audience in the cinema stood up and sang the national anthem, and their hearts surged.

Watching the Olympics in cinemas: covering more than 800 cinemas in Beijing, Shanghai, Shenzhen and Chengdu.

"Watching the Olympics in the cinema" is the first time in China to broadcast the Olympic Games live on the cinema screen. At the same time, the Olympic Games were broadcast on the main station "100 cities and 1000 screens". The audience felt the fighting style of Olympic athletes in the diverse scenes between domestic cinemas and urban streets.

The film list of the live broadcast of "Watching the Olympics in the Cinema" was attended by the China team and at 18: 00 Beijing time — The popular games that started at 21: 00 are mainly, covering more than 800 cinemas in Beijing, Shanghai, Shenzhen, Chengdu and other cities. Among them, table tennis, badminton, women’s volleyball and other traditional advantage events of China delegation were welcomed by the audience.

The introduction of the Olympic Games into cinemas not only provides a new channel for the masses to watch the Paris Olympic Games, but also builds a new platform for the audience to appreciate the elegance of China athletes, feel the spirit of sports and unite national feelings.

In addition, this year’s Paris Olympic Games brought a brand-new watching experience to the national audience with the help of the general station "100 cities and 1000 screens". Through 1075 ultra-high-definition large screens of diversified scenes such as core business districts, city squares and transportation hubs in 112 cities including Tianjin, Shanghai, Fujian and Sichuan, the contents of 8k ultra-high-definition Olympic Games will be continuously broadcast, so that urban audiences can share the wonderful moments of this sports feast.

Today, I took the time to go to the 4S shop and test drive the two-wheel drive version. To tell the truth, after reading so many photos online, it’s better to actually experience the real car.

The appearance of this car is very charming, the front face is full, the silver logo is added, and there are quite a few decorative strips on the wheel hub cover, which is a high-end feeling as a whole.

The interior workmanship can be felt very fine. In addition to the leather bag near the door and the central control, the roof is also wrapped with suede material, which is very comfortable to the touch. The triple screen and head-up display are also very easy to use. Let’s sum up the space in one sentence. People and things are enough.

At present, I have visited several 4S stores, and the prices are different. If you buy a car, I suggest shopping around more. At present, the price is calculated. The most expensive loan is 16w, and the cheapest loan is 14.9w I am going to grind it again and book one at the full price. # China Star Let the World See Dongfang Yao # Geely Automobile #L # Xingyue L Dongfang Yao # Good Car Recommendation # Test Drive